WO2012140089A1 - Intraocular injection device - Google Patents

Intraocular injection device Download PDF

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Publication number
WO2012140089A1
WO2012140089A1 PCT/EP2012/056588 EP2012056588W WO2012140089A1 WO 2012140089 A1 WO2012140089 A1 WO 2012140089A1 EP 2012056588 W EP2012056588 W EP 2012056588W WO 2012140089 A1 WO2012140089 A1 WO 2012140089A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
foot
magnifying
delivery device
exemplary embodiment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/056588
Other languages
French (fr)
Inventor
Christopher James Smith
David Heighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority to CA2832378A priority Critical patent/CA2832378A1/en
Priority to JP2014504302A priority patent/JP2014517733A/en
Priority to EP12712700.9A priority patent/EP2696802B1/en
Priority to US14/009,506 priority patent/US20140114243A1/en
Priority to DK12712700.9T priority patent/DK2696802T3/en
Publication of WO2012140089A1 publication Critical patent/WO2012140089A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts

Definitions

  • the present invention relates to a drug delivery device, especially an apparatus for an intraocular injection.
  • the present invention comprises a device for intraocular injection comprising a drug delivery device, a foot at a distal end of the drug delivery device for positioning the drug delivery device with respect to an injection site, and a magnifying device coupled to one of the drug delivery device and the foot for magnifying a view of the injection site.
  • the drug delivery device comprises a housing compartment for receiving a cartridge or a syringe.
  • the drug delivery device comprises a spring biasing a needle arrangement of the cartridge in a proximal position.
  • the magnifying device may comprise a prism element, preferably an annular prism element, having its focus on the injection site.
  • the magnifying device may be located at a distal end of the drug delivery device or a proximal end of the foot.
  • the magnifying device may comprise a barrel lens located at a distal end of the drug delivery device or on the foot.
  • the magnifying device may comprise a lens located at a distal end of the foot.
  • the magnifying device may be an integral part of the drug delivery device or
  • the magnifying device may be releasably attached to the drug delivery device or the foot.
  • the foot may include a ring for aligning with the cornea.
  • FIG. 1 shows a sectional view of a distal part of a device for intraocular injection according to an exemplary embodiment of the present invention
  • Fig. 2 shows a sectional view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 ,
  • Fig. 3 shows an isometric view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 ,
  • Fig. 4 shows a sectional view of a foot similar to the distal portion of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 ,
  • Fig. 5 shows an isometric view of the exemplary embodiment of the foot shown in Fig. 4,
  • Fig. 6 shows a sectional view of the distal part of a device for intraocular injection according to an exemplary embodiment of the present invention
  • Fig. 7 shows a sectional view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 6
  • Fig. 8 shows an isometric view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 6,
  • Fig. 9 shows an isometric view of a foot similar to the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 6,
  • Fig. 10 shows a sectional view of the exemplary embodiment of the foot shown in Fig. 9, Fig. 1 1 shows a sectional view of the distal part of a device for intraocular injection according to an exemplary embodiment of the present invention
  • Fig. 12 shows a sectional view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 1 .
  • Figures 1 to 3 show an exemplary embodiment of a device for intraocular injection 1 , more particularly an intraocular injection device.
  • a body of the device 1 may form a housing compartment for receiving a cartridge 2 (or a drug delivery device, e.g., a syringe) containing a medicinal product, for example steroids or monoclonal antibodies used to treat macular degeneration.
  • a drug delivery device e.g., a syringe
  • a distal end (lower end in the figures) of the cartridge 2 is provided with a needle arrangement 3.
  • the drug delivery device may further comprise a spring 4 arranged within the housing compartment to bias the cartridge 2 together with the needle arrangement 3 in the proximal direction.
  • the cartridge 2 together with the needle arrangement 3 may be pushed in the distal direction during injection thus compressing the spring 4 (until it abuts the distal end of the housing compartment) and administering the medicinal product.
  • the device 1 may include a foot 5 or spacer located at its distal end.
  • the foot 5 may be provided with a positioning device to aid the accurate placement of the device relative to an injection site I.
  • the foot 5 is provided with a ring 6 which may be sized and shaped to encircle a cornea of a human eye 7. In use, the foot 5 is placed in contact with the eye 7 and the ring 6 is positioned around the cornea.
  • the positioning device may be any size or shape (e.g., circular, semi-circular, arcuate, etc.) which facilitates placement and positioning of the drug delivery device 1 .
  • the positioning device may have a width which ensures that the injection will not penetrate the cornea, but will be directed through the conjunctiva and sclera into the vitreous body.
  • a magnifying device 8 is provided and positioned to magnify a view of the injection site I.
  • the magnifying device 8 may be an annular prism lens formed around a circumference of a distal portion of the drug delivery device 1.
  • the use of an annular prism lens may facilitate viewing of the injection site I from multiple angles.
  • the magnifying device 8 may be any size and/or shape and be located at any position on or relative to the device 1 , so long as there is a clear line of sight between the magnifying device 8 and the injection site I.
  • the foot 5 is shown as a separate element which may be releasably or permanently attached to, or formed integrally with, the body of a device 1 .
  • a proximal portion of the foot 5 may include a coupling mechanism, e.g., threads, snap-fit, bayonet-fit, friction fit, etc., for coupling to a distal end of the body.
  • the coupling mechanism may also include an audible feedback ("click") when it has been secured to the body of the device 1 .
  • Figures 6 to 8 depict another exemplary embodiment of a device for intraocular injection 1 '.
  • the magnifying device may be a barrel lens 9 provided on the foot 5' to provide a magnified view of the injection site I.
  • the barrel lens 9 may be substantially designed as a cylindrical body having an axis extending perpendicular to an axis of the device 1 '.
  • the magnifying device may be a disc-shaped lens provided on the foot 5'.
  • the barrel lens 9 may be provided as an integral part of the foot 5'.
  • the barrel lens 9 may be separable from the foot 5'.
  • the foot 5' may either be an integral part of the device 1 ' or may be provided as a separate part for attachment to the device 1 ', as described above.
  • FIG. 1 1 and 12 depicting a distal portion of a device for intraocular injection including a foot 5" having a magnifying property.
  • a lens element 10 may be integrated into the foot 5", or the foot 5" may be manufactured from a material with a magnifying property.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Prostheses (AREA)

Abstract

Described is a device for intraocular injection comprising a drug delivery device, a foot (5) at a distal end of the drug delivery device for positioning the drug delivery device with respect to an injection site, and a magnifying device (8) coupled to one of the drug delivery device and the foot for magnifying a view of the injection site.

Description

Description INTRAOCULAR INJECTION DEVICE
The present invention relates to a drug delivery device, especially an apparatus for an intraocular injection.
Background
In the field of intraocular injections, it is generally important to visualize the injection site prior to, during and after the injection. However, given the small operating space, such visualization is difficult. US 4,743,234 and US 6,001 ,082 disclose magnifier means for use with hypodermic syringes. However, the known magnifying means do not improve the visibility of the injection site but rather hinder a direct view of the injection site and are cumbersome in use. Summary of the Invention
In an exemplary embodiment, the present invention comprises a device for intraocular injection comprising a drug delivery device, a foot at a distal end of the drug delivery device for positioning the drug delivery device with respect to an injection site, and a magnifying device coupled to one of the drug delivery device and the foot for magnifying a view of the injection site. The drug delivery device comprises a housing compartment for receiving a cartridge or a syringe. The drug delivery device comprises a spring biasing a needle arrangement of the cartridge in a proximal position. The magnifying device may comprise a prism element, preferably an annular prism element, having its focus on the injection site. The magnifying device may be located at a distal end of the drug delivery device or a proximal end of the foot. The magnifying device may comprise a barrel lens located at a distal end of the drug delivery device or on the foot. The magnifying device may comprise a lens located at a distal end of the foot.
The magnifying device may be an integral part of the drug delivery device or
permanently attached to the drug delivery device. In another exemplary embodiment, the magnifying device may be releasably attached to the drug delivery device or the foot.
The foot may include a ring for aligning with the cornea. Brief Description of the Drawings
In the following, the invention will be described by way of an example and with
reference to the schematic drawings in which: Fig. 1 shows a sectional view of a distal part of a device for intraocular injection according to an exemplary embodiment of the present invention;
Fig. 2 shows a sectional view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 ,
Fig. 3 shows an isometric view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 ,
Fig. 4 shows a sectional view of a foot similar to the distal portion of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 ,
Fig. 5 shows an isometric view of the exemplary embodiment of the foot shown in Fig. 4,
Fig. 6 shows a sectional view of the distal part of a device for intraocular injection according to an exemplary embodiment of the present invention,
Fig. 7 shows a sectional view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 6, Fig. 8 shows an isometric view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 6,
Fig. 9 shows an isometric view of a foot similar to the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 6,
Fig. 10 shows a sectional view of the exemplary embodiment of the foot shown in Fig. 9, Fig. 1 1 shows a sectional view of the distal part of a device for intraocular injection according to an exemplary embodiment of the present invention, and
Fig. 12 shows a sectional view of the distal part of the exemplary embodiment of the device for intraocular injection shown in Fig. 1 1 .
Detailed Description
Figures 1 to 3 show an exemplary embodiment of a device for intraocular injection 1 , more particularly an intraocular injection device. A body of the device 1 may form a housing compartment for receiving a cartridge 2 (or a drug delivery device, e.g., a syringe) containing a medicinal product, for example steroids or monoclonal antibodies used to treat macular degeneration. A distal end (lower end in the figures) of the cartridge 2 is provided with a needle arrangement 3. Those of skill in the art will understand that the combination of the cartridge 2 and the needle arrangement 3 may be in the form of a prefilled syringe. The drug delivery device may further comprise a spring 4 arranged within the housing compartment to bias the cartridge 2 together with the needle arrangement 3 in the proximal direction. The cartridge 2 together with the needle arrangement 3 may be pushed in the distal direction during injection thus compressing the spring 4 (until it abuts the distal end of the housing compartment) and administering the medicinal product.
In an exemplary embodiment, the device 1 may include a foot 5 or spacer located at its distal end. The foot 5 may be provided with a positioning device to aid the accurate placement of the device relative to an injection site I. In an exemplary embodiment shown in Figures 1 to 3, the foot 5 is provided with a ring 6 which may be sized and shaped to encircle a cornea of a human eye 7. In use, the foot 5 is placed in contact with the eye 7 and the ring 6 is positioned around the cornea. Those of skill in the art will understand that the positioning device may be any size or shape (e.g., circular, semi-circular, arcuate, etc.) which facilitates placement and positioning of the drug delivery device 1 . In an exemplary embodiment, the positioning device may have a width which ensures that the injection will not penetrate the cornea, but will be directed through the conjunctiva and sclera into the vitreous body.
In the exemplary embodiment shown in Figures 1 to 3, a magnifying device 8 is provided and positioned to magnify a view of the injection site I. In an exemplary embodiment, the magnifying device 8 may be an annular prism lens formed around a circumference of a distal portion of the drug delivery device 1. In the exemplary embodiment, the use of an annular prism lens may facilitate viewing of the injection site I from multiple angles. However, those of skill in the art will understand that the magnifying device 8 may be any size and/or shape and be located at any position on or relative to the device 1 , so long as there is a clear line of sight between the magnifying device 8 and the injection site I.
In an exemplary embodiment shown in Figures 4 and 5, the foot 5 is shown as a separate element which may be releasably or permanently attached to, or formed integrally with, the body of a device 1 . In an exemplary embodiment in which the foot 5 is separable from the body of the device 1 , a proximal portion of the foot 5 may include a coupling mechanism, e.g., threads, snap-fit, bayonet-fit, friction fit, etc., for coupling to a distal end of the body. The coupling mechanism may also include an audible feedback ("click") when it has been secured to the body of the device 1 .
Figures 6 to 8 depict another exemplary embodiment of a device for intraocular injection 1 '. In this exemplary embodiment, the magnifying device may be a barrel lens 9 provided on the foot 5' to provide a magnified view of the injection site I. The barrel lens 9 may be substantially designed as a cylindrical body having an axis extending perpendicular to an axis of the device 1 '. In another exemplary embodiment, the magnifying device may be a disc-shaped lens provided on the foot 5'. As shown in the exemplary embodiments depicted in Figures 9 and 10, the barrel lens 9 may be provided as an integral part of the foot 5'. Alternatively, the barrel lens 9 may be separable from the foot 5'. In this exemplary embodiment, the foot 5' may either be an integral part of the device 1 ' or may be provided as a separate part for attachment to the device 1 ', as described above.
A further exemplary embodiment of the present invention is shown in Figures 1 1 and 12 depicting a distal portion of a device for intraocular injection including a foot 5" having a magnifying property. For example, a lens element 10 may be integrated into the foot 5", or the foot 5" may be manufactured from a material with a magnifying property.
Those of skill in the art will understand that modifications (additions and/or removals) of various components of the apparatuses, methods and/or systems and embodiments described herein may be made without departing from the full scope and spirit of the present invention, which encompass such modifications and any and all equivalents thereof.

Claims

Claims 1 . A device for intraocular injection comprising:
a drug delivery device;
a foot (5) at a distal end of the drug delivery device for positioning the drug delivery device with respect to an injection site; and
a magnifying device (8) coupled to one of the drug delivery device and the foot (5) for magnifying a view of the injection site.
2. The device according to claim 1 , wherein the drug delivery device comprises a housing compartment for receiving a cartridge (2) or a syringe.
3. The device according to claims 1 or 2, wherein the drug delivery device comprises a spring (4) biasing a needle arrangement (3) of the cartridge (2) in a proximal position.
4. The device according to any of the preceding claims, wherein the magnifying device (8) comprises a prism element, preferably an annular prism element, having its focus on the injection site.
5. The device according to any of the preceding claims, wherein the magnifying device (8) is located at a distal end of the drug delivery device or a proximal end of the foot (5).
6. The device according to claims 1 to 3, wherein the magnifying device (8) comprises a barrel lens (9).
7. The device according to claims 2 and 6, wherein the barrel lens (9) is located at a distal end of the drug delivery device or on the foot (5).
8. The device according to claims 1 to 3, wherein the magnifying device (8) comprises a lens (10) located at a distal end of the foot (5).
9. The device according to any of the preceding claims, wherein the magnifying device (8) is an integral part of the drug delivery device or permanently attached to the drug delivery device.
10. The device according to claims 1 to 8, wherein the magnifying device (8) is releasably attached to the drug delivery device or the foot (5).
1 1 . The device according to any of the preceding claims, wherein the foot (5) includes a ring for aligning with the cornea.
PCT/EP2012/056588 2011-04-15 2012-04-11 Intraocular injection device Ceased WO2012140089A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2832378A CA2832378A1 (en) 2011-04-15 2012-04-11 Intraocular injection device
JP2014504302A JP2014517733A (en) 2011-04-15 2012-04-11 Intraocular injection device
EP12712700.9A EP2696802B1 (en) 2011-04-15 2012-04-11 Intraocular injection device
US14/009,506 US20140114243A1 (en) 2011-04-15 2012-04-11 Intraocular Injection Device
DK12712700.9T DK2696802T3 (en) 2011-04-15 2012-04-11 INTRAOCULAR INJECTION DEVICE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11162721A EP2510902A1 (en) 2011-04-15 2011-04-15 Intraocular injection device
EP11162721.2 2011-04-15

Publications (1)

Publication Number Publication Date
WO2012140089A1 true WO2012140089A1 (en) 2012-10-18

Family

ID=45024113

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/056588 Ceased WO2012140089A1 (en) 2011-04-15 2012-04-11 Intraocular injection device

Country Status (6)

Country Link
US (1) US20140114243A1 (en)
EP (2) EP2510902A1 (en)
JP (1) JP2014517733A (en)
CA (1) CA2832378A1 (en)
DK (1) DK2696802T3 (en)
WO (1) WO2012140089A1 (en)

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CN107708623A (en) * 2015-04-14 2018-02-16 艾湾色斯公司 Electroporation device

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US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
JP5996544B2 (en) 2010-10-15 2016-09-21 クリアサイド・バイオメディカル・インコーポレーテッドＣｌｅａｒｓｉｄｅ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ Eye access device
EP2564819A1 (en) * 2011-09-02 2013-03-06 Sanofi-Aventis Deutschland GmbH Intraocular injection device
MX373894B (en) 2012-11-08 2020-07-09 Clearside Biomedical Inc Methods and devices for the treatment of ocular diseases in human subjects
BR112015027762A2 (en) 2013-05-03 2017-08-29 Clearside Biomedical Inc APPLIANCE AND METHODS FOR OCULAR INJECTION
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
EP3157598A4 (en) 2014-06-20 2018-05-16 Clearside Biomedical, Inc. Variable diameter cannula and methods for controlling insertion depth for medicament delivery
USD750223S1 (en) 2014-10-14 2016-02-23 Clearside Biomedical, Inc. Medical injector for ocular injection
US11071643B2 (en) 2014-11-28 2021-07-27 Visionisti Oy Ocular therapeutics tool
US10390901B2 (en) 2016-02-10 2019-08-27 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
EP3452165A1 (en) 2016-05-02 2019-03-13 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
IL305537B2 (en) 2016-08-12 2025-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US12090294B2 (en) 2017-05-02 2024-09-17 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle

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Also Published As

Publication number Publication date
EP2696802B1 (en) 2015-03-11
EP2696802A1 (en) 2014-02-19
JP2014517733A (en) 2014-07-24
EP2510902A1 (en) 2012-10-17
US20140114243A1 (en) 2014-04-24
CA2832378A1 (en) 2012-10-18
DK2696802T3 (en) 2015-06-22

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