WO2009140659A3 - Treating dyspnea associated with acute heart failure with relaxin - Google Patents

Treating dyspnea associated with acute heart failure with relaxin Download PDF

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Publication number
WO2009140659A3
WO2009140659A3 PCT/US2009/044249 US2009044249W WO2009140659A3 WO 2009140659 A3 WO2009140659 A3 WO 2009140659A3 US 2009044249 W US2009044249 W US 2009044249W WO 2009140659 A3 WO2009140659 A3 WO 2009140659A3
Authority
WO
WIPO (PCT)
Prior art keywords
relaxin
heart failure
acute heart
dyspnea associated
acute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/044249
Other languages
French (fr)
Other versions
WO2009140659A2 (en
Inventor
Elaine Unemori
Sam L. Teichman
Gad Cotter
Dennis R. Stewart
Martha Jo Whitehouse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corthera Inc
Original Assignee
Corthera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HK11105324.3A priority Critical patent/HK1151229B/en
Priority to PL09747740T priority patent/PL2288373T3/en
Priority to CA2724540A priority patent/CA2724540C/en
Priority to ES09747740.0T priority patent/ES2546287T3/en
Priority to CN2009801177504A priority patent/CN102036679A/en
Priority to EP09747740.0A priority patent/EP2288373B1/en
Priority to MX2010012450A priority patent/MX2010012450A/en
Priority to NZ589009A priority patent/NZ589009A/en
Priority to AU2009246114A priority patent/AU2009246114B2/en
Priority to HRP20150845TT priority patent/HRP20150845T1/en
Priority to JP2011509783A priority patent/JP5651586B2/en
Priority to SI200931246T priority patent/SI2288373T1/en
Priority to EA201001771A priority patent/EA022948B1/en
Priority to DK09747740.0T priority patent/DK2288373T3/en
Priority to BRPI0913011A priority patent/BRPI0913011A2/en
Application filed by Corthera Inc filed Critical Corthera Inc
Priority to UAA201012879A priority patent/UA99953C2/en
Priority to US12/992,356 priority patent/US8415301B2/en
Publication of WO2009140659A2 publication Critical patent/WO2009140659A2/en
Publication of WO2009140659A3 publication Critical patent/WO2009140659A3/en
Priority to ZA2010/07449A priority patent/ZA201007449B/en
Priority to IL208992A priority patent/IL208992A/en
Priority to TNP2010000504A priority patent/TN2010000504A1/en
Anticipated expiration legal-status Critical
Priority to MA33418A priority patent/MA32389B1/en
Priority to US13/784,963 priority patent/US9205132B2/en
Priority to IL228244A priority patent/IL228244A/en
Priority to PH12016500711A priority patent/PH12016500711A1/en
Priority to IL247351A priority patent/IL247351A0/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
PCT/US2009/044249 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure Ceased WO2009140659A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
BRPI0913011A BRPI0913011A2 (en) 2008-05-16 2009-05-15 method of treating dyspnea associated with acute heart failure
CA2724540A CA2724540C (en) 2008-05-16 2009-05-15 Treating dyspnea associated with acute heart failure with relaxin
ES09747740.0T ES2546287T3 (en) 2008-05-16 2009-05-15 Relaxin for use in the treatment of dyspnea associated with acute heart failure
CN2009801177504A CN102036679A (en) 2008-05-16 2009-05-15 Treatment of dyspnea associated with acute heart failure with relaxin
EP09747740.0A EP2288373B1 (en) 2008-05-16 2009-05-15 Relaxin for use in treating of dyspnea associated with acute heart failure
MX2010012450A MX2010012450A (en) 2008-05-16 2009-05-15 Treating dyspnea associated with acute heart failure with relaxin.
NZ589009A NZ589009A (en) 2008-05-16 2009-05-15 Treating dyspnea associated with acute heart failure with h2 relaxin
AU2009246114A AU2009246114B2 (en) 2008-05-16 2009-05-15 Treating dyspnea associated with acute heart failure with relaxin
HRP20150845TT HRP20150845T1 (en) 2008-05-16 2009-05-15 Relaxin for use in treating of dyspnea associated with acute heart failure
JP2011509783A JP5651586B2 (en) 2008-05-16 2009-05-15 Treatment of dyspnea associated with acute heart failure with relaxin
SI200931246T SI2288373T1 (en) 2008-05-16 2009-05-15 Relaxin for use in treating of dyspnea associated with acute heart failure
EA201001771A EA022948B1 (en) 2008-05-16 2009-05-15 Treatment of dyspnea associated with acute heart failure with relaxin
DK09747740.0T DK2288373T3 (en) 2008-05-16 2009-05-15 RELAXIN FOR USE IN A PROCESS FOR THE TREATMENT OF dyspnea ASSOCIATED WITH HJERTEISSUFICIENS
HK11105324.3A HK1151229B (en) 2008-05-16 2009-05-15 Relaxin for use in treating of dyspnea associated with acute heart failure
UAA201012879A UA99953C2 (en) 2008-05-16 2009-05-15 Treatment of dyspnea associated with acute heart failure
PL09747740T PL2288373T3 (en) 2008-05-16 2009-05-15 Relaxin for use in treating of dyspnea associated with acute heart failure
US12/992,356 US8415301B2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure by administering H2 relaxin
ZA2010/07449A ZA201007449B (en) 2008-05-16 2010-10-19 Treating dyspnea associated with accute heart failure within relaxin
IL208992A IL208992A (en) 2008-05-16 2010-10-28 Use of a pharmaceutically active h2 relaxin in the manufacture of medicaments for treating dyspnea associated with acute heart failure and acute decompensated heart failure
TNP2010000504A TN2010000504A1 (en) 2009-05-15 2010-10-29 Treating dyspnea associated with acute heart failure with relaxin
MA33418A MA32389B1 (en) 2008-05-16 2010-12-10 Method to treat dyspnea associated with acute heart failure
US13/784,963 US9205132B2 (en) 2008-05-16 2013-03-05 Method of lowering mortality
IL228244A IL228244A (en) 2008-05-16 2013-09-02 2h Active Relaxin Human Pharmacist for Use as a Medication to Treat Severe Heart Failure
PH12016500711A PH12016500711A1 (en) 2008-05-16 2016-04-15 Method of treating dyspnea associated with acute heart failure
IL247351A IL247351A0 (en) 2008-05-16 2016-08-18 Pharmaceutically active human h2 relaxin for use as a medicament for treating dyspnea associated with acute heart failure

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12788908P 2008-05-16 2008-05-16
US61/127,889 2008-05-16
US19054508P 2008-08-28 2008-08-28
US61/190,545 2008-08-28
US20124008P 2008-12-08 2008-12-08
US61/201,240 2008-12-08
US16433309P 2009-03-27 2009-03-27
US61/164,333 2009-03-27

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/992,356 A-371-Of-International US8415301B2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure by administering H2 relaxin
EP14167842.5A Previously-Filed-Application EP2829280A1 (en) 2008-05-16 2009-05-15 Treating dyspnea associated with acute heart failure with H2 relaxin
US13/784,963 Continuation US9205132B2 (en) 2008-05-16 2013-03-05 Method of lowering mortality

Publications (2)

Publication Number Publication Date
WO2009140659A2 WO2009140659A2 (en) 2009-11-19
WO2009140659A3 true WO2009140659A3 (en) 2010-07-22

Family

ID=40834101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/044249 Ceased WO2009140659A2 (en) 2008-05-16 2009-05-15 Method of treating dyspnea associated with acute heart failure

Country Status (30)

Country Link
US (7) US8053411B2 (en)
EP (2) EP2288373B1 (en)
JP (4) JP5651586B2 (en)
CN (3) CN102036679A (en)
AR (1) AR071810A1 (en)
AU (1) AU2009246114B2 (en)
BR (1) BRPI0913011A2 (en)
CA (1) CA2724540C (en)
CR (1) CR11749A (en)
CY (1) CY1116925T1 (en)
DK (1) DK2288373T3 (en)
EA (2) EA201500552A1 (en)
ES (1) ES2546287T3 (en)
GB (2) GB2459983B (en)
HK (1) HK1202054A1 (en)
HR (1) HRP20150845T1 (en)
HU (1) HUE025483T2 (en)
IL (3) IL208992A (en)
MA (1) MA32389B1 (en)
MX (1) MX2010012450A (en)
MY (2) MY159803A (en)
NZ (3) NZ589009A (en)
PL (1) PL2288373T3 (en)
PT (1) PT2288373E (en)
SG (2) SG10201609580YA (en)
SI (1) SI2288373T1 (en)
TW (1) TWI386202B (en)
UA (1) UA99953C2 (en)
WO (1) WO2009140659A2 (en)
ZA (1) ZA201007449B (en)

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CA2724540C (en) 2008-05-16 2014-07-08 Corthera, Inc. Treating dyspnea associated with acute heart failure with relaxin
EP2544706B1 (en) 2010-03-10 2015-06-17 The University Of Melbourne Modulating aquaporins with relaxin
US9465039B2 (en) 2010-08-06 2016-10-11 Mycartis Nv Perlecan as a biomarker for renal dysfunction
EA030886B1 (en) * 2010-08-17 2018-10-31 Амбркс, Инк. Modified relaxin polypeptides comprising a non-naturally encoded amino acid linked to a polymer and their uses
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
RU2014103288A (en) * 2011-07-01 2015-08-10 Байер Интеллектчуал Проперти Гмбх RELAXIN FUSED POLYPEPTIDES AND THEIR APPLICATION
AU2013202269A1 (en) * 2011-10-26 2013-05-16 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
CA2864100A1 (en) * 2012-02-14 2013-08-22 The Regents Of The University Of California Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
US9452973B2 (en) 2012-05-04 2016-09-27 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Modulators of the relaxin receptor 1
KR102299073B1 (en) * 2012-10-26 2021-09-09 치에시 파마슈티시 에스.피.아. Methods for controlling blood pressure and reducing dyspnea in heart failure
PT2981258T (en) * 2013-04-05 2020-10-19 Scpharmaceuticals Inc Pharmaceutical formulations for subcutaneous administration of furosemide
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
MX2016010087A (en) * 2014-02-03 2016-10-07 Novartis Ag Filters for infusion sets.
EP2946788A1 (en) * 2014-05-23 2015-11-25 Immundiagnostik AG Method and composition for treating heart failure with preserved ejection fraction
US20170100460A1 (en) * 2014-06-13 2017-04-13 Novartis Ag Use of serelaxin to reduce gdf-15
PT3387019T (en) 2015-12-09 2022-01-14 Scripps Research Inst Relaxin immunoglobulin fusion proteins and methods of use
WO2017139164A1 (en) 2016-02-12 2017-08-17 Cardiac Pacemakers, Inc. Systems and methods for patient monitoring
PE20191716A1 (en) 2017-02-08 2019-12-05 Bristol Myers Squibb Co MODIFIED RELAXIN POLYPEPTIDES INCLUDING A PHARMACOKINETIC ENHANCER AND THEIR USES
US11832970B2 (en) 2017-07-26 2023-12-05 Cardiac Pacemakers, Inc. Worsening heart failure stratification
CN107335051A (en) * 2017-08-18 2017-11-10 温州医科大学附属第医院 A kind of pharmaceutical composition for protecting chronic heart failure renal function
ES3041602T3 (en) 2018-12-10 2025-11-13 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
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US11246851B2 (en) 2019-01-04 2022-02-15 Sq Innovation Ag Pharmaceutical compositions of furosemide and uses thereof
PH12021551811A1 (en) 2019-01-31 2022-03-21 Scpharmaceuticals Inc Concentrated liquid pharmaceutical formulations of furosemide and methods of administering the same
JP2025528469A (en) 2022-08-31 2025-08-28 リラクセラ ファルマツォイティッシュ ゲゼルシャフト エムベーハー ウント コー． カーゲー Immunosuppressant drugs and methods of treatment
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Also Published As

Publication number Publication date
PL2288373T3 (en) 2015-11-30
WO2009140659A2 (en) 2009-11-19
US9205132B2 (en) 2015-12-08
BRPI0913011A2 (en) 2019-09-03
US20120040903A1 (en) 2012-02-16
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