WO2009074524A3 - Verfahren zur enzymatischen reduktion von alpha-dehydroaminosäuren unter verwendung von enoat dehydrogenasen - Google Patents

Verfahren zur enzymatischen reduktion von alpha-dehydroaminosäuren unter verwendung von enoat dehydrogenasen Download PDF

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Publication number
WO2009074524A3
WO2009074524A3 PCT/EP2008/066977 EP2008066977W WO2009074524A3 WO 2009074524 A3 WO2009074524 A3 WO 2009074524A3 EP 2008066977 W EP2008066977 W EP 2008066977W WO 2009074524 A3 WO2009074524 A3 WO 2009074524A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
beta
enzymatic reduction
dehydroamino acids
enoate reductases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/066977
Other languages
English (en)
French (fr)
Other versions
WO2009074524A2 (de
Inventor
Rainer STÜRMER
Bernhard Hauer
Thomas Friedrich
Kurt Faber
Melanie Hall
Peter Macheroux
Clemens STÜCKLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to CN2008801201710A priority Critical patent/CN101903528A/zh
Priority to US12/746,973 priority patent/US20100304448A1/en
Priority to EP08860523A priority patent/EP2229449A2/de
Priority to JP2010536486A priority patent/JP5992142B2/ja
Publication of WO2009074524A2 publication Critical patent/WO2009074524A2/de
Publication of WO2009074524A3 publication Critical patent/WO2009074524A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Verfahren zur enzymatischen Herstellung von Aminosäuren der allgemeinen Formel (3) oder (4) aus alpha-Dehydroaminosäuren der allgemeinen Formel (1) oder (2) wobei R1, R2 unabhängig voneinander für H, C1-C6- Alkyl, C2-C6-Alkenyl, einen gegebenenfalls substituierten carbo- oder heterocyclischen, aromatischen oder nichtaromatischen Rest oder einen Alkylaryrest, oder einen Carboxylrest ( - COOR) steht, R3 für H, Formyl, Acetyl, Propionyl, Benzyl, Benzyloxycarbonyl, BOC, Alloc steht, R für H, C1-C6- Alkyl, Aryl steht, durch Reduktion einer Verbindung der Formel (1) oder (2) in Gegenwart einer Reduktase.
PCT/EP2008/066977 2007-12-10 2008-12-08 Verfahren zur enzymatischen reduktion von alpha-dehydroaminosäuren unter verwendung von enoat dehydrogenasen Ceased WO2009074524A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2008801201710A CN101903528A (zh) 2007-12-10 2008-12-08 使用烯醇还原酶酶促还原α-和β-脱氢氨基酸的方法
US12/746,973 US20100304448A1 (en) 2007-12-10 2008-12-08 Method for the enzymatic reduction of alpha- and beta-dehydroamino acids using enoate reductases
EP08860523A EP2229449A2 (de) 2007-12-10 2008-12-08 Verfahren zur enzymatischen reduktion von alpha- und beta-dehydroaminosäuren
JP2010536486A JP5992142B2 (ja) 2007-12-10 2008-12-08 エノエートレダクターゼを用いるα−およびβ−デヒドロアミノ酸の酵素的還元法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07122758 2007-12-10
EP07122758.1 2007-12-10

Publications (2)

Publication Number Publication Date
WO2009074524A2 WO2009074524A2 (de) 2009-06-18
WO2009074524A3 true WO2009074524A3 (de) 2009-08-27

Family

ID=40638100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/066977 Ceased WO2009074524A2 (de) 2007-12-10 2008-12-08 Verfahren zur enzymatischen reduktion von alpha-dehydroaminosäuren unter verwendung von enoat dehydrogenasen

Country Status (5)

Country Link
US (1) US20100304448A1 (de)
EP (1) EP2229449A2 (de)
JP (1) JP5992142B2 (de)
CN (1) CN101903528A (de)
WO (1) WO2009074524A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2145904A1 (de) * 2008-07-18 2010-01-20 Basf Se Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern sowie dafür zu verwendende Esterasen
US20120070867A1 (en) 2009-06-04 2012-03-22 Basf Se process for the enzymatic reduction of enoates
EP2478098B1 (de) 2009-09-15 2017-03-15 Basf Se Herstellung von beta-aminosäuren
WO2011033039A1 (en) 2009-09-16 2011-03-24 Basf Se An enzymatically catalyzed method of preparing mono-acylated polyols
CN115232853A (zh) * 2022-09-05 2022-10-25 山东中京生物科技有限公司 一种酶法去除鹅去氧胆酸中22-ene-CDCA的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088106A2 (en) * 2000-11-17 2002-11-07 Medivir Ab Cysteine protease inhibitors
WO2008025831A1 (de) * 2006-09-01 2008-03-06 Basf Se Verfahren zur enzymatischen reduktion von alkinderivaten
WO2008058951A1 (de) * 2006-11-15 2008-05-22 Basf Se Verfahren zur enzymatischen reduktion von alkenderivaten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2398046A1 (fr) * 1977-07-18 1979-02-16 Inst Francais Du Petrole Synthese enzymatique de la l-carnitine
DE19931847A1 (de) * 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
JP4729919B2 (ja) * 2004-12-21 2011-07-20 三菱化学株式会社 微生物の培養方法及び光学活性カルボン酸の製造方法
JP2010040386A (ja) * 2008-08-06 2010-02-18 Toshiba Corp 携帯型電子機器

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088106A2 (en) * 2000-11-17 2002-11-07 Medivir Ab Cysteine protease inhibitors
WO2008025831A1 (de) * 2006-09-01 2008-03-06 Basf Se Verfahren zur enzymatischen reduktion von alkinderivaten
WO2008058951A1 (de) * 2006-11-15 2008-05-22 Basf Se Verfahren zur enzymatischen reduktion von alkenderivaten

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FITZPATRICK, T.B. ET AL.: "Characterization of YqjM, an Old Yellow Enzyme Homolog from Bacillus subtilis Involved in the Oxidative Stress Response", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 22, 2003, pages 19891 - 19897, XP002439308 *
HALL, M. ET AL.: "Asymmetric Bioreduction of Activated Alkenes Using Cloned 12-Oxophytodienoate Reductase Isoenzymes OPR-1 and OPR-3 from Lycopersicon esculentum (Tomato): A Striking Change of Stereoselectivity", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 46, no. 21, 18 May 2007 (2007-05-18), pages 3934 - 3937, XP002465483 *
NIINO, Y.S. ET AL.: "A New Old Yellow Enzyme of Saccharomyces cerevisiae", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 5, 1995, pages 1983 - 1991, XP002252406 *
STUERMER, R. ET AL.: "Asymmetric bioreduction of activated C=C bonds using enoate reductases from the old yellow enzyme family", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 11, no. 2, 5 April 2007 (2007-04-05), pages 203 - 213, XP022022266 *

Also Published As

Publication number Publication date
CN101903528A (zh) 2010-12-01
JP2011505799A (ja) 2011-03-03
US20100304448A1 (en) 2010-12-02
JP5992142B2 (ja) 2016-09-14
WO2009074524A2 (de) 2009-06-18
EP2229449A2 (de) 2010-09-22

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