WO2009115509A3 - Antigenic protein fragments of streptococcus pneumoniae - Google Patents

Antigenic protein fragments of streptococcus pneumoniae Download PDF

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Publication number
WO2009115509A3
WO2009115509A3 PCT/EP2009/053121 EP2009053121W WO2009115509A3 WO 2009115509 A3 WO2009115509 A3 WO 2009115509A3 EP 2009053121 W EP2009053121 W EP 2009053121W WO 2009115509 A3 WO2009115509 A3 WO 2009115509A3
Authority
WO
WIPO (PCT)
Prior art keywords
streptococcus pneumoniae
protein fragments
antigenic protein
epitopes
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/053121
Other languages
French (fr)
Other versions
WO2009115509A2 (en
Inventor
Concetta Beninati
Franco Felici
Marco Oggioni
Gianni Pozzi
Susanna Ricci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Siena
Original Assignee
Universita degli Studi di Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Siena filed Critical Universita degli Studi di Siena
Priority to US12/933,214 priority Critical patent/US8246964B2/en
Priority to EP09723240.9A priority patent/EP2265633B1/en
Publication of WO2009115509A2 publication Critical patent/WO2009115509A2/en
Publication of WO2009115509A3 publication Critical patent/WO2009115509A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1275—Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and the treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.
PCT/EP2009/053121 2008-03-19 2009-03-17 Antigenic protein fragments of streptococcus pneumoniae Ceased WO2009115509A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/933,214 US8246964B2 (en) 2008-03-19 2009-03-17 Antigenic protein fragments of Streptococcus pneumoniae
EP09723240.9A EP2265633B1 (en) 2008-03-19 2009-03-17 Antigenic protein fragments of streptococcus pneumoniae

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08425177.6 2008-03-19
EP08425177A EP2108656A1 (en) 2008-03-19 2008-03-19 Antigenic protein fragments of streptococcus pneumoniae

Publications (2)

Publication Number Publication Date
WO2009115509A2 WO2009115509A2 (en) 2009-09-24
WO2009115509A3 true WO2009115509A3 (en) 2009-12-10

Family

ID=39673137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/053121 Ceased WO2009115509A2 (en) 2008-03-19 2009-03-17 Antigenic protein fragments of streptococcus pneumoniae

Country Status (3)

Country Link
US (1) US8246964B2 (en)
EP (2) EP2108656A1 (en)
WO (1) WO2009115509A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8775574B2 (en) * 2008-11-26 2014-07-08 Red Hat, Inc. Remote network management having multi-node awareness
CN102443053B (en) * 2010-10-15 2013-04-17 华中农业大学 Application of using streptococcus suis type-2 hy0245 gene encoded proteins as protective antigens
WO2018227177A1 (en) 2017-06-10 2018-12-13 Inventprise, Llc Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
WO2019151371A1 (en) * 2018-01-31 2019-08-08 ニュートリー株式会社 Prophylactic and/or therapeutic agent for pneumococcal infection
KR102073088B1 (en) * 2018-06-04 2020-02-04 (주)인트론바이오테크놀로지 Novel Streptococcus suis bacteriophage Str-SUP-2 and its use for preventing proliferation of Streptococcus suis
WO2022035816A1 (en) 2020-08-10 2022-02-17 Inventprise, Llc Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020813A1 (en) * 2001-03-27 2005-01-27 Vega Masignani Streptococcus pneumoniae proteins and nucleic acids
US7122368B1 (en) * 1997-07-02 2006-10-17 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US20060263846A1 (en) * 2003-04-15 2006-11-23 Intercell Ag S. penumoniae antigens

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265176B1 (en) 1985-10-29 2001-07-24 Cordis Corporation Dot immunoassay on plastic sheets
JP4545869B2 (en) 2000-02-23 2010-09-15 日本ケミファ株式会社 Method for measuring physiologically active sample substance using porous filter
CN1455866A (en) 2000-11-03 2003-11-12 肯顿有限公司 Detection of infectious agents using antigen mmics
WO2003010198A1 (en) 2001-07-26 2003-02-06 Kenton Srl Identification of specific tumour antigens by selection of cdna libraries with sera and use of said antigens in diagnostic techniques
WO2003011902A1 (en) 2001-07-27 2003-02-13 Kenton S.R.L. Identification of specific tumour antigens by selection of cdna libraries with sera
PL374109A1 (en) 2002-03-21 2005-09-19 Kenton S.R.L. Antigen fragments for the diagnosis of toxoplasma gondii
AU2003253301A1 (en) 2003-07-31 2004-07-14 Franco Felici Peptides mimicking vibrio cholerae o139 capsular polysaccharide and their use to elicit protective immune response
US7424370B2 (en) * 2004-02-06 2008-09-09 Council Of Scientific And Industrial Research Computational method for identifying adhesin and adhesin-like proteins of therapeutic potential
EP1940462A2 (en) 2005-12-23 2008-07-09 GlaxoSmithKline Biologicals S.A. Conjugate vaccines
WO2007081583A2 (en) 2006-01-04 2007-07-19 Children's Medical Center Corporation Anti-pneumococcal preparations and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122368B1 (en) * 1997-07-02 2006-10-17 Sanofi Pasteur Limited Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
US20050020813A1 (en) * 2001-03-27 2005-01-27 Vega Masignani Streptococcus pneumoniae proteins and nucleic acids
US20060263846A1 (en) * 2003-04-15 2006-11-23 Intercell Ag S. penumoniae antigens

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEGHETTO ELISA ET AL: "Discovery of novel Streptococcus pneumoniae antigens by screening a whole-genome lambda-display library.", FEMS MICROBIOLOGY LETTERS SEP 2006, vol. 262, no. 1, September 2006 (2006-09-01), pages 14 - 21, XP002491945, ISSN: 0378-1097 *
HOSKINS J ET AL: "Genome of the Bacterium Streptococcus pneumoniae Strain R6", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 183, no. 19, 1 October 2001 (2001-10-01), pages 5709 - 5717, XP002231307, ISSN: 0021-9193 *
MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITÀ E DELLA RICERCA: "Caratterizzazione ed applicazioni biotecnologiche di antigeni di Streptococcus pneumoniae, identificati mediante librerie di tipo "lambda display" da genoma completo.", PROGRAMMI DI RICERCA - ANNO 2005 / PROT. 2005059403, 2005, pages 1 - 2, XP002493116, Retrieved from the Internet <URL:http://prin.cineca.it/php4/suddivisionefondi/2005/pdf_vis_modello.php?db=MIUR9&modello=A&PREF_X_TABELLE=SFCOF05&c=20&codice=95799184070505160774627923916472095337&chiave=ASDSDADSADSADSA> [retrieved on 20080822] *
NG WAI-LEUNG; TSUI HO-CHING TIFFANY; WINKLER MALCOLM E: "Regulation of the pspA virulence factor and essential pcsB murein biosynthetic genes by the phosphorylated VicR (YycF) response regulator in Streptococcus pneumoniae", JOURNAL OF BACTERIOLOGY, vol. 187, no. 21, November 2005 (2005-11-01), pages 7444 - 7459, XP002549018, ISSN: 0021-9193 *

Also Published As

Publication number Publication date
WO2009115509A2 (en) 2009-09-24
EP2265633B1 (en) 2015-04-29
US20110076301A1 (en) 2011-03-31
EP2108656A1 (en) 2009-10-14
EP2265633A2 (en) 2010-12-29
US8246964B2 (en) 2012-08-21

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