WO2009036082A3 - Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use - Google Patents

Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use Download PDF

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Publication number
WO2009036082A3
WO2009036082A3 PCT/US2008/075883 US2008075883W WO2009036082A3 WO 2009036082 A3 WO2009036082 A3 WO 2009036082A3 US 2008075883 W US2008075883 W US 2008075883W WO 2009036082 A3 WO2009036082 A3 WO 2009036082A3
Authority
WO
WIPO (PCT)
Prior art keywords
combinations
methods
chemotherapeutic agents
inhibitor compounds
phosphoinositide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/075883
Other languages
French (fr)
Other versions
WO2009036082A2 (en
Inventor
Marcia Belvin
Lori Friedman
Klaus Hoeflich
Deepak Sampath
Ulka Vijapurkar
Jeffrey Wallin
Leisa Johnson
Mallika Singh
Sonal Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Genentech Inc
Original Assignee
F Hoffmann La Roche AG
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39942941&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009036082(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2010524965A priority Critical patent/JP5658565B2/en
Priority to AU2008298948A priority patent/AU2008298948B2/en
Priority to EP08799418.2A priority patent/EP2205242B1/en
Priority to ES08799418.2T priority patent/ES2537352T3/en
Priority to CN200880116412.4A priority patent/CN101939006B/en
Priority to MX2010002543A priority patent/MX338504B/en
Priority to CA2699202A priority patent/CA2699202C/en
Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Priority to RU2010112837/15A priority patent/RU2523890C2/en
Priority to HK10111710.4A priority patent/HK1145287B/en
Priority to BRPI0816769A priority patent/BRPI0816769A2/en
Publication of WO2009036082A2 publication Critical patent/WO2009036082A2/en
Publication of WO2009036082A3 publication Critical patent/WO2009036082A3/en
Priority to IL204333A priority patent/IL204333A/en
Anticipated expiration legal-status Critical
Priority to ZA2010/02475A priority patent/ZA201002475B/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Combinations of PI3K inhibitor compounds having Formulas (I) and (II) and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for treating hyperproliferative disorders such as cancer. Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
PCT/US2008/075883 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use Ceased WO2009036082A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
HK10111710.4A HK1145287B (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
RU2010112837/15A RU2523890C2 (en) 2007-09-12 2008-09-10 Combinations of inhibitors of phosphoinositide 3-kinase and chemiotherapeutic agents and methods of application
EP08799418.2A EP2205242B1 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
ES08799418.2T ES2537352T3 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods for their use
CN200880116412.4A CN101939006B (en) 2007-09-12 2008-09-10 Phosphoinositide 3-kinase inhibitor compounds is combined and using method with chemotherapeutics
MX2010002543A MX338504B (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use.
CA2699202A CA2699202C (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
JP2010524965A JP5658565B2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents and methods of use
BRPI0816769A BRPI0816769A2 (en) 2007-09-12 2008-09-10 combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
AU2008298948A AU2008298948B2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
IL204333A IL204333A (en) 2007-09-12 2010-03-07 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents
ZA2010/02475A ZA201002475B (en) 2007-09-12 2010-04-08 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents,and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97177307P 2007-09-12 2007-09-12
US60/971,773 2007-09-12

Publications (2)

Publication Number Publication Date
WO2009036082A2 WO2009036082A2 (en) 2009-03-19
WO2009036082A3 true WO2009036082A3 (en) 2009-11-19

Family

ID=39942941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/075883 Ceased WO2009036082A2 (en) 2007-09-12 2008-09-10 Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use

Country Status (18)

Country Link
US (3) US8247397B2 (en)
EP (1) EP2205242B1 (en)
JP (1) JP5658565B2 (en)
KR (1) KR101584823B1 (en)
CN (1) CN101939006B (en)
AR (1) AR068402A1 (en)
AU (1) AU2008298948B2 (en)
BR (1) BRPI0816769A2 (en)
CA (1) CA2699202C (en)
CL (1) CL2008002687A1 (en)
ES (1) ES2537352T3 (en)
IL (1) IL204333A (en)
MX (1) MX338504B (en)
PE (2) PE20140100A1 (en)
RU (1) RU2523890C2 (en)
TW (1) TWI471134B (en)
WO (1) WO2009036082A2 (en)
ZA (1) ZA201002475B (en)

Cited By (1)

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US11529350B2 (en) 2019-07-03 2022-12-20 Sumitomo Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof

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