WO2009031593A1 - シルセスキオキサンを含む造影剤 - Google Patents

シルセスキオキサンを含む造影剤 Download PDF

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Publication number
WO2009031593A1
WO2009031593A1 PCT/JP2008/065905 JP2008065905W WO2009031593A1 WO 2009031593 A1 WO2009031593 A1 WO 2009031593A1 JP 2008065905 W JP2008065905 W JP 2008065905W WO 2009031593 A1 WO2009031593 A1 WO 2009031593A1
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
formula
group
agent containing
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065905
Other languages
English (en)
French (fr)
Inventor
Yoshiki Chujo
Kazuo Tanaka
Kensuke Naka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto University NUC
Original Assignee
Kyoto University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto University NUC filed Critical Kyoto University NUC
Priority to EP08829487A priority Critical patent/EP2189167A4/en
Priority to US12/733,464 priority patent/US8299283B2/en
Priority to CA2698945A priority patent/CA2698945A1/en
Priority to JP2009531263A priority patent/JPWO2009031593A1/ja
Publication of WO2009031593A1 publication Critical patent/WO2009031593A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/21—Cyclic compounds having at least one ring containing silicon, but no carbon in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Silicon Polymers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

本発明は、１）造影能が高く、２）毒性が低く、且つ、３）簡便に製造できる造影剤を提供する。 一般式（Ｉ） [化１] ［式中、Ｒ１はＳｉと炭素で結合する基であり、一般式（ＩＩ） [化２] ［式中、ｐは１～５の整数を示し、ｑはそれぞれ同一又は異なって１～５の整数を示し、Ｒ２はそれぞれ同一又は異なって、水素原子、アルキル基、アラルキル基又はアシル基を示す。］ 或いは、一般式（ＩＩＩ） [化３] ［式中、ｐ、ｑ及びＲ２は前記に同じ。］ で表される基を末端に有する置換基であり、Ｒ１はそれぞれ同一又は異なっていてもよい。］ で表されるシルセスキオキサンを含む造影剤。
PCT/JP2008/065905 2007-09-03 2008-09-03 シルセスキオキサンを含む造影剤 Ceased WO2009031593A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08829487A EP2189167A4 (en) 2007-09-03 2008-09-03 CONTRASTANT WITH SILSESQUIOXAN
US12/733,464 US8299283B2 (en) 2007-09-03 2008-09-03 Contrast agent containing silsesquioxane
CA2698945A CA2698945A1 (en) 2007-09-03 2008-09-03 Contrast agent containing silsesquioxane
JP2009531263A JPWO2009031593A1 (ja) 2007-09-03 2008-09-03 シルセスキオキサンを含む造影剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-228382 2007-09-03
JP2007228382 2007-09-03

Publications (1)

Publication Number Publication Date
WO2009031593A1 true WO2009031593A1 (ja) 2009-03-12

Family

ID=40428907

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065905 Ceased WO2009031593A1 (ja) 2007-09-03 2008-09-03 シルセスキオキサンを含む造影剤

Country Status (5)

Country Link
US (1) US8299283B2 (ja)
EP (1) EP2189167A4 (ja)
JP (1) JPWO2009031593A1 (ja)
CA (1) CA2698945A1 (ja)
WO (1) WO2009031593A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL411196A1 (pl) * 2015-02-11 2015-11-09 Uniwersytet Im. Adama Mickiewicza W Poznaniu Nowe funkcjonalizowane nienasycone pochodne (dimetylowinylogermoksy) heptapodstawionych silseskwioksanów oraz sposób ich otrzymywania
CN114044907B (zh) * 2021-12-15 2022-11-11 兴宇汽车零部件股份有限公司 一种膨胀阻燃功能化poss阻燃剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006201711A (ja) * 2005-01-24 2006-08-03 Fuji Photo Film Co Ltd 感光性組成物、該感光性組成物に用いる化合物及び該感光性組成物を用いたパターン形成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU735018B2 (en) * 1997-03-18 2001-06-28 Toshihiro Akaike MRI contrast media recognizing microenvironmental changes
JP2000086538A (ja) 1998-09-17 2000-03-28 Toshihiro Akaike Ｍｒｉ用造影剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006201711A (ja) * 2005-01-24 2006-08-03 Fuji Photo Film Co Ltd 感光性組成物、該感光性組成物に用いる化合物及び該感光性組成物を用いたパターン形成方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FRANK J. FEHER, CHEM.COMMUN., vol. 3, 1998, pages 323 - 324, XP008131350 *
FRANK J. FEHER, J.CHEM.SOC.DALTON TRANS., vol. 9, 1999, pages 1491 - 1497, XP008131476 *
HONGZHI LIU, POLYMER, vol. 46, 2005, pages 157 - 165, XP004678194 *
KENSUAKE NAKA, LANGMUIR, vol. 23, no. 17, 14 August 2007 (2007-08-14), pages 9057 - 9063, XP008131349 *
See also references of EP2189167A4 *

Also Published As

Publication number Publication date
EP2189167A1 (en) 2010-05-26
US8299283B2 (en) 2012-10-30
US20100256404A1 (en) 2010-10-07
CA2698945A1 (en) 2009-03-12
JPWO2009031593A1 (ja) 2010-12-16
EP2189167A4 (en) 2012-08-01

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