WO2009026427A3 - Liposome compositions for in vivo administration of boronic acid compounds - Google Patents

Liposome compositions for in vivo administration of boronic acid compounds Download PDF

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Publication number
WO2009026427A3
WO2009026427A3 PCT/US2008/073840 US2008073840W WO2009026427A3 WO 2009026427 A3 WO2009026427 A3 WO 2009026427A3 US 2008073840 W US2008073840 W US 2008073840W WO 2009026427 A3 WO2009026427 A3 WO 2009026427A3
Authority
WO
WIPO (PCT)
Prior art keywords
boronic acid
acid compounds
vivo administration
liposome compositions
acid compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/073840
Other languages
French (fr)
Other versions
WO2009026427A2 (en
Inventor
Yuanpeng Zhang
Anthony Huang
Bing Luo
Jinkang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to CN200880105576A priority Critical patent/CN101795671A/en
Priority to AU2008288917A priority patent/AU2008288917A1/en
Priority to EP08798353A priority patent/EP2190411A2/en
Priority to BRPI0815613 priority patent/BRPI0815613A2/en
Priority to CA2697042A priority patent/CA2697042A1/en
Priority to JP2010522020A priority patent/JP2010536874A/en
Priority to MX2010002100A priority patent/MX2010002100A/en
Priority to EA201070296A priority patent/EA201070296A1/en
Publication of WO2009026427A2 publication Critical patent/WO2009026427A2/en
Publication of WO2009026427A3 publication Critical patent/WO2009026427A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Liposome formulations for administration of a boronic acid compound are described. The liposomes are comprised of a phospholipid having two acyl chains with between 20-22 carbon atoms in each chain and a boronic acid compound entrapped in the liposomes. In a preferred embodiment, the boronic acid compound is in the form of a complex with meglumine.
PCT/US2008/073840 2007-08-21 2008-08-21 Liposome compositions for in vivo administration of boronic acid compounds Ceased WO2009026427A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN200880105576A CN101795671A (en) 2007-08-21 2008-08-21 Liposome compositions for in vivo administration of boronic acid compounds
AU2008288917A AU2008288917A1 (en) 2007-08-21 2008-08-21 Liposome compositions for in vivo administration of boronic acid compounds
EP08798353A EP2190411A2 (en) 2007-08-21 2008-08-21 Liposome compositions for in vivo administration of boronic acid compounds
BRPI0815613 BRPI0815613A2 (en) 2007-08-21 2008-08-21 Liposomal compositions for in vivo administration of boronic acid compounds.
CA2697042A CA2697042A1 (en) 2007-08-21 2008-08-21 Liposome compositions for in vivo administration of boronic acid compounds
JP2010522020A JP2010536874A (en) 2007-08-21 2008-08-21 Liposome composition for in vivo administration of boronic acid compounds
MX2010002100A MX2010002100A (en) 2007-08-21 2008-08-21 COMPOSITIONS OF LIPOSOMES FOR IN VIVO ADMINISTRATION OF BORONIC ACID COMPOUNDS.
EA201070296A EA201070296A1 (en) 2007-08-21 2008-08-21 LIPOSOMIC COMPOSITIONS FOR THE INTRODUCTION IN VIVO OF BORONIC ACID CONNECTIONS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95704507P 2007-08-21 2007-08-21
US60/957,045 2007-08-21

Publications (2)

Publication Number Publication Date
WO2009026427A2 WO2009026427A2 (en) 2009-02-26
WO2009026427A3 true WO2009026427A3 (en) 2009-09-24

Family

ID=39772942

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/073840 Ceased WO2009026427A2 (en) 2007-08-21 2008-08-21 Liposome compositions for in vivo administration of boronic acid compounds

Country Status (13)

Country Link
US (1) US20090092661A1 (en)
EP (1) EP2190411A2 (en)
JP (1) JP2010536874A (en)
KR (1) KR20100095507A (en)
CN (1) CN101795671A (en)
AU (1) AU2008288917A1 (en)
BR (1) BRPI0815613A2 (en)
CA (1) CA2697042A1 (en)
CO (1) CO6260056A2 (en)
EA (1) EA201070296A1 (en)
EC (1) ECSP109981A (en)
MX (1) MX2010002100A (en)
WO (1) WO2009026427A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010089768A2 (en) * 2009-01-09 2010-08-12 Sun Pharma Advanced Research Company Limited Pharmaceutical composition
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
EP2547333B1 (en) * 2010-03-18 2017-08-23 Innopharma, Inc. Stable bortezomib formulations
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
GB201020860D0 (en) * 2010-12-09 2011-01-26 Univ Wolverhampton Disulfiram formulation and uses thereof
WO2013086526A1 (en) * 2011-12-09 2013-06-13 The Regents Of The University Of California Liposomal drug encapsulation
EP2819673B1 (en) * 2012-03-02 2016-09-07 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions comprising boronic acid compounds
JP2015524411A (en) * 2012-07-18 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Liposome composition of epoxy ketone-based proteasome inhibitor
KR102554628B1 (en) * 2013-02-01 2023-07-12 존원 파마, 인코포레이티드 Remote loading of sparingly water-soluble drugs into liposomes
CN103142509B (en) * 2013-03-06 2018-01-02 石药集团中奇制药技术（石家庄）有限公司 A kind of injection bortezomib pharmaceutical composition
UA116380C2 (en) 2013-05-30 2018-03-12 Нанобіотікс Pharmaceutical composition, preparation and uses thereof
WO2015117136A1 (en) * 2014-02-03 2015-08-06 Ohio State Innovation Foundation Boronic acid esters and pharmaceutical formulations thereof
WO2016022549A1 (en) 2014-08-04 2016-02-11 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into lipid vesicles
TW201628656A (en) * 2014-11-25 2016-08-16 奈諾生技公司 Pharmaceutical composition, preparation and uses thereof
HUE056175T2 (en) 2014-11-25 2022-01-28 Curadigm Sas Pharmaceutical compositions, preparation and uses thereof
JP6836510B2 (en) 2014-11-25 2021-03-03 キュラディグム・エスアエスＣｕｒａｄｉｇｍ Ｓａｓ Pharmaceutical compositions combining at least two different nanoparticles and pharmaceutical compounds, their preparation and use
WO2016171446A1 (en) * 2015-04-20 2016-10-27 동아에스티 주식회사 Stabilized pharmaceutical preparation containing peptide boronic acid compound
US11096962B2 (en) 2015-05-28 2021-08-24 Nanobiotix Nanoparticles for use as a therapeutic vaccine
CN106265536B (en) * 2016-08-24 2019-01-11 江苏豪森药业集团有限公司 Bortezomib pharmaceutical composition and preparation method thereof
CN109045272A (en) * 2018-08-01 2018-12-21 厦门市壳聚糖生物科技有限公司 A kind of bortezomib phosphatide complexes and the preparation method and application thereof
CN112915094A (en) * 2021-03-26 2021-06-08 东南大学 Preparation method of bortezomib liposome preparation
CN119947708A (en) * 2022-09-30 2025-05-06 上海济昀生物科技有限公司 Liposome and its preparation method and application
WO2024067849A1 (en) * 2022-09-30 2024-04-04 上海济煜医药科技有限公司 Liposome pharmaceutical composition, preparation method therefor, and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661044A1 (en) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Drug-containing liposomes
WO2001085131A2 (en) * 2000-05-11 2001-11-15 Celator Technologies Inc. Lipid carrier compositions for improved drug retention
EP1466916A1 (en) * 2002-09-09 2004-10-13 Trigen Limited Peptide boronic acids useful in making salts thereof
WO2006052733A1 (en) * 2004-11-05 2006-05-18 Alza Corporation Liposomal formulation of bortezomib (ps-341)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0825852B1 (en) * 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
US7351427B2 (en) * 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0661044A1 (en) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Drug-containing liposomes
WO2001085131A2 (en) * 2000-05-11 2001-11-15 Celator Technologies Inc. Lipid carrier compositions for improved drug retention
EP1466916A1 (en) * 2002-09-09 2004-10-13 Trigen Limited Peptide boronic acids useful in making salts thereof
WO2006052733A1 (en) * 2004-11-05 2006-05-18 Alza Corporation Liposomal formulation of bortezomib (ps-341)

Also Published As

Publication number Publication date
CO6260056A2 (en) 2011-03-22
JP2010536874A (en) 2010-12-02
CA2697042A1 (en) 2009-02-26
AU2008288917A1 (en) 2009-02-26
EP2190411A2 (en) 2010-06-02
WO2009026427A2 (en) 2009-02-26
CN101795671A (en) 2010-08-04
ECSP109981A (en) 2010-04-30
EA201070296A1 (en) 2010-08-30
MX2010002100A (en) 2010-03-26
US20090092661A1 (en) 2009-04-09
KR20100095507A (en) 2010-08-31
BRPI0815613A2 (en) 2015-03-24

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