WO2009026086A3 - Medical devices having sol-gel derived ceramic regions with molded submicron surface features - Google Patents

Medical devices having sol-gel derived ceramic regions with molded submicron surface features Download PDF

Info

Publication number
WO2009026086A3
WO2009026086A3 PCT/US2008/073109 US2008073109W WO2009026086A3 WO 2009026086 A3 WO2009026086 A3 WO 2009026086A3 US 2008073109 W US2008073109 W US 2008073109W WO 2009026086 A3 WO2009026086 A3 WO 2009026086A3
Authority
WO
WIPO (PCT)
Prior art keywords
molded
sol
medical devices
surface features
gel derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/073109
Other languages
French (fr)
Other versions
WO2009026086A2 (en
Inventor
Jan Weber
Liliana Atanasoska
Michele Zoromski
Robert W. Warner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Scimed Life Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scimed Life Systems Inc filed Critical Scimed Life Systems Inc
Priority to JP2010521169A priority Critical patent/JP2010536431A/en
Priority to EP08827976A priority patent/EP2190491B1/en
Publication of WO2009026086A2 publication Critical patent/WO2009026086A2/en
Anticipated expiration legal-status Critical
Publication of WO2009026086A3 publication Critical patent/WO2009026086A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/10—Inorganic materials
    • A61L29/106—Inorganic materials other than carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

According to one aspect of the present invention, implantable or insertable medical devices are provided, which contain sol-gel derived ceramic regions which have molded submicron surface features.
PCT/US2008/073109 2007-08-17 2008-08-14 Medical devices having sol-gel derived ceramic regions with molded submicron surface features Ceased WO2009026086A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2010521169A JP2010536431A (en) 2007-08-17 2008-08-14 Medical device having a sol-gel ceramic region with molded submicron surface features
EP08827976A EP2190491B1 (en) 2007-08-17 2008-08-14 Process for the manufacture of medical devices having sol-gel derived ceramic regions with molded submicron surface features

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/893,849 2007-08-17
US11/893,849 US20090048659A1 (en) 2007-08-17 2007-08-17 Medical devices having sol-gel derived ceramic regions with molded submicron surface features

Publications (2)

Publication Number Publication Date
WO2009026086A2 WO2009026086A2 (en) 2009-02-26
WO2009026086A3 true WO2009026086A3 (en) 2010-03-11

Family

ID=39768788

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/073109 Ceased WO2009026086A2 (en) 2007-08-17 2008-08-14 Medical devices having sol-gel derived ceramic regions with molded submicron surface features

Country Status (4)

Country Link
US (1) US20090048659A1 (en)
EP (1) EP2190491B1 (en)
JP (1) JP2010536431A (en)
WO (1) WO2009026086A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250058B1 (en) * 2000-03-24 2007-07-31 Abbott Cardiovascular Systems Inc. Radiopaque intraluminal stent
EP1922052B1 (en) * 2005-08-08 2010-11-03 Angstrom Medica, Inc. Cement products and methods of making and using the same
JP2010500917A (en) 2006-06-15 2010-01-14 マイクロベンション， インコーポレイテッド Embolization device composed of expandable polymer
AU2008345590B2 (en) 2007-12-21 2014-10-30 Microvention, Inc. Hydrogel filaments for biomedical uses
US8298466B1 (en) 2008-06-27 2012-10-30 Abbott Cardiovascular Systems Inc. Method for fabricating medical devices with porous polymeric structures
US8389083B2 (en) * 2008-10-17 2013-03-05 Boston Scientific Scimed, Inc. Polymer coatings with catalyst for medical devices
DE102009005031A1 (en) * 2009-01-17 2010-07-22 Deutsches Zentrum für Luft- und Raumfahrt e.V. Isoelastic, biocompatible implant materials
BRPI1014645B1 (en) 2009-04-30 2020-07-07 Technip France method and system for sharing mooring lines
CN102791183B (en) 2009-10-26 2015-07-08 微排放器公司 Embolization device constructed from expansile polymer
US9566147B2 (en) 2010-11-17 2017-02-14 Abbott Cardiovascular Systems, Inc. Radiopaque intraluminal stents comprising cobalt-based alloys containing one or more platinum group metals, refractory metals, or combinations thereof
US11298251B2 (en) 2010-11-17 2022-04-12 Abbott Cardiovascular Systems, Inc. Radiopaque intraluminal stents comprising cobalt-based alloys with primarily single-phase supersaturated tungsten content
EP2648791A1 (en) * 2010-12-08 2013-10-16 Boston Scientific Scimed, Inc. Drug eluting balloons with ability for double treatment
US9456823B2 (en) 2011-04-18 2016-10-04 Terumo Corporation Embolic devices
US9724494B2 (en) 2011-06-29 2017-08-08 Abbott Cardiovascular Systems, Inc. Guide wire device including a solderable linear elastic nickel-titanium distal end section and methods of preparation therefor
US8841412B2 (en) 2011-08-11 2014-09-23 Abbott Cardiovascular Systems Inc. Controlling moisture in and plasticization of bioresorbable polymer for melt processing
WO2013050525A1 (en) * 2011-10-07 2013-04-11 Materialise N.V. Methods for the manufacture of intraluminal endoprosthesis
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
AU2013274199B2 (en) 2012-06-14 2016-08-11 Microvention, Inc. Polymeric treatment compositions
JP6322890B2 (en) * 2013-02-18 2018-05-16 住友電気工業株式会社 Group III nitride composite substrate and method for manufacturing the same, and method for manufacturing group III nitride semiconductor device
WO2014057748A1 (en) 2012-10-12 2014-04-17 住友電気工業株式会社 Group iii nitride composite substrate, manufacturing method therefor, and group iii nitride semiconductor device manufacturing method
WO2014062696A1 (en) 2012-10-15 2014-04-24 Microvention, Inc. Polymeric treatment compositions
US9923063B2 (en) 2013-02-18 2018-03-20 Sumitomo Electric Industries, Ltd. Group III nitride composite substrate and method for manufacturing the same, laminated group III nitride composite substrate, and group III nitride semiconductor device and method for manufacturing the same
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
EP3137124B1 (en) 2014-04-29 2019-01-09 Microvention, Inc. Polymers including active agents
EP3040090B1 (en) * 2014-12-31 2019-05-29 Cook Medical Technologies LLC Medical devices and methods of making
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
KR101812024B1 (en) * 2016-06-10 2017-12-27 한국기계연구원 A Heating Wire and A PLANAR HEATING SHEET comprising THE SAME
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
JP7362598B2 (en) 2017-10-09 2023-10-17 マイクロベンション インコーポレイテッド radioactive liquid embolic material
US12151049B2 (en) 2019-10-14 2024-11-26 Abbott Cardiovascular Systems, Inc. Methods for manufacturing radiopaque intraluminal stents comprising cobalt-based alloys with supersaturated tungsten content

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709379B1 (en) * 1998-11-02 2004-03-23 Alcove Surfaces Gmbh Implant with cavities containing therapeutic agents
WO2005082277A1 (en) * 2004-02-18 2005-09-09 Stanford University Drug delivery systems using mesoporous oxide films
US20060199876A1 (en) * 2005-03-04 2006-09-07 The University Of British Columbia Bioceramic composite coatings and process for making same
EP1891988A1 (en) * 2006-08-07 2008-02-27 Debiotech S.A. Anisotropic nanoporous coatings for medical implants

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6355198B1 (en) * 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
DE19731021A1 (en) * 1997-07-18 1999-01-21 Meyer Joerg In vivo degradable metallic implant
US7066234B2 (en) * 2001-04-25 2006-06-27 Alcove Surfaces Gmbh Stamping tool, casting mold and methods for structuring a surface of a work piece
NL1016779C2 (en) * 2000-12-02 2002-06-04 Cornelis Johannes Maria V Rijn Mold, method for manufacturing precision products with the aid of a mold, as well as precision products, in particular microsieves and membrane filters, manufactured with such a mold.
US20060142853A1 (en) * 2003-04-08 2006-06-29 Xingwu Wang Coated substrate assembly
US20060129215A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060125144A1 (en) * 2004-12-14 2006-06-15 Jan Weber Stent and stent manufacturing methods
US7935379B2 (en) * 2005-11-14 2011-05-03 Boston Scientific Scimed, Inc. Coated and imprinted medical devices and methods of making the same
US20080050415A1 (en) * 2006-08-25 2008-02-28 Boston Scientic Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
EP2114480B1 (en) * 2006-12-28 2016-01-06 Boston Scientific Limited Medical devices and methods of making the same
US8187255B2 (en) * 2007-02-02 2012-05-29 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US20090157172A1 (en) * 2007-07-24 2009-06-18 Boston Scientific Scrimed, Inc. Stents with polymer-free coatings for delivering a therapeutic agent
US7931683B2 (en) * 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US20090030504A1 (en) * 2007-07-27 2009-01-29 Boston Scientific Scimed, Inc. Medical devices comprising porous inorganic fibers for the release of therapeutic agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6709379B1 (en) * 1998-11-02 2004-03-23 Alcove Surfaces Gmbh Implant with cavities containing therapeutic agents
WO2005082277A1 (en) * 2004-02-18 2005-09-09 Stanford University Drug delivery systems using mesoporous oxide films
US20060199876A1 (en) * 2005-03-04 2006-09-07 The University Of British Columbia Bioceramic composite coatings and process for making same
EP1891988A1 (en) * 2006-08-07 2008-02-27 Debiotech S.A. Anisotropic nanoporous coatings for medical implants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YIM E K F ET AL: "Significance of synthetic nanostructures in dictating cellular response", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE, ELSEVIER, NL, vol. 1, no. 1, 1 March 2005 (2005-03-01), pages 10 - 21, XP025360155, ISSN: 1549-9634, [retrieved on 20050301] *

Also Published As

Publication number Publication date
JP2010536431A (en) 2010-12-02
EP2190491B1 (en) 2012-08-08
US20090048659A1 (en) 2009-02-19
EP2190491A2 (en) 2010-06-02
WO2009026086A2 (en) 2009-02-26

Similar Documents

Publication Publication Date Title
WO2009026086A3 (en) Medical devices having sol-gel derived ceramic regions with molded submicron surface features
USD617825S1 (en) Pair of through-the-lens medical/dental loupes
USD592692S1 (en) Through-the-lens medical/dental loupes
USD592691S1 (en) Through-the-lens medical/dental loupes
USD653344S1 (en) Dental implant
WO2010019645A3 (en) Medical devices having electrodeposited conductive polymer coatings
WO2009018037A3 (en) Medical devices comprising porous inorganic fibers for the release of therapeutic agents
WO2008121508A3 (en) Implantable medical devices fabricated from block copolymers
MX2009008347A (en) Oxabicycloheptanes and oxabicycloheptenes, their preparation and use.
WO2008124660A3 (en) Methods and compositions for the treatment of cancer
WO2008137235A3 (en) Implantable medical devices fabricated from polymers with radiopaque groups
WO2009129246A3 (en) Compositions and methods for preparing and using same
BRPI0811853A2 (en) One-piece ceramic dental implant.
WO2007112020A3 (en) Medical devices having polymer brushes
WO2009033082A3 (en) Medical devices containing silicate and carbon particles
WO2008088507A3 (en) Blood-contacting medical devices for the release of nitric oxide and anti-restenotic agents
WO2008097619A3 (en) Variant buttiauxella sp. phytases having altered properties
PL2086642T3 (en) Dnase for the treatment of male sub-fertility
WO2009132070A3 (en) Thiol-vinyl and thiol-yne systems for shape memory polymers
WO2010062396A3 (en) Virus like particle compositions and methods of use
WO2008154143A3 (en) Elastomeric copolymer coatings for implantable medical devices
WO2009099768A3 (en) Biodegradable coatings for implantable medical devices
WO2013055949A3 (en) Pyrazol-3-ones that activate pro-apoptotic bax
LT2252300T (en) Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis
WO2011134869A3 (en) Hydrophilic polyorganosiloxanes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08827976

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2010521169

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008827976

Country of ref document: EP