WO2012033842A3 - Methods, apparatuses and systems for collection of tissue sections - Google Patents

Methods, apparatuses and systems for collection of tissue sections Download PDF

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Publication number
WO2012033842A3
WO2012033842A3 PCT/US2011/050704 US2011050704W WO2012033842A3 WO 2012033842 A3 WO2012033842 A3 WO 2012033842A3 US 2011050704 W US2011050704 W US 2011050704W WO 2012033842 A3 WO2012033842 A3 WO 2012033842A3
Authority
WO
WIPO (PCT)
Prior art keywords
microtome
collection
collection apparatus
reservoir
apparatuses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/050704
Other languages
French (fr)
Other versions
WO2012033842A2 (en
Inventor
Kenneth Jeffrey Hayworth
Richard Schalek
Juan Carlos Tapia
Narayanan Kasthuri
Jeff Lichtman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Priority to EP11824074.6A priority Critical patent/EP2614376B1/en
Priority to US13/821,028 priority patent/US9784648B2/en
Publication of WO2012033842A2 publication Critical patent/WO2012033842A2/en
Publication of WO2012033842A3 publication Critical patent/WO2012033842A3/en
Anticipated expiration legal-status Critical
Priority to US15/670,784 priority patent/US10288532B2/en
Priority to US16/395,931 priority patent/US10704992B2/en
Priority to US16/921,076 priority patent/US11085853B2/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B16/00—Devices specially adapted for vivisection or autopsy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/061—Blade details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/065—Drive details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/065—Drive details
    • G01N2001/066—Drive details electric
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G01N2001/068—Illumination means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Methods, apparatuses and systems for facilitating automated or semi- automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
PCT/US2011/050704 2010-09-07 2011-09-07 Methods, apparatuses and systems for collection of tissue sections Ceased WO2012033842A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP11824074.6A EP2614376B1 (en) 2010-09-07 2011-09-07 Methods and systems for collection of tissue sections
US13/821,028 US9784648B2 (en) 2010-09-07 2011-09-07 Methods, apparatuses and systems for collection of tissue sections
US15/670,784 US10288532B2 (en) 2010-09-07 2017-08-07 Methods, apparatuses and systems for collection of tissue sections
US16/395,931 US10704992B2 (en) 2010-09-07 2019-04-26 Methods, apparatuses and systems for collection of tissue sections
US16/921,076 US11085853B2 (en) 2010-09-07 2020-07-06 Methods, apparatuses and systems for collection of tissue sections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38048410P 2010-09-07 2010-09-07
US61/380,484 2010-09-07
US39318510P 2010-10-14 2010-10-14
US61/393,185 2010-10-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/821,028 A-371-Of-International US9784648B2 (en) 2010-09-07 2011-09-07 Methods, apparatuses and systems for collection of tissue sections
US15/670,784 Continuation US10288532B2 (en) 2010-09-07 2017-08-07 Methods, apparatuses and systems for collection of tissue sections

Publications (2)

Publication Number Publication Date
WO2012033842A2 WO2012033842A2 (en) 2012-03-15
WO2012033842A3 true WO2012033842A3 (en) 2012-06-14

Family

ID=45811146

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/050704 Ceased WO2012033842A2 (en) 2010-09-07 2011-09-07 Methods, apparatuses and systems for collection of tissue sections

Country Status (3)

Country Link
US (4) US9784648B2 (en)
EP (1) EP2614376B1 (en)
WO (1) WO2012033842A2 (en)

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US10571368B2 (en) 2015-06-30 2020-02-25 Clarapath, Inc. Automated system and method for advancing tape to transport cut tissue sections
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EP3865927B1 (en) * 2016-04-21 2023-08-02 President And Fellows Of Harvard College Tape for collecting tissue samples
US10724929B2 (en) 2016-05-13 2020-07-28 Clarapath, Inc. Automated tissue sectioning and storage system
EP3529583A1 (en) * 2016-10-21 2019-08-28 Ruprecht-Karls-Universität Heidelberg Microtome, scanning electron microscope and method for preparing thin slices from a sample and method for analysing thin slices produced from a sample in a scanning electron microscope and use of a magnetic tape for the purpose of depositing and transporting of thin slices of samples in the field of scanning electron microscopy
WO2018089578A1 (en) * 2016-11-10 2018-05-17 President And Fellows Of Harvard College Gridtape imaging stage
WO2019017291A1 (en) * 2017-07-19 2019-01-24 平田機工株式会社 Specimen preparation method and specimen preparation device
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DE102017129537A1 (en) 2017-12-12 2019-06-13 Karlsruher Institut für Technologie Microtome and method of making thin sections from a sample using a microtome
US11754473B2 (en) * 2018-03-28 2023-09-12 Strateos, Inc. Method and apparatus to manipulate biological sections
EP3556552A1 (en) * 2018-04-20 2019-10-23 Universität Heidelberg Plastic film used for depositing and transporting of thin slices of samples
CN109132685B (en) * 2018-09-04 2020-12-15 华中科技大学苏州脑空间信息研究院 A method of slicing and collecting
DE102018132227B4 (en) * 2018-12-14 2025-01-09 Leica Mikrosysteme Gmbh Method for generating a series of sections, method for three-dimensional reconstruction of a microscopic sample and microtome system
CN109612767A (en) * 2018-12-30 2019-04-12 河南农业大学 A method for collecting porcine pituitary gland and hypothalamus
US20220283058A1 (en) * 2019-08-06 2022-09-08 The University Of Kansas Apparatus and methods for ultramicrotome specimen preparation
CN110596068B (en) * 2019-10-11 2021-02-02 中国科学院自动化研究所 Strip sequence slice optical imaging device and imaging method based on line scanning
JP7354437B2 (en) * 2019-10-30 2023-10-02 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー Blade roller device, blade changing device and microtome
US12158404B2 (en) 2020-02-22 2024-12-03 Clarapath, Inc. Facing and quality control in microtomy
EP3926579A1 (en) 2020-06-17 2021-12-22 Leica Mikrosysteme GmbH Method for generating a series of sections, method for three-dimensional reconstruction of a microscopic sample, microtome system and computer program
WO2022056001A1 (en) 2020-09-08 2022-03-17 Clarapath, Inc. Automated tissue section transfer system with high throughput
JP2023547619A (en) 2020-10-23 2023-11-13 クララパス， インコーポレイテッド Preliminary diagnosis of cut tissue sections
WO2022241261A1 (en) * 2021-05-13 2022-11-17 Clarapath, Inc. Systems and methods for section transfer
DE102021118581A1 (en) 2021-07-19 2023-01-19 Forschungszentrum Jülich GmbH Section collection device for use in a microtome or ultramicrotome
US12498298B2 (en) 2021-12-20 2025-12-16 Clarapath, Inc. Automated tissue section system with cut quality prediction
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Also Published As

Publication number Publication date
US20140026683A1 (en) 2014-01-30
US10704992B2 (en) 2020-07-07
EP2614376A2 (en) 2013-07-17
WO2012033842A2 (en) 2012-03-15
US11085853B2 (en) 2021-08-10
EP2614376A4 (en) 2018-05-30
EP2614376B1 (en) 2022-11-02
US20180080856A1 (en) 2018-03-22
US20200393332A1 (en) 2020-12-17
US9784648B2 (en) 2017-10-10
US20190250071A1 (en) 2019-08-15
US10288532B2 (en) 2019-05-14

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