WO2009038760A3 - Human gm-csf antigen binding proteins - Google Patents

Human gm-csf antigen binding proteins Download PDF

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Publication number
WO2009038760A3
WO2009038760A3 PCT/US2008/010888 US2008010888W WO2009038760A3 WO 2009038760 A3 WO2009038760 A3 WO 2009038760A3 US 2008010888 W US2008010888 W US 2008010888W WO 2009038760 A3 WO2009038760 A3 WO 2009038760A3
Authority
WO
WIPO (PCT)
Prior art keywords
antigen binding
csf
human
binding proteins
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/010888
Other languages
French (fr)
Other versions
WO2009038760A2 (en
Inventor
Jacqueline A Kirchner
Kenneth A Brasel
Kara Olson
Jose Carlos Escobar
Dauphine Barone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2008302747A priority Critical patent/AU2008302747B2/en
Priority to UAA201004467A priority patent/UA97414C2/en
Priority to KR1020107008307A priority patent/KR101274356B1/en
Priority to BRPI0817007 priority patent/BRPI0817007A2/en
Priority to MX2010002968A priority patent/MX2010002968A/en
Priority to JP2010525835A priority patent/JP2010538676A/en
Priority to NZ583787A priority patent/NZ583787A/en
Priority to CA2698667A priority patent/CA2698667C/en
Priority to CN200880116214A priority patent/CN101861336A/en
Priority to EP08832053A priority patent/EP2205636A2/en
Priority to US12/675,013 priority patent/US8268311B2/en
Priority to EA201000490A priority patent/EA201000490A1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of WO2009038760A2 publication Critical patent/WO2009038760A2/en
Publication of WO2009038760A3 publication Critical patent/WO2009038760A3/en
Anticipated expiration legal-status Critical
Priority to ZA2010/02160A priority patent/ZA201002160B/en
Priority to US13/589,935 priority patent/US8481704B2/en
Priority to US13/914,905 priority patent/US20130259799A1/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)

Abstract

Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit GM-CSF-induced activation of human monocytes.
PCT/US2008/010888 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins Ceased WO2009038760A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
UAA201004467A UA97414C2 (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins
KR1020107008307A KR101274356B1 (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins
BRPI0817007 BRPI0817007A2 (en) 2007-09-18 2008-09-18 Isolated antigen-binding protein, nucleic acid molecule, vector, host cell, methods for preparing antigen-binding protein, for treating or preventing a condition, for inhibiting granulocyte macrophage colony stimulating factor binding to the extracellular portion of granulocyte macrophage colony stimulating factor receptor, and to inhibit granulocyte macrophage colony stimulating factor activity, and, pharmaceutical composition
MX2010002968A MX2010002968A (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins.
JP2010525835A JP2010538676A (en) 2007-09-18 2008-09-18 Human GM-CSF antigen binding protein
NZ583787A NZ583787A (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins
CA2698667A CA2698667C (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins
EP08832053A EP2205636A2 (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins
CN200880116214A CN101861336A (en) 2007-09-18 2008-09-18 Human GM-CSF Antigen Binding Protein
AU2008302747A AU2008302747B2 (en) 2007-09-18 2008-09-18 Human GM-CSF antigen binding proteins
EA201000490A EA201000490A1 (en) 2007-09-18 2008-09-18 ANTIGEN-BINDING PROTEINS CONNECTING THE GM-CSF HUMAN PROTEIN
US12/675,013 US8268311B2 (en) 2007-09-18 2008-09-18 Human GM-CSF antigen binding proteins
ZA2010/02160A ZA201002160B (en) 2007-09-18 2010-03-26 Human gm-csf antigen binding proteins
US13/589,935 US8481704B2 (en) 2007-09-18 2012-08-20 Nucleic acid molecule encoding human GM-CSF antigen binding proteins
US13/914,905 US20130259799A1 (en) 2007-09-18 2013-06-11 Human gm-csf antigen binding proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99434307P 2007-09-18 2007-09-18
US60/994,343 2007-09-18
US8755108P 2008-08-08 2008-08-08
US61/087,551 2008-08-08

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/675,013 A-371-Of-International US8268311B2 (en) 2007-09-18 2008-09-18 Human GM-CSF antigen binding proteins
US13/589,935 Division US8481704B2 (en) 2007-09-18 2012-08-20 Nucleic acid molecule encoding human GM-CSF antigen binding proteins

Publications (2)

Publication Number Publication Date
WO2009038760A2 WO2009038760A2 (en) 2009-03-26
WO2009038760A3 true WO2009038760A3 (en) 2009-08-20

Family

ID=40210593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/010888 Ceased WO2009038760A2 (en) 2007-09-18 2008-09-18 Human gm-csf antigen binding proteins

Country Status (18)

Country Link
US (3) US8268311B2 (en)
EP (2) EP2236519A1 (en)
JP (1) JP2010538676A (en)
KR (1) KR101274356B1 (en)
CN (1) CN101861336A (en)
AR (1) AR066164A1 (en)
AU (1) AU2008302747B2 (en)
BR (1) BRPI0817007A2 (en)
CA (1) CA2698667C (en)
CL (1) CL2008002750A1 (en)
CR (1) CR11374A (en)
EA (1) EA201000490A1 (en)
MX (1) MX2010002968A (en)
NZ (1) NZ583787A (en)
PE (1) PE20091193A1 (en)
TW (1) TW200918553A (en)
WO (1) WO2009038760A2 (en)
ZA (1) ZA201002160B (en)

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