WO2009103739A1 - Heterocyclic inhibitors of stearoyl-coa desaturase - Google Patents

Heterocyclic inhibitors of stearoyl-coa desaturase Download PDF

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Publication number
WO2009103739A1
WO2009103739A1 PCT/EP2009/051926 EP2009051926W WO2009103739A1 WO 2009103739 A1 WO2009103739 A1 WO 2009103739A1 EP 2009051926 W EP2009051926 W EP 2009051926W WO 2009103739 A1 WO2009103739 A1 WO 2009103739A1
Authority
WO
WIPO (PCT)
Prior art keywords
stearoyl
coa desaturase
heterocyclic inhibitors
derivatives
modulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/051926
Other languages
French (fr)
Inventor
Sultan Chowdhury
Natalie Dales
Julia Fonarev
Jianmin Fu
Duanjie Hou
Qi Jia
Vishnumurthy Kodumuru
Natalia Pokrovskaia
Shaoyi Sun
Zaihui Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Novartis AG
Original Assignee
Xenon Pharmaceuticals Inc
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40740143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009103739(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to MX2010009158A priority Critical patent/MX2010009158A/en
Priority to UAA201010238A priority patent/UA105000C2/en
Priority to JP2010547169A priority patent/JP5507474B2/en
Priority to EP09711989.5A priority patent/EP2245029B1/en
Priority to BRPI0907826 priority patent/BRPI0907826A2/en
Priority to EA201001315A priority patent/EA022797B1/en
Priority to CA2715947A priority patent/CA2715947C/en
Priority to NZ587350A priority patent/NZ587350A/en
Application filed by Xenon Pharmaceuticals Inc, Novartis AG filed Critical Xenon Pharmaceuticals Inc
Priority to AU2009216769A priority patent/AU2009216769A1/en
Priority to CN200980113852.9A priority patent/CN102007123B/en
Priority to HK10111248.5A priority patent/HK1144808B/en
Publication of WO2009103739A1 publication Critical patent/WO2009103739A1/en
Priority to ZA2010/05725A priority patent/ZA201005725B/en
Priority to TNP2010000378A priority patent/TN2010000378A1/en
Priority to IL207578A priority patent/IL207578A/en
Priority to CUP2010000170A priority patent/CU23890B1/en
Anticipated expiration legal-status Critical
Priority to MA33156A priority patent/MA32150B1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides heterocyclic derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
PCT/EP2009/051926 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase Ceased WO2009103739A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CN200980113852.9A CN102007123B (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-CoA desaturase
UAA201010238A UA105000C2 (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase
JP2010547169A JP5507474B2 (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-CoA desaturase
EP09711989.5A EP2245029B1 (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase
BRPI0907826 BRPI0907826A2 (en) 2008-02-20 2009-02-18 heterocyclic stearoyl coa desaturase inhibitors
EA201001315A EA022797B1 (en) 2008-02-20 2009-02-18 THIAZOLE DERIVATIVES AS STEAROYL-CoA- DESATURASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THEM, AND USE THEREOF
CA2715947A CA2715947C (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase
NZ587350A NZ587350A (en) 2008-02-20 2009-02-18 Thiazole derivatives featuring an imidazolidine or triazole derivative as inhibitors of stearoyl-CoA desaturase
AU2009216769A AU2009216769A1 (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-CoA desaturase
MX2010009158A MX2010009158A (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase.
HK10111248.5A HK1144808B (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase
ZA2010/05725A ZA201005725B (en) 2008-02-20 2010-08-11 Heterocyclic inhibitors of stearoyl-coa desaturase
IL207578A IL207578A (en) 2008-02-20 2010-08-12 Heterocyclic inhibitors of stearoyl-coa desaturase, pharmaceutical compositions comprising them and their use in the preparation of medicaments
TNP2010000378A TN2010000378A1 (en) 2009-02-18 2010-08-12 Heterocyclic inhibitors of stearoyl-coa desaturase
CUP2010000170A CU23890B1 (en) 2008-02-20 2010-08-19 ESTEAROIL-COA-DESATURASA HETEROCYCLIC INHIBITORS
MA33156A MA32150B1 (en) 2008-02-20 2010-09-09 Heterocyclic inhibitors of stearoyl-coa desaturase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3013708P 2008-02-20 2008-02-20
US61/030,137 2008-02-20

Publications (1)

Publication Number Publication Date
WO2009103739A1 true WO2009103739A1 (en) 2009-08-27

Family

ID=40740143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/051926 Ceased WO2009103739A1 (en) 2008-02-20 2009-02-18 Heterocyclic inhibitors of stearoyl-coa desaturase

Country Status (28)

Country Link
US (2) US8049016B2 (en)
EP (1) EP2245029B1 (en)
JP (2) JP5507474B2 (en)
KR (1) KR101584826B1 (en)
CN (1) CN102007123B (en)
AR (1) AR070429A1 (en)
AU (1) AU2009216769A1 (en)
BR (1) BRPI0907826A2 (en)
CA (1) CA2715947C (en)
CL (1) CL2009000381A1 (en)
CO (1) CO6290655A2 (en)
CR (1) CR11629A (en)
CU (1) CU23890B1 (en)
EA (1) EA022797B1 (en)
EC (1) ECSP10010411A (en)
HN (1) HN2010001647A (en)
IL (1) IL207578A (en)
JO (1) JO3014B1 (en)
MA (1) MA32150B1 (en)
MX (1) MX2010009158A (en)
MY (1) MY156317A (en)
NZ (1) NZ587350A (en)
PE (1) PE20091473A1 (en)
SV (1) SV2010003650A (en)
TW (1) TWI457338B (en)
UA (1) UA105000C2 (en)
WO (1) WO2009103739A1 (en)
ZA (1) ZA201005725B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011039358A1 (en) * 2009-10-01 2011-04-07 Novartis Ag Pyrazole derivatives which modulate stearoyl-coa desaturase
US8049016B2 (en) 2008-02-20 2011-11-01 Novartis Ag Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes
US8063084B2 (en) 2006-08-15 2011-11-22 Novartis Ag Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels
US8829193B2 (en) 2008-03-03 2014-09-09 Novartis Ag PIM kinase inhibitors and methods of their use
US8987457B2 (en) 2012-05-21 2015-03-24 Novartis Ag Ring-substituted N-pyridinyl amides as kinase inhibitors
WO2018129403A1 (en) 2017-01-06 2018-07-12 Yumanity Therapeutics Methods for the treatment of neurological disorders
US11873298B2 (en) 2017-10-24 2024-01-16 Janssen Pharmaceutica Nv Compounds and uses thereof
US11970486B2 (en) 2016-10-24 2024-04-30 Janssen Pharmaceutica Nv Compounds and uses thereof
US20240182462A1 (en) * 2019-12-20 2024-06-06 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof
US12098146B2 (en) 2019-01-24 2024-09-24 Janssen Pharmaceutica Nv Compounds and uses thereof
US12180221B2 (en) 2018-03-23 2024-12-31 Janssen Pharmaceutica Nv Compounds and uses thereof
US12268687B2 (en) 2019-11-13 2025-04-08 Janssen Pharmaceutica Nv Compounds and uses thereof

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
EP2121671A1 (en) * 2006-12-20 2009-11-25 Novartis AG 2-substituted 5-membered heterocycles as scd inhibitors
AU2013259344A1 (en) * 2012-05-11 2014-11-13 Abbvie Inc. Nampt inhibitors
EP3511332A4 (en) * 2016-09-08 2020-03-25 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. NOVEL 2-ACYLAMINOTHIAZOLE DERIVATIVE, PREPARATION PROCESS AND USE THEREOF
WO2021083182A1 (en) * 2019-10-28 2021-05-06 南京明德新药研发有限公司 Uricosuric agent, synthetic method therefor, and pharmaceutical application thereof
GB202012969D0 (en) * 2020-08-19 2020-09-30 Univ Of Oxford Inhibitor compounds

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WO2006034440A2 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2007130075A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2008024390A2 (en) * 2006-08-24 2008-02-28 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders
WO2008127349A2 (en) * 2006-08-15 2008-10-23 Novartis Ag Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level

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Publication number Priority date Publication date Assignee Title
WO2006034440A2 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2007130075A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
WO2008127349A2 (en) * 2006-08-15 2008-10-23 Novartis Ag Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level
WO2008024390A2 (en) * 2006-08-24 2008-02-28 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8063084B2 (en) 2006-08-15 2011-11-22 Novartis Ag Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels
US8293768B2 (en) 2006-08-15 2012-10-23 Novartis Ag Organic compounds
US8049016B2 (en) 2008-02-20 2011-11-01 Novartis Ag Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes
US8318949B2 (en) 2008-02-20 2012-11-27 Novartis Ag Organic compounds
US8829193B2 (en) 2008-03-03 2014-09-09 Novartis Ag PIM kinase inhibitors and methods of their use
WO2011039358A1 (en) * 2009-10-01 2011-04-07 Novartis Ag Pyrazole derivatives which modulate stearoyl-coa desaturase
CN102574841A (en) * 2009-10-01 2012-07-11 诺瓦提斯公司 Pyrazole derivatives which modulate stearoyl-coa desaturase
US8987457B2 (en) 2012-05-21 2015-03-24 Novartis Ag Ring-substituted N-pyridinyl amides as kinase inhibitors
US9173883B2 (en) 2012-05-21 2015-11-03 Novartis Ag Ring-substituted N-pyridinyl amides as kinase inhibitors
US11970486B2 (en) 2016-10-24 2024-04-30 Janssen Pharmaceutica Nv Compounds and uses thereof
US10973810B2 (en) 2017-01-06 2021-04-13 Yumanity Therapeutics, Inc. Methods for the treatment of neurological disorders
WO2018129403A1 (en) 2017-01-06 2018-07-12 Yumanity Therapeutics Methods for the treatment of neurological disorders
US12433880B2 (en) 2017-01-06 2025-10-07 Janssen Pharmaceutica Nv Methods for the treatment of neurological disorders
US11873298B2 (en) 2017-10-24 2024-01-16 Janssen Pharmaceutica Nv Compounds and uses thereof
US12275723B2 (en) 2017-10-24 2025-04-15 Janssen Pharmaceutica Nv Compounds and uses thereof
US12180221B2 (en) 2018-03-23 2024-12-31 Janssen Pharmaceutica Nv Compounds and uses thereof
US12098146B2 (en) 2019-01-24 2024-09-24 Janssen Pharmaceutica Nv Compounds and uses thereof
US12268687B2 (en) 2019-11-13 2025-04-08 Janssen Pharmaceutica Nv Compounds and uses thereof
US20240182462A1 (en) * 2019-12-20 2024-06-06 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof
US12312345B2 (en) * 2019-12-20 2025-05-27 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof

Also Published As

Publication number Publication date
CU20100170A7 (en) 2011-10-31
US8049016B2 (en) 2011-11-01
TW200942534A (en) 2009-10-16
JP2011512384A (en) 2011-04-21
UA105000C2 (en) 2014-04-10
HN2010001647A (en) 2013-11-11
CU23890B1 (en) 2013-04-19
EA201001315A1 (en) 2011-06-30
JO3014B1 (en) 2016-09-05
CA2715947C (en) 2016-10-25
TWI457338B (en) 2014-10-21
MX2010009158A (en) 2010-09-24
CA2715947A1 (en) 2009-08-27
CO6290655A2 (en) 2011-06-20
US20090264444A1 (en) 2009-10-22
US20120014906A1 (en) 2012-01-19
MA32150B1 (en) 2011-03-01
AR070429A1 (en) 2010-04-07
US8318949B2 (en) 2012-11-27
JP2014132025A (en) 2014-07-17
CL2009000381A1 (en) 2010-09-10
PE20091473A1 (en) 2009-10-23
EP2245029B1 (en) 2015-04-15
HK1144808A1 (en) 2011-03-11
SV2010003650A (en) 2011-07-05
CR11629A (en) 2010-11-16
JP5507474B2 (en) 2014-05-28
EP2245029A1 (en) 2010-11-03
EA022797B1 (en) 2016-03-31
CN102007123A (en) 2011-04-06
MY156317A (en) 2016-02-15
JP5813162B2 (en) 2015-11-17
IL207578A0 (en) 2010-12-30
KR101584826B1 (en) 2016-01-18
BRPI0907826A2 (en) 2019-12-10
AU2009216769A1 (en) 2009-08-27
NZ587350A (en) 2012-07-27
KR20100117677A (en) 2010-11-03
IL207578A (en) 2014-11-30
CN102007123B (en) 2014-04-30
ECSP10010411A (en) 2010-09-30
ZA201005725B (en) 2011-04-28

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