WO2009098191A3 - Method to produce hyperpolarised amino acids and aminosulphonic acids - Google Patents

Method to produce hyperpolarised amino acids and aminosulphonic acids Download PDF

Info

Publication number
WO2009098191A3
WO2009098191A3 PCT/EP2009/051172 EP2009051172W WO2009098191A3 WO 2009098191 A3 WO2009098191 A3 WO 2009098191A3 EP 2009051172 W EP2009051172 W EP 2009051172W WO 2009098191 A3 WO2009098191 A3 WO 2009098191A3
Authority
WO
WIPO (PCT)
Prior art keywords
acids
aminosulphonic
amino
amino acids
hyperpolarised
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/051172
Other languages
French (fr)
Other versions
WO2009098191A2 (en
Inventor
Mathilde H. Lerche
Magnus Karlsson
Pernille R. Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Priority to CN2009801037778A priority Critical patent/CN101932340A/en
Priority to EP09707879A priority patent/EP2237802A2/en
Priority to JP2010544727A priority patent/JP2011514313A/en
Priority to US12/864,521 priority patent/US20110008261A1/en
Publication of WO2009098191A2 publication Critical patent/WO2009098191A2/en
Publication of WO2009098191A3 publication Critical patent/WO2009098191A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a dynamic nuclear polarisation (DNP) method for producing hyperpolarised amino acids and amino sulphonic acids and compositions for use in the method. As a sample, an ammonium salt of an amino acid, an ammonium salt of an aminosulphonic acid, a carboxylate salt of an amino acid, a sulphonate salt of an aminosulphonic acid or mixtures therof is used.
PCT/EP2009/051172 2008-02-04 2009-02-03 Method to produce hyperpolarised amino acids and aminosulphonic acids Ceased WO2009098191A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2009801037778A CN101932340A (en) 2008-02-04 2009-02-03 Process for producing hyperpolarized amino acids and sulfamic acids
EP09707879A EP2237802A2 (en) 2008-02-04 2009-02-03 Method to produce hyperpolarised amino acids and aminosulphonic acids
JP2010544727A JP2011514313A (en) 2008-02-04 2009-02-03 Method for producing hyperpolarized amino acid and aminosulfonic acid
US12/864,521 US20110008261A1 (en) 2008-02-04 2009-02-03 Method to produce hyperpolarised amino acids and aminosulphonic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08002001.9 2008-02-04
EP08002001 2008-02-04

Publications (2)

Publication Number Publication Date
WO2009098191A2 WO2009098191A2 (en) 2009-08-13
WO2009098191A3 true WO2009098191A3 (en) 2009-12-30

Family

ID=40436248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/051172 Ceased WO2009098191A2 (en) 2008-02-04 2009-02-03 Method to produce hyperpolarised amino acids and aminosulphonic acids

Country Status (5)

Country Link
US (1) US20110008261A1 (en)
EP (1) EP2237802A2 (en)
JP (1) JP2011514313A (en)
CN (1) CN101932340A (en)
WO (1) WO2009098191A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2348327B1 (en) * 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
EP2833924B1 (en) 2012-04-02 2019-05-08 Bracco Imaging S.p.A Hyperpolarized amino acids
US10408895B2 (en) * 2013-03-15 2019-09-10 Bruker Biospin Corporation Polarization sample geometry
US9606200B2 (en) * 2013-08-27 2017-03-28 Bruker Biospin Corporation Sample-preparation method to manipulate nuclear spin-relaxation times, including to facilitate ultralow temperature hyperpolarization
WO2015040877A1 (en) * 2013-09-20 2015-03-26 国立大学法人九州大学 Nuclear magnetic resonance molecular sensor
US10088536B2 (en) * 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (en) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт New gadolinium chelate compounds with high relaxivity for use in magnetic resonance imaging
IL321215B2 (en) 2018-11-23 2026-05-01 Bayer Ag Formulation of contrast media and process of preparation thereof
CN112735799B (en) * 2020-12-10 2022-12-20 华东理工大学 Novel magnetic material and preparation method thereof
US20230400538A1 (en) * 2022-06-10 2023-12-14 GE Precision Healthcare LLC Use of lactic acid in hyperpolarization for magnetic resonance applications

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003023432A1 (en) * 2001-09-12 2003-03-20 Amersham Health As A method of using spectral-spatial exitation at magnetic resonance imaging
WO2005024440A2 (en) * 2003-08-21 2005-03-17 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
WO2007052274A2 (en) * 2005-11-06 2007-05-10 Brain Watch Ltd. Magnetic resonance imaging and spectroscopy means and methods thereof
WO2007064226A2 (en) * 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
WO2007069909A2 (en) * 2005-12-16 2007-06-21 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
WO2007111515A2 (en) * 2006-03-29 2007-10-04 Ge Healthcare As Method to produce hyperpolarised carboxylates and sulphonates
WO2008026937A1 (en) * 2006-08-30 2008-03-06 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) and compounds and compositions for use in the method
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003023432A1 (en) * 2001-09-12 2003-03-20 Amersham Health As A method of using spectral-spatial exitation at magnetic resonance imaging
WO2005024440A2 (en) * 2003-08-21 2005-03-17 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
WO2007052274A2 (en) * 2005-11-06 2007-05-10 Brain Watch Ltd. Magnetic resonance imaging and spectroscopy means and methods thereof
WO2007064226A2 (en) * 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
WO2007069909A2 (en) * 2005-12-16 2007-06-21 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
WO2007111515A2 (en) * 2006-03-29 2007-10-04 Ge Healthcare As Method to produce hyperpolarised carboxylates and sulphonates
WO2008026937A1 (en) * 2006-08-30 2008-03-06 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) and compounds and compositions for use in the method
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof

Also Published As

Publication number Publication date
JP2011514313A (en) 2011-05-06
CN101932340A (en) 2010-12-29
WO2009098191A2 (en) 2009-08-13
EP2237802A2 (en) 2010-10-13
US20110008261A1 (en) 2011-01-13

Similar Documents

Publication Publication Date Title
ATE533048T1 (en) PRODUCTION OF LIQUID MIXTURES
WO2012090124A3 (en) IN SITU GENERATION OF PEROXYCARBOXYLIC ACIDS AT ALKALINE pH, AND METHODS OF USE THEREOF
DE602005024664D1 (en) SULFURIC COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
WO2008081849A1 (en) Method for quantification of peptide and protein
ATE550319T1 (en) METHOD FOR PRODUCING AN AMINOACETYLPYRROLIDINE CARBONITRILE DERIVATIVE
WO2010041892A3 (en) Novel application of aimp1 polypeptide
WO2012076985A8 (en) Granzyme b inhibitor compositions, methods and uses for promoting wound healing
GB2433349A (en) A method and system for assessing a musical performance
WO2009109597A8 (en) Method for producing alpha- santalene
JP2011514313A5 (en)
EA201201275A1 (en) HETEROCYCLIC INHIBITORS GLUTAMINILCYCLASES (QC, EC 2.3.2.5)
WO2011107530A3 (en) Inhibitors of glutaminyl cyclase
WO2007066232A3 (en) Salts of fatty acids and methods of making and using thereof
EP2508864A3 (en) Method for recovering metal and kit for recovery of metal for use in the same
WO2007111515A3 (en) Method to produce hyperpolarised carboxylates and sulphonates
WO2012085279A3 (en) Method for cross-linking peptides
ATE354295T1 (en) METHOD FOR REDUCING BITTERNESS OF AMINO ACID
DE602005013652D1 (en) OXYGENIC BEVERAGE COMPOSITION AND METHOD FOR THE PRODUCTION THEREOF BY USE OF AN AQUEOUS PROTEIN COMPONENT
WO2009117498A3 (en) Methods of making cyclododecatriene and methods of making laurolactone
GB201014028D0 (en) In-situ reagent
PE20120380A1 (en) ACCELERATOR MIX
ATE371705T1 (en) AQUEOUS BITUUM EMULSION
SG159481A1 (en) Stabilization of thermolysin in aqueous solution
EP2508863A3 (en) Method for recovering metal, and reagent and kit for recovery of metal for use in the same
WO2008013669A3 (en) Alpha hydroxy acid sustained release formulation

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980103777.8

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09707879

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009707879

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2010544727

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12864521

Country of ref document: US