WO2011031073A3 - 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도 - Google Patents

신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도 Download PDF

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Publication number
WO2011031073A3
WO2011031073A3 PCT/KR2010/006139 KR2010006139W WO2011031073A3 WO 2011031073 A3 WO2011031073 A3 WO 2011031073A3 KR 2010006139 W KR2010006139 W KR 2010006139W WO 2011031073 A3 WO2011031073 A3 WO 2011031073A3
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WIPO (PCT)
Prior art keywords
tetra
macrocyclic compound
aza macrocyclic
preparing same
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/006139
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English (en)
French (fr)
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WO2011031073A2 (ko
Inventor
유정수
달판 퍈다
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Industry Academic Cooperation Foundation of KNU
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Industry Academic Cooperation Foundation of KNU
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Publication date
Application filed by Industry Academic Cooperation Foundation of KNU filed Critical Industry Academic Cooperation Foundation of KNU
Priority to EP10815618.3A priority Critical patent/EP2476683B1/en
Priority to US13/395,346 priority patent/US9061078B2/en
Publication of WO2011031073A2 publication Critical patent/WO2011031073A2/ko
Publication of WO2011031073A3 publication Critical patent/WO2011031073A3/ko
Anticipated expiration legal-status Critical
Priority to US14/645,967 priority patent/US9353120B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 진단영상용 조영제 및 방사성 의약품 등으로 사용할 수 있는 신규한 구조의 교차가교된 테트라아자 거대고리 화합물 및 그 제조방법을 제공한다. 본 발명의 테트라아자 거대고리 화합물은 종래의 교차가교된 테트라아자 거대고리 화합물에 비하여 낮은 온도에서 안정한 금속 착물을 형성하고 생물활성물질 및 화학활성물질과 손쉽게 컨쥬게이션을 시킬 수 있는 장점이 있다.
PCT/KR2010/006139 2009-09-09 2010-09-09 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도 Ceased WO2011031073A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10815618.3A EP2476683B1 (en) 2009-09-09 2010-09-09 Novel tetra-aza macrocyclic compound, method for preparing same, and use thereof
US13/395,346 US9061078B2 (en) 2009-09-09 2010-09-09 Tetraaza macrocyclic compound, preparation method thereof and use thereof
US14/645,967 US9353120B2 (en) 2009-09-09 2015-03-12 Tetraaza macrocyclic compound, preparation method thereof and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2009-0084943 2009-09-09
KR20090084943 2009-09-09
KR1020100073954A KR101199570B1 (ko) 2009-09-09 2010-07-30 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도
KR10-2010-0073954 2010-07-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/395,346 A-371-Of-International US9061078B2 (en) 2009-09-09 2010-09-09 Tetraaza macrocyclic compound, preparation method thereof and use thereof
US14/645,967 Division US9353120B2 (en) 2009-09-09 2015-03-12 Tetraaza macrocyclic compound, preparation method thereof and use thereof

Publications (2)

Publication Number Publication Date
WO2011031073A2 WO2011031073A2 (ko) 2011-03-17
WO2011031073A3 true WO2011031073A3 (ko) 2011-08-04

Family

ID=43934348

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/006139 Ceased WO2011031073A2 (ko) 2009-09-09 2010-09-09 신규한 테트라아자 거대고리 화합물, 제조방법 및 그 용도

Country Status (4)

Country Link
US (2) US9061078B2 (ko)
EP (1) EP2476683B1 (ko)
KR (1) KR101199570B1 (ko)
WO (1) WO2011031073A2 (ko)

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WO2012037648A1 (en) * 2010-09-20 2012-03-29 Nordion (Canada) Inc. Process for chelating copper ions using cb-te2a bifunctional chelate
EP2871186B1 (en) * 2013-11-12 2016-09-21 Université de Bretagne Occidentale Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof
WO2015179955A1 (en) * 2014-05-30 2015-12-03 The Governing Council Of The University Of Toronto Uba5 inhibitors
KR102374087B1 (ko) * 2019-04-25 2022-03-16 경북대학교 산학협력단 면역 컨쥬게이트 및 그의 용도
US20220040499A1 (en) * 2020-08-10 2022-02-10 Charles Martin, III Biodegradable adhesive with radioisotopes
CN116583527A (zh) 2020-09-03 2023-08-11 库瑞姆美国有限责任公司 用于64Cu-DOTATATE放大规模的放射性标记和制剂
US11541134B1 (en) 2021-08-02 2023-01-03 Rayzebio, Inc. Stabilized compositions of radionuclides and uses thereof
EP4148051A1 (en) * 2021-09-10 2023-03-15 Ustav organicke chemie a biochemie AV CR, v.v.i. Compounds for complexation of rare earth elements and/or s-, p-, d- block metals, their coordination compounds, peptide conjugates, method of their preparation and use thereof
WO2023178313A2 (en) * 2022-03-18 2023-09-21 The Research Foundation For The State University Of New York Radiopharmaceutical compositions, synthetic methods, and methods of treatment
WO2025137443A1 (en) 2023-12-22 2025-06-26 Rayzebio, Inc. Radiopharmaceutical compositions targeting somatostatin receptors and uses thereof
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Also Published As

Publication number Publication date
KR20110027555A (ko) 2011-03-16
EP2476683A2 (en) 2012-07-18
US9353120B2 (en) 2016-05-31
US9061078B2 (en) 2015-06-23
EP2476683A4 (en) 2013-06-19
EP2476683B1 (en) 2019-04-03
US20150291608A1 (en) 2015-10-15
KR101199570B1 (ko) 2012-11-13
US20120219495A1 (en) 2012-08-30
WO2011031073A2 (ko) 2011-03-17

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