WO2013122575A3 - Small molecule having antiviral properties - Google Patents

Small molecule having antiviral properties Download PDF

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Publication number
WO2013122575A3
WO2013122575A3 PCT/US2012/025070 US2012025070W WO2013122575A3 WO 2013122575 A3 WO2013122575 A3 WO 2013122575A3 US 2012025070 W US2012025070 W US 2012025070W WO 2013122575 A3 WO2013122575 A3 WO 2013122575A3
Authority
WO
WIPO (PCT)
Prior art keywords
antiviral properties
small molecule
molecule
antiviral
properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/025070
Other languages
French (fr)
Other versions
WO2013122575A2 (en
Inventor
Oleg Nikolayevich CHUPAKHIN
Oleg Ivanovich KISILEV
Vladimir Leonidovich RUSINOV
Valery Nikolaevich CHARUSHIN
Nina Pablovna TUGOVA
Natliya Roseyvna MEDVEDERA
Evgeny Hartsisovich ULOMSKII
David Mark Evans
Ella Germanovna DYEVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GRL
Original Assignee
GRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GRL filed Critical GRL
Priority to JP2014557606A priority Critical patent/JP2015507007A/en
Priority to PCT/US2012/025070 priority patent/WO2013122575A2/en
Priority to EP12868920.5A priority patent/EP2819517A2/en
Publication of WO2013122575A2 publication Critical patent/WO2013122575A2/en
Publication of WO2013122575A3 publication Critical patent/WO2013122575A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This patent disclosure describes a new scaffold for a small molecule having antiviral properties, molecule having antiviral properties with demonstrated low toxicity is disclosed.
PCT/US2012/025070 2012-02-14 2012-02-14 Small molecule having antiviral properties Ceased WO2013122575A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2014557606A JP2015507007A (en) 2012-02-14 2012-02-14 Small molecules with antiviral properties
PCT/US2012/025070 WO2013122575A2 (en) 2012-02-14 2012-02-14 Small molecule having antiviral properties
EP12868920.5A EP2819517A2 (en) 2012-02-14 2012-02-14 Small molecule having antiviral properties

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/025070 WO2013122575A2 (en) 2012-02-14 2012-02-14 Small molecule having antiviral properties

Publications (2)

Publication Number Publication Date
WO2013122575A2 WO2013122575A2 (en) 2013-08-22
WO2013122575A3 true WO2013122575A3 (en) 2014-05-01

Family

ID=48984871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/025070 Ceased WO2013122575A2 (en) 2012-02-14 2012-02-14 Small molecule having antiviral properties

Country Status (3)

Country Link
EP (1) EP2819517A2 (en)
JP (1) JP2015507007A (en)
WO (1) WO2013122575A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015016818A1 (en) * 2013-07-29 2015-02-05 Ghias Asghar Novel azolo-1,2,4-triazine derived antiviral oral therapeutic
WO2018035509A2 (en) * 2016-08-19 2018-02-22 Grl, Inc. Small molecules having antiviral properties

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
RU2294936C1 (en) * 2005-06-29 2007-03-10 Государственное Образовательное Учреждение Высшего Профессионального Образования Уральский Государственный Технический Университет-УПИ 2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4h)-one sodium salt dihydrate possessing antiviral activity
US20080014189A1 (en) * 2002-11-15 2008-01-17 Pierce Albert C Diaminotriazoles useful as inhibitors of protein kinases
RU2343154C2 (en) * 2007-01-31 2009-01-10 Общество с ограниченной ответственностью Научно-техническое предприятие "Лиганд" METHOD OF OBTAINING SODIUM SALT OF 2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZIN-7-ONE, DIHYDRATE
RU2345080C2 (en) * 2007-02-16 2009-01-27 ГОУ ВПО Уральский государственный технический университет-УПИ 4-(4'-HYDROXYBUTYL)-6-PHENYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZIN-7-ON
US20090156602A1 (en) * 2004-11-24 2009-06-18 Nigel Graham Cooke Organic Compounds
RU2376307C1 (en) * 2008-05-27 2009-12-20 Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук 4-((Z)-4'-HYDROXYBUTENE-2'-YL)-2-R-6-FURYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZINE-7-ONS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602007009865D1 (en) * 2006-11-23 2010-11-25 Novartis Ag 5-Sulphinylmethyl-1,2,4-triazole-1,5-acuprimidine-7-olderivates as CXCR2-antagonists

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405619A (en) * 1981-09-02 1983-09-20 Diamond Shamrock Corporation Antiinflammatory substituted-1,2,4-triazolo[4,3-b]-1,2,4-triazines
US20080014189A1 (en) * 2002-11-15 2008-01-17 Pierce Albert C Diaminotriazoles useful as inhibitors of protein kinases
US20090156602A1 (en) * 2004-11-24 2009-06-18 Nigel Graham Cooke Organic Compounds
RU2294936C1 (en) * 2005-06-29 2007-03-10 Государственное Образовательное Учреждение Высшего Профессионального Образования Уральский Государственный Технический Университет-УПИ 2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7(4h)-one sodium salt dihydrate possessing antiviral activity
RU2343154C2 (en) * 2007-01-31 2009-01-10 Общество с ограниченной ответственностью Научно-техническое предприятие "Лиганд" METHOD OF OBTAINING SODIUM SALT OF 2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZIN-7-ONE, DIHYDRATE
RU2345080C2 (en) * 2007-02-16 2009-01-27 ГОУ ВПО Уральский государственный технический университет-УПИ 4-(4'-HYDROXYBUTYL)-6-PHENYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZIN-7-ON
RU2376307C1 (en) * 2008-05-27 2009-12-20 Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук 4-((Z)-4'-HYDROXYBUTENE-2'-YL)-2-R-6-FURYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZINE-7-ONS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DEEV ET AL.: "1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors", BIOORGANIC CHEMISTRY, vol. 38, 2010, pages 265 - 270, XP027429512 *
KHALYMBADZHA ET AL.: "Synthesis of acyclic nucleoside analogues based on 1,2,4-triazolo [1,5- a]pyrimidin-7-ones by one-step Vorbr uggen glycosylation", TETRAHEDRON, vol. 70, 2014, pages 1298 - 1305, XP028817727 *

Also Published As

Publication number Publication date
EP2819517A2 (en) 2015-01-07
JP2015507007A (en) 2015-03-05
WO2013122575A2 (en) 2013-08-22

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