WO2012104275A3 - Nanoparticles delivery systems, preparation and uses thereof - Google Patents

Nanoparticles delivery systems, preparation and uses thereof Download PDF

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Publication number
WO2012104275A3
WO2012104275A3 PCT/EP2012/051507 EP2012051507W WO2012104275A3 WO 2012104275 A3 WO2012104275 A3 WO 2012104275A3 EP 2012051507 W EP2012051507 W EP 2012051507W WO 2012104275 A3 WO2012104275 A3 WO 2012104275A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
delivery systems
nanoparticles delivery
nanoparticles
thermosensitive liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/051507
Other languages
French (fr)
Other versions
WO2012104275A2 (en
Inventor
Agnès Pottier
Laurent Levy
Marie-Edith MEYRE
Matthieu Germain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanobiotix SA
Original Assignee
Nanobiotix SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES12702019T priority Critical patent/ES2702561T3/en
Priority to JP2013550905A priority patent/JP6158714B2/en
Priority to US13/981,757 priority patent/US9956175B2/en
Priority to PL12702019T priority patent/PL2670394T3/en
Priority to BR112013019404A priority patent/BR112013019404A2/en
Priority to DK12702019.6T priority patent/DK2670394T3/en
Priority to EA201391119A priority patent/EA024930B1/en
Priority to CN201280007205.1A priority patent/CN103429227B/en
Priority to EP12702019.6A priority patent/EP2670394B1/en
Application filed by Nanobiotix SA filed Critical Nanobiotix SA
Priority to CA2825564A priority patent/CA2825564A1/en
Priority to AU2012213538A priority patent/AU2012213538A1/en
Priority to KR1020137023246A priority patent/KR20140053843A/en
Publication of WO2012104275A2 publication Critical patent/WO2012104275A2/en
Publication of WO2012104275A3 publication Critical patent/WO2012104275A3/en
Priority to IL227665A priority patent/IL227665A/en
Anticipated expiration legal-status Critical
Priority to ZA2013/06464A priority patent/ZA201306464B/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present application relates to thermosensitive liposomes encapsulating nanoparticles which can be used in the health sector, in particular in human health. The invention also relates to pharmaceutical and diagnostic compositions comprising thermosensitive liposomes as defined previously, as well as to their uses.
PCT/EP2012/051507 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof Ceased WO2012104275A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP12702019.6A EP2670394B1 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
US13/981,757 US9956175B2 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
CA2825564A CA2825564A1 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
BR112013019404A BR112013019404A2 (en) 2011-01-31 2012-01-31 nanoparticle transfer systems, preparation and their uses
DK12702019.6T DK2670394T3 (en) 2011-01-31 2012-01-31 NANOPARTICLE DELIVERY SYSTEMS, PREPARATION AND APPLICATIONS THEREOF
EA201391119A EA024930B1 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
CN201280007205.1A CN103429227B (en) 2011-01-31 2012-01-31 Nano-particle delivery system, it is prepared and application
ES12702019T ES2702561T3 (en) 2011-01-31 2012-01-31 Nanoparticle supply systems, preparation and uses thereof
PL12702019T PL2670394T3 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
JP2013550905A JP6158714B2 (en) 2011-01-31 2012-01-31 Nanoparticle delivery system, its manufacture and use
AU2012213538A AU2012213538A1 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
KR1020137023246A KR20140053843A (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof
IL227665A IL227665A (en) 2011-01-31 2013-07-25 Nanoparticles delivery systems, preparation and uses thereof
ZA2013/06464A ZA201306464B (en) 2011-01-31 2013-08-28 Nanoparticles delivery systems,preparation and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161437817P 2011-01-31 2011-01-31
EP11305096 2011-01-31
US61/437,817 2011-01-31
EP11305096.7 2011-01-31

Publications (2)

Publication Number Publication Date
WO2012104275A2 WO2012104275A2 (en) 2012-08-09
WO2012104275A3 true WO2012104275A3 (en) 2012-11-01

Family

ID=44202131

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/051507 Ceased WO2012104275A2 (en) 2011-01-31 2012-01-31 Nanoparticles delivery systems, preparation and uses thereof

Country Status (13)

Country Link
US (1) US9956175B2 (en)
EP (1) EP2670394B1 (en)
JP (2) JP6158714B2 (en)
KR (1) KR20140053843A (en)
CN (1) CN103429227B (en)
AU (1) AU2012213538A1 (en)
CA (1) CA2825564A1 (en)
DK (1) DK2670394T3 (en)
EA (1) EA024930B1 (en)
IL (1) IL227665A (en)
PL (1) PL2670394T3 (en)
WO (1) WO2012104275A2 (en)
ZA (1) ZA201306464B (en)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
US8715150B2 (en) 2009-11-02 2014-05-06 Pulse Therapeutics, Inc. Devices for controlling magnetic nanoparticles to treat fluid obstructions
EP2670393B8 (en) 2011-01-31 2016-10-05 Nanobiotix Method of monitoring the release from liposomes of a product of interest using superparamagnetic nanoparticles.
WO2012104275A2 (en) 2011-01-31 2012-08-09 Nanobiotix Nanoparticles delivery systems, preparation and uses thereof
EA029635B1 (en) 2011-12-16 2018-04-30 Нанобиотикс Use of a nanoparticle comprising metallic material covered with hafnium oxide material in oncology and composition comprising same
WO2014074475A1 (en) * 2012-11-07 2014-05-15 Emmetrope Ophthalmics Llc Magnetic eye shields and methods of treatment and diagnosis using the same
US20140271899A1 (en) * 2013-03-14 2014-09-18 Peroxyium, Inc., Delaware C Corp. Method of enhancing the biodistribution and tissue targeting properties of therapeutic ceco2 particles via nano-encapsulation and coating
WO2014191569A1 (en) 2013-05-30 2014-12-04 Nanobiotix Pharmaceutical composition, preparation and uses thereof
EP3139964B1 (en) 2014-05-06 2019-04-24 Memorial Sloan Kettering Cancer Center Magnetoenzymatic carrier system for imaging and targeted delivery and release of active agents
ES2774365T3 (en) 2014-11-25 2020-07-20 Curadigm Sas Pharmaceutical composition, preparation and uses thereof
SG11201704143YA (en) * 2014-11-25 2017-06-29 Nanobiotix Pharmaceutical composition, preparation and uses thereof
UA123665C2 (en) 2014-11-25 2021-05-12 Кюрадігм Сас Pharmaceutical composition, preparation and uses thereof
EP3229776B1 (en) 2014-11-25 2023-06-28 Curadigm Sas Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof
EP3223796B1 (en) 2014-11-25 2021-07-21 Curadigm Sas Pharmaceutical compositions, preparation and uses thereof
UA124572C2 (en) 2015-05-28 2021-10-13 Нанобіотікс Nanoparticles for use as a therapeutic vaccine
CN105902400B (en) * 2016-06-17 2019-10-11 四川百奥可生物科技有限责任公司 A kind of particle and its preparation method and application of wrapping biological enzyme
AU2018390163B2 (en) 2017-12-19 2024-05-02 Nanobiotix Nanoparticles for use in enhancing brain performances or in treating stress
HUE068741T2 (en) 2017-12-19 2025-01-28 Nanobiotix Nanoparticles for use for treating a neuronal disorder
US11918315B2 (en) * 2018-05-03 2024-03-05 Pulse Therapeutics, Inc. Determination of structure and traversal of occlusions using magnetic particles
CN109387641B (en) * 2018-12-20 2022-04-15 深圳职业技术学院 Device and method for detecting cecropin B by using magnetic iron oxide nanoparticles as signal amplifier
CA3163946A1 (en) * 2019-12-05 2021-06-10 The General Hospital Corporation Compositions and methods for tunable magnetic nanoparticles
WO2023186923A1 (en) 2022-03-30 2023-10-05 Meta Materials Inc. Implanted agent delivery system
CN115558100B (en) * 2022-09-30 2023-12-22 桂林理工大学 A modified transmission electron microscope grid and its preparation method and application

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US20090004258A1 (en) * 2007-06-27 2009-01-01 National Health Research Institutes Drug Release from Thermosensitive Liposomes by Applying an Alternative Magnetic Field

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Also Published As

Publication number Publication date
CA2825564A1 (en) 2012-08-09
DK2670394T3 (en) 2019-01-14
CN103429227A (en) 2013-12-04
KR20140053843A (en) 2014-05-08
US9956175B2 (en) 2018-05-01
US20140056813A1 (en) 2014-02-27
ZA201306464B (en) 2014-04-30
AU2012213538A1 (en) 2013-08-15
JP2017193550A (en) 2017-10-26
JP2014510040A (en) 2014-04-24
IL227665A (en) 2017-03-30
EA201391119A1 (en) 2014-01-30
PL2670394T3 (en) 2019-03-29
EP2670394A2 (en) 2013-12-11
JP6158714B2 (en) 2017-07-05
EP2670394B1 (en) 2018-11-21
WO2012104275A2 (en) 2012-08-09
CN103429227B (en) 2017-12-19
IL227665A0 (en) 2013-09-30
EA024930B1 (en) 2016-11-30
AU2012213538A2 (en) 2013-09-26

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