WO2010078512A2 - Production of substituted phenylene aromatic diesters - Google Patents

Production of substituted phenylene aromatic diesters Download PDF

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Publication number
WO2010078512A2
WO2010078512A2 PCT/US2009/069942 US2009069942W WO2010078512A2 WO 2010078512 A2 WO2010078512 A2 WO 2010078512A2 US 2009069942 W US2009069942 W US 2009069942W WO 2010078512 A2 WO2010078512 A2 WO 2010078512A2
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Prior art keywords
tert
butyl
bmpd
methylcatechol
forming
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PCT/US2009/069942
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French (fr)
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WO2010078512A4 (en
WO2010078512A3 (en
Inventor
Tak W. Leung
Gary A. Roth
Tao Tao
Kuanqiang Gao
Linfeng Chen
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Dow Global Technologies LLC
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Dow Global Technologies LLC
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Priority to CN200980157529.1A priority Critical patent/CN102333749B/en
Priority to US12/651,142 priority patent/US8507717B2/en
Priority to EP09796927A priority patent/EP2373604A2/en
Priority to JP2011544626A priority patent/JP5461583B2/en
Priority to BRPI0918707A priority patent/BRPI0918707A2/en
Application filed by Dow Global Technologies LLC filed Critical Dow Global Technologies LLC
Priority to RU2011132141/04A priority patent/RU2553475C2/en
Priority to MX2011007152A priority patent/MX2011007152A/en
Priority to SG2011048048A priority patent/SG172438A1/en
Publication of WO2010078512A2 publication Critical patent/WO2010078512A2/en
Publication of WO2010078512A3 publication Critical patent/WO2010078512A3/en
Publication of WO2010078512A4 publication Critical patent/WO2010078512A4/en
Anticipated expiration legal-status Critical
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Definitions

  • the present disclosure relates to the production of substituted phenylene aromatic diesters.
  • Substituted phenylene aromatic diesters are used as internal electron donors in the preparation of procatalyst compositions for the production of olefm-based polymers.
  • Ziegler-Natta catalysts containing 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate as internal electron donor show high catalyst activity and high selectivity during polymerization.
  • such catalysts produce olefin-based polymer (such as propylene-based polymer) with high isotacticity and broad molecular weight distribution.
  • the art recognizes the need for olefin-based polymers and propylene-based polymers with improved properties. Desired are multiple and/or alternate synthesis pathways for the production of substituted phenylene aromatic diester to ensure a cost-effective, and reliable supply of the same.
  • the present disclosure is directed to the production of substituted phenylene aromatic diesters and 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate in particular.
  • Disclosed herein are synthesis pathways for the production of a precursor to the 5-tert-butyl- 3 -methyl- 1 ,2-phenylene dibenzoate, namely 5-tert-butyl-3-rnethylcatechol. Provision of this precursor, as presented in this disclosure advantageously simplifies production of 5-tert- butyl-3 -methyl- 1 ,2-phenylene dibenzoate and enables large-scale production thereof with common, inexpensive starting materials.
  • a process which includes reacting, under reaction conditions, 5-tert-butyl-3-methylcatechol
  • WHD/6867784 1 (BMC) with an aromatic carboxylic acid or an aromatic carboxylic acid derivative, and forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD).
  • a process includes alkylating, under reaction conditions, 3-methylcathecol with tert- butanol or isobutylene, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes oxidizing, under reaction conditions, 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes oxidizing, under reaction conditions, 4-tert-butyl-2-methylphenol, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes hydrolyzing, under reaction conditions, 2-halo-4-tert-butyl-6-methylphenol, and forming 5-tert-butyl-3-methylcatechol.
  • a process includes hydrogenolyzing, under reaction conditions, 5-tert-butyl-3- aminomethylcatechol, and forming 5-tert-butyl-3-methylcatechol.
  • An advantage of the present disclosure is an improved process for the production of substituted phenylene aromatic diester, such as 5 -tert-butyl-3 -methyl- 1,2-phenylene dibenzoate.
  • An advantage of the present disclosure is the provision of a precursor to 5-tert- butyl-3 -methyl 1,2-phenylene dibenzoate, namely, 5 -tert-butyl-3 -methylcatechol.
  • An advantage of the present disclosure is the provision of a plurality of synthesis pathways to produce 5-tert-butyl-3 -methylcatechol.
  • An advantage of the present disclosure is the production of 5 -tert-butyl-3 -methyl- 1 ,2-phenylene dibenzoate using inexpensive starting materials.
  • An advantage of the present disclosure is numerous synthesis pathways for the production of substituted phenylene aromatic diester, such as 5-tert-butyl-3-methyl- 1,2- phenylene dibenzoate, thereby ensuring a reliable supply of same for the production of propylene-based polymers.
  • An advantage of the present disclosure is a process for large scale production of substituted phenylene aromatic diester.
  • An advantage of the present disclosure is an environmentally-safe, non-toxic production process for substituted phenylene aromatic diester.
  • An advantage of the present disclosure is the large scale production of substituted phenylene aromatic diester.
  • An advantage of the present disclosure is a simple, time-effective, and/or cost- effective purification process for substituted phenylene aromatic diester.
  • Figure 1 is a flowchart showing a process for producing a substituted phenylene aromatic diester in accordance with an embodiment of the present disclosure.
  • Figure 2 is a flowchart showing a process for producing a substituted phenylene aromatic diester in accordance with an embodiment of the present disclosure.
  • the present disclosure is directed to the production of substituted phenylene aromatic diester.
  • 5-tert-butyl-3-methylcatechol (or "BMC") is found to be an effective precursor for the production of the substituted phenylene aromatic diester, 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate (or "BMPD”).
  • BMPD is an effective internal electron donor in Ziegler-Natta catalysts.
  • the processes disclosed herein advantageously provide economical (both time and monetary economies), simplified, up-scalable, synthesis pathways to BMC with yields acceptable for commercial/industrial application thereof. Economical access of BMC correspondingly contributes to economical production of 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate.
  • 5-tert-butyl-3-methylcatechol has the structure (I) provided below.
  • a process for producing BMC includes alkylating 3-methylcathecol with tert-butanol or isobutylene under reaction
  • alkylating or “alkylation,” or “alkylation reaction” is the introduction of an alkyl radical into an organic compound.
  • An "organic compound” is a chemical compound that contains a carbon atom.
  • reaction conditions are temperature, pressure, reactant concentrations, solvent concentrations, reactant mixing/addition parameters, and/or other conditions within a reaction vessel that promote reaction between the reagents and formation of the resultant product.
  • alkylation occurs with the addition of an inorganic acid (such as sulfuric acid) to a mixture of the 3-methylcatechol and the tert- butanol in heptane.
  • the process includes the preparation of the 3-methylcatechol.
  • the process includes oxidizing 2-hydroxy-3-methylbenzaldehyde under reaction conditions and forming the 3-methylcatechol (Rx 2).
  • the oxidizing agent is a peroxide, such as hydrogen peroxide, which is added to the 2-hydroxy-3-methylaldehyde in an aqueous basic solution.
  • the process includes the preparation of the 2-hydroxy-3- methylbenzaldehyde (Rx 3).
  • the process includes formylating o-cresol with paraformaldehyde under reaction conditions, and forming 2-hydroxy-3-methylbenzaldehyde.
  • the 2- hydroxy-3- methylbenzaldehyde is subsequently oxidized to form the 3-methylcatechol.
  • the formylation reaction may occur by formylating the o-cresol with paraformaldehyde, magnesium chloride (MgCl 2 ) and triethylamine (Et 3 N) in refluxing tetrahydrofuran (THF).
  • the reaction yields ortho-formylation of the o-cresol.
  • Another suitable formylation reaction is the Reimer-Tiemann reaction (i. e. , ortho-formylation of the o-cresol in chloroform/sodium hydroxide).
  • 3-methylcatechol is prepared directly from o-cresol.
  • the process includes oxidizing, under reaction conditions, o-cresol, and forming the 3- methylcatechol (Rx 4).
  • the oxidizing agent is a peroxide, such as hydrogen peroxide.
  • the process further includes alkylating the 3-methylcathecol and forming the BMC as disclosed above.
  • reaction 4 A nonlimiting representation of reaction 4 is provided in pathway (III) below.
  • another process for producing BMC includes oxidizing 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde, under reaction conditions, and forming 5-tert-butyl-3-methylcatechol (Rx 5).
  • the oxidizing agent is a peroxide, such as hydrogen peroxide.
  • the process includes synthesis of the 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde.
  • the process includes formylating, under reaction conditions, 4-tert- butyl-2-methylphenol with paraformaldehyde and forming the 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde (Rx 6).
  • Formylation may occur by way of any suitable formylation reaction as disclosed herein.
  • the process includes the synthesis of the 4-tert-butyl-2- methylphenol.
  • the process includes alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol to form 4-tert-butyl-2-methylphenol (Rx 7). Alkylation may occur by way of any suitable alkylation reaction as disclosed herein.
  • the compound, o-cresol surprisingly has been found as an advantageous starting material for the production of BMC.
  • the compound o-cresol is inexpensive and provides a methyl group directly adjacent to an
  • the -OH group of o-cresol is a strong para-director for an electrophilic substitution reaction, enabling ready alkylation of o-cresol to 4-tert-butyl-2- methylphenol.
  • the 4-tert-butyl-2-methylphenol is subsequently formylated, under reaction conditions, to form the 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde.
  • the present disclosure provides another process for producing BMC.
  • a process is provided and includes oxidizing, under reaction conditions, 4-tert- butyl-2-methylphenol, and forming 5-tert-butyl-3-methylcatechol (Rx 8). Oxidation may occur by way of addition of a peroxide to the 4-tert-butyl-2-methylcresol in a basic aqueous solution.
  • the process includes synthesis of the 4-tert-butyl-2- methylphenol.
  • the process includes alkylating, under reaction conditions, o-cresol with tert- butanol or isobutylene, and forming the 4-tert-butyl-2-methylphenol (Rx 9). Alkylation may occur by way of any suitable alkylation reaction as disclosed herein.
  • the 4-tert-butyl-2- methylcresol is subsequently oxidized to form the BMC.
  • a process includes hydrolyzing, under reaction conditions, 2- halo-4-tert-butyl-6-methylphenol, and forming 5-tert-butyl-3-methylcatechol (Rx 10).
  • hydrolyzing or “hydrolysis,” or “hydrolysis reaction” is a chemical reaction whereby water splits into H+ and OH- ions and the OH- ion replaces a functional group.
  • halo is a halogen atom — F, Cl, Br, I. In an embodiment, the halogen atom is bromine yielding 2-bromo-4-tert-butyl-6-methylphenol.
  • the halogen atom is chlorine yielding 2-chloro-4-tert-butyl-6-methylphenol.
  • the hydrolysis reaction is catalyzed by a base and/or a salt, such as such as copper (II) sulfate.
  • the process includes the synthesis of the 2-halo-4-tert-butyl-6- methylphenol.
  • the process includes halogenating, under reaction conditions, 4-tert-butyl-2- methylphenol, and forming the 2-halo-4-tert-butyl-6-methylphenol (Rx 11).
  • the term "halogenating,” or “halogenation,” or “halogenation reaction,” is the introduction of a halogen radical into an organic compound.
  • Halogenation occurs by reacting the 4-tert-butyl- 2-methylphenol with a halogenating agent, such as a brominating agent or a chlorinating agent.
  • a halogenating agent such as a brominating agent or a chlorinating agent.
  • suitable halogenating agents include N-bromosuccinamine (NBS), a brominating agent, and/or N-chlorosuccinamine (NCS), a chlorinating agent.
  • Halogenation may also occur by reacting the 4-tert-butyl-2-methylphenol with elemental halogen.
  • the term "X 2 " in pathway (VI) below denotes the reaction with elemental halogen.
  • the elemental halogen and may be Cl 2 or Br 2 .
  • the process includes synthesis of the 4-tert-butyl-2- methylphenol.
  • the 4-tert-butyl-2-methylphenol is formed by alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol as disclosed above (Rx 12).
  • the 4-tert-butyl-2-methylphenol is formed by alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol as disclosed above (Rx 12).
  • WHD/6867784 1 butyl-2-methylphenol is subsequently halogenated to form the 2-halo-4-tert-butyl-6- methylphenol.
  • a process includes hydrogenolyzing, under reaction conditions, 5-tert-butyl-3-aminomethylcatechol, and forming 5-tert-butyl-3-methylcatechol (Rx 13).
  • the term "hydrogenolyzing,” or “hydrogenolysis,” or “hydrogenolysis reaction” is a chemical reaction whereby a carbon-carbon or carbon-heteroatom single bond is cleaved by hydrogen.
  • suitable hydrogenolyzing agents include catalytic hydrogenolyzing agents (such as palladium catalysts) and borohydrides, such as sodium cyano-borohydride.
  • the process includes the synthesis of the 5-tert-butyl-3- aminomethylcateghol.
  • the process includes an aminoalkylating, under reaction conditions, 4-tert-butylcatechol, and forming the 5-tert-butyl-3-aminomethylcatechol (Rx 14).
  • the 5-tert- butyl-3-aminomethylcatechol is subsequently hydrogenolyzed to form the 5-tert-butyl-3- methylcatechol.
  • Aminoalkylation occurs by way of the Mannich reaction.
  • the "Mannich reaction” is an organic reaction which aminoalkylates an acidic proton located next to a carbonyl functional group with formaldehyde and ammonia or any primary or secondary amine.
  • a process for producing 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate includes reacting BMC, under reaction conditions, with a member selected from an aromatic carboxylic acid and/or an aromatic carboxylic acid derivative, and subsequently forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD).
  • BMC is prepared by any of the synthesis pathways as previously disclosed herein.
  • an "aromatic carboxylic acid” is a compound containing at least one benzene ring with at least one carboxyl group directly bonded to the benzene ring. It is understood that the aromatic carboxylic acid may be a monocyclic structure or a polycyclic structure. The aromatic carboxylic acid may be a mono- or a poly-carboxylic acid. Nonlimiting examples of suitable aromatic carboxylic acids include benzoic acid, 1- naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and phenanthrene-3 -carboxylic acid.
  • a “derivative of an aromatic carboxylic acid” or “an aromatic carboxylic acid derivative,” as used herein, is an aromatic acyl halide, an aromatic anhydride, an aromatic carboxylate salt, or any combination thereof. It is understood that the derivative of the
  • aromatic carboxylic acid may be a monocyclic structure or a poly cyclic structure.
  • suitable aromatic acyl halides include halides of any of the aromatic carboxylic acids disclosed above (i.e., an acyl halide of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2- carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 -carboxylic acid).
  • aromatic acyl halides include benzoyl chloride, benzoyl fluoride, benzoyl bromide, and benzoyl iodide, naphthoyl chloride, naphthoyl fluoride, naphthoyl bromide, naphthoyl iodide, and any combination of the foregoing aromatic acyl halides.
  • Nonlimiting examples of suitable aromatic anhydrides include anhydride of the aromatic carboxylic acids disclosed above, (i.e., an anhydride of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 - carboxylic acid).
  • suitable aromatic anhydrides include benzoic anhydride and any combination of the foregoing aromatic anhydrides.
  • Nonlimiting examples of suitable aromatic carboxylate salts include potassium, sodium, or lithium salt of the aromatic carboxylic acids disclosed above (i.e., salts of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H- phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 -carboxylic acid).
  • suitable aromatic carboxylate salts include potassium benzoate, sodium benzoate, lithium benzoate, potassium 2-naphthoate, sodium 2-naphthoate, and any combination of the foregoing aromatic carboxylate salts.
  • the aromatic carboxylic acid, or derivative thereof may be substituted.
  • substituted aromatic carboxylic acid or derivative thereof is an aromatic carboxylic acid, or derivative thereof, whereby at least one of the benzene-ring substituents (other than the carboxyl group) is a substituted hydrocarbyl group having 1 to 20 carbon atoms, an unsubstituted hydrocarbyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a heteroatom, and combinations thereof.
  • substituted aromatic carboxylic acid or derivative thereof includes substituted aromatic
  • WHD/6867784.1 carboxylic acid, substituted aromatic acyl halide, substituted aromatic anhydride, and/or substituted aromatic carboxylate salt.
  • hydrocarbyl and “hydrocarbon” refer to substituents containing only hydrogen and carbon atoms, including branched or unbranched, saturated or unsaturated, cyclic, polycyclic, fused, or acyclic species, and combinations thereof.
  • hydrocarbyl groups include alkyl-, cycloalkyl-, alkenyl-, alkadienyl-, cycloalkenyl-, cycloalkadienyl-, aryl-, aralkyl, alkylaryl, and alkynyl- groups.
  • substituted hydrocarbyl and “substituted hydrocarbon” refer to a hydrocarbyl group that is substituted with one or more nonhydrocarbyl substituent groups.
  • a nonlimiting example of a nonhydrocarbyl substituent group is a heteroatom.
  • a heteroatom refers to an atom other than carbon or hydrogen.
  • the heteroatom can be a non-carbon atom from Groups IV, V, VI, and VII of the Periodic Table.
  • Nonlimiting examples of heteroatoms include: halogens (F, Cl, Br, I), N, O, P, B, S, and Si.
  • a substituted hydrocarbyl group also includes a halohydrocarbyl group and/or a silicon-containing hydrocarbyl group.
  • halohydrocarbyl group refers to a hydrocarbyl group that is substituted with one or more halogen atoms.
  • sicon-containing hydrocarbyl group is a hydrocarbyl group that is substituted with one or more silicon atoms. The silicon atom(s) may or may not be in the carbon chain.
  • BMPD is formed by reacting BMC, under reaction conditions, with an aromatic carboxylic acid derivative, benzoyl chloride.
  • the process includes reacting BMC with benzoyl chloride in the presence of a base under reaction conditions, and forming BMPD (Rx 15).
  • base include pyridine, triethylamine, trimethylamine, and/or molecular sieves.
  • a nonlimiting representation of reaction 15 is provided in pathway (VIII) below.
  • BMPD 5 -tert-buty 1-3 -methyl- 1 ,2-phenylene dibenzoate
  • the reaction includes adding benzoyl chloride to a mixture of BMC, pyridine, and dichloromethane. Pyridine absorbs HCl, a by-product of the reaction.
  • the process includes forming the BMPD by adding the benzoyl chloride to a reaction mixture composed of the BMC, acetonitrile and triethylamine. Triethylamine absorbs HCl, a by-product of the reaction.
  • acetonitrile and triethylamine advantageously provides an environmentally safe, and low health risk (nontoxic) process for BMPD production, and large-scale (i.e., greater than 10 g, or greater than 1 kg) production of BMPD in particular.
  • the process includes adding water to the reaction mixture (containing BMPD, acetonitrile triethylamine, benzoyl chloride, and BMC); and precipitating the BMPD.
  • the solvent, acetonitrile is soluble in water. Bounded by no particular theory, addition of the water quenches the reaction and changes the solubility of the solvent to precipitate the BMPD from solution (the "BMPD-precipitate").
  • Provision of the acetonitrile solvent system advantageously provides a simple, cost-effective and effective procedure for BMPD production, suitable for commercial or industrial scale.
  • Figure 1 shows a nonlimiting flowchart for BMPD production.
  • the process includes purifying the BMPD, and forming a BMPD composition comprising greater than 98 wt %, or greater than 99 wt % BMPD.
  • WHD/6867784.1 purification of the BMPD includes performing one or more procedures on the BMPD- precipitate: recrystallization, extraction, concentration, washing, distillation, and any combination of the foregoing.
  • the purification includes dissolving the BMPD-precipitate in a non-aqueous solvent (such as ethyl a cetate), and extracting with water.
  • a non-aqueous solvent such as ethyl a cetate
  • water extraction removes ionic impurities and/or ionic byproducts from the non-aqueous phase thereby purifying the BMPD.
  • the non-aqueous phase is dried (over MgSO 4 ) and concentrated by way of roto-evaporation (the "concentrate") in conjunction with a hydrocarbon wash (heptane) to remove organic by-products/impurities. Recrystallization yields a purified BMPD composition composed of greater than 98 wt %, or greater than 99 wt %, BMPD.
  • the purification includes distilling the concentrate in conjunction with a hydrocarbon wash (heptane). Filtration and drying yields a purified BMPD composition composed of greater than 98 wt %, or greater than 99 wt % BMPD.
  • Figure 2 shows a nonlimiting flowchart for the purification of the BMPD-precipitate.
  • the BMPD is advantageously applied as an internal electron donor in procatalyst/catalyst compositions for the production of olefm-based polymers (propylene- based polymers in particular) as disclosed in U.S. provisional application no. 61/141,902 filed on December 31, 2008 and U.S. provisional application no. 61/141,959 filed on December 31, 2008, the entire content of each application incorporated by reference herein.
  • DEFINITIONS DEFINITIONS
  • compositions claimed herein through use of the term “comprising” may include any additional additive, adjuvant, or compound whether polymeric or otherwise, unless stated to the contrary.
  • any numerical range recited herein includes all values from the lower value to the upper value, in increments of one unit, provided that there is a separation of at least 2 units between any lower value and any higher value.
  • amount of a component, or a value of a compositional or a physical property such as, for example, amount of a blend component, softening temperature, melt index, etc.
  • amount of a blend component, softening temperature, melt index, etc. is between 1 and 100
  • all individual values, such as, 1, 2, 3, etc., and all subranges, such as, 1 to 20, 55 to 70, 197 to 100, etc., are expressly enumerated in this specification.
  • any numerical range recited herein includes any value or subrange within the stated range. Numerical ranges have been recited, as discussed herein, reference melt index, melt flow rate, and other properties.
  • blend or "polymer blend,” as used herein, is a blend of two or more polymers. Such a blend may or may not be miscible (not phase separated at molecular level). Such a blend may or may not be phase separated. Such a blend may or may not contain one or more domain configurations, as determined from transmission electron spectroscopy, light scattering, x-ray scattering, and other methods known in the art.
  • composition includes a mixture of materials which comprise the composition, as well as reaction products and decomposition products formed from the materials of the composition.
  • polymer is a macromolecular compound prepared by polymerizing monomers of the same or different type.
  • Polymer includes homopolymers, copolymers, terpolymers, interpolymers, and so on.
  • interpolymer means a polymer prepared by the polymerization of at least two types of monomers or comonomers.
  • copolymers which usually refers to polymers prepared from two different types of monomers or comonomers
  • terpolymers which usually refers to polymers prepared from three different types of monomers or comonomers
  • tetrapolymers which usually refers to polymers prepared from four different types of monomers or comonomers
  • olefin-based polymer is a polymer containing, in polymerized form, a majority weight percent of an olefin, for example ethylene or propylene, based on the total weight of the polymer.
  • olefin-based polymers include ethylene-based polymers and propylene-based polymers.
  • propylene-based polymer refers to a polymer that comprises a majority weight percent polymerized propylene monomer (based on the total amount of polymerizable monomers), and optionally may comprise at least one polymerized comonomer.
  • alkyl refers to a branched or unbranched, saturated or unsaturated acyclic hydrocarbon radical.
  • suitable alkyl radicals include, for example, methyl, ethyl, n-propyl, i-propyl, 2-propenyl (or allyl), vinyl, n-butyl, t- butyl, i-butyl (or 2-methylpropyl), etc.
  • the alkyls have 1 and 20 carbon atoms.
  • substituted alkyl refers to an alkyl as just described in which one or more hydrogen atom bound to any carbon of the alkyl is replaced by another group such as a halogen, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, halogen, haloalkyl, hydroxy, amino, phosphido, alkoxy, amino, thio, nitro, and combinations thereof.
  • Suitable substituted alkyls include, for example, benzyl, trifluoromethyl and the like.
  • aryl refers to an aromatic substituent which may be a single aromatic ring or multiple aromatic rings which are fused together, linked covalently,
  • WHD/6867784 1 or linked to a common group such as a methylene or ethylene moiety.
  • the aromatic ring(s) may include phenyl, naphthyl, anthracenyl, and biphenyl, among others.
  • the aryls have 1 and 20 carbon atoms.
  • substituted phenylene aromatic diester includes substituted 1,2- phenylene aromatic diester, substituted 1,3 -phenylene aromatic diester, and substituted 1,4-phenylene aromatic diester.
  • the substituted phenylene diester is a 1,2- phenylene aromatic diester with the structure (A) below:
  • R 1 -R 14 are the same or different.
  • Each of Ri-R 14 is selected from a hydrogen, substituted hydrocarbyl group having 1 to 20 carbon atoms, an unsubstituted hydrocarbyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a heteroatom, and combinations thereof.
  • At least one of Ri-Ri 4 is not hydrogen
  • Example 1 Conversion of 3-methylcatechol to S-tert-butyl-S-methylcatechol
  • a 100-mL 3 -neck round bottom flask, equipped with stirrer, reflux condenser, thermometer, dropping funnel is charged with 6.8 g of 2-hydroxy-3-methylaldehyde and 25 mL of 2N NaOH aqueous solution.
  • a diluted H 2 O 2 is added in portion of 10 mL to maintain internal temperature between 40 0 C to 50 0 C.
  • the temperature rises to 45 0 C and a dark solution results.
  • the temperature is allowed to fall to 4O 0 C before a second portion of hydrogen peroxide is added.
  • a 1-L 4-neck round bottom flask, equipped with stirrer, reflux condenser, thermometer, nitrogen inlet and bubbler is charged with 20.64 mL of o-cresol and 14.0 g of paraformaldehyde.
  • THF is charged via syringe followed by addition of triethylamine via dropping funnel.
  • o-cresol is added slowly via syringe, resulting in an opaque, light pink mixture that is refluxed for 4 hours.
  • the reaction is cooled and diluted with 200 mL of ether, washed with 1 N HCl, water, and dried over Na 2 SO 4 .
  • a 500 mL three-neck round bottom flask with thermowell is fitted with an addition funnel/N 2 inlet, mechanical stirrer and a stopper. After the system is purged with N 2 the vessel is loaded with the 5-tert-butyl-3-methylcatechol (20.0 g, 0.11 mol) and CH 3 CN (100 mL). The mixture is stirred at ambient temperature until all the solids are dissolved. To the vessel is added triethylamine (26.8 g, 0.27 mol) and the internal temperature of the reaction is taken to 1O 0 C using a dry ice/water bath. Benzoyl chloride (34.4 g, 0.24 mol) is added dropwise keeping the temperature at 10-20 0 C. The addition takes about 30 minutes. The ice bath is removed and the thick slurry is allowed to stir at ambient temperature for 1 hour.
  • a 1 -liter three neck round bottom flask with thermowell is fitted with a N 2 inlet, mechanical stirrer and a stopper.
  • water 400 mL
  • the slurry from above is added in eight portions over about 20 min.
  • the resulting slurry is stirred at ambient temperature for 30 minutes and then the solid is collected via filtration.
  • the crude solid is dissolved in EtOAc (150 mL) and extracted with water (75 mL).
  • the aqueous phase is discarded and the EtOAc phase is dried over MgSO 4 .
  • the MgSO 4 is removed by filtration providing 175 g of light brown solution.
  • the solution is concentrated on a rotary evaporator (45-5O 0 C bath @ 150-200 mmHg) taking 96 g of solvent
  • a 5L three-neck round bottom flask with thermowell is fitted with an addition funnel/N 2 inlet, mechanical stirrer and a stopper. After the system is purged with N 2 the pot is loaded with the starting 5-tert-butyl-3-methylcatechol (314.3 g, 1.75 mol) and CH 3 CN (1570 mL). The mixture is stirred at ambient temperature until all the solids are dissolved. To the pot is added triethylamine (423 g, 4.17 mol) and the internal temperature of the reaction is taken to 1O 0 C using a dry ice/water bath. Benzoyl chloride (543 g, 3.84 mol) is added dropwise keeping the temperature at 10-20 0 C. Initially only half of the benzoyl chloride is added into the additional funnel to prevent all of the material from being added at once. The entire addition takes about 2 hours. The ice bath is removed and the thick slurry is allowed to stir at ambient temperature overnight.
  • a total of 1243.4 g is produced at 92% yield with a melting point 110-112 0 C.
  • the material has a purity greater than 99 wt %.

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Abstract

The present disclosure is directed to the production of 5-tert-butyl-3-methyl-l,2- phenylene dibenzoate and the purification thereof. Synthesis pathways for a precursor to 5- tert-butyl-3 -methyl- 1,2-phenylene dibenzoate are provided. The precursor is 5-tert-butyl-3-methylcatechol.

Description

PRODUCTION OF SUBSTITUTED PHENYLENE AROMATIC DIESTERS
PRIORITY CLAIM
[0001] The present application claims priority to U.S. provisional application no. 61/141,902 filed on December 31, 2008 and U.S. provisional application no. 61/141,959 filed on December 31, 2008, the entire content of each application incorporated by reference herein.
BACKGROUND
[0002] The present disclosure relates to the production of substituted phenylene aromatic diesters.
[0003] Substituted phenylene aromatic diesters are used as internal electron donors in the preparation of procatalyst compositions for the production of olefm-based polymers. In particular, Ziegler-Natta catalysts containing 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate as internal electron donor show high catalyst activity and high selectivity during polymerization. In addition, such catalysts produce olefin-based polymer (such as propylene-based polymer) with high isotacticity and broad molecular weight distribution. [0004] The art recognizes the need for olefin-based polymers and propylene-based polymers with improved properties. Desired are multiple and/or alternate synthesis pathways for the production of substituted phenylene aromatic diester to ensure a cost-effective, and reliable supply of the same.
SUMMARY
[0005] The present disclosure is directed to the production of substituted phenylene aromatic diesters and 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate in particular. Disclosed herein are synthesis pathways for the production of a precursor to the 5-tert-butyl- 3 -methyl- 1 ,2-phenylene dibenzoate, namely 5-tert-butyl-3-rnethylcatechol. Provision of this precursor, as presented in this disclosure advantageously simplifies production of 5-tert- butyl-3 -methyl- 1 ,2-phenylene dibenzoate and enables large-scale production thereof with common, inexpensive starting materials.
[0006] The present disclosure provides a process. In an embodiment, a process is provided which includes reacting, under reaction conditions, 5-tert-butyl-3-methylcatechol
WHD/6867784 1 (BMC) with an aromatic carboxylic acid or an aromatic carboxylic acid derivative, and forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD).
[0007] The disclosure provides another process. In an embodiment, a process is provided and includes alkylating, under reaction conditions, 3-methylcathecol with tert- butanol or isobutylene, and forming 5-tert-butyl-3-methylcatechol.
[0008] The disclosure provides another process. In an embodiment, a process is provided and includes oxidizing, under reaction conditions, 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde, and forming 5-tert-butyl-3-methylcatechol.
[0009] The disclosure provides another process. In an embodiment, a process is provided and includes oxidizing, under reaction conditions, 4-tert-butyl-2-methylphenol, and forming 5-tert-butyl-3-methylcatechol.
[0010] The disclosure provides another process. In an embodiment, a process is provided and includes hydrolyzing, under reaction conditions, 2-halo-4-tert-butyl-6-methylphenol, and forming 5-tert-butyl-3-methylcatechol.
[0011] The disclosure provides another process. In an embodiment, a process is provided and includes hydrogenolyzing, under reaction conditions, 5-tert-butyl-3- aminomethylcatechol, and forming 5-tert-butyl-3-methylcatechol.
[0012] An advantage of the present disclosure is an improved process for the production of substituted phenylene aromatic diester, such as 5 -tert-butyl-3 -methyl- 1,2-phenylene dibenzoate.
[0013] An advantage of the present disclosure is the provision of a precursor to 5-tert- butyl-3 -methyl 1,2-phenylene dibenzoate, namely, 5 -tert-butyl-3 -methylcatechol. [0014] An advantage of the present disclosure is the provision of a plurality of synthesis pathways to produce 5-tert-butyl-3 -methylcatechol.
[0015] An advantage of the present disclosure is the production of 5 -tert-butyl-3 -methyl- 1 ,2-phenylene dibenzoate using inexpensive starting materials.
[0016] An advantage of the present disclosure is numerous synthesis pathways for the production of substituted phenylene aromatic diester, such as 5-tert-butyl-3-methyl- 1,2- phenylene dibenzoate, thereby ensuring a reliable supply of same for the production of propylene-based polymers.
WHD/6867784 1 [0017] An advantage of the present disclosure is a process for large scale production of substituted phenylene aromatic diester.
[0018] An advantage of the present disclosure is an environmentally-safe, non-toxic production process for substituted phenylene aromatic diester.
[0019] An advantage of the present disclosure is the large scale production of substituted phenylene aromatic diester.
[0020] An advantage of the present disclosure is a simple, time-effective, and/or cost- effective purification process for substituted phenylene aromatic diester.
BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 is a flowchart showing a process for producing a substituted phenylene aromatic diester in accordance with an embodiment of the present disclosure. [0022] Figure 2 is a flowchart showing a process for producing a substituted phenylene aromatic diester in accordance with an embodiment of the present disclosure.
DETAILED DESCRIPTION
[0023] The present disclosure is directed to the production of substituted phenylene aromatic diester. 5-tert-butyl-3-methylcatechol (or "BMC") is found to be an effective precursor for the production of the substituted phenylene aromatic diester, 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate (or "BMPD"). BMPD is an effective internal electron donor in Ziegler-Natta catalysts. The processes disclosed herein advantageously provide economical (both time and monetary economies), simplified, up-scalable, synthesis pathways to BMC with yields acceptable for commercial/industrial application thereof. Economical access of BMC correspondingly contributes to economical production of 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate.
[0024] 5-tert-butyl-3-methylcatechol (BMC) has the structure (I) provided below.
(I)
Figure imgf000005_0001
[0025] In an embodiment, a process for producing BMC is provided. The process includes alkylating 3-methylcathecol with tert-butanol or isobutylene under reaction
WHD/6867784.1 conditions, and forming 5-tert-butyl-3-methylcatechol (BMC) (Reaction 1 or Rx 1). The term "alkylating," or "alkylation," or "alkylation reaction" is the introduction of an alkyl radical into an organic compound. An "organic compound" is a chemical compound that contains a carbon atom. As used herein, "reaction conditions," are temperature, pressure, reactant concentrations, solvent concentrations, reactant mixing/addition parameters, and/or other conditions within a reaction vessel that promote reaction between the reagents and formation of the resultant product. In an embodiment, alkylation occurs with the addition of an inorganic acid (such as sulfuric acid) to a mixture of the 3-methylcatechol and the tert- butanol in heptane.
[0026] In an embodiment, the process includes the preparation of the 3-methylcatechol. The process includes oxidizing 2-hydroxy-3-methylbenzaldehyde under reaction conditions and forming the 3-methylcatechol (Rx 2). In a further embodiment, the oxidizing agent is a peroxide, such as hydrogen peroxide, which is added to the 2-hydroxy-3-methylaldehyde in an aqueous basic solution.
[0027] In an embodiment, the process includes the preparation of the 2-hydroxy-3- methylbenzaldehyde (Rx 3). The process includes formylating o-cresol with paraformaldehyde under reaction conditions, and forming 2-hydroxy-3-methylbenzaldehyde. The term "formylating," or "formylation," or "formylation reaction" is a chemical reaction whereby an organic compound is functionalized with a formyl group (-CH=O). The 2- hydroxy-3- methylbenzaldehyde is subsequently oxidized to form the 3-methylcatechol. [0028] The formylation reaction may occur by formylating the o-cresol with paraformaldehyde, magnesium chloride (MgCl2) and triethylamine (Et3N) in refluxing tetrahydrofuran (THF). The reaction yields ortho-formylation of the o-cresol. Another suitable formylation reaction is the Reimer-Tiemann reaction (i. e. , ortho-formylation of the o-cresol in chloroform/sodium hydroxide).
[0029] In an embodiment, 3-methylcatechol is prepared directly from o-cresol. The process includes oxidizing, under reaction conditions, o-cresol, and forming the 3- methylcatechol (Rx 4). In a further embodiment, the oxidizing agent is a peroxide, such as hydrogen peroxide. The process further includes alkylating the 3-methylcathecol and forming the BMC as disclosed above.
WHD/6867784 1 [0030] A nonlimiting representation of reactions 1 , 2, and 3 is provided in pathway (II) below.
Figure imgf000007_0001
[0031] A nonlimiting representation of reaction 4 is provided in pathway (III) below.
Figure imgf000007_0002
[0032] In an embodiment, another process for producing BMC is provided. The process includes oxidizing 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde, under reaction conditions, and forming 5-tert-butyl-3-methylcatechol (Rx 5). In a further embodiment, the oxidizing agent is a peroxide, such as hydrogen peroxide.
[0033] In an embodiment, the process includes synthesis of the 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde. The process includes formylating, under reaction conditions, 4-tert- butyl-2-methylphenol with paraformaldehyde and forming the 5-tert-butyl-3-methyl-2- hydroxybenzaldehyde (Rx 6). Formylation may occur by way of any suitable formylation reaction as disclosed herein.
[0034] In an embodiment, the process includes the synthesis of the 4-tert-butyl-2- methylphenol. The process includes alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol to form 4-tert-butyl-2-methylphenol (Rx 7). Alkylation may occur by way of any suitable alkylation reaction as disclosed herein. The compound, o-cresol, surprisingly has been found as an advantageous starting material for the production of BMC.
WHD/6867784.1 The compound o-cresol is inexpensive and provides a methyl group directly adjacent to an
-OH group on the aromatic ring. The -OH group of o-cresol is a strong para-director for an electrophilic substitution reaction, enabling ready alkylation of o-cresol to 4-tert-butyl-2- methylphenol. The 4-tert-butyl-2-methylphenol is subsequently formylated, under reaction conditions, to form the 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde.
[0035] A nonlimiting representation of reactions 5, 6, and 7 is provided in pathway (IV) below.
Figure imgf000008_0001
Rx 7 Rx 6 Rx 5 (I)
[0036] The present disclosure provides another process for producing BMC. In an embodiment, a process is provided and includes oxidizing, under reaction conditions, 4-tert- butyl-2-methylphenol, and forming 5-tert-butyl-3-methylcatechol (Rx 8). Oxidation may occur by way of addition of a peroxide to the 4-tert-butyl-2-methylcresol in a basic aqueous solution.
[0037] In an embodiment, the process includes synthesis of the 4-tert-butyl-2- methylphenol. The process includes alkylating, under reaction conditions, o-cresol with tert- butanol or isobutylene, and forming the 4-tert-butyl-2-methylphenol (Rx 9). Alkylation may occur by way of any suitable alkylation reaction as disclosed herein. The 4-tert-butyl-2- methylcresol is subsequently oxidized to form the BMC.
[0038] A nonlimiting representation of reactions 8 and 9 is provided in pathway (V) below.
WHD/6867784.1
Figure imgf000009_0001
[0039] The present disclosure provides another process for producing BMC. In an embodiment, a process is provided and includes hydrolyzing, under reaction conditions, 2- halo-4-tert-butyl-6-methylphenol, and forming 5-tert-butyl-3-methylcatechol (Rx 10). As used herein, "hydrolyzing," or "hydrolysis," or "hydrolysis reaction" is a chemical reaction whereby water splits into H+ and OH- ions and the OH- ion replaces a functional group. The term "halo" is a halogen atom — F, Cl, Br, I. In an embodiment, the halogen atom is bromine yielding 2-bromo-4-tert-butyl-6-methylphenol. In another embodiment, the halogen atom is chlorine yielding 2-chloro-4-tert-butyl-6-methylphenol. In an embodiment, the hydrolysis reaction is catalyzed by a base and/or a salt, such as such as copper (II) sulfate. [0040] In an embodiment, the process includes the synthesis of the 2-halo-4-tert-butyl-6- methylphenol. The process includes halogenating, under reaction conditions, 4-tert-butyl-2- methylphenol, and forming the 2-halo-4-tert-butyl-6-methylphenol (Rx 11). The term "halogenating," or "halogenation," or "halogenation reaction," is the introduction of a halogen radical into an organic compound. Halogenation occurs by reacting the 4-tert-butyl- 2-methylphenol with a halogenating agent, such as a brominating agent or a chlorinating agent. Nonlimiting examples of suitable halogenating agents include N-bromosuccinamine (NBS), a brominating agent, and/or N-chlorosuccinamine (NCS), a chlorinating agent. Halogenation may also occur by reacting the 4-tert-butyl-2-methylphenol with elemental halogen. The term "X2" in pathway (VI) below denotes the reaction with elemental halogen. The elemental halogen and may be Cl2 or Br2.
[0041] In an embodiment, the process includes synthesis of the 4-tert-butyl-2- methylphenol. The 4-tert-butyl-2-methylphenol is formed by alkylating, under reaction conditions, o-cresol with isobutylene or t-butanol as disclosed above (Rx 12). The 4-tert-
WHD/6867784 1 butyl-2-methylphenol is subsequently halogenated to form the 2-halo-4-tert-butyl-6- methylphenol.
[0042] A nonlimiting representation of reactions 10, 11, and 12 is provided in pathway
(VI) below.
Figure imgf000010_0001
Rx 12 Rx I l Rx IO (I)
[0043] The present disclosure provides another process for producing BMC. In an embodiment, a process is provided and includes hydrogenolyzing, under reaction conditions, 5-tert-butyl-3-aminomethylcatechol, and forming 5-tert-butyl-3-methylcatechol (Rx 13). The term "hydrogenolyzing," or "hydrogenolysis," or "hydrogenolysis reaction" is a chemical reaction whereby a carbon-carbon or carbon-heteroatom single bond is cleaved by hydrogen. Nonlimiting examples of suitable hydrogenolyzing agents include catalytic hydrogenolyzing agents (such as palladium catalysts) and borohydrides, such as sodium cyano-borohydride. [0044] In an embodiment, the process includes the synthesis of the 5-tert-butyl-3- aminomethylcateghol. The process includes an aminoalkylating, under reaction conditions, 4-tert-butylcatechol, and forming the 5-tert-butyl-3-aminomethylcatechol (Rx 14). The 5-tert- butyl-3-aminomethylcatechol is subsequently hydrogenolyzed to form the 5-tert-butyl-3- methylcatechol. Aminoalkylation occurs by way of the Mannich reaction. The "Mannich reaction" is an organic reaction which aminoalkylates an acidic proton located next to a carbonyl functional group with formaldehyde and ammonia or any primary or secondary amine.
WHD/6867784.1 [0045] A nonlimiting representation of reactions 13 and 14 is provided in pathway (VII) below.
Figure imgf000011_0001
Rx 14 Rx 13 (I)
[0046] In an embodiment, a process for producing 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD) is provided. The process includes reacting BMC, under reaction conditions, with a member selected from an aromatic carboxylic acid and/or an aromatic carboxylic acid derivative, and subsequently forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD). The BMC is prepared by any of the synthesis pathways as previously disclosed herein.
[0047] As used herein, an "aromatic carboxylic acid" is a compound containing at least one benzene ring with at least one carboxyl group directly bonded to the benzene ring. It is understood that the aromatic carboxylic acid may be a monocyclic structure or a polycyclic structure. The aromatic carboxylic acid may be a mono- or a poly-carboxylic acid. Nonlimiting examples of suitable aromatic carboxylic acids include benzoic acid, 1- naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and phenanthrene-3 -carboxylic acid. [0048] A "derivative of an aromatic carboxylic acid" or "an aromatic carboxylic acid derivative," as used herein, is an aromatic acyl halide, an aromatic anhydride, an aromatic carboxylate salt, or any combination thereof. It is understood that the derivative of the
WHD/6867784.1 aromatic carboxylic acid may be a monocyclic structure or a poly cyclic structure. Nonlimiting examples of suitable aromatic acyl halides include halides of any of the aromatic carboxylic acids disclosed above (i.e., an acyl halide of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2- carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 -carboxylic acid). Further nonlimiting examples of suitable aromatic acyl halides include benzoyl chloride, benzoyl fluoride, benzoyl bromide, and benzoyl iodide, naphthoyl chloride, naphthoyl fluoride, naphthoyl bromide, naphthoyl iodide, and any combination of the foregoing aromatic acyl halides.
[0049] Nonlimiting examples of suitable aromatic anhydrides include anhydride of the aromatic carboxylic acids disclosed above, (i.e., an anhydride of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H-phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 - carboxylic acid). Further nonlimiting examples of suitable aromatic anhydrides include benzoic anhydride and any combination of the foregoing aromatic anhydrides. [0050] Nonlimiting examples of suitable aromatic carboxylate salts include potassium, sodium, or lithium salt of the aromatic carboxylic acids disclosed above (i.e., salts of one or more of the following: benzoic acid, 1 -naphthoic acid, 2-naphthoic acid, 6H- phenalene-2-carboxylic acid, anthracene-2-carboxylic acid, phenanthrene-2-carboxylic acid, and/or phenanthrene-3 -carboxylic acid). Further nonlimiting examples of suitable aromatic carboxylate salts include potassium benzoate, sodium benzoate, lithium benzoate, potassium 2-naphthoate, sodium 2-naphthoate, and any combination of the foregoing aromatic carboxylate salts.
[0051] The aromatic carboxylic acid, or derivative thereof may be substituted. The term "substituted aromatic carboxylic acid or derivative thereof," as used herein, is an aromatic carboxylic acid, or derivative thereof, whereby at least one of the benzene-ring substituents (other than the carboxyl group) is a substituted hydrocarbyl group having 1 to 20 carbon atoms, an unsubstituted hydrocarbyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a heteroatom, and combinations thereof. Thus, the term "substituted aromatic carboxylic acid or derivative thereof includes substituted aromatic
WHD/6867784.1 carboxylic acid, substituted aromatic acyl halide, substituted aromatic anhydride, and/or substituted aromatic carboxylate salt.
[0052] As used herein, the term "hydrocarbyl" and "hydrocarbon" refer to substituents containing only hydrogen and carbon atoms, including branched or unbranched, saturated or unsaturated, cyclic, polycyclic, fused, or acyclic species, and combinations thereof. Nonlimiting examples of hydrocarbyl groups include alkyl-, cycloalkyl-, alkenyl-, alkadienyl-, cycloalkenyl-, cycloalkadienyl-, aryl-, aralkyl, alkylaryl, and alkynyl- groups. [0053] As used herein, the terms "substituted hydrocarbyl" and "substituted hydrocarbon" refer to a hydrocarbyl group that is substituted with one or more nonhydrocarbyl substituent groups. A nonlimiting example of a nonhydrocarbyl substituent group is a heteroatom. As used herein, a "heteroatom" refers to an atom other than carbon or hydrogen. The heteroatom can be a non-carbon atom from Groups IV, V, VI, and VII of the Periodic Table. Nonlimiting examples of heteroatoms include: halogens (F, Cl, Br, I), N, O, P, B, S, and Si. A substituted hydrocarbyl group also includes a halohydrocarbyl group and/or a silicon-containing hydrocarbyl group. As used herein, the term "halohydrocarbyl group" refers to a hydrocarbyl group that is substituted with one or more halogen atoms. As used herein, the term "silicon-containing hydrocarbyl group" is a hydrocarbyl group that is substituted with one or more silicon atoms. The silicon atom(s) may or may not be in the carbon chain.
[0054] In an embodiment, BMPD is formed by reacting BMC, under reaction conditions, with an aromatic carboxylic acid derivative, benzoyl chloride. The process includes reacting BMC with benzoyl chloride in the presence of a base under reaction conditions, and forming BMPD (Rx 15). Nonlimiting examples of base include pyridine, triethylamine, trimethylamine, and/or molecular sieves. A nonlimiting representation of reaction 15 is provided in pathway (VIII) below.
WHD/6867784.1
Figure imgf000014_0001
Rx 15 (I) (IX)
[0055] 5 -tert-buty 1-3 -methyl- 1 ,2-phenylene dibenzoate (BMPD) is shown as structure (IX) above. BMC, structure (I) above, is prepared by any of the foregoing processes/pathways. In other words, the process of producing BMPD may also include any of the foregoing processes for producing BMC.
[0056] In an embodiment, the reaction includes adding benzoyl chloride to a mixture of BMC, pyridine, and dichloromethane. Pyridine absorbs HCl, a by-product of the reaction. [0057] In an embodiment, the process includes forming the BMPD by adding the benzoyl chloride to a reaction mixture composed of the BMC, acetonitrile and triethylamine. Triethylamine absorbs HCl, a by-product of the reaction. Use of acetonitrile and triethylamine advantageously provides an environmentally safe, and low health risk (nontoxic) process for BMPD production, and large-scale (i.e., greater than 10 g, or greater than 1 kg) production of BMPD in particular.
[0058] In an embodiment, the process includes adding water to the reaction mixture (containing BMPD, acetonitrile triethylamine, benzoyl chloride, and BMC); and precipitating the BMPD. The solvent, acetonitrile, is soluble in water. Bounded by no particular theory, addition of the water quenches the reaction and changes the solubility of the solvent to precipitate the BMPD from solution (the "BMPD-precipitate"). Provision of the acetonitrile solvent system advantageously provides a simple, cost-effective and effective procedure for BMPD production, suitable for commercial or industrial scale. Figure 1 shows a nonlimiting flowchart for BMPD production.
[0059] In an embodiment, the process includes purifying the BMPD, and forming a BMPD composition comprising greater than 98 wt %, or greater than 99 wt % BMPD. The
WHD/6867784.1 purification of the BMPD includes performing one or more procedures on the BMPD- precipitate: recrystallization, extraction, concentration, washing, distillation, and any combination of the foregoing.
[0060] In an embodiment, the purification includes dissolving the BMPD-precipitate in a non-aqueous solvent (such as ethyl a cetate), and extracting with water. Limited to no particular theory, it is believed water extraction removes ionic impurities and/or ionic byproducts from the non-aqueous phase thereby purifying the BMPD. The non-aqueous phase is dried (over MgSO4) and concentrated by way of roto-evaporation (the "concentrate") in conjunction with a hydrocarbon wash (heptane) to remove organic by-products/impurities. Recrystallization yields a purified BMPD composition composed of greater than 98 wt %, or greater than 99 wt %, BMPD.
[0061] In an embodiment, the purification includes distilling the concentrate in conjunction with a hydrocarbon wash (heptane). Filtration and drying yields a purified BMPD composition composed of greater than 98 wt %, or greater than 99 wt % BMPD. Figure 2 shows a nonlimiting flowchart for the purification of the BMPD-precipitate. [0062] The BMPD is advantageously applied as an internal electron donor in procatalyst/catalyst compositions for the production of olefm-based polymers (propylene- based polymers in particular) as disclosed in U.S. provisional application no. 61/141,902 filed on December 31, 2008 and U.S. provisional application no. 61/141,959 filed on December 31, 2008, the entire content of each application incorporated by reference herein. [0063] DEFINITIONS
[0064] All references to the Periodic Table of the Elements herein shall refer to the
Periodic Table of the Elements, published and copyrighted by CRC Press, Inc., 2003. Also, any references to a Group or Groups shall be to the Groups or Groups reflected in this Periodic Table of the Elements using the IUPAC system for numbering groups. Unless stated to the contrary, implicit from the context, or customary in the art, all parts and percents are based on weight. For purposes of United States patent practice, the contents of any patent, patent application, or publication referenced herein are hereby incorporated by reference in their entirety (or the equivalent US version thereof is so incorporated by reference), especially with respect to the disclosure of synthetic techniques, definitions (to
WHD/6867784 1 the extent not inconsistent with any definitions provided herein) and general knowledge in the art.
[0065] The term "comprising," and derivatives thereof, is not intended to exclude the presence of any additional component, step or procedure, whether or not the same is disclosed herein. In order to avoid any doubt, all compositions claimed herein through use of the term "comprising" may include any additional additive, adjuvant, or compound whether polymeric or otherwise, unless stated to the contrary. In contrast, the term, "consisting essentially of excludes from the scope of any succeeding recitation any other component, step or procedure, excepting those that are not essential to operability. The term "consisting of excludes any component, step or procedure not specifically delineated or listed. The term "or", unless stated otherwise, refers to the listed members individually as well as in any combination.
[0066] Any numerical range recited herein, includes all values from the lower value to the upper value, in increments of one unit, provided that there is a separation of at least 2 units between any lower value and any higher value. As an example, if it is stated that the amount of a component, or a value of a compositional or a physical property, such as, for example, amount of a blend component, softening temperature, melt index, etc., is between 1 and 100, it is intended that all individual values, such as, 1, 2, 3, etc., and all subranges, such as, 1 to 20, 55 to 70, 197 to 100, etc., are expressly enumerated in this specification. For values which are less than one, one unit is considered to be 0.0001, 0.001, 0.01 or 0.1, as appropriate. These are only examples of what is specifically intended, and all possible combinations of numerical values between the lowest value and the highest value enumerated, are to be considered to be expressly stated in this application. In other words, any numerical range recited herein includes any value or subrange within the stated range. Numerical ranges have been recited, as discussed herein, reference melt index, melt flow rate, and other properties.
[0067] The terms "blend" or "polymer blend," as used herein, is a blend of two or more polymers. Such a blend may or may not be miscible (not phase separated at molecular level). Such a blend may or may not be phase separated. Such a blend may or may not contain one or more domain configurations, as determined from transmission electron spectroscopy, light scattering, x-ray scattering, and other methods known in the art.
WHD/6867784.1 [0068] The term "composition," as used herein, includes a mixture of materials which comprise the composition, as well as reaction products and decomposition products formed from the materials of the composition.
[0069] The term "polymer" is a macromolecular compound prepared by polymerizing monomers of the same or different type. "Polymer" includes homopolymers, copolymers, terpolymers, interpolymers, and so on. The term "interpolymer" means a polymer prepared by the polymerization of at least two types of monomers or comonomers. It includes, but is not limited to, copolymers (which usually refers to polymers prepared from two different types of monomers or comonomers, terpolymers (which usually refers to polymers prepared from three different types of monomers or comonomers), tetrapolymers (which usually refers to polymers prepared from four different types of monomers or comonomers), and the like.
[0070] The term "olefin-based polymer" is a polymer containing, in polymerized form, a majority weight percent of an olefin, for example ethylene or propylene, based on the total weight of the polymer. Nonlimiting examples of olefin-based polymers include ethylene-based polymers and propylene-based polymers.
[0071] The term, "propylene-based polymer," as used herein, refers to a polymer that comprises a majority weight percent polymerized propylene monomer (based on the total amount of polymerizable monomers), and optionally may comprise at least one polymerized comonomer.
[0072] The term "alkyl," as used herein, refers to a branched or unbranched, saturated or unsaturated acyclic hydrocarbon radical. Nonlimiting examples of suitable alkyl radicals include, for example, methyl, ethyl, n-propyl, i-propyl, 2-propenyl (or allyl), vinyl, n-butyl, t- butyl, i-butyl (or 2-methylpropyl), etc. The alkyls have 1 and 20 carbon atoms.
[0073] The term "substituted alkyl," as used herein, refers to an alkyl as just described in which one or more hydrogen atom bound to any carbon of the alkyl is replaced by another group such as a halogen, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, halogen, haloalkyl, hydroxy, amino, phosphido, alkoxy, amino, thio, nitro, and combinations thereof. Suitable substituted alkyls include, for example, benzyl, trifluoromethyl and the like.
[0074] The term "aryl," as used herein, refers to an aromatic substituent which may be a single aromatic ring or multiple aromatic rings which are fused together, linked covalently,
WHD/6867784 1 or linked to a common group such as a methylene or ethylene moiety. The aromatic ring(s) may include phenyl, naphthyl, anthracenyl, and biphenyl, among others. The aryls have 1 and 20 carbon atoms.
[0075] The term "substituted phenylene aromatic diester" includes substituted 1,2- phenylene aromatic diester, substituted 1,3 -phenylene aromatic diester, and substituted 1,4-phenylene aromatic diester. In an embodiment, the substituted phenylene diester is a 1,2- phenylene aromatic diester with the structure (A) below:
Figure imgf000018_0001
[0076] wherein R1-R14 are the same or different. Each of Ri-R14 is selected from a hydrogen, substituted hydrocarbyl group having 1 to 20 carbon atoms, an unsubstituted hydrocarbyl group having 1 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a heteroatom, and combinations thereof. At least one of Ri-Ri4 is not hydrogen
[0077] TEST METHODS
[0078] 1H nuclear magnetic resonance (NMR) data is obtained via a Briiker 400 MHz spectrometer in CDCl3 (in ppm).
[0079] By way of example, and not limitation, examples of the present disclosure are provided.
[0080] EXAMPLES
[0081] Example 1: Conversion of 3-methylcatechol to S-tert-butyl-S-methylcatechol
(Reaction 1)
[0082] A 1000 mL three neck flask equipped with stirrer, condenser and thermometer is charged with 3-methylcatechol (25.0 g, 0.20 mole), terf-butanol (38.0 mL, 0.40 mole) and
500 mL of heptane; followed by addition of sulfuric acid (98%, 20 g) slowly. The mixture is
WHD/6867784 1 heated to 8O0C for 6 hrs until gas chromatography (GC) indicates the completion of the reaction. The solvent is removed in vacuo, and the residue is dissolved in CH2Cl2 and washed with water, NaHCO3 (aq.), brine and dried (Na2SO4). Filtration and concentration yield 5-tert-butyl-3-methylcatechol (36 g, 84%). 1H NMR: 6.79 (s, IH), 6.75 (s, IH), 5.01 (br, IH), 2.29 (s, 3H), 1.29 (s, 9H).
[0083] Example 2: Conversion of 2-hydroxy-3-methylbenzaIdehyde to 3- methylcatechol (Reaction 2)
[0084] A 100-mL 3 -neck round bottom flask, equipped with stirrer, reflux condenser, thermometer, dropping funnel is charged with 6.8 g of 2-hydroxy-3-methylaldehyde and 25 mL of 2N NaOH aqueous solution. With stirring, a diluted H2O2 is added in portion of 10 mL to maintain internal temperature between 40 0C to 50 0C. After addition of the first portion of hydrogen peroxide, the temperature rises to 450C and a dark solution results. The temperature is allowed to fall to 4O0C before a second portion of hydrogen peroxide is added. After all the peroxide is added, the reaction mixture is allowed to cool to room temperature and is saturated with sodium chloride, and extracted with ether (3x50 mL). The combined extracts are dried over sodium sulfate, the ether is removed, and distilled to give product. 1H NMR: 6.73 (m, 3H), 2.89 (s, 3H).
[0085] Example 3: Conversion of o-cresol to 2-hydroxy-3-methylbenzaldehyde (Reaction 3)
[0086] A 1-L 4-neck round bottom flask, equipped with stirrer, reflux condenser, thermometer, nitrogen inlet and bubbler is charged with 20.64 mL of o-cresol and 14.0 g of paraformaldehyde. THF is charged via syringe followed by addition of triethylamine via dropping funnel. After stirring for another 10 min, o-cresol is added slowly via syringe, resulting in an opaque, light pink mixture that is refluxed for 4 hours. The reaction is cooled and diluted with 200 mL of ether, washed with 1 N HCl, water, and dried over Na2SO4. After removal of solvent under vacuum, the residue is purified by distillation to give 15.6 grams (57%) of product. 1H NMR: 11.3 (s, IH), 9.89 (s, IH), 7.41 (d, J = 7.44 Hz, 2H), 6.95 (t, J = 7.5 Hz, IH), 2.30 (s, 3H).
[0087] Example 4: Conversion of S-tert-butyl-3-methylcatecliol to 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate (Reaction 15)
WHD/6867784 ] [0088] A 250-ml round bottom flask is charged with S-tert-butyl-S-methylcatechol (BMC) (0.025 mol), pyridine (0.05 mol, 1.0 equiv.), and dichloromethane (50 ml). The flask is cooled in an ice-water bath, and benzoyl chloride (0.1 mol, 1.0 equiv.) is added dropwise. Upon completion of addition, the reaction mixture is warmed to room temperature and stirred overnight. The mixture is diluted with additional dichloromethane, and washed with saturated NH4C1/1N HCl, water, saturated sodium bicarbonate, and brine consequently. The organic layer is collected and dried over magnesium sulfate. After filtration, the filtrate is concentrated, and the residue is dried in vacuo. Most of the crude products are pure enough, which can also be further purified by recrystallization from ethanol (for solid) or by distillation in vacuo to yield the product as white to yellow solid/liquid. Crude yield 98%. 1H NMR (500 MHz, CDCl3, ppm): 8.08 (dd, 2H), 8.03 (dd, 2H), 7.53 (tt, IH), 7.50 (tt, IH), 7.38 (t, 2H), 7.34 (t, 2H), 7.21 (d, IH), 7.19 (d, IH), 2.28 (s, 3H), 1.34 (s, 9H). Example 5: Conversion of S-tert-butyl-S-methylcatechol to 5-tert-butyI-3-methyl-l,2- phenylene dibenzoate (Reaction 15)
[0089] A 500 mL three-neck round bottom flask with thermowell is fitted with an addition funnel/N2 inlet, mechanical stirrer and a stopper. After the system is purged with N2 the vessel is loaded with the 5-tert-butyl-3-methylcatechol (20.0 g, 0.11 mol) and CH3CN (100 mL). The mixture is stirred at ambient temperature until all the solids are dissolved. To the vessel is added triethylamine (26.8 g, 0.27 mol) and the internal temperature of the reaction is taken to 1O0C using a dry ice/water bath. Benzoyl chloride (34.4 g, 0.24 mol) is added dropwise keeping the temperature at 10-200C. The addition takes about 30 minutes. The ice bath is removed and the thick slurry is allowed to stir at ambient temperature for 1 hour.
[0090] A 1 -liter three neck round bottom flask with thermowell is fitted with a N2 inlet, mechanical stirrer and a stopper. To the flask is added water (400 mL). The slurry from above is added in eight portions over about 20 min. The resulting slurry is stirred at ambient temperature for 30 minutes and then the solid is collected via filtration. [0091] The crude solid is dissolved in EtOAc (150 mL) and extracted with water (75 mL). The aqueous phase is discarded and the EtOAc phase is dried over MgSO4. The MgSO4 is removed by filtration providing 175 g of light brown solution. The solution is concentrated on a rotary evaporator (45-5O0C bath @ 150-200 mmHg) taking 96 g of solvent
WHD/6867784.1 overhead. Heptane (150 mL) is added and concentration is continued taking an additional 55 g of solvent overhead. The flask is removed from the roto-vap and a stir bar is added. A few seed crystals are added and the mixture stirred at room temperature. Crystallization begins almost immediately. The slurry is stirred at room temperature for about 1 hour and then the product is collected via filtration. The cake is washed with heptane (40 mL) and then dried to a constant weight (5 mmHg/40°C) providing the product as off white crystals (35 g, 81 %). [0092] Example 6: Conversion of S-tert-butyl-S-methylcatechol to 5-tert-butyl-3- methyl-l,2-phenylene dibenzoate (Reaction 15)
[0093] A 5L three-neck round bottom flask with thermowell is fitted with an addition funnel/N2 inlet, mechanical stirrer and a stopper. After the system is purged with N2 the pot is loaded with the starting 5-tert-butyl-3-methylcatechol (314.3 g, 1.75 mol) and CH3CN (1570 mL). The mixture is stirred at ambient temperature until all the solids are dissolved. To the pot is added triethylamine (423 g, 4.17 mol) and the internal temperature of the reaction is taken to 1O0C using a dry ice/water bath. Benzoyl chloride (543 g, 3.84 mol) is added dropwise keeping the temperature at 10-200C. Initially only half of the benzoyl chloride is added into the additional funnel to prevent all of the material from being added at once. The entire addition takes about 2 hours. The ice bath is removed and the thick slurry is allowed to stir at ambient temperature overnight.
[0094] A 12-liter three neck round bottom flask equipped with a bottom drain, thermowell fitted with a N2 inlet, mechanical stirrer and a stopper. To the flask is added water (6.3 L). The slurry from above is added in portions over about 15 minutes and the reactor is rinsed with water (100 mL) and CH3CN (50 mL). The resulting slurry is stirred at ambient temperature for 2 hours and then the solid is collected via filtration. The solid is then placed in a storage container to allow for the second batch to be completed. The two batches are worked up together. [0095] A second batch is run in the same manner. [0096] Work up:
[0097] The crude solid from 2 batches of the reaction of Example 6 (total 1968 g, water wet) is dissolved in EtOAc (4.8 L), extracted with water (2400 mL) and allowed to stir at ambient temperature overnight. The aqueous phase is discarded and the light brown solution of EtOAc (5529 g) is divided in two portions to distill.
WHD/6867784.1 [0098] Distillation #1
[0099] The solution (2824.9 g) is concentrated by overhead short-path distillation (40- 450C overhead temperature, 250-300 mmHg) taking 1718 g of solvent overhead. Heptane (2.4 L) is added and concentration is continued taking an additional 926 g of solvent overhead. The mixture is allowed to cool to room temperature and is stirred overnight. The product is collected via filtration and the cake is washed with heptane (620 mL) and then dried to a constant weight (5 mmHg/25°C) providing the product as off white crystals (636.6 g)-
[00100] Distillation #2
[00101] The solution (2692.4 g) is concentrated by overhead short-path distillation (40- 450C overhead temperature, 250-300 mmHg) taking 1545 g of solvent overhead. Heptane (2.4 L) is added and concentration is continued taking an additional 864 g of solvent overhead. The mixture is allowed to cool to room temperature and is stirred overnight. The product is collected via filtration and the cake is washed with heptane (620 mL) and then dried to a constant weight (5 mmHg/25°C) providing the product as off white crystals (606.8 g)-
[00102] A total of 1243.4 g is produced at 92% yield with a melting point 110-1120C.
The material has a purity greater than 99 wt %.
[00103] It is specifically intended that the present disclosure not be limited to the embodiments and illustrations contained herein, but include modified forms of those embodiments including portions of the embodiments and combinations of elements of different embodiments as come within the scope of the following claims.
WHD/6867784.1

Claims

CLAIMS We Claim:
1. A process comprising: reacting, under reaction conditions, 5-tert-butyl-3-methylcatechol (BMC) with a member selected from the group consisting of an aromatic carboxylic acid and an aromatic carboxylic acid derivative; and forming 5-tert-butyl-3-methyl-l,2-phenylene dibenzoate (BMPD).
2. The process of claim 1 comprising preparing the BMC by a process of any of claims 7-10.
3. The process of any of claims 1-2 comprising adding benzoyl chloride to a reaction mixture comprising the BMC, acetonitrile and triethylamine; and forming the BMPD.
4. The process of any of claims 1 -3 comprising adding water to the reaction mixture; and precipitating the BMPD.
5. The process of any of claims 1-4 comprising dissolving the precipitated BMPD and extracting with water.
6. The process of any of claims 1-5 comprising forming a BMPD composition comprising greater than 98 wt % BMPD.
7. A process comprising: alkylating, under reaction conditions, 3-methylcathecol with a member selected from the group consisting of tert-butanol and isobutylene; and forming 5-tert-butyl-3-methylcatechol.
8. A process comprising: oxidizing, under reaction conditions, 5-tert-butyl-3-methyl-2-hydroxybenzaldehyde; and forming 5-tert-butyl-3-methylcatechol.
9. A process comprising: oxidizing, under reaction conditions, 4-tert-butyl-2-methylphenol; and forming 5 -tert-butyl-3 -methylcatechol .
WHD/6867784 1
10. A process comprising : hydrolyzing, under reaction conditions, 2-halo-4-tert-butyl-6-methylphenol; and forming 5 -tert-butyl-3 -methylcatechol .
WHD/6867784 1
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012135189A3 (en) * 2011-03-29 2012-12-27 Dow Global Technologies Llc Production of substituted phenylene aromatic diesters
JP2014529624A (en) * 2011-08-30 2014-11-13 ダウ グローバル テクノロジーズ エルエルシー Formation of substituted phenylene dibenzoates for use as internal electron donors and procatalysts for polymer preparation
US10358505B2 (en) 2010-12-21 2019-07-23 W. R. Grace & Co.-Conn. Process for production of high melt flow propylene-based polymer and product from same
CN120483875A (en) * 2025-07-10 2025-08-15 营口市向阳催化剂有限责任公司 Process for the preparation of substituted phenylene aromatic diesters and use thereof in the preparation of catalysts

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893003B2 (en) * 2007-08-24 2011-02-22 Dow Global Technologies Inc. Catalyst composition with mixed selectivity control agent and method
CN101848946B (en) 2007-08-24 2013-06-12 陶氏环球技术有限责任公司 Gas-phase polymerization process
EP2315790B1 (en) * 2008-08-21 2018-04-25 W.R. Grace & CO. - CONN. High melt flow propylene impact copolymer and method
JP5731988B2 (en) * 2008-12-31 2015-06-10 ダブリュー・アール・グレイス・アンド・カンパニー−コネチカット Propylene-based polymer, article and manufacturing process thereof
JP6046349B2 (en) * 2008-12-31 2016-12-14 ダブリュー・アール・グレイス・アンド・カンパニー−コネチカット Production of substituted phenylene aromatic diesters
US8378045B2 (en) * 2008-12-31 2013-02-19 Dow Global Technologies Llc Thermoformed article with high stiffness and good optics
PL2373702T3 (en) 2008-12-31 2018-07-31 W.R. Grace & Co.-Conn. Procatalyst composition with substituted 1,2-phenylene aromatic diester internal donor and method
US8263520B2 (en) * 2009-12-02 2012-09-11 Dow Global Technologies Llc Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture
MY159696A (en) * 2010-02-26 2017-01-13 W R Grace & Co -Conn Halogenated amide ester and internal electron donor with same
WO2011106494A1 (en) 2010-02-26 2011-09-01 Dow Global Technologies Llc Procatalyst composition with substituted amide ester internal electron donor
CN101845171A (en) * 2010-04-20 2010-09-29 广州呈和科技有限公司 Polypropylene reinforcement nucleating agent composition
US20140107274A1 (en) * 2010-12-20 2014-04-17 Braskem America, Inc. Propylene-based compositions of enhanced appearance and excellent mold flowability
US9434796B2 (en) 2010-12-21 2016-09-06 W. R. Grace & Co.-Conn. Catalyst composition with alkoxyalkyl ester internal electron donor and polymer from same
US20120157295A1 (en) * 2010-12-21 2012-06-21 Linfeng Chen Process for Producing Procatalyst Composition with Alkoxyalkyl Ester Internal Electron Donor and Product
US8604146B2 (en) * 2010-12-21 2013-12-10 Dow Global Technologies Llc Catalyst composition with alkoxyalkyl ester internal electron donor and polymer from same
US9382342B2 (en) 2010-12-21 2016-07-05 W. R. Grace & Co.-Conn. Procatalyst composition with alkoxyalkyl 2-propenoate internal electron donor and polymer from same
US20120157645A1 (en) * 2010-12-21 2012-06-21 Linfeng Chen Procatalyst Composition with Alkoxypropyl Ester Internal Electron Donor and Polymer From Same
US9382343B2 (en) 2010-12-21 2016-07-05 W. R. Grace & Co.-Conn. Procatalyst composition with alkoxypropyl ester internal electron donor and polymer from same
EP2681248A1 (en) * 2011-03-01 2014-01-08 Dow Global Technologies LLC Process for improving bulk density with multi-contact procatalyst and product
CN103403088B (en) 2011-03-10 2016-02-10 巴塞尔聚烯烃意大利有限责任公司 Polyolefin-based container
CA2742454C (en) * 2011-06-09 2018-06-12 Nova Chemicals Corporation Methods for controlling ethylene copolymer properties
RU2014106216A (en) * 2011-07-28 2015-09-10 У.Р.Грейс Энд Ко.-Конн. PROPYLENE BASED POLYMER WITH LOW CONTENT OF ASH AND METHOD
EP2736930B1 (en) * 2011-07-28 2016-04-06 W.R. Grace & Co.-Conn. Propylene/ethylene copolymer film for heat seal
EP2607384A1 (en) * 2011-12-21 2013-06-26 Basell Poliolefine Italia S.r.l. Catalyst system for the polymerization of olefins
EP2610274A1 (en) * 2011-12-30 2013-07-03 Borealis AG Propylene random copolymer
KR101677602B1 (en) * 2012-07-14 2016-11-18 인디언 오일 코퍼레이션 리미티드 Ziegler-natta catalyst systems comprising a 1,2-phenylenedioate as internal donor and process for preparing the same
US9790291B2 (en) * 2013-03-14 2017-10-17 Formosa Plastics Corporation, Usa Non-phthalate compounds as electron donors for polyolefin catalysts
ES2652323T5 (en) * 2013-05-22 2021-10-19 Borealis Ag Propylene Copolymer for Thin Wall Packaging
US10336840B2 (en) 2013-10-29 2019-07-02 W. R. Grace & Co.-Conn. Propylene ethylene random copolymer suitable for pipe
CN105705528B (en) * 2013-11-15 2018-11-09 陶氏环球技术有限责任公司 Polyolefin composition and method of producing same
RU2731442C2 (en) 2013-11-21 2020-09-02 У.Р. Грейс Энд Ко.-Конн Obtaining propylene-based polymers with high content of comonomer
MX366147B (en) 2013-11-22 2019-06-28 Borealis Ag Low emission propylene homopolymer.
PL3074429T3 (en) 2013-11-26 2024-07-08 W.R. Grace & Co. - Conn. Producing propylene impact copolymers and products
CN105764936B (en) * 2013-11-27 2018-05-11 格雷斯公司 Polymerization method of main catalyst particle and impact copolymer
EP3083723B1 (en) 2013-12-20 2022-01-19 Saudi Basic Industries Corporation Catalyst system for polymerisation of an olefin
KR102365377B1 (en) 2013-12-20 2022-02-21 사우디 베이식 인더스트리즈 코포레이션 Catalyst system for polymerisation of an olefin
BR112016013951B1 (en) 2013-12-20 2022-02-22 Sabic Global Technologies B.V. PROCESS FOR THE PREPARATION OF A PRO-CATALYST FOR POLYMERIZATION OF AN OLEFIN, USE OF A BENZAMIDE, CATALYST COMPOSITION, PRO-CATALYST AND PROCESS FOR THE PREPARATION OF POLYOLEFINS INCLUDING THE SAME
MX2016008039A (en) 2013-12-20 2017-05-12 Saudi Basic Ind Corp Catalyst system for polymerization of an olefin.
EP3083722B1 (en) * 2013-12-20 2021-11-10 Saudi Basic Industries Corporation Catalyst system for polymerisation of an olefin
JP2017502148A (en) * 2013-12-23 2017-01-19 ブラスケム アメリカ インコーポレイテッドＢｒａｓｋｅｍ Ａｍｅｒｉｃａ，Ｉｎｃ． Propylene-based composition with improved appearance and excellent fluidity
CN105899599B (en) 2014-01-15 2018-10-02 埃克森美孚化学专利公司 Propylene-Based Impact Copolymers
US10465025B2 (en) 2014-01-15 2019-11-05 Exxonmobil Chemical Patents Inc. Low comonomer propylene-based impact copolymers
US11267916B2 (en) 2014-02-07 2022-03-08 Eastman Chemical Company Adhesive composition comprising amorphous propylene-ethylene copolymer and polyolefins
US10647795B2 (en) 2014-02-07 2020-05-12 Eastman Chemical Company Adhesive composition comprising amorphous propylene-ethylene copolymer and polyolefins
US10696765B2 (en) 2014-02-07 2020-06-30 Eastman Chemical Company Adhesive composition comprising amorphous propylene-ethylene copolymer and propylene polymer
US10308740B2 (en) 2014-02-07 2019-06-04 Eastman Chemical Company Amorphous propylene-ethylene copolymers
US10723824B2 (en) 2014-02-07 2020-07-28 Eastman Chemical Company Adhesives comprising amorphous propylene-ethylene copolymers
US9428598B2 (en) 2014-02-07 2016-08-30 Eastman Chemical Company Amorphous propylene-ethylene copolymers
JP6720142B2 (en) * 2014-08-21 2020-07-08 ダウ グローバル テクノロジーズ エルエルシー Adhesive composition
KR102388264B1 (en) * 2014-08-21 2022-04-20 다우 글로벌 테크놀로지스 엘엘씨 Hot melt adhesive composition
EP3015503A1 (en) 2014-10-27 2016-05-04 Borealis AG Heterophasic polypropylene with improved stiffness/impact balance
US9593184B2 (en) 2014-10-28 2017-03-14 Formosa Plastics Corporation, Usa Oxalic acid diamides as modifiers for polyolefin catalysts
CN107075207B (en) 2014-11-19 2018-07-27 博里利斯股份公司 Injection molded article based on Noblen
BR112017026534B1 (en) * 2015-06-12 2021-12-07 Sabic Global Technologies B.V. HETEROPHASE PROPYLENE COPOLYMER, ITS PROCESS FOR MANUFACTURING AND USE, ARTICLE THAT COMPRISES IT
BR112018008756A2 (en) * 2015-11-02 2018-10-30 Braskem America Inc homopolymer propylene and polypropylene based polymeric resins, impact copolymer polypropylene composition, and molded article
EP3184587B1 (en) * 2015-12-21 2020-03-18 Borealis AG Extruded articles with improved optical properties
US10633463B2 (en) 2015-12-31 2020-04-28 Braskem America, Inc. Non-phthalate catalyst system and its use in the polymerization of olefins
US9777084B2 (en) 2016-02-19 2017-10-03 Formosa Plastics Corporation, Usa Catalyst system for olefin polymerization and method for producing olefin polymer
WO2017178046A1 (en) 2016-04-13 2017-10-19 Borealis Ag Injection molded article based on propylene homopolymer
EP3260489B1 (en) 2016-06-24 2019-12-25 Borealis AG Novel polypropylene compositions with low fogging
US11427660B2 (en) 2016-08-17 2022-08-30 Formosa Plastics Corporation, Usa Organosilicon compounds as electron donors for olefin polymerization catalysts and methods of making and using same
CN110023351B (en) * 2016-10-06 2022-04-26 格雷斯公司 Main catalyst composition prepared by combining internal electron donors
US9815920B1 (en) 2016-10-14 2017-11-14 Formosa Plastics Corporation, Usa Olefin polymerization catalyst components and process for the production of olefin polymers therewith
WO2018167305A1 (en) * 2017-03-17 2018-09-20 Sabic Global Technologies B.V. Process for preparing a procatalyst for polymerization of olefins
EP3596136A1 (en) * 2017-03-17 2020-01-22 SABIC Global Technologies B.V. Process for the polymerization of a polyolefin
JP7222912B2 (en) * 2017-04-12 2023-02-15 ダブリュー・アール・グレース・アンド・カンパニー－コーン Method for producing low VOC content propylene copolymer
US10822438B2 (en) 2017-05-09 2020-11-03 Formosa Plastics Corporation Catalyst system for enhanced stereo-specificity of olefin polymerization and method for producing olefin polymer
US10124324B1 (en) 2017-05-09 2018-11-13 Formosa Plastics Corporation, Usa Olefin polymerization catalyst components and process for the production of olefin polymers therewith
US11390700B2 (en) 2017-05-18 2022-07-19 Borealis Ag Propylene-ethylene random copolymer with improved irradiation resistance
RU2692246C1 (en) * 2017-06-15 2019-06-24 Индийская Нефтяная Корпорация Лимитэд External donor for olefin polymerization
TWI766025B (en) * 2017-06-28 2022-06-01 日商迪愛生股份有限公司 Active ester compound and curable composition
WO2019004418A1 (en) * 2017-06-30 2019-01-03 三井化学株式会社 Propylene-based polymer, method for preparing same, propylene-based resin composition, and molded body
US10920053B2 (en) 2017-10-16 2021-02-16 Exxonmobil Chemical Patents Inc. Propylene impact copolymer blends with improved gloss
WO2019094216A1 (en) 2017-11-13 2019-05-16 W.R. Grace & Co.-Conn. Catalyst components for propylene polymerization
WO2019141462A1 (en) 2018-01-22 2019-07-25 Borealis Ag Nucleated c3c4 copolymers
EP4215582B1 (en) 2018-04-10 2024-12-04 Borealis AG Bimodal polypropylene random copolymer with improved gamma-irradiation resistance
CN108484810B (en) * 2018-05-04 2020-08-21 江苏煦和新材料有限公司 A kind of method for preparing high melt strength polypropylene
EP3617238A1 (en) 2018-08-28 2020-03-04 Borealis AG Propylene random copolymer with specific comonomer distribution
WO2020176341A1 (en) * 2019-02-27 2020-09-03 Milliken & Company Method for making heterophasic polymer compositions
PL3947552T3 (en) * 2019-04-05 2024-12-02 W. R. Grace & Co.-Conn. Polypropylene copolymer composition having subzero impact resistance
US11891460B2 (en) * 2019-05-10 2024-02-06 W. R. Grace & Co.-Conn. Activated catalyst components for olefin polymerization
EP4031590A4 (en) * 2019-09-18 2023-10-11 W. R. Grace & Co.-Conn CATALYST COMPOSITION FOR POLYOLEFINIC POLYMERS
KR20230029678A (en) * 2020-06-29 2023-03-03 더블유.알. 그레이스 앤드 캄파니-콘. Phthalate-free polypropylene homopolymer with high stiffness properties
EP4178802A4 (en) * 2020-07-11 2024-08-14 W. R. Grace & Co.-Conn PROPYLENE-BUTENE COPOLYMER AND COMPOSITIONS THEREOF
KR20230091125A (en) * 2020-10-23 2023-06-22 더블유.알. 그레이스 앤드 캄파니-콘. Impact resistant polypropylene polymer composition with reduced VOC content
EP4359448A1 (en) 2021-06-25 2024-05-01 Braskem, S.A. Propylene preliminary polymerization
US12435168B2 (en) * 2022-09-12 2025-10-07 Formosa Plastics Corporation, U.S.A. High ductility, high modulus and phthalate free impact resistant propylene copolymer
CN120380039A (en) 2022-12-23 2025-07-25 北欧化工股份公司 Polypropylene copolymer production method
JP2026504551A (en) 2023-02-10 2026-02-05 ダブリュー・アール・グレース・アンド・カンパニー－コーン Processes for separating solvents from waste streams
US20250066513A1 (en) 2023-08-23 2025-02-27 Formosa Plastics Corporation, U.S.A. Catalyst System For Enhanced Stereo-Specificity Of Olefin Polymerization
US20250066514A1 (en) 2023-08-24 2025-02-27 Formosa Plastics Corporation, U.S.A. Catalysts component and process for the production of polypropylene having high melt flow rate with high isotacticity
US20250109218A1 (en) 2023-09-29 2025-04-03 Formosa Plastics Corporation, U.S.A. Method for preparing catalyst component for polymerization of polyolefin without the use of internal electron donors
US20250115687A1 (en) 2023-10-06 2025-04-10 Formosa Plastics Corporation, U.S.A. Production method for solid catalyst component for polymerizing olefins, and catalyst for polymerizaing olefins
US20250115686A1 (en) 2023-10-09 2025-04-10 Formosa Plastics Corporation, U.S.A. Olefin polymerization catalyst components containing silane and process for the production of polypropylene having high isotacticity at high melt flow rate
US20250297039A1 (en) 2024-03-19 2025-09-25 Formosa Plastics Corporation, U.S.A. Olefin polymerization catalyst components containing diglycidylester components and its use for the production of polypropylene having high isotacticity at high melt flow rate
WO2025219533A1 (en) 2024-04-18 2025-10-23 Borealis Gmbh Process for the preparation of a propylene homopolymer
WO2025219537A1 (en) 2024-04-18 2025-10-23 Borealis Gmbh Process for propylene polymerization with optimized prepolymerization conditions
EP4682176A1 (en) * 2024-07-17 2026-01-21 Borealis GmbH Zinc adipate-nucleated propylene-ethylene random copolymer compositions
WO2026063967A1 (en) 2024-09-19 2026-03-26 Formosa Plastics Corporation, Usa Olefin polymerization ziegler-natta catalyst components and process for the production of olefin polymers therewith
WO2026067166A1 (en) * 2024-09-25 2026-04-02 国家能源投资集团有限责任公司 Internal electron donor compound, catalyst component and olefin polymerization method

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3214469A (en) 1958-01-15 1965-10-26 Polaroid Corp Dihydroxyphenylalkanoic acid amide derivatives
US5066737A (en) 1990-10-22 1991-11-19 Shell Oil Company Olefin polymerization catalyst
US5151399A (en) 1990-10-18 1992-09-29 Shell Oil Company Olefin polymerization catalyst
US5077357A (en) 1990-10-22 1991-12-31 Shell Oil Company Olefin polymerization catalyst
US5082907A (en) 1990-10-18 1992-01-21 Shell Oil Company Olefin polymerization catalyst
US5106806A (en) 1990-10-18 1992-04-21 Shell Oil Company Olefin polymerization catalyst
ZA716958B (en) 1970-10-30 1973-01-31 Hoffmann La Roche Phenylalanine amides
US3925338A (en) 1973-03-16 1975-12-09 Monsanto Co Control of polymer particle size in olefin polymerization
DE2658866C3 (en) * 1976-12-24 1979-10-31 Bayer Ag, 5090 Leverkusen Process for the preparation of polyhydric substituted phenols
IT1209255B (en) * 1980-08-13 1989-07-16 Montedison Spa CATALYSTS FOR THE POLYMERIZATION OF OLEFINE.
US4442276A (en) * 1982-02-12 1984-04-10 Mitsui Petrochemical Industries, Ltd. Process for polymerizing or copolymerizing olefins
JPS5991107A (en) 1982-11-17 1984-05-25 Toho Titanium Co Ltd Production of catalyst component for olefin polymerization
JPS6023404A (en) 1983-07-20 1985-02-06 Toho Titanium Co Ltd Catalytic component and catalyst for polymerizing olefins
US4612299A (en) 1984-07-09 1986-09-16 Amoco Corporation Magnesium carboxylate supports
US4540679A (en) 1984-03-23 1985-09-10 Amoco Corporation Magnesium hydrocarbyl carbonate supports
US4866022A (en) 1984-03-23 1989-09-12 Amoco Corporation Olefin polymerization catalyst
US4579836A (en) 1985-05-22 1986-04-01 Amoco Corporation Exhaustively prepolymerized supported alpha-olefin polymerization catalyst
US4614830A (en) * 1985-08-09 1986-09-30 Sterling Drug Inc. Esterification process
JPH06104693B2 (en) 1986-01-06 1994-12-21 東邦チタニウム株式会社 Catalyst for olefin polymerization
JPS62205140A (en) * 1986-03-03 1987-09-09 Mitsubishi Paper Mills Ltd Plasticizer for use in polymer
EP0268685B2 (en) 1986-05-06 1996-08-07 Toho Titanium Co. Ltd. Catalyst for polymerizing olefins
US4710482A (en) 1986-06-18 1987-12-01 Shell Oil Company Olefin polymerization catalyst component
JPS63277944A (en) * 1987-03-03 1988-11-15 Kiroku Sozai Sogo Kenkyusho:Kk Heat sensitive label for temperature management
CA1310955C (en) 1987-03-13 1992-12-01 Mamoru Kioka Process for polymerization of olefins and polymerization catalyst
EP0284708B1 (en) 1987-04-03 1996-01-31 Fina Technology, Inc. Metallocene catalyst systems for olefin polymerization having a silicon hydrocarbyl bridge.
US4927797A (en) 1987-04-09 1990-05-22 Fina Technology, Inc. Catalyst system for the polymerization of olefins
US5066738A (en) 1987-04-09 1991-11-19 Fina Technology, Inc. Polymerization of olefins with an improved catalyst system using a new electron donor
US4882380A (en) * 1987-07-07 1989-11-21 Union Carbide Chemicals And Plastics Company Inc. Process for the production of impact polypropylene copolymers
JPH01224351A (en) * 1988-03-02 1989-09-07 Mitsui Petrochem Ind Ltd Production of aryl aromatic carboxylates
EP0350170B2 (en) 1988-06-17 2001-09-12 Mitsui Chemicals, Inc. Process for polymerising olefins and polymerisation catalyst therefor
US5247031A (en) 1988-09-13 1993-09-21 Mitsui Petrochemical Industries, Ltd. Olefin polymerization catalyst component, process for production thereof, olefin polymerization catalyst, and process for polymerizing olefins
KR920007040B1 (en) 1988-09-14 1992-08-24 미쓰이세끼유 가가꾸 고오교오 가부시끼가이샤 Polymerizing catalyst of olefins and process for the preparation of olefin polimerization
US4946816A (en) 1989-08-21 1990-08-07 Amoco Corporation Morphology-controlled olefin polymerization catalyst
JP2909550B2 (en) * 1989-08-31 1999-06-23 三井化学株式会社 Method for producing alkylphenols
US5247032A (en) 1989-12-29 1993-09-21 Mitsui Petrochemical Industries, Ltd. Solid catalyst components for olefin polymerization and processes for the polymerization of olefin using same
JP2940684B2 (en) 1989-12-29 1999-08-25 三井化学株式会社 Solid catalyst component for olefin polymerization and method for polymerizing olefin using the catalyst component
US5034361A (en) 1990-05-24 1991-07-23 Shell Oil Company Catalyst precursor production
US5146028A (en) 1990-10-18 1992-09-08 Shell Oil Company Olefin polymerization catalyst and process of polymerization
US5229342A (en) 1990-10-18 1993-07-20 Shell Oil Company Olefin polymerization catalyst
DE4117144A1 (en) * 1991-05-25 1992-11-26 Basf Ag HIGHLY FLOWABLE PROPYLENE ETHYLENE COPOLYMERISATE
JP2699047B2 (en) 1992-10-22 1998-01-19 昭和電工株式会社 Method for producing propylene polymer
GB9300318D0 (en) * 1993-01-08 1993-03-03 Oxford Analytical Instr Ltd Improvements relating to sample monitoring
IL117114A (en) 1995-02-21 2000-02-17 Montell North America Inc Components and catalysts for the polymerization ofolefins
US5674630A (en) * 1995-05-08 1997-10-07 Union Carbide Chemicals & Plastics Technology Corporation Polymer compositions and cast films
JPH09227437A (en) * 1995-12-19 1997-09-02 Daiso Co Ltd Production of catechol derivative
JP3697011B2 (en) 1997-02-27 2005-09-21 三井化学株式会社 Propylene polymer
GB2323363A (en) 1997-03-19 1998-09-23 Shell Int Research Propylene polymer composition
FI980342A0 (en) * 1997-11-07 1998-02-13 Borealis As Polymerroer och -roerkopplingar
ATE234310T1 (en) * 1997-12-23 2003-03-15 Borealis Tech Oy PRODUCT CONTAINING MAGNESIUM, HALOGEN AND ALKOXY
KR100334163B1 (en) * 1998-12-04 2002-10-25 삼성종합화학주식회사 Olefin Polymerization or Copolymerization Method
FI991057A0 (en) 1999-05-07 1999-05-07 Borealis As High stiffness propylene polymers and process for their preparation
JP3808243B2 (en) * 1999-07-27 2006-08-09 三井化学株式会社 Soft resin composition
JP3986216B2 (en) 1999-08-19 2007-10-03 三井化学株式会社 Non-aqueous electrolyte and secondary battery using the same
JP2001096926A (en) * 1999-10-04 2001-04-10 Showa Highpolymer Co Ltd Phenolic three-core body composition and developer composed of the composition used for heat-sensitive recording material
US6554154B1 (en) 2000-02-11 2003-04-29 Solo Cup Company Thermoformed container having improved strength to weight ratio in sidewall
JP2002012583A (en) * 2000-04-28 2002-01-15 Sumitomo Chem Co Ltd Method for producing amine derivative
DE60104509T2 (en) * 2000-05-31 2005-08-11 Basell Poliolefine Italia S.P.A. PROPYLENE POLYMERIC COMPOSITION WITH IMPROVED IMPACT TOLERANCE AND VERY GOOD OPTICAL PROPERTIES
ATE543859T1 (en) 2000-12-22 2012-02-15 Basell Poliolefine Srl POLYOLEFIN FILM FOR THERMOFORMING
US6534574B1 (en) 2001-03-24 2003-03-18 Milliken & Company Highly nucleated thermoplastic articles
US6825146B2 (en) 2001-05-29 2004-11-30 Union Carbide Chemicals & Plastics Technology Corporation Olefin polymerization catalyst compositions and method of preparation
DE60106219T2 (en) * 2001-06-27 2006-03-09 Borealis Technology Oy Propylene copolymer with random comonomer distribution and process for its preparation
US6960635B2 (en) 2001-11-06 2005-11-01 Dow Global Technologies Inc. Isotactic propylene copolymers, their preparation and use
CN1169845C (en) * 2002-02-07 2004-10-06 中国石油化工股份有限公司 Solid catalyst component for olefin polymerization and catalyst containing same and use thereof
EP1364986A1 (en) * 2002-05-21 2003-11-26 Borealis Technology Oy Polypropylene compositions especially for pipes
EP1507806B1 (en) * 2002-05-29 2006-10-11 Basell Poliolefine Italia S.r.l. Butene-1 (co)polymers and process for their preparation
EP1515996A2 (en) * 2002-06-14 2005-03-23 Union Carbide Chemicals & Plastics Technology Corporation Catalyst composition and polymerization process using mixtures of electron donors
ES2335409T3 (en) * 2003-06-24 2010-03-26 UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC CATALYTIC COMPOSITION AND POLYMERIZATION PROCESS USING MIXER OF DONATORS AND ELECTRONS OF SILAN TYPE.
CN1229400C (en) * 2003-09-18 2005-11-30 中国石油化工股份有限公司 Catalyst compoment used for olefinic polymerization and its catalyst
US20060223956A1 (en) 2003-09-23 2006-10-05 Linfeng Chen Catalyst composition with mixed sca and propylene polymerization process
EP1668046B8 (en) 2003-09-23 2021-04-21 W.R. Grace & CO. - CONN. Self limiting catalyst composition and propylene polymerization process
JP2005112764A (en) * 2003-10-07 2005-04-28 Toagosei Co Ltd Method for producing aromatic ester
FR2869035B1 (en) 2004-04-16 2006-07-14 Pierre Fabre Medicament Sa EPIPODOPHYLLOTOXIN AMINOALKYLAMINOACETAMIDE (POLY) DERIVATIVES AND PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS AS ANTI-CANCER AGENT
JP4413069B2 (en) 2004-04-28 2010-02-10 富士フイルム株式会社 Lithographic printing plate and lithographic printing method
US7351778B2 (en) * 2004-04-30 2008-04-01 China Petroleum & Chemical Corporation Catalyst component for olefin polymerization and catalyst comprising the same
EP1778780B1 (en) 2004-08-18 2009-01-14 Basell Poliolefine Italia S.r.l. Stretch blow-molded containers from ziegler natta propylene polymer compositions
AU2005279786B2 (en) 2004-08-31 2012-01-19 Dow Global Technologies Llc Composition suitable for thermoformable sheets and articles made therefrom
US20070202285A1 (en) 2004-12-15 2007-08-30 Fina Technology, Inc. Articles having improved clarity, prepared from propylene-ethylene copolymers
AU2005319179B2 (en) 2004-12-21 2011-10-13 Dow Global Technologies Llc Polypropylene-based adhesive compositions
US7491781B2 (en) 2005-03-08 2009-02-17 Ineos Usa Llc Propylene polymer catalyst donor component
DE602006007572D1 (en) 2005-05-12 2009-08-13 Basell Poliolefine Srl PROPYLENE ETHYLENE COPOLYMERS AND MANUFACTURING METHOD THEREFOR
ATE469928T1 (en) 2005-10-21 2010-06-15 Basell Polyolefine Gmbh STATISTICAL POLYPROPYLENE COPOLYMERS WITH HIGH MELTS FLOW RATES FOR INJECTION MOLDING AND MELBLOW APPLICATIONS
CN100532405C (en) * 2005-10-26 2009-08-26 中国石油化工股份有限公司 Catalyst component for ethylene polymerization and its preparation method
JP2007175028A (en) * 2005-12-28 2007-07-12 Koojin Bio Kk Closed cell culture container, closed cell culture kit, and method for producing closed cell culture container
MX2008015361A (en) 2006-06-01 2008-12-16 Sunoco Inc R&M High crystallinity, high melt flow rate polypropylene.
TW200817315A (en) 2006-06-16 2008-04-16 Sanol Arznei Schwarz Gmbh Entacapone-derivatives
ES2536254T3 (en) 2006-06-30 2015-05-21 Borealis Technology Oy Random polypropylene copolymer with high melt flow
CN101490101B (en) * 2006-07-18 2011-11-02 三井化学株式会社 Solid titanium catalyst ingredient, catalyst for olefin polymerization, and method of olefin polymerization
JP4857093B2 (en) 2006-11-29 2012-01-18 日本ポリプロ株式会社 Deep drawn container
PL2185600T3 (en) 2007-08-24 2019-07-31 W.R. Grace & Co. - Conn. Self-limiting catalyst composition with no silane
US7893003B2 (en) * 2007-08-24 2011-02-22 Dow Global Technologies Inc. Catalyst composition with mixed selectivity control agent and method
CN101848946B (en) 2007-08-24 2013-06-12 陶氏环球技术有限责任公司 Gas-phase polymerization process
JP5740159B2 (en) * 2007-12-21 2015-06-24 ダブリュー・アール・グレイス・アンド・カンパニー−コネチカット Self-limiting catalyst composition having a bidentate internal donor
JP4944058B2 (en) 2008-03-31 2012-05-30 株式会社エフピコ Polypropylene resin sheet and polypropylene resin container
CN101318886B (en) * 2008-07-04 2011-05-04 浙江理工大学 Process for synthesizing o-hydroxyl-phenyl-alkyl ketone
US8003558B2 (en) * 2008-07-29 2011-08-23 Basf Corporation Internal donor for olefin polymerization catalysts
EP2315790B1 (en) * 2008-08-21 2018-04-25 W.R. Grace & CO. - CONN. High melt flow propylene impact copolymer and method
JP5731988B2 (en) * 2008-12-31 2015-06-10 ダブリュー・アール・グレイス・アンド・カンパニー−コネチカット Propylene-based polymer, article and manufacturing process thereof
PL2373702T3 (en) 2008-12-31 2018-07-31 W.R. Grace & Co.-Conn. Procatalyst composition with substituted 1,2-phenylene aromatic diester internal donor and method
US8378045B2 (en) * 2008-12-31 2013-02-19 Dow Global Technologies Llc Thermoformed article with high stiffness and good optics
JP6046349B2 (en) * 2008-12-31 2016-12-14 ダブリュー・アール・グレイス・アンド・カンパニー−コネチカット Production of substituted phenylene aromatic diesters
US8263520B2 (en) 2009-12-02 2012-09-11 Dow Global Technologies Llc Two atom bridged dicarbonate compounds as internal donors in catalysts for polypropylene manufacture

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIEBIGS ANN. CHEM., vol. 688, 1965, pages 134 - 149
Z. NATURFORSCHG., vol. 18B, 1963, pages 1002 - 1009

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10358505B2 (en) 2010-12-21 2019-07-23 W. R. Grace & Co.-Conn. Process for production of high melt flow propylene-based polymer and product from same
US11254756B2 (en) 2010-12-21 2022-02-22 W.R. Grace & Co.-Conn. Process for production of high melt flow propylene-based polymer and product from same
US11993672B2 (en) 2010-12-21 2024-05-28 W.R. Grace & Co.-Conn. Production of high melt flow propylene-based polymer and product from same
WO2012135189A3 (en) * 2011-03-29 2012-12-27 Dow Global Technologies Llc Production of substituted phenylene aromatic diesters
US20140012035A1 (en) * 2011-03-29 2014-01-09 Linfeng Chen Production of Substituted Phenylene Aromatic Diesters
CN103562172A (en) * 2011-03-29 2014-02-05 陶氏环球技术有限责任公司 Preparation of substituted phenylene aromatic diesters
JP2014519477A (en) * 2011-03-29 2014-08-14 ダウ グローバル テクノロジーズ エルエルシー Production of substituted phenylene aromatic diesters
JP2014529624A (en) * 2011-08-30 2014-11-13 ダウ グローバル テクノロジーズ エルエルシー Formation of substituted phenylene dibenzoates for use as internal electron donors and procatalysts for polymer preparation
US9133286B2 (en) 2011-08-30 2015-09-15 W. R. Grace & Co.-Conn Production of substituted phenylene dibenzoate internal electron donor and procatalyst with same
CN120483875A (en) * 2025-07-10 2025-08-15 营口市向阳催化剂有限责任公司 Process for the preparation of substituted phenylene aromatic diesters and use thereof in the preparation of catalysts
CN120483875B (en) * 2025-07-10 2025-10-21 营口市向阳催化剂有限责任公司 Preparation method of substituted phenylene aromatic diester and its application in catalyst preparation

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