WO2009129267A3 - Small molecule inhibitors of the pleckstrin homology domain and methods for using same - Google Patents

Small molecule inhibitors of the pleckstrin homology domain and methods for using same Download PDF

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Publication number
WO2009129267A3
WO2009129267A3 PCT/US2009/040575 US2009040575W WO2009129267A3 WO 2009129267 A3 WO2009129267 A3 WO 2009129267A3 US 2009040575 W US2009040575 W US 2009040575W WO 2009129267 A3 WO2009129267 A3 WO 2009129267A3
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WIPO (PCT)
Prior art keywords
methods
same
small molecule
homology domain
pleckstrin homology
Prior art date
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Ceased
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PCT/US2009/040575
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French (fr)
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WO2009129267A2 (en
Inventor
Daruka Mahadevan
Emmanuelle J. Meuillet
Eugene A. Mash
Vijay M. Gohkale
Garth Powis
Shuxing Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
The University of Texas System
The University of Texas at Austin
University of Arizona
Arizona State University
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The University of Texas System
The University of Texas at Austin
University of Arizona
Arizona State University
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Application filed by The University of Texas System, The University of Texas at Austin, University of Arizona, Arizona State University filed Critical The University of Texas System
Priority to MX2010011258A priority Critical patent/MX2010011258A/en
Priority to US12/937,898 priority patent/US8420678B2/en
Priority to EP09733451A priority patent/EP2291349A2/en
Priority to CA2721371A priority patent/CA2721371C/en
Priority to AU2009236256A priority patent/AU2009236256B9/en
Publication of WO2009129267A2 publication Critical patent/WO2009129267A2/en
Publication of WO2009129267A3 publication Critical patent/WO2009129267A3/en
Anticipated expiration legal-status Critical
Priority to US13/789,209 priority patent/US8962663B2/en
Priority to US14/589,360 priority patent/US9320734B2/en
Ceased legal-status Critical Current

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Abstract

Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
PCT/US2009/040575 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same Ceased WO2009129267A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
MX2010011258A MX2010011258A (en) 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same.
US12/937,898 US8420678B2 (en) 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
EP09733451A EP2291349A2 (en) 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
CA2721371A CA2721371C (en) 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
AU2009236256A AU2009236256B9 (en) 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
US13/789,209 US8962663B2 (en) 2008-04-14 2013-03-07 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
US14/589,360 US9320734B2 (en) 2008-04-14 2015-01-05 Small molecule inhibitors of the pleckstrin homology domain and methods for using same

Applications Claiming Priority (4)

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US12405308P 2008-04-14 2008-04-14
US61/124,053 2008-04-14
US19949708P 2008-11-17 2008-11-17
US61/199,497 2008-11-17

Related Child Applications (2)

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US12/937,898 A-371-Of-International US8420678B2 (en) 2008-04-14 2009-04-14 Small molecule inhibitors of the pleckstrin homology domain and methods for using same
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493437B2 (en) 2010-08-18 2016-11-15 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as Wnt/ β-catenin signaling pathway activators
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2291349A2 (en) * 2008-04-14 2011-03-09 The Board of Regents of The University of Texas System Small molecule inhibitors of the pleckstrin homology domain and methods for using same
CA2747419C (en) 2009-01-12 2014-07-08 Icagen, Inc. Sulfonamide derivatives
US20120189670A1 (en) * 2009-09-14 2012-07-26 Kirkpatrick D Lynn Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same
JP5872552B2 (en) 2010-07-09 2016-03-01 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ Chemical compound
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US20260125613A1 (en) 2024-11-07 2026-05-07 Algreen Limited Thermal hydrolysis of microalgae species for the production of bio-crude and other bioactive molecules

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821222A (en) * 1971-11-22 1974-06-28 Chevron Res Hydrocarbyl sulfenylmercapto pyrimidines
US4017489A (en) * 1975-07-10 1977-04-12 The Goodyear Tire & Rubber Company Process of preparing unsymmetrical disulfides
DE2556011A1 (en) * 1975-12-12 1977-06-23 Merck Patent Gmbh Antifungal and antibacterial thiadiazolyl disulphide derivs. - prepd. e.g. by reacting thiols with thidiazole-sulphenyl halides
DE3443225A1 (en) * 1983-11-28 1985-06-05 Otsuka Kagaku K.K., Osaka METHOD FOR PRODUCING AZETIDINONE DERIVATIVES
US4694015A (en) * 1984-11-13 1987-09-15 Sanofi Pharmaceutical or veterinary compositions containing thiosulfonate derivatives
WO2003076436A1 (en) * 2002-03-09 2003-09-18 Astrazeneca Ab Derivatives of 4- (imidazol-5-yl)-2-(4-sulfoanilino) pyrimidine with cdk inhibitory activity
US20040092524A1 (en) * 2000-10-10 2004-05-13 Michel Perez Novel aminophenyl piperazine or aminophenyl piperidine derivatives inhibiting prenyl transferase proteins and method for preparing same
WO2005000862A2 (en) * 2003-06-24 2005-01-06 Isis Innovation Limited Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
WO2005097758A1 (en) * 2004-03-26 2005-10-20 Amphora Discovery Corporation Certain triazole-based compounds, compositions, and uses thereof
US20070213378A1 (en) * 2006-03-10 2007-09-13 Lymphosign Inc. Compounds for modulating cell proliferation, compositions and methods related thereto
US20070293516A1 (en) * 2006-04-04 2007-12-20 Regents Of The University Of California Kinase antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA775563A (en) * 1968-01-09 Frank W. Horner Limited Hypoglycemic thiadiazoles
US4990523A (en) * 1989-06-19 1991-02-05 A. H. Robins Company, Incorporated Treatment of chronic inflammatory joint disease with arylsulfonamides
CA2531418A1 (en) * 2003-07-08 2005-01-20 Novartis Ag Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds
SE0402635D0 (en) * 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
DE602006018172D1 (en) 2005-10-06 2010-12-23 Sanofi Aventis CYCLIC N-α1,3,4Ü-THIADIAZOL-2-YL-BENZSULFONAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
EP2291349A2 (en) * 2008-04-14 2011-03-09 The Board of Regents of The University of Texas System Small molecule inhibitors of the pleckstrin homology domain and methods for using same
US20120189670A1 (en) 2009-09-14 2012-07-26 Kirkpatrick D Lynn Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821222A (en) * 1971-11-22 1974-06-28 Chevron Res Hydrocarbyl sulfenylmercapto pyrimidines
US4017489A (en) * 1975-07-10 1977-04-12 The Goodyear Tire & Rubber Company Process of preparing unsymmetrical disulfides
DE2556011A1 (en) * 1975-12-12 1977-06-23 Merck Patent Gmbh Antifungal and antibacterial thiadiazolyl disulphide derivs. - prepd. e.g. by reacting thiols with thidiazole-sulphenyl halides
DE3443225A1 (en) * 1983-11-28 1985-06-05 Otsuka Kagaku K.K., Osaka METHOD FOR PRODUCING AZETIDINONE DERIVATIVES
US4694015A (en) * 1984-11-13 1987-09-15 Sanofi Pharmaceutical or veterinary compositions containing thiosulfonate derivatives
US20040092524A1 (en) * 2000-10-10 2004-05-13 Michel Perez Novel aminophenyl piperazine or aminophenyl piperidine derivatives inhibiting prenyl transferase proteins and method for preparing same
WO2003076436A1 (en) * 2002-03-09 2003-09-18 Astrazeneca Ab Derivatives of 4- (imidazol-5-yl)-2-(4-sulfoanilino) pyrimidine with cdk inhibitory activity
WO2005000862A2 (en) * 2003-06-24 2005-01-06 Isis Innovation Limited Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
WO2005097758A1 (en) * 2004-03-26 2005-10-20 Amphora Discovery Corporation Certain triazole-based compounds, compositions, and uses thereof
US20070213378A1 (en) * 2006-03-10 2007-09-13 Lymphosign Inc. Compounds for modulating cell proliferation, compositions and methods related thereto
US20070293516A1 (en) * 2006-04-04 2007-12-20 Regents Of The University Of California Kinase antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANWAR M ET AL: "Reactions of some 5-aryl-2-thiono-1,3,4-thiadia-zoles", REVUE ROUMAINE DE CHIMIE - ROMANIAN JOURNAL OF CHEMISTRY, EDITURA ACADEMIEI ROMANE, RO, vol. 26, 1 January 1981 (1981-01-01), pages 1127 - 1134, XP008107898, ISSN: 0035-3930 *
MAHIEU J-P ET AL: "SYNTHESIS OF NEW THIOSULFONATES AND DISULFIDES FROM SULFONYL CHLORIDES AND THIOLS", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS GROUP, PHILADELPHIA, PA, vol. 16, 1 January 1986 (1986-01-01), pages 1709 - 1722, XP008107897, ISSN: 0039-7911 *
RUNGE F VON ET AL: "Uber einige unsymmertische heterocyclische Disulfide. II", JOURNAL FUER PRAKTISCHE CHEMIE, LEIPZIG, DE, vol. 21, 1 January 1963 (1963-01-01), pages 39 - 49, XP008107858, ISSN: 0021-8383 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9862714B2 (en) 2009-03-02 2018-01-09 Stemsynergy Therapeutics, Inc. Methods and compositions useful in treating cancer and reducing Wnt mediated effects in a cell
US9493437B2 (en) 2010-08-18 2016-11-15 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as Wnt/ β-catenin signaling pathway activators
US9533976B2 (en) 2013-02-22 2017-01-03 Samumed, Llc γ-diketones as WNT/β-catenin signaling pathway activators

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