WO2009030483A3 - Calcium phosphate based delivery of growth and differentiation factors to compromised bone - Google Patents

Calcium phosphate based delivery of growth and differentiation factors to compromised bone Download PDF

Info

Publication number
WO2009030483A3
WO2009030483A3 PCT/EP2008/007248 EP2008007248W WO2009030483A3 WO 2009030483 A3 WO2009030483 A3 WO 2009030483A3 EP 2008007248 W EP2008007248 W EP 2008007248W WO 2009030483 A3 WO2009030483 A3 WO 2009030483A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth
differentiation factors
calcium phosphate
based delivery
phosphate based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/007248
Other languages
French (fr)
Other versions
WO2009030483A2 (en
Inventor
Rudolf A Venbrocks
Raimund W Kinne
Klaus D Jandt
Joerg Bossert
Peter Hortschansky
Klaus Schmuck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Biotech Jena GmbH
DePuy Biotech GmbH
Original Assignee
DePuy Biotech Jena GmbH
DePuy Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DePuy Biotech Jena GmbH, DePuy Biotech GmbH filed Critical DePuy Biotech Jena GmbH
Priority to EP08785830.4A priority Critical patent/EP2200537B1/en
Publication of WO2009030483A2 publication Critical patent/WO2009030483A2/en
Publication of WO2009030483A3 publication Critical patent/WO2009030483A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Composite Materials (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Resorbable calciumphosphate (CaP) based compositions comprising growth and differentiation factors (GDF) and their uses in bone regeneration and preventive treatment, in particular of osteoporotic bone, are disclosed.
PCT/EP2008/007248 2007-09-05 2008-09-05 Calcium phosphate based delivery of growth and differentiation factors to compromised bone Ceased WO2009030483A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08785830.4A EP2200537B1 (en) 2007-09-05 2008-09-05 Calcium phosphate based delivery of growth and differentiation factors to compromised bone

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US97025807P 2007-09-05 2007-09-05
US60/970,258 2007-09-05
US11/928,889 2007-10-30
US11/928,889 US20090061002A1 (en) 2007-09-05 2007-10-30 Calcium phospate based delivery of growth and differentiation factors to compromised bone
EP07022543A EP2033598A1 (en) 2007-09-05 2007-11-21 Calcium phosphate based delivery of growth and differentiation factors to compromised bone
EP07022543.8 2007-11-21

Publications (2)

Publication Number Publication Date
WO2009030483A2 WO2009030483A2 (en) 2009-03-12
WO2009030483A3 true WO2009030483A3 (en) 2009-04-23

Family

ID=39267908

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/007248 Ceased WO2009030483A2 (en) 2007-09-05 2008-09-05 Calcium phosphate based delivery of growth and differentiation factors to compromised bone

Country Status (3)

Country Link
US (1) US20090061002A1 (en)
EP (2) EP2033598A1 (en)
WO (1) WO2009030483A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8344106B1 (en) * 2011-08-03 2013-01-01 Robert den Hoed Collagen mixture and method of making the same
GB201122257D0 (en) * 2011-12-23 2012-02-01 Queen Mary & Westfield College A composition for making a cement or an implant
US11324806B2 (en) * 2018-10-19 2022-05-10 Warsaw Orthopedic, Inc. Sustained delivery of a growth differentiation factor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19647853A1 (en) * 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Compounds with improved cartilage and / or bone inducing activity
US20050170012A1 (en) * 2001-03-02 2005-08-04 Stryker Corporation Porous beta-tricalcium phosphate granules for regeneration of bone tissue
EP1604693A1 (en) * 2004-06-09 2005-12-14 Scil Technology GmbH In situ forming scaffold, its manufacturing and use

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE33161E (en) * 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
USRE33221E (en) * 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
US5962028A (en) * 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US5053212A (en) * 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US5129905A (en) * 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
JPH06509207A (en) 1991-07-09 1994-10-13 シーメンス アクチエンゲゼルシヤフト electromagnetic switching relay
ATE238417T1 (en) * 1991-11-04 2003-05-15 Inst Genetics Llc RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE
US6120760A (en) * 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
ZA936478B (en) 1992-09-03 1994-09-30 Regeneron Pharma Dorsal tissue affecting factor and compositions
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
WO1995018856A1 (en) 1993-12-30 1995-07-13 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing hedgehog-like proteins
ES2287635T3 (en) * 1994-01-26 2007-12-16 Kyphon Inc. IMPROVED FLAMMABLE DEVICE FOR USE IN SURGICAL METHODS RELATED TO BONE FIXATION.
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6117456A (en) * 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6458162B1 (en) * 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
ES2341641T3 (en) * 2000-07-21 2010-06-24 The Spineology Group, Llc AN EXPANSIBLE POROUS MESH BAG DEVICE AND ITS USE FOR OSEA SURGERY.
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
ATE303169T1 (en) * 2001-11-19 2005-09-15 Scil Technology Gmbh HOMOGENEOUSLY COATED DEVICE WITH OSTEOINDUCTIVE AND OSTEOCONDUCTIVE PROPERTIES
US20060182780A1 (en) * 2005-02-16 2006-08-17 Riley Susan L Resorbable hollow devices for implantation and delivery of therapeutic agents
US20060195115A1 (en) * 2005-02-23 2006-08-31 Ferree Bret A Method and apparatus for kyphoplasty

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19647853A1 (en) * 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Compounds with improved cartilage and / or bone inducing activity
US20050170012A1 (en) * 2001-03-02 2005-08-04 Stryker Corporation Porous beta-tricalcium phosphate granules for regeneration of bone tissue
EP1604693A1 (en) * 2004-06-09 2005-12-14 Scil Technology GmbH In situ forming scaffold, its manufacturing and use

Also Published As

Publication number Publication date
EP2200537B1 (en) 2015-11-11
EP2200537A2 (en) 2010-06-30
WO2009030483A2 (en) 2009-03-12
US20090061002A1 (en) 2009-03-05
EP2033598A1 (en) 2009-03-11

Similar Documents

Publication Publication Date Title
WO2010102266A8 (en) Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
WO2010003696A3 (en) Bone implant application
WO2010065784A3 (en) Methods, devices, and compositions for dermal filling
WO2008100384A3 (en) Activin-actriia antagonists and uses for promoting bone growth in cancer patients
WO2008019024A3 (en) Bone graft composites and methods of treating bone defects
WO2012134059A3 (en) Complex support body for regenerating bones and cartilage, method for manufacturing complex support body, and composition for treating bones and cartilage containing same as active ingredient
WO2008130989A3 (en) Prosthetic implants
WO2009092082A3 (en) Composite implants and methods of making and using the same
WO2008089466A3 (en) Fibrin gel for controlled release of tgf-beta and uses thereof
WO2010088213A3 (en) Self-clearing self-cutting implant
WO2009101503A3 (en) Use of natural active substances in cosmetic or therapeutic compositions
WO2006052451A3 (en) Implantable collagen compositions
WO2009100280A3 (en) 3-dimensional silk hydroxyapatite compositions
MX359402B (en) Nonaqueous compositions for bone hemostasis, and methods for their use and manufacture.
WO2008141308A3 (en) Gene expression and pain
EP4275618A3 (en) Fenestrated implant
WO2009120365A3 (en) Methods and compositions for the delivery of agents
WO2009123720A3 (en) Methods and compositions for medical articles produced from proteinaceous compounds
WO2010109226A3 (en) Scaffold
WO2009092094A3 (en) Method and device for repair of degenerative cartilage
HK1216085A1 (en) Cement-forming compositions, monetite cements, implants and methods for correcting bone defects
WO2012068376A3 (en) Keratin compositions for treatment of bone deficiency or injury
WO2008058233A3 (en) In vivo bioreactors and methods of making and using same
WO2011163398A3 (en) Biomimetic peptides for bone augmentation
WO2012129106A8 (en) Boron composite surface coatings and their application on implantable devices to accelerate osseous healing

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08785830

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008785830

Country of ref document: EP