WO2010136132A3 - Zweikammer zylinder-kolben-einheit zur lyophilisation, lagerung, rekonstitution und applikation von injektionslösungen für einen injektor und verfahren zum befüllen der zylinder-kolben-einheit - Google Patents

Zweikammer zylinder-kolben-einheit zur lyophilisation, lagerung, rekonstitution und applikation von injektionslösungen für einen injektor und verfahren zum befüllen der zylinder-kolben-einheit Download PDF

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Publication number
WO2010136132A3
WO2010136132A3 PCT/EP2010/002974 EP2010002974W WO2010136132A3 WO 2010136132 A3 WO2010136132 A3 WO 2010136132A3 EP 2010002974 W EP2010002974 W EP 2010002974W WO 2010136132 A3 WO2010136132 A3 WO 2010136132A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
cylinder
piston
piston unit
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/002974
Other languages
English (en)
French (fr)
Other versions
WO2010136132A2 (de
Inventor
Rudolf Matusch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200910053729 external-priority patent/DE102009053729A1/de
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Priority to JP2012512231A priority Critical patent/JP5653420B2/ja
Priority to ES10721994.1T priority patent/ES2533979T3/es
Priority to EP10721994.1A priority patent/EP2435111B1/de
Publication of WO2010136132A2 publication Critical patent/WO2010136132A2/de
Publication of WO2010136132A3 publication Critical patent/WO2010136132A3/de
Priority to US13/304,530 priority patent/US9238109B2/en
Anticipated expiration legal-status Critical
Priority to US14/941,858 priority patent/US10022500B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A61M5/3007—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules with specially designed jet passages at the injector's distal end

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Eine Kolben-Zylinder-Einheit (1) für einen nadelfreien Injektor, beispielsweise zur Bereitstellung einer sterilen Injektionslösung, mit einer in einem Zylinder (2) angeordneten Kammer (3) zur Aufnahme einer Injektionslösung (4), einer Stirnwand (5) mit mindestens einer Düsenbohrung bzw. einem Austrittselement (6) und einem in der Kammer (3) beweglich angeordneten zweiten Kolben (7), ist dadurch gekennzeichnet, - dass die Kammer (3) zweiteilig mit einer ersten Kammer (8) und einer konzentrischen zweiten Kammer (9) ausgebildet ist, wobei der Querschnitt der ersten Kammer (8) größer ist als der Querschnitt der zweiten Kammer (9), - dass die erste Kammer (8) durch einen ersten Kolben (10) und die zweite Kammer (9) durch den zweiten Kolben (7) verschlossen ausgebildet ist, wobei die erste Kammer (8) von der zweiten Kammer (9) getrennt ist, und - dass der zweite Kolben (7) mit mindestens einem Überleitungskanal (16) oder - dass die erste Kammer (8) mit mindestens einem verschließbaren, axial ausgerichteten Gefriertrocknungskanal (34) und die zweite Kammer (9) mit mindestens einem axial ausgerichteten Überleitungskanal (36), an den jeweils hinteren Enden der Kammern (8, 9) ausgebildet ist. Die Erfindung betrifft darüber hinaus ein Verfahren zum Befüllen der Zylinder-Kolben-Einheit (1).
PCT/EP2010/002974 2009-05-29 2010-05-14 Zweikammer zylinder-kolben-einheit zur lyophilisation, lagerung, rekonstitution und applikation von injektionslösungen für einen injektor und verfahren zum befüllen der zylinder-kolben-einheit Ceased WO2010136132A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2012512231A JP5653420B2 (ja) 2009-05-29 2010-05-14 凍結乾燥、貯蔵、再構成のための二重チャンバーシリンダー−ピストンユニット及び注射器用の注射液の適用及びシリンダー−ピストンユニットの充填方法
ES10721994.1T ES2533979T3 (es) 2009-05-29 2010-05-14 Unidad de cilindro-pistón de dos cámaras para la liofilización, almacenamiento, reconstitución y aplicación de soluciones de inyección para un inyector y procedimiento para llenar la unidad de cilindro-pistón
EP10721994.1A EP2435111B1 (de) 2009-05-29 2010-05-14 Zweikammer zylinder-kolben-einheit zur lyophilisation, lagerung, rekonstitution und applikation von injektionslösungen für einen injektor und verfahren zum befüllen der zylinder-kolben-einheit
US13/304,530 US9238109B2 (en) 2009-05-29 2011-11-25 Dual-chamber cylinder-piston unit for the lyophilisation, storage, reconstitution and application of injection solutions for an injector, and method for filling the cylinder-piston unit
US14/941,858 US10022500B2 (en) 2009-05-29 2015-11-16 Dual-chamber cylinder-piston unit for the lyophilisation, storage, reconstitution and application of injection solutions for an injector, and method for filling the cylinder-piston unit

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102009023335.0 2009-05-29
DE102009023335A DE102009023335A1 (de) 2009-05-29 2009-05-29 Zweikammer Zylinder-Kolben-Einheit zur Lyophilisation, Lagerung, Rekonstitution und Applikation von Injektionslösungen für einen Injektor und Verfahren zum Befüllen der Zylinder-Kolben-Einheit
DE102009053729.5 2009-11-18
DE200910053729 DE102009053729A1 (de) 2009-11-18 2009-11-18 Zweikammer-Zylinder-Kolben-Einheit zur Lyophilisation, Lagerung, Rekonstitution und Applikation von Injektionslösungen für einen Injektor und Verfahren zum Befüllen der Zylinder-Kolben-Einheit

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/304,530 Continuation-In-Part US9238109B2 (en) 2009-05-29 2011-11-25 Dual-chamber cylinder-piston unit for the lyophilisation, storage, reconstitution and application of injection solutions for an injector, and method for filling the cylinder-piston unit

Publications (2)

Publication Number Publication Date
WO2010136132A2 WO2010136132A2 (de) 2010-12-02
WO2010136132A3 true WO2010136132A3 (de) 2011-02-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/002974 Ceased WO2010136132A2 (de) 2009-05-29 2010-05-14 Zweikammer zylinder-kolben-einheit zur lyophilisation, lagerung, rekonstitution und applikation von injektionslösungen für einen injektor und verfahren zum befüllen der zylinder-kolben-einheit

Country Status (8)

Country Link
US (2) US9238109B2 (de)
EP (1) EP2435111B1 (de)
JP (1) JP5653420B2 (de)
AR (1) AR076931A1 (de)
DE (1) DE102009023335A1 (de)
ES (1) ES2533979T3 (de)
TW (1) TW201109059A (de)
WO (1) WO2010136132A2 (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013116289A (ja) 2011-12-05 2013-06-13 Daikyo Seiko Ltd 医薬品用注射器
US10085729B2 (en) * 2014-03-06 2018-10-02 Ethicon, Inc. Methods and devices for forming biomedical coatings using variable mixing ratios of multi-part compositions
US10159793B2 (en) * 2014-06-30 2018-12-25 Portal Instruments, Inc. Nozzle for use in an ultra-high velocity injection device
CA3005132A1 (en) 2015-11-18 2017-05-26 Sio2 Medical Products, Inc. Coated syringe for ophthalmic formulations containing a vegf antagonist
EP3377100B1 (de) 2015-11-18 2025-02-26 Formycon AG Vorgefüllte pharmazeutische verpackung mit einer flüssigen formulierung eines vegf-antagonisten
US10901253B2 (en) * 2018-10-02 2021-01-26 Aristocrat Technologies Australia Pty Limited Button deck assembly for an electronic gaming machine and method for making the same
US11288912B2 (en) 2020-03-04 2022-03-29 Aristocrat Technologies, Inc. Electronic gaming machine including hybrid virtual and physical button area
USD1029942S1 (en) 2020-04-14 2024-06-04 Aristocrat Technologies, Inc. (ATI) Gaming machine
WO2025181800A1 (en) * 2024-02-29 2025-09-04 Dali Medical Devices Ltd Dual chamber container and methods of use thereof

Citations (4)

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Publication number Priority date Publication date Assignee Title
FR2082128A5 (en) * 1970-03-04 1971-12-10 Idees Syringe - for preserving and injecting medicaments
EP0688570A2 (de) * 1994-06-21 1995-12-27 Wilhelm Gmeiner Insulinspritze
US20040097874A1 (en) * 2000-10-10 2004-05-20 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
WO2007034020A1 (es) * 2005-09-19 2007-03-29 Elastomeric Systems S.L. Unidad para mezcla y suministro de sustancias inyectables

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FR2613628A1 (fr) 1987-04-10 1988-10-14 Emerit Andre Seringue a usage unique
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DE102005062206B3 (de) 2005-12-24 2006-12-14 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit dauergeladenem Federenergiespeicher
DE102006040888B3 (de) 2006-08-31 2007-11-08 Lts Lohmann Therapie-Systeme Ag Verschlusssystem für Behältnisse
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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
FR2082128A5 (en) * 1970-03-04 1971-12-10 Idees Syringe - for preserving and injecting medicaments
EP0688570A2 (de) * 1994-06-21 1995-12-27 Wilhelm Gmeiner Insulinspritze
US20040097874A1 (en) * 2000-10-10 2004-05-20 Meridian Medical Technologies, Inc. Separation assembly for drug delivery device
WO2007034020A1 (es) * 2005-09-19 2007-03-29 Elastomeric Systems S.L. Unidad para mezcla y suministro de sustancias inyectables

Also Published As

Publication number Publication date
DE102009023335A1 (de) 2010-12-02
US9238109B2 (en) 2016-01-19
AR076931A1 (es) 2011-07-20
JP2012527913A (ja) 2012-11-12
EP2435111A2 (de) 2012-04-04
JP5653420B2 (ja) 2015-01-14
US20120067984A1 (en) 2012-03-22
ES2533979T3 (es) 2015-04-16
TW201109059A (en) 2011-03-16
US20160067405A1 (en) 2016-03-10
US10022500B2 (en) 2018-07-17
EP2435111B1 (de) 2015-03-11
WO2010136132A2 (de) 2010-12-02

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