WO2011149288A2 - 복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물 - Google Patents

복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물 Download PDF

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Publication number
WO2011149288A2
WO2011149288A2 PCT/KR2011/003873 KR2011003873W WO2011149288A2 WO 2011149288 A2 WO2011149288 A2 WO 2011149288A2 KR 2011003873 W KR2011003873 W KR 2011003873W WO 2011149288 A2 WO2011149288 A2 WO 2011149288A2
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WIPO (PCT)
Prior art keywords
tyrosine kinases
pharmaceutical composition
composition containing
inhibitory activity
activity against
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Ceased
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PCT/KR2011/003873
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English (en)
French (fr)
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WO2011149288A3 (ko
Inventor
양범석
김용주
박태교
우성호
이향숙
김선영
조종운
이홍범
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Korea Institute of Science and Technology KIST
Ligachem Biosciences Inc
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Korea Institute of Science and Technology KIST
Legochem Biosciences Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45004583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2011149288(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/KR2010/003332 external-priority patent/WO2011149126A1/ko
Priority to ES11786920.6T priority Critical patent/ES2647586T3/es
Priority to CN201180026042.7A priority patent/CN102971327B/zh
Priority to JP2013512543A priority patent/JP5613323B2/ja
Priority to EP11786920.6A priority patent/EP2578590B1/en
Application filed by Korea Institute of Science and Technology KIST, Legochem Biosciences Inc filed Critical Korea Institute of Science and Technology KIST
Priority to KR1020127030670A priority patent/KR101478302B1/ko
Priority to DK11786920.6T priority patent/DK2578590T3/da
Priority to US13/699,970 priority patent/US9062066B2/en
Publication of WO2011149288A2 publication Critical patent/WO2011149288A2/ko
Publication of WO2011149288A3 publication Critical patent/WO2011149288A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

본 발명은 타이로신 카이네이즈에 대해 저해능을 가지는 항염증 화합물 및 이를 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명에 따른 화합물은 복수의 타이로신 카이네이즈들의 활성을 억제할 수 있어, 이와 관련된 염증성 질환이나 자가면역질환 등을 예방 또는 치료하는데 유용하게 사용될 수 있다.
PCT/KR2011/003873 2010-05-26 2011-05-26 복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물 Ceased WO2011149288A2 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US13/699,970 US9062066B2 (en) 2010-05-26 2011-05-26 Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
DK11786920.6T DK2578590T3 (da) 2010-05-26 2011-05-26 Anti-inflammatorisk forbindelse med inhibitorisk aktivitet mod flere tyrosinkinaser og farmaceutisk sammensætning indeholdende samme
CN201180026042.7A CN102971327B (zh) 2010-05-26 2011-05-26 具有多种酪氨酸激酶抑制活性的抗炎化合物以及含有这些化合物的药物组成物
JP2013512543A JP5613323B2 (ja) 2010-05-26 2011-05-26 複数のチロシンキナーゼに対する阻害活性を有する抗炎症化合物およびこれを含む薬学的組成物
EP11786920.6A EP2578590B1 (en) 2010-05-26 2011-05-26 Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases, and pharmaceutical composition containing same
ES11786920.6T ES2647586T3 (es) 2010-05-26 2011-05-26 Compuesto antiinflamatorio que tiene actividad inhibidora contra múltiples tirosina cinasas, y composición farmacéutica que contiene el mismo
KR1020127030670A KR101478302B1 (ko) 2010-05-26 2011-05-26 복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KRPCT/KR2010/003332 2010-05-26
KR20100049368 2010-05-26
PCT/KR2010/003332 WO2011149126A1 (ko) 2010-05-26 2010-05-26 타이로신 카이네이즈 저해능을 가지는 항염증 화합물을 포함하는 약학적 조성물
KR10-2010-0049368 2010-05-26

Publications (2)

Publication Number Publication Date
WO2011149288A2 true WO2011149288A2 (ko) 2011-12-01
WO2011149288A3 WO2011149288A3 (ko) 2012-04-19

Family

ID=45004583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/003873 Ceased WO2011149288A2 (ko) 2010-05-26 2011-05-26 복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물

Country Status (9)

Country Link
US (1) US9062066B2 (ko)
EP (1) EP2578590B1 (ko)
JP (1) JP5613323B2 (ko)
KR (1) KR101478302B1 (ko)
CN (1) CN102971327B (ko)
DK (1) DK2578590T3 (ko)
ES (1) ES2647586T3 (ko)
HU (1) HUE035589T2 (ko)
WO (1) WO2011149288A2 (ko)

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US10813917B2 (en) * 2009-12-11 2020-10-27 Medregen, Llc Treatment methods utilizing stem cell mobilizers and immunosuppressive agents
WO2013166295A1 (en) 2012-05-02 2013-11-07 Georgetown University Treating neural disease with tyrosine kinase inhibitors
KR101540051B1 (ko) * 2013-11-27 2015-07-28 한국과학기술연구원 피부 노화 방지 또는 피부 상태 개선용 조성물
JP2017527615A (ja) * 2014-09-02 2017-09-21 シーダーズ−サイナイ メディカル センター 線維化疾患及び癌を治療するための組成物及び方法
WO2017096262A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
WO2018081777A1 (en) * 2016-10-31 2018-05-03 Georgetown University Compositions and methods for treating neurodegenerative disorders
US11426406B2 (en) 2017-02-09 2022-08-30 Georgetown University Compositions and methods for treating lysosomal storage disorders
JP7629200B2 (ja) 2018-11-20 2025-02-13 ジョージタウン ユニバーシティ 神経変性、筋変性及びリソソーム蓄積障害を治療するための組成物及び方法
CN110368498A (zh) * 2019-08-26 2019-10-25 瑞希(重庆)生物科技有限公司 一种促进伤口愈合的制剂及其制备方法
WO2024096569A1 (ko) * 2022-11-02 2024-05-10 주식회사 지와이생명과학 싸이에노피리딘 화합물을 포함하는 경피 또는 국소 투여용 조성물

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Also Published As

Publication number Publication date
US20130072482A1 (en) 2013-03-21
HUE035589T2 (en) 2018-05-28
JP5613323B2 (ja) 2014-10-22
EP2578590B1 (en) 2017-08-16
DK2578590T3 (da) 2017-11-20
KR20130031266A (ko) 2013-03-28
KR101478302B1 (ko) 2014-12-31
ES2647586T3 (es) 2017-12-22
EP2578590A4 (en) 2013-12-04
CN102971327B (zh) 2016-04-20
JP2013527199A (ja) 2013-06-27
CN102971327A (zh) 2013-03-13
EP2578590A2 (en) 2013-04-10
WO2011149288A3 (ko) 2012-04-19
US9062066B2 (en) 2015-06-23

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