WO2009117558A3 - Destruction of microbial products by enzymatic digestion - Google Patents
Destruction of microbial products by enzymatic digestion Download PDFInfo
- Publication number
- WO2009117558A3 WO2009117558A3 PCT/US2009/037632 US2009037632W WO2009117558A3 WO 2009117558 A3 WO2009117558 A3 WO 2009117558A3 US 2009037632 W US2009037632 W US 2009037632W WO 2009117558 A3 WO2009117558 A3 WO 2009117558A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dialysis component
- destruction
- enzymatic digestion
- microbial products
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Methods of treating a dialysis component by providing a dialysis component and contacting the dialysis component with an enzyme are provided. The enzyme breaks down microbial contaminants in the dialysis component. The enzyme may be separated from the dialysis component to provide a purified dialysis component. The purified dialysis component may be substantially free of microbial contaminants that cause a cytokine response in humans.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011500949A JP5438751B2 (en) | 2008-03-20 | 2009-03-19 | Destruction of microbial products by enzymatic digestion |
| EP09721748.3A EP2273995B2 (en) | 2008-03-20 | 2009-03-19 | Destruction of microbial products by enzymatic digestion |
| MX2010010271A MX2010010271A (en) | 2008-03-20 | 2009-03-19 | Destruction of microbial products by enzymatic digestion. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3829708P | 2008-03-20 | 2008-03-20 | |
| US61/038,297 | 2008-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2009117558A2 WO2009117558A2 (en) | 2009-09-24 |
| WO2009117558A3 true WO2009117558A3 (en) | 2010-07-15 |
Family
ID=41089530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2009/037632 Ceased WO2009117558A2 (en) | 2008-03-20 | 2009-03-19 | Destruction of microbial products by enzymatic digestion |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8349813B2 (en) |
| EP (1) | EP2273995B2 (en) |
| JP (1) | JP5438751B2 (en) |
| MX (1) | MX2010010271A (en) |
| WO (1) | WO2009117558A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2966843B1 (en) * | 2010-11-03 | 2013-04-26 | Roquette Freres | PROCESS FOR THE DECONTAMINATION OF STARCH HYDROLYSATES FOR THE PREPARATION OF GLUCOSE POLYMERS FOR PERITONEAL DIALYSIS |
| JP6388475B2 (en) * | 2011-03-18 | 2018-09-12 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Peritoneal dialysis solution containing glucose polymer |
| US10351895B2 (en) * | 2014-02-07 | 2019-07-16 | Roquette Freres | Biological dosage of peptidoglycans |
| CA2968467A1 (en) | 2016-05-27 | 2017-11-27 | Cook Medical Technologies Llc | Filtration system and process for peritoneal dialysis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0207676A2 (en) * | 1985-06-22 | 1987-01-07 | M L Laboratories Plc | Polymers for use in continuous peritoneal dialysis |
| DE19640841A1 (en) * | 1996-10-02 | 1998-05-14 | Fresenius Medical Care De Gmbh | Preparation of ultra-pure infusion or dialysis solution |
| US20050191717A1 (en) * | 2004-02-27 | 2005-09-01 | Leo Martis | Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3669878A (en) * | 1968-12-02 | 1972-06-13 | Health Education And Welfare U | Treatment of dialysate solution for removal of urea |
| US3669880A (en) * | 1969-06-30 | 1972-06-13 | Cci Aerospace Corp | Recirculation dialysate system for use with an artificial kidney machine |
| US3707967A (en) * | 1970-10-01 | 1973-01-02 | Tecna Corp | Steady flow regenerative peritoneal dialysis system and method |
| US3884808A (en) * | 1973-06-20 | 1975-05-20 | Res Dev Systems Inc | Wearable, self-regenerating dialysis appliance |
| NL7703937A (en) * | 1977-04-12 | 1978-10-16 | Organon Teknika Bv | DEVICE EQUIPPED WITH A SORBENT FOR THE PURIFICATION OF BLOOD; A SORBENT SUITABLE FOR ORAL USE AND A PROCESS FOR MANUFACTURE OF THE SORBENT. |
| US4364747A (en) * | 1977-08-29 | 1982-12-21 | The Regents Of The University Of Minnesota | System for regenerative thermally reversed adsorption |
| PT69258A (en) | 1978-02-27 | 1979-03-01 | Lilly Co Eli | Process for preparing a dialysis composition |
| DE2823985C2 (en) * | 1978-06-01 | 1986-01-02 | Akzo Gmbh, 5600 Wuppertal | Dialysis membrane |
| SE428427B (en) * | 1979-01-04 | 1983-07-04 | Gambro Lundia Ab | WANT TO DISPOSE WASTE METABOLITES SPECIFICALLY NON-GIFTING POISONS, FROM A SOLUTION THROUGH ALTERNATE ADSORPTION AND DESORPTION |
| SE7905956L (en) * | 1979-07-09 | 1981-01-10 | Gambro Dialysatoren | COLUMN FOR TREATMENT OF A LIQUID MEDIUM A PARTICULAR MATERIAL |
| US4386611A (en) * | 1980-06-02 | 1983-06-07 | Warner Lambert Technologies, Inc. | Tonometer with improved fluid discharged tube |
| DE3101159C2 (en) | 1981-01-16 | 1985-08-22 | Udipi Ramakrishna Dr. 5100 Aachen Shettigar | Process for purifying blood and artificial kidney for carrying out the process |
| EP0064393A3 (en) | 1981-05-04 | 1982-12-29 | Purdue Research Foundation | Sorbent mixture for use in hemodialysis |
| DD210385A3 (en) | 1982-06-28 | 1984-06-06 | Medizin Labortechnik Veb K | DIALYSIS DEVICE WITH REGENERATION SYSTEM FOR THE CONTINUOUS AMBULANT PERITONEAL DIALYSIS |
| US4460555A (en) * | 1983-08-25 | 1984-07-17 | Organon Teknika Corporation | Ammonia scavenger |
| US4650587A (en) * | 1982-09-09 | 1987-03-17 | Akzona Incorporated | Ammonia scavenger |
| JPS59122520A (en) * | 1982-12-28 | 1984-07-16 | Toyo Soda Mfg Co Ltd | Anion exchange membrane having excellent durability |
| US4765907A (en) * | 1984-03-28 | 1988-08-23 | Research Development Systems, Inc. | Wearable, continuously internally operable and externally regenerable dialysis device |
| US4661246A (en) * | 1984-10-01 | 1987-04-28 | Ash Medical Systems, Inc. | Dialysis instrument with dialysate side pump for moving body fluids |
| JPS61171506A (en) * | 1985-01-25 | 1986-08-02 | Shokubai Kasei Kogyo Kk | Decompositional adsorbent of urea dissolved in liquid |
| JPS61231187A (en) * | 1985-04-05 | 1986-10-15 | Sasaki Kagaku Kk | Dissolving agent for rust, fur waste matter from human body and serum protein, on artificial dialyzer, medical instrument or the like |
| EP0218900B1 (en) * | 1985-09-10 | 1992-01-22 | Research Corporation Technologies, Inc. | Osmotic agents for peritoneal dialysis |
| DE3623796A1 (en) * | 1986-07-15 | 1988-01-28 | Dow Chemical Rheinwerk Gmbh | DEVICE AND ADSORPTION METHOD FOR THE SELECTIVE REMOVAL OF IONS FROM LIQUIDS |
| EP0311244B1 (en) * | 1987-08-25 | 1993-05-19 | Kureha Kagaku Kogyo Kabushiki Kaisha | Complex of magnesium oxide and titanium dioxide as a phosphate adsorbent |
| US5618710A (en) * | 1990-08-03 | 1997-04-08 | Vertex Pharmaceuticals, Inc. | Crosslinked enzyme crystals |
| US5919369A (en) * | 1992-02-06 | 1999-07-06 | Hemocleanse, Inc. | Hemofiltration and plasmafiltration devices and methods |
| US5277820A (en) * | 1992-02-06 | 1994-01-11 | Hemocleanse, Inc. | Device and method for extracorporeal blood treatment |
| US5536412A (en) * | 1992-02-06 | 1996-07-16 | Hemocleanse, Inc. | Hemofiltration and plasmafiltration devices and methods |
| DE4239442C2 (en) * | 1992-11-24 | 2001-09-13 | Sebo Gmbh | Use of an adsorbent material modified with polynuclear metal oxide hydroxides for the selective elimination of inorganic phosphate from protein-containing liquids |
| US6380163B1 (en) * | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| DE4309410A1 (en) * | 1993-03-19 | 1995-02-16 | Stange Jan | Material, process and equipment for the selective separation of freely dissolved and substance-bound substances from liquid substance mixtures as well as process for the production of the material |
| HU216042B (en) | 1993-07-14 | 1999-04-28 | B. Braun Medical Kft. | Apparatus for regenerating fluid contaminated with organic materials preferably one of dialysis as well as method and electrode for combined measuring of organic materials and hypochlorit-ion |
| US5618441A (en) * | 1995-06-07 | 1997-04-08 | Rosa; Jim | Single microcontroller execution of control and safety system functions in a dialysis machine |
| US5944684A (en) * | 1995-08-31 | 1999-08-31 | The Regents Of The University Of California | Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications |
| US6309673B1 (en) * | 1999-09-10 | 2001-10-30 | Baxter International Inc. | Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy |
| US6627164B1 (en) * | 2000-11-28 | 2003-09-30 | Renal Solutions, Inc. | Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same |
| US20040229771A1 (en) * | 2003-05-15 | 2004-11-18 | Reinhold Deppisch | Method of reducing decline of or preserving residual renal function |
| KR101352222B1 (en) | 2005-12-22 | 2014-02-04 | 백스터 인터내셔널 인코포레이티드 | Improved monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products |
| US8715221B2 (en) * | 2006-03-08 | 2014-05-06 | Fresenius Medical Care Holdings, Inc. | Wearable kidney |
-
2009
- 2009-03-19 JP JP2011500949A patent/JP5438751B2/en not_active Expired - Fee Related
- 2009-03-19 US US12/407,516 patent/US8349813B2/en active Active
- 2009-03-19 MX MX2010010271A patent/MX2010010271A/en active IP Right Grant
- 2009-03-19 WO PCT/US2009/037632 patent/WO2009117558A2/en not_active Ceased
- 2009-03-19 EP EP09721748.3A patent/EP2273995B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0207676A2 (en) * | 1985-06-22 | 1987-01-07 | M L Laboratories Plc | Polymers for use in continuous peritoneal dialysis |
| DE19640841A1 (en) * | 1996-10-02 | 1998-05-14 | Fresenius Medical Care De Gmbh | Preparation of ultra-pure infusion or dialysis solution |
| US20050191717A1 (en) * | 2004-02-27 | 2005-09-01 | Leo Martis | Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions |
Non-Patent Citations (1)
| Title |
|---|
| TOURE F ET AL: "Icodextrin-induced peritonitis: Study of five cases and comparison with bacterial peritonitis", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB LNKD- DOI:10.1111/J.1523-1755.2004.00430.X, vol. 65, no. 2, 1 February 2004 (2004-02-01), pages 654 - 660, XP002330508, ISSN: 0085-2538 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009117558A2 (en) | 2009-09-24 |
| EP2273995B2 (en) | 2023-11-15 |
| JP2011515160A (en) | 2011-05-19 |
| US8349813B2 (en) | 2013-01-08 |
| JP5438751B2 (en) | 2014-03-12 |
| EP2273995A2 (en) | 2011-01-19 |
| EP2273995B1 (en) | 2016-01-13 |
| MX2010010271A (en) | 2010-12-02 |
| US20090239821A1 (en) | 2009-09-24 |
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