WO2009146911A3 - Organ-on-a-chip-device - Google Patents

Organ-on-a-chip-device Download PDF

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Publication number
WO2009146911A3
WO2009146911A3 PCT/EP2009/004008 EP2009004008W WO2009146911A3 WO 2009146911 A3 WO2009146911 A3 WO 2009146911A3 EP 2009004008 W EP2009004008 W EP 2009004008W WO 2009146911 A3 WO2009146911 A3 WO 2009146911A3
Authority
WO
WIPO (PCT)
Prior art keywords
chip
organoids
well
stem cell
organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2009/004008
Other languages
French (fr)
Other versions
WO2009146911A2 (en
Inventor
Uwe Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN200980120885.6A priority Critical patent/CN102257124B/en
Priority to AU2009254177A priority patent/AU2009254177B2/en
Priority to CA2727003A priority patent/CA2727003C/en
Priority to DK09757294.5T priority patent/DK2335370T3/en
Priority to US12/996,015 priority patent/US20110086382A1/en
Priority to EP09757294.5A priority patent/EP2335370B1/en
Priority to JP2011512022A priority patent/JP5774477B2/en
Priority to HK11113717.2A priority patent/HK1159157B/en
Application filed by Individual filed Critical Individual
Priority to RU2010154493/14A priority patent/RU2517046C2/en
Publication of WO2009146911A2 publication Critical patent/WO2009146911A2/en
Anticipated expiration legal-status Critical
Publication of WO2009146911A3 publication Critical patent/WO2009146911A3/en
Priority to US14/309,905 priority patent/US20140302549A1/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Fluid Mechanics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Microscoopes, Condenser (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to a self-contained sensor controlled organ on a chip-device, which allows establishing or maintaining organs or organoids as well as stem cell niches in a miniaturized chip format, suitable for online observation by live cell imaging and for example two photon microscopy and their use for, e.g. testing the activity, pharmacodynamic and pharmacokinetic of compounds or to study self-assembly, homeostasis, damage, regeneration or interaction of organs or organoids and stem cell niches, as well as phenomena of maturation, aging, death and chronobiology.
PCT/EP2009/004008 2008-06-04 2009-06-04 Organ-on-a-chip-device Ceased WO2009146911A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2011512022A JP5774477B2 (en) 2008-06-04 2009-06-04 On-chip organ device
CA2727003A CA2727003C (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device
DK09757294.5T DK2335370T3 (en) 2008-06-04 2009-06-04 Organ-at-a-chip device
US12/996,015 US20110086382A1 (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device
EP09757294.5A EP2335370B1 (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device
CN200980120885.6A CN102257124B (en) 2008-06-04 2009-06-04 organ-on-a-chip device
AU2009254177A AU2009254177B2 (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device
HK11113717.2A HK1159157B (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device
RU2010154493/14A RU2517046C2 (en) 2008-06-04 2009-06-04 "organ-on-chip" device
US14/309,905 US20140302549A1 (en) 2008-06-04 2014-06-20 Organ-on-a-chip-device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5876608P 2008-06-04 2008-06-04
US61/058,766 2008-06-04

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/996,015 A-371-Of-International US20110086382A1 (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device
US14/309,905 Continuation US20140302549A1 (en) 2008-06-04 2014-06-20 Organ-on-a-chip-device

Publications (2)

Publication Number Publication Date
WO2009146911A2 WO2009146911A2 (en) 2009-12-10
WO2009146911A3 true WO2009146911A3 (en) 2011-09-15

Family

ID=41398604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/004008 Ceased WO2009146911A2 (en) 2008-06-04 2009-06-04 Organ-on-a-chip-device

Country Status (10)

Country Link
US (2) US20110086382A1 (en)
EP (3) EP2730644A3 (en)
JP (1) JP5774477B2 (en)
CN (1) CN102257124B (en)
AU (1) AU2009254177B2 (en)
CA (1) CA2727003C (en)
DK (1) DK2335370T3 (en)
RU (1) RU2517046C2 (en)
SG (1) SG193829A1 (en)
WO (1) WO2009146911A2 (en)

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