WO2009069418A1 - Appareil et procédé de mesure de la fluidité sanguine - Google Patents

Appareil et procédé de mesure de la fluidité sanguine Download PDF

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Publication number
WO2009069418A1
WO2009069418A1 PCT/JP2008/069529 JP2008069529W WO2009069418A1 WO 2009069418 A1 WO2009069418 A1 WO 2009069418A1 JP 2008069529 W JP2008069529 W JP 2008069529W WO 2009069418 A1 WO2009069418 A1 WO 2009069418A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
blood fluidity
fluidity measurement
deformability
measurement apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/069529
Other languages
English (en)
Japanese (ja)
Inventor
Shuji Ichitani
Osamu Toyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Konica Minolta Opto Inc
Original Assignee
Konica Minolta Opto Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Opto Inc filed Critical Konica Minolta Opto Inc
Priority to EP08853229.6A priority Critical patent/EP2216639A4/fr
Priority to JP2009543726A priority patent/JP5146463B2/ja
Priority to CN2008801176831A priority patent/CN101874201B/zh
Priority to US12/744,604 priority patent/US20100249621A1/en
Publication of WO2009069418A1 publication Critical patent/WO2009069418A1/fr
Anticipated expiration legal-status Critical
Priority to US14/568,972 priority patent/US20150098626A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
    • G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F3/00—Measuring the volume flow of fluids or fluent solid material wherein the fluid passes through the meter in successive and more or less isolated quantities, the meter being driven by the flow
    • G01F3/36—Measuring the volume flow of fluids or fluent solid material wherein the fluid passes through the meter in successive and more or less isolated quantities, the meter being driven by the flow with stationary measuring chambers having constant volume during measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/20—Analysis of motion
    • G06T7/215—Motion-based segmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1027—Determining speed or velocity of a particle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G01N2015/1495—Deformation of particles
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G06T2207/30104—Vascular flow; Blood flow; Perfusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Ecology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Multimedia (AREA)
  • Theoretical Computer Science (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La capacité de déformation des globules sanguins est quantifiée sur une courte période. Un appareil de mesure de la fluidité sanguine comprend une caméra (6) qui photographie le flux sanguin dans deux zones choisies dans la zone interne (A), la zone d'entrée (B), et la zone de sortie (C) d'une porte d'échantillonnage (30), une partie de traitement d'images (7) qui calcule la vitesse des globules sanguins contenus dans le sang à partir de l'image prise par la caméra (6), et des moyens (81) de calcul de la capacité de déformation qui calculent la capacité de déformation des globules sanguins telle que la fluidité du sang à partir de la vitesse.
PCT/JP2008/069529 2007-11-28 2008-10-28 Appareil et procédé de mesure de la fluidité sanguine Ceased WO2009069418A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08853229.6A EP2216639A4 (fr) 2007-11-28 2008-10-28 Appareil et procédé de mesure de la fluidité sanguine
JP2009543726A JP5146463B2 (ja) 2007-11-28 2008-10-28 血液流動性計測装置及び血液流動性計測方法
CN2008801176831A CN101874201B (zh) 2007-11-28 2008-10-28 血液流动性测量装置及血液流动性测量方法
US12/744,604 US20100249621A1 (en) 2007-11-28 2008-10-28 Blood fluidity measurement apparatus and blood fluidity measurement method
US14/568,972 US20150098626A1 (en) 2007-11-28 2014-12-12 Blood fluidity measurement apparatus and blood fluidity measurement method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007306975 2007-11-28
JP2007-306975 2007-11-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/744,604 A-371-Of-International US20100249621A1 (en) 2007-11-28 2008-10-28 Blood fluidity measurement apparatus and blood fluidity measurement method
US14/568,972 Division US20150098626A1 (en) 2007-11-28 2014-12-12 Blood fluidity measurement apparatus and blood fluidity measurement method

Publications (1)

Publication Number Publication Date
WO2009069418A1 true WO2009069418A1 (fr) 2009-06-04

Family

ID=40678321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069529 Ceased WO2009069418A1 (fr) 2007-11-28 2008-10-28 Appareil et procédé de mesure de la fluidité sanguine

Country Status (5)

Country Link
US (2) US20100249621A1 (fr)
EP (1) EP2216639A4 (fr)
JP (1) JP5146463B2 (fr)
CN (1) CN101874201B (fr)
WO (1) WO2009069418A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137470A1 (fr) * 2009-05-29 2010-12-02 コニカミノルタオプト株式会社 Dispositif de mesure de la déformabilité et méthode de mesure de la déformabilité
WO2012040067A3 (fr) * 2010-09-22 2012-05-31 The Regents Of The University Of California Procédé et dispositif pour des mesures à haut débit de déformabilité cellulaire
US9151705B2 (en) 2012-10-24 2015-10-06 The Regents Of The University Of California System and method for deforming and analyzing particles
US10252260B2 (en) 2016-04-01 2019-04-09 CytoVale Inc. System and method for deforming particles
US11123734B2 (en) 2019-07-31 2021-09-21 CytoVale Inc. System and method for immune activity determination
US11548003B1 (en) 2022-01-13 2023-01-10 CytoVale Inc. System and method for determining an immune activation state
US11592371B1 (en) 2022-01-13 2023-02-28 CytoVale Inc. System and method for determining an immune activation state
US11964281B2 (en) 2022-02-03 2024-04-23 CytoVale Inc. System and method for correcting patient index

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101577845B (zh) 2009-06-01 2012-11-14 中兴通讯股份有限公司 一种倒换控制命令处理的方法及装置
CN107058101B (zh) * 2011-10-17 2021-06-01 麻省理工学院 细胞内传递
CN102743165B (zh) * 2012-07-31 2013-11-20 刘常春 基于光电容积脉搏波的血液在体流动性测量装置
EP3033184B1 (fr) 2013-08-16 2021-03-31 Massachusetts Institute of Technology Administration sélective de matériau à des cellules
JP7523203B2 (ja) 2014-10-31 2024-07-26 マサチューセッツ インスティテュート オブ テクノロジー 生体分子の免疫細胞への送達
WO2016077761A1 (fr) 2014-11-14 2016-05-19 Massachusetts Institute Of Technology Acheminement de composés et de compositions dans des cellules activé par des perturbations et un champ
CN107250373A (zh) 2015-01-12 2017-10-13 麻省理工学院 通过微流体递送实现的基因编辑
SG10201912910PA (en) 2015-07-09 2020-02-27 Massachusetts Inst Technology Delivery of materials to anucleate cells
EP3344575B1 (fr) 2015-09-04 2020-04-15 SQZ Biotechnologies Company Administration intracellulaire de biomolécules à des cellules comprenant une paroi cellulaire
JP7602702B2 (ja) 2016-05-03 2024-12-19 ステムセル テクノロジーズ カナダ インコーポレーテッド 寛容性を誘導するための生体分子の細胞内送達
US12599656B2 (en) 2018-03-12 2026-04-14 Stemcell Technologies Canada Inc. Methods for treating HPV-associated diseases
CA3131701A1 (fr) 2019-02-28 2020-09-03 Sqz Biotechnologies Company Administration de biomolecules a des pbmc pour modifier une reponse immunitaire
US11679388B2 (en) 2019-04-08 2023-06-20 Sqz Biotechnologies Company Cartridge for use in a system for delivery of a payload into a cell
CN115146514B (zh) * 2022-07-31 2024-06-25 东南大学 一种模拟预测血流中血细胞流变行为的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02257931A (ja) 1988-12-24 1990-10-18 Hamamatsu Photonics Kk 血管内血流計測装置及び計測方法
JPH0618539A (ja) 1992-07-02 1994-01-25 Mitsubishi Kasei Corp 移動物体の速度検出方法および装置
JP2685544B2 (ja) 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
JP2001264318A (ja) 2000-03-15 2001-09-26 Japan Science & Technology Corp 白血球接着現象の解析装置及び解析方法
JP2005106778A (ja) * 2003-10-02 2005-04-21 Fuji Photo Film Co Ltd フィルターチップ及びそれを用いた細胞及び粒子の流れ特性観察方法
JP2006223761A (ja) 2005-02-21 2006-08-31 Minoru Tomita 生体構成要素速度測定装置、及びそのプログラム

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JPH02262057A (ja) * 1989-03-31 1990-10-24 Aloka Co Ltd 赤血球変形能測定装置
EP0517760A1 (fr) * 1990-02-24 1992-12-16 University Of Hertfordshire Mesure biorheologique
CN2081535U (zh) * 1990-12-28 1991-07-24 天津中医学院 红外多切变粘度测定仪
US5257529A (en) * 1990-12-28 1993-11-02 Nissho Corporation Method and device for measurement of viscosity of liquids
AU1570892A (en) * 1991-03-04 1992-10-06 Kensey Nash Corporation Apparatus and method for determining deformability of red blood cells of a living being
CN1192351A (zh) * 1998-03-26 1998-09-09 王明时 血粘度快速测量仪
JP4385049B2 (ja) * 2003-06-23 2009-12-16 セウォン メディテック インコーポレイテッド 血球変形性測定装置

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JP2685544B2 (ja) 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
JPH02257931A (ja) 1988-12-24 1990-10-18 Hamamatsu Photonics Kk 血管内血流計測装置及び計測方法
JPH0618539A (ja) 1992-07-02 1994-01-25 Mitsubishi Kasei Corp 移動物体の速度検出方法および装置
JP2001264318A (ja) 2000-03-15 2001-09-26 Japan Science & Technology Corp 白血球接着現象の解析装置及び解析方法
JP2005106778A (ja) * 2003-10-02 2005-04-21 Fuji Photo Film Co Ltd フィルターチップ及びそれを用いた細胞及び粒子の流れ特性観察方法
JP2006223761A (ja) 2005-02-21 2006-08-31 Minoru Tomita 生体構成要素速度測定装置、及びそのプログラム

Non-Patent Citations (3)

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Title
See also references of EP2216639A4
TSUTOMU TAJIKAWA ET AL.: "Micro-channel Array o Mochiita Mosaikekkanchu no Sekkekkyu no Kyodo to Henkeino ni Kansuru Seitaigai Jikken", THE VISUALIZATION SOCIETY OF JAPAN RONBUNSHU, vol. 25, no. 12, 2005, pages 84 - 91, XP008135842 *
TSUTOMU TAJIKAWA ET AL.: "Visualization and Observation of Deformation of Human Red Blood Cell Passing Through a Micro-channel Array as a Model of Human blood Capilary", TRANSACTION OF THE VISUALIZATION SOCIETY OF JAPAN, vol. 25, no. 12, December 2005 (2005-12-01), pages 84 - 91

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010137470A1 (fr) * 2009-05-29 2010-12-02 コニカミノルタオプト株式会社 Dispositif de mesure de la déformabilité et méthode de mesure de la déformabilité
WO2012040067A3 (fr) * 2010-09-22 2012-05-31 The Regents Of The University Of California Procédé et dispositif pour des mesures à haut débit de déformabilité cellulaire
US8935098B2 (en) 2010-09-22 2015-01-13 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US12546699B2 (en) 2010-09-22 2026-02-10 The Regents Of The University Of California Method for determining properties of flowing leukocytes
US12546700B2 (en) 2010-09-22 2026-02-10 The Regents Of The University Of California Method for testing leukocytes for a disease state
US11169078B2 (en) 2010-09-22 2021-11-09 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US9897532B2 (en) 2010-09-22 2018-02-20 The Regents Of The University Of California Method and device for high throughput cell deformability measurements
US10969327B2 (en) 2012-10-24 2021-04-06 The Regents Of The University Of California System and method for deforming and analyzing particles
US12007321B2 (en) 2012-10-24 2024-06-11 The Regents Of The University Of California System and method for deforming and analyzing particles
US10295455B2 (en) 2012-10-24 2019-05-21 The Regents Of The University Of California System and method for deforming and analyzing particles
US10107735B2 (en) 2012-10-24 2018-10-23 The Regents Of The University Of California System and method for deforming and analyzing particles
US9638620B2 (en) 2012-10-24 2017-05-02 The Regents Of The University Of California System for deforming and analyzing particles
US9151705B2 (en) 2012-10-24 2015-10-06 The Regents Of The University Of California System and method for deforming and analyzing particles
US9464977B2 (en) 2012-10-24 2016-10-11 The Regents Of The University Of California System and method for deforming, imaging and analyzing particles
US10252260B2 (en) 2016-04-01 2019-04-09 CytoVale Inc. System and method for deforming particles
US11123734B2 (en) 2019-07-31 2021-09-21 CytoVale Inc. System and method for immune activity determination
US11986824B2 (en) 2019-07-31 2024-05-21 CytoVale Inc. System and method for immune activity determination
US12478966B2 (en) 2019-07-31 2025-11-25 CytoVale Inc. System and method for immune activity determination
US12025542B2 (en) 2022-01-13 2024-07-02 CytoVale Inc. System and method for determining an immune activation state
US11592371B1 (en) 2022-01-13 2023-02-28 CytoVale Inc. System and method for determining an immune activation state
US11548003B1 (en) 2022-01-13 2023-01-10 CytoVale Inc. System and method for determining an immune activation state
US11964281B2 (en) 2022-02-03 2024-04-23 CytoVale Inc. System and method for correcting patient index
US12023675B2 (en) 2022-02-03 2024-07-02 CytoVale Inc. System and method for correcting patient index

Also Published As

Publication number Publication date
JP5146463B2 (ja) 2013-02-20
CN101874201A (zh) 2010-10-27
CN101874201B (zh) 2012-08-15
EP2216639A4 (fr) 2014-01-15
JPWO2009069418A1 (ja) 2011-04-07
EP2216639A1 (fr) 2010-08-11
US20150098626A1 (en) 2015-04-09
US20100249621A1 (en) 2010-09-30

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