WO2010080710A3 - Sample collection and measurement in a single container by back scattering interferometry - Google Patents

Sample collection and measurement in a single container by back scattering interferometry Download PDF

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Publication number
WO2010080710A3
WO2010080710A3 PCT/US2010/000047 US2010000047W WO2010080710A3 WO 2010080710 A3 WO2010080710 A3 WO 2010080710A3 US 2010000047 W US2010000047 W US 2010000047W WO 2010080710 A3 WO2010080710 A3 WO 2010080710A3
Authority
WO
WIPO (PCT)
Prior art keywords
back scattering
analysis
measurement
sample collection
single container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/000047
Other languages
French (fr)
Other versions
WO2010080710A2 (en
Inventor
Scot Weinberger
Darryl J. Bornhop
Stephen Dotson
Bruce J. Richardson
Daniel Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Molecular Sensing Inc
Original Assignee
Vanderbilt University
Molecular Sensing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University, Molecular Sensing Inc filed Critical Vanderbilt University
Priority to EP10729387A priority Critical patent/EP2386060A2/en
Publication of WO2010080710A2 publication Critical patent/WO2010080710A2/en
Publication of WO2010080710A3 publication Critical patent/WO2010080710A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

This invention provides a device and method for collection and analysis of heterogeneous samples in a single sample container by back scattering interferometry. The sample container is configured to allow collection of a heterogeneous sample, such as blood, from a subject, separation of insoluble materials, such as blood cells by, for example, centrifugation, and mounting on a back scattering interferometer for analysis. In certain embodiments the container is a capillary tube and the interferometer comprises a mounting to hold the capillary tube in position for analysis. The device and method allow point-of-care analysis of samples.
PCT/US2010/000047 2009-01-12 2010-01-08 Sample collection and measurement in a single container by back scattering interferometry Ceased WO2010080710A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10729387A EP2386060A2 (en) 2009-01-12 2010-01-08 Sample collection and measurement in a single container by back scattering interferometry

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14405409P 2009-01-12 2009-01-12
US61/144,054 2009-01-12

Publications (2)

Publication Number Publication Date
WO2010080710A2 WO2010080710A2 (en) 2010-07-15
WO2010080710A3 true WO2010080710A3 (en) 2010-11-25

Family

ID=42317094

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/000047 Ceased WO2010080710A2 (en) 2009-01-12 2010-01-08 Sample collection and measurement in a single container by back scattering interferometry

Country Status (3)

Country Link
US (1) US20100184056A1 (en)
EP (1) EP2386060A2 (en)
WO (1) WO2010080710A2 (en)

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US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
EP2572787B1 (en) * 2011-09-23 2020-05-27 Nano Temper Technologies GmbH Capillary for detecting properties of chemical and/or biological fluids
CN102590167A (en) * 2012-02-15 2012-07-18 江南大学 Method for determining activity of endotrypsin A
US20150057949A1 (en) * 2012-04-19 2015-02-26 Molecular Sensing, Inc. Event Detection For Back-Scattering Interferometry
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
EP2892496B1 (en) 2012-09-06 2017-06-28 Theranos, Inc. Devices for bodily fluid sample collection
US9636062B2 (en) 2012-09-06 2017-05-02 Theranos, Inc. Systems, devices, and methods for bodily fluid sample collection
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
US20140342371A1 (en) * 2012-12-05 2014-11-20 Theranos, Inc. Bodily Fluid Sample Collection and Transport
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
CA2903013C (en) * 2013-03-08 2021-05-11 Siemens Healthcare Diagnostics Inc. Tube characterization station
US9795929B2 (en) 2013-03-15 2017-10-24 Theranos, Inc. Systems, devices, and methods for bodily fluid separation materials
EP2972184A4 (en) 2013-03-15 2016-11-30 Theranos Inc METHOD AND APPARATUS FOR SAMPLING AND SEPARATION
CN113331832A (en) 2014-03-12 2021-09-03 赛拉诺斯知识产权有限责任公司 Device and method for bodily fluid sample collection
EP3247988A4 (en) 2015-01-23 2018-12-19 Vanderbilt University A robust interferometer and methods of using same
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
WO2017044888A1 (en) 2015-09-09 2017-03-16 Theranos, Inc. Methods and devices for sample collection and sample separation
EP3408649B1 (en) 2016-01-29 2023-06-14 Vanderbilt University Free-solution response function interferometry
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
US11179723B2 (en) * 2017-03-28 2021-11-23 Redbud Labs, Inc. System, fluidics cartridge, and methods for using actuated surface-attached posts for processing cells
CN111164389B (en) * 2017-08-10 2022-09-02 联邦科学及工业研究组织 Apparatus and method for monitoring material flow parameters along a channel
US11270402B2 (en) * 2019-08-22 2022-03-08 Novanta Corporation Vial content detection using illuminated background pattern
CN111812215B (en) * 2020-07-22 2021-06-29 南京航空航天大学 A method for monitoring structural damage of aircraft

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Also Published As

Publication number Publication date
WO2010080710A2 (en) 2010-07-15
US20100184056A1 (en) 2010-07-22
EP2386060A2 (en) 2011-11-16

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