WO2013132460A3 - Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism - Google Patents

Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism Download PDF

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Publication number
WO2013132460A3
WO2013132460A3 PCT/IB2013/051819 IB2013051819W WO2013132460A3 WO 2013132460 A3 WO2013132460 A3 WO 2013132460A3 IB 2013051819 W IB2013051819 W IB 2013051819W WO 2013132460 A3 WO2013132460 A3 WO 2013132460A3
Authority
WO
WIPO (PCT)
Prior art keywords
energy metabolism
iron adsorption
disorder
methods
impaired energy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2013/051819
Other languages
French (fr)
Other versions
WO2013132460A2 (en
Inventor
Tilmann B. Walk
Bennard Van Ravenzwaay
Werner Mellert
Eric Fabian
Volker Strauss
Hennicke Kamp
Jan C. Wiemer
Ralf Looser
Michael Manfred Herold
Alexandre Prokoudine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF China Co Ltd
BASF SE
Original Assignee
BASF China Co Ltd
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF China Co Ltd, BASF SE filed Critical BASF China Co Ltd
Priority to EP13757232.7A priority Critical patent/EP2822454A2/en
Priority to CA2863366A priority patent/CA2863366A1/en
Priority to US14/382,870 priority patent/US20150044702A1/en
Priority to JP2014560507A priority patent/JP2015517090A/en
Publication of WO2013132460A2 publication Critical patent/WO2013132460A2/en
Anticipated expiration legal-status Critical
Publication of WO2013132460A3 publication Critical patent/WO2013132460A3/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/90—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving iron binding capacity of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention pertains to the field of diagnostics for iron adsorption disorder or impaired energy metabolism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing iron adsorption disorder or impaired energy metabolism. It also relates to a method for determining whether a compound is capable of inducing such iron adsorption disorder or impaired energy metabolism in a subject and to a method of identifying a drug for treating iron adsorption disorder or impaired energy metabolism. Furthermore, the present invention relates to a device and a kit for diagnosing iron adsorption disorder or impaired energy metabolism.
PCT/IB2013/051819 2012-03-09 2013-03-07 Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism Ceased WO2013132460A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP13757232.7A EP2822454A2 (en) 2012-03-09 2013-03-07 Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism
CA2863366A CA2863366A1 (en) 2012-03-09 2013-03-07 Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism
US14/382,870 US20150044702A1 (en) 2012-03-09 2013-03-07 Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism
JP2014560507A JP2015517090A (en) 2012-03-09 2013-03-07 Means and methods for assessing disorders associated with iron absorption disorders or energy metabolism disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261608693P 2012-03-09 2012-03-09
EP12158865 2012-03-09
EP12158865.1 2012-03-09
US61/608,693 2012-03-09

Publications (2)

Publication Number Publication Date
WO2013132460A2 WO2013132460A2 (en) 2013-09-12
WO2013132460A3 true WO2013132460A3 (en) 2016-09-01

Family

ID=49117454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/051819 Ceased WO2013132460A2 (en) 2012-03-09 2013-03-07 Means and methods for assessing disorders related to impaired iron adsorption or energy metabolism

Country Status (5)

Country Link
US (1) US20150044702A1 (en)
EP (1) EP2822454A2 (en)
JP (1) JP2015517090A (en)
CA (1) CA2863366A1 (en)
WO (1) WO2013132460A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2476597C (en) * 2002-02-28 2011-05-17 Metanomics Gmbh & Co. Kgaa Mass spectrometry method for analysing mixtures of substances
EP2369346B1 (en) * 2006-03-24 2014-08-27 Metanomics GmbH Method for diagnosing diabetes type II
CA2724422A1 (en) * 2008-05-28 2009-12-23 Basf Se Means and methods for assessing increased peroxisomal proliferation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEI JI ET AL.: "Effects of ascorbic acid and citric acid on iron bioavailability in an in vitro digestion/ Caco-2 cell culture model", J SOUTH MED UNIV, vol. 28, no. 10, 2008, pages 1743 - 1747, XP 055327423 *
S.M.I, KAZMI ET AL.: "6-AMINONICOTINAMIDE:EEG CHANGES AND EFFECTS ON THE ACTIVITIES OF ENZYMES RELATED TO GLUTAMATE METABOLISM IN RAT BRAIN REGIONS", PHARMACOLOGICAL RESEARCH COMMUNICATIONS, vol. 18, no. 8, 1986, pages 747 - 758, XP 024888489, DOI: doi:10.1016/0031-6989(86)90116-5 *
WANG YU-PING ET AL.: "EFFECTS OF ACUTE HYPOXIA ON PLASMA METABOLOME IN MICE", CHIN J APPL PHYSIOL, vol. 25, no. 2, 2009, pages 177 - 180, XP008182562 *

Also Published As

Publication number Publication date
WO2013132460A2 (en) 2013-09-12
US20150044702A1 (en) 2015-02-12
EP2822454A2 (en) 2015-01-14
JP2015517090A (en) 2015-06-18
CA2863366A1 (en) 2013-09-12

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