WO2010056038A2 - 신규한 트리시클릭 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 - Google Patents

신규한 트리시클릭 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 Download PDF

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WO2010056038A2
WO2010056038A2 PCT/KR2009/006618 KR2009006618W WO2010056038A2 WO 2010056038 A2 WO2010056038 A2 WO 2010056038A2 KR 2009006618 W KR2009006618 W KR 2009006618W WO 2010056038 A2 WO2010056038 A2 WO 2010056038A2
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preparation
pharmaceutically acceptable
pharmaceutical composition
acceptable salts
composition containing
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English (en)
French (fr)
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WO2010056038A3 (ko
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김명화
김승현
구세광
박준호
조보영
천광우
예인해
최종희
류동규
박지선
이한창
최지수
김영철
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Jeil Pharmaceutical Co Ltd
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Jeil Pharmaceutical Co Ltd
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Priority to HK12104738.5A priority Critical patent/HK1164292B/xx
Priority to CN200980150285.4A priority patent/CN102245612B/zh
Priority to AU2009314760A priority patent/AU2009314760B2/en
Priority to RU2011123799/04A priority patent/RU2470934C1/ru
Priority to DK09826270.2T priority patent/DK2364983T3/da
Priority to ES09826270.2T priority patent/ES2443127T3/es
Priority to PL09826270T priority patent/PL2364983T3/pl
Priority to BRPI0915273-3A priority patent/BRPI0915273B1/pt
Priority to EP09826270.2A priority patent/EP2364983B1/en
Priority to CA2743257A priority patent/CA2743257C/en
Priority to US13/128,030 priority patent/US8815891B2/en
Priority to MX2011004957A priority patent/MX2011004957A/es
Priority to JP2011536240A priority patent/JP5403709B2/ja
Publication of WO2010056038A2 publication Critical patent/WO2010056038A2/ko
Publication of WO2010056038A3 publication Critical patent/WO2010056038A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Abstract

본 발명은 우수한 폴리(ADP-리보오스)폴리머라제(PARP) 저해 활성을 갖는 신규한 트리시클릭 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명의 트리시클릭 유도체는 폴리(ADP-리보오스)폴리머라제의 활성을 억제함으로써, PARP의 과잉활성에 의해 유발되는 질환, 특히 신경병리성 동통, 신경퇴화질환, 심혈관계 질환, 당뇨로 인한 신경병증, 염증성 질환, 골다공증 및 암의 예방 또는 치료에 유용하게 사용될 수 있다.
PCT/KR2009/006618 2008-11-11 2009-11-11 신규한 트리시클릭 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 Ceased WO2010056038A2 (ko)

Priority Applications (13)

Application Number Priority Date Filing Date Title
HK12104738.5A HK1164292B (en) 2008-11-11 2009-11-11 Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
CN200980150285.4A CN102245612B (zh) 2008-11-11 2009-11-11 新型三环衍生物或其药物可接受的盐、其制备方法和含有它们的药物组合物
AU2009314760A AU2009314760B2 (en) 2008-11-11 2009-11-11 Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
RU2011123799/04A RU2470934C1 (ru) 2008-11-11 2009-11-11 Новое трициклическое производное или его фармацевтически приемлемые соли, способ их получения и содержащая их фармацевтическая композиция
DK09826270.2T DK2364983T3 (da) 2008-11-11 2009-11-11 Nyt tricyklisk derivat eller farmaceutisk acceptable salte deraf, fremgangsmåde til fremstilling deraf og farmaceutisk sammensætning indeholdende disse
ES09826270.2T ES2443127T3 (es) 2008-11-11 2009-11-11 Nuevos derivados tricíclicos o sales de éstos farmacéuticamente aceptables, su procedimiento de fabricación y composiciones farmacéuticas que los contienen
PL09826270T PL2364983T3 (pl) 2008-11-11 2009-11-11 Nowa pochodna tricykliczna lub jej farmaceutycznie dopuszczalne sole, sposób jej wytwarzania, oraz zawierająca ją kompozycja farmaceutyczna
BRPI0915273-3A BRPI0915273B1 (pt) 2008-11-11 2009-11-11 Derivado tricíclico ou seus sais farmaceuticamente aceitáveis e seus métodos de preparação
EP09826270.2A EP2364983B1 (en) 2008-11-11 2009-11-11 Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
CA2743257A CA2743257C (en) 2008-11-11 2009-11-11 Novel tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
US13/128,030 US8815891B2 (en) 2008-11-11 2009-11-11 Tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
MX2011004957A MX2011004957A (es) 2008-11-11 2009-11-11 Nuevo derivado triciclico o las sales farmaceuticamente aceptables del mismo, metodo de preparacion del mismo, y composicion farmaceutica que contiene el mismo.
JP2011536240A JP5403709B2 (ja) 2008-11-11 2009-11-11 新規なトリサイクリック誘導体またはその薬学的に許容可能な塩、それらの製造方法およびそれらを含む薬学的組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080111808 2008-11-11
KR10-2008-0111808 2008-11-11

Publications (2)

Publication Number Publication Date
WO2010056038A2 true WO2010056038A2 (ko) 2010-05-20
WO2010056038A3 WO2010056038A3 (ko) 2010-09-16

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PCT/KR2009/006618 Ceased WO2010056038A2 (ko) 2008-11-11 2009-11-11 신규한 트리시클릭 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물

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Country Link
US (1) US8815891B2 (ko)
EP (1) EP2364983B1 (ko)
JP (1) JP5403709B2 (ko)
KR (1) KR100968175B1 (ko)
CN (1) CN102245612B (ko)
AU (1) AU2009314760B2 (ko)
BR (1) BRPI0915273B1 (ko)
CA (1) CA2743257C (ko)
DK (1) DK2364983T3 (ko)
ES (1) ES2443127T3 (ko)
MX (1) MX2011004957A (ko)
PL (1) PL2364983T3 (ko)
PT (1) PT2364983E (ko)
RU (1) RU2470934C1 (ko)
WO (1) WO2010056038A2 (ko)

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WO2016200101A3 (ko) * 2015-06-09 2017-02-02 제일약품주식회사 트리사이클릭 유도체 화합물, 이의 제조방법 및 이를 포함하는 약학적 조성물
US12054479B1 (en) 2022-03-14 2024-08-06 Slap Pharmaceuticals Llc Multicyclic compounds
US12528826B2 (en) 2019-10-14 2026-01-20 Cancer Research Technology Limited [1,4]oxazepino[2,3-c]quinolinone derivatives as BCL6 inhibitors

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PL3292116T3 (pl) 2015-02-02 2022-02-21 Valo Health, Inc. 3-arylo-4-amidobicykliczne kwasy [4,5,0]hydroksamowe jako inhibitory hdac
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EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
KR20180062804A (ko) * 2016-12-01 2018-06-11 사회복지법인 삼성생명공익재단 트리시클릭 유도체 또는 이의 약학적으로 허용 가능한 염을 포함하는 허혈성 급성 신손상 예방 또는 치료용 약학적 조성물
JP7091336B2 (ja) * 2016-12-22 2022-06-27 グローバル ブラッド セラピューティクス インコーポレイテッド ヒストンメチルトランスフェラーゼ阻害剤
WO2018226998A1 (en) 2017-06-09 2018-12-13 Global Blood Therapeutics, Inc. Azaindole compounds as histone methyltransferase inhibitors
CA3095371A1 (en) * 2018-04-13 2019-10-17 Cancer Research Technology Limited Bcl6 inhibitors
WO2020072675A1 (en) 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)
US20220110936A1 (en) * 2019-02-02 2022-04-14 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Pharmaceutical composition for treatment of neurodegenerative diseases or diseases caused by abnormality of rna binding protein and applications thereof
MX2022001200A (es) * 2019-07-29 2022-02-21 Jeil Pharmaceutical Co Ltd Metodo para el tratamiento de accidente cerebrovascular usando un derivado triciclico.
KR20210014024A (ko) 2019-07-29 2021-02-08 제일약품주식회사 트리사이클릭 유도체를 이용한 뇌졸중의 치료 방법
KR20220149268A (ko) * 2021-04-30 2022-11-08 주식회사 온코크로스 트리사이클로 유도체 화합물을 포함하는 대사질환 예방 또는 치료용 조성물
CN115554303B (zh) * 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用
WO2023061406A1 (zh) * 2021-10-12 2023-04-20 微境生物医药科技(上海)有限公司 含三并环结构的parp抑制剂、及其制备方法和医药用途
WO2024258904A1 (en) * 2023-06-13 2024-12-19 University Of Georgia Research Foundation, Inc. Tetrahydroacridinone analogues for treatment and prevention of malaria

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AU2016276806B2 (en) * 2015-06-09 2019-02-14 Onconic Therapeutics Inc. Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same
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DK2364983T3 (da) 2013-12-09
PL2364983T3 (pl) 2014-04-30
CN102245612A (zh) 2011-11-16
EP2364983B1 (en) 2013-10-23
EP2364983A4 (en) 2012-05-09
CA2743257C (en) 2014-02-11
EP2364983A2 (en) 2011-09-14
CA2743257A1 (en) 2010-05-20
JP2012508273A (ja) 2012-04-05
MX2011004957A (es) 2011-08-12
JP5403709B2 (ja) 2014-01-29
ES2443127T3 (es) 2014-02-17
BRPI0915273B1 (pt) 2021-08-03
BRPI0915273A2 (pt) 2015-08-04
KR100968175B1 (ko) 2010-07-07
PT2364983E (pt) 2014-01-07
CN102245612B (zh) 2014-11-05
AU2009314760B2 (en) 2011-11-10
US20110218193A1 (en) 2011-09-08
WO2010056038A3 (ko) 2010-09-16
HK1164292A1 (en) 2012-09-21
KR20100053468A (ko) 2010-05-20
RU2470934C1 (ru) 2012-12-27
AU2009314760A1 (en) 2011-06-30
US8815891B2 (en) 2014-08-26

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