WO2014067342A1 - 具有高吸湿性的伤口敷料及其制备方法和用途 - Google Patents

具有高吸湿性的伤口敷料及其制备方法和用途 Download PDF

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Publication number
WO2014067342A1
WO2014067342A1 PCT/CN2013/082801 CN2013082801W WO2014067342A1 WO 2014067342 A1 WO2014067342 A1 WO 2014067342A1 CN 2013082801 W CN2013082801 W CN 2013082801W WO 2014067342 A1 WO2014067342 A1 WO 2014067342A1
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WIPO (PCT)
Prior art keywords
fiber
wound dressing
sol
highly hygroscopic
fibers
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Ceased
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PCT/CN2013/082801
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English (en)
French (fr)
Inventor
王晓东
莫小慧
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Foshan United Medical Technologies Ltd
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Foshan United Medical Technologies Ltd
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Priority to US14/438,324 priority Critical patent/US20150282991A1/en
Priority to EP13850943.5A priority patent/EP2898903B1/en
Publication of WO2014067342A1 publication Critical patent/WO2014067342A1/zh
Anticipated expiration legal-status Critical
Priority to US17/149,784 priority patent/US20210137742A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01034—Non-adhesive bandages or dressings characterised by a property
    • A61F13/01042—Absorbency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A61F13/01012—Non-adhesive bandages or dressings characterised by the material being made of natural material, e.g. cellulose-, protein-, collagen-based
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/04—Packaging single articles
    • B65B5/045—Packaging single articles in bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/08—Sterilising wrappers or receptacles prior to, or during, packaging by irradiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/12—Sterilising contents prior to, or during, packaging
    • B65B55/16—Sterilising contents prior to, or during, packaging by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00238—Wound bandages characterised by way of knitting or weaving
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/042—Force radial
    • F04C2270/0421—Controlled or regulated

Definitions

  • the present invention relates to a wound dressing having high hygroscopicity and a preparation method and use thereof. Background technique
  • wound dressings with high moisture absorption are desirable in the care of ulcerative wounds, in particular fibrous wound dressings having sol properties, such as calcium alginate wound dressings, chitosan wound dressings, modified cellulose wound dressings. Wait. These dressings are characterized by high moisture absorption and high moisture retention, which provides a relatively moist environment for wound healing.
  • a significant disadvantage of such dressings is the low strength of the dressing, especially the low wet strength. Wound dressings with low wet strength are more susceptible to breakage during removal and increase the difficulty of wound care work, and are more likely to cause wound or peripheral skin infections.
  • wounds produce a large amount of exudate during the healing process, and some wounds can exude up to 50 ml of exudate within 24 hours. Therefore, it is clinically necessary to have a highly hygroscopic sol-like fibrous wound dressing to absorb these exudates, but it is also desirable to improve the wet strength of the dressing so that the dressing has a certain strength after absorption saturation and can be removed in a single piece.
  • the dressing absorbs up to 20 times its own exudate.
  • the most common larger wound dressings (10 x 20 cm) typically weigh 2-3 g and can absorb up to 60 g or more after sufficient absorption. This requires the wound dressing to have a wet strength of 60 g (0.6 N) or more to prevent the dressing dressing from being damaged due to low wet strength and damage to the dressing.
  • WO 2009/0287130 has made some attempts in this respect to interlace some sewing threads on a dressing by means of a puncturing on the basis of a carboxymethylcellulose dressing (Aquacd). After the dressing is fully absorbed, these interwoven sewing threads provide strength to the dressing like the "rebar" in reinforced concrete, maintaining the overall removal performance of the dressing. However, the dressing also exposes the non-solent sewing thread to the wound, which weakens the advantage that the sol fiber does not adhere to the wound. Summary of the invention
  • the present invention provides a wound dressing having high hygroscopicity, the wound dressing comprising A base layer formed of non-sol fibers and a pile layer formed of sol fibers, which are woven on the bottom layer by weaving and have a free pile length of 1-100 mm, preferably 5-50 mm.
  • the term "free pile length" means the average length of a single sol fiber when not woven into the bottom layer.
  • the wound dressing according to the invention has a hygroscopicity of 6 g/100 cm 2 or higher as tested according to the method of EN 13726-1:2002 /AC:2003.
  • a hygroscopicity 6 g/100 cm 2 or higher as tested according to the method of EN 13726-1:2002 /AC:2003.
  • the wound dressing of the present invention can naturally curl into a cylindrical shape with the underlayer and the outer layer of the pile, which would be an ideal filling dressing for cave-type wounds.
  • the sol-like fibers on the outside of the cylindrical dressing absorb the wound exudate, while the inner bottom layer retains its strength, so that the dressing can still be broken without being removed after being sufficiently hygroscopic. Can be removed in one piece.
  • the sol fibers have a fineness of from 1 to 10 dtex, preferably from 2 to 5 dtex. According to the invention, the sol fibers have a length of from 10 to 120 mm, preferably from 10 to 75 mm.
  • the non-sol fiber has a fineness of 50 to 500 dtex, preferably 50 to 200 dtexo.
  • the sol-like fiber refers to a fiber which forms a colloidal state after absorbing liquid water (or A solution containing calcium and sodium ions (English Pharmacopoeia 1993, supplemented in 1995) or physiological saline containing sodium ions).
  • a solution refers to a solution containing 8.298 g of sodium chloride and 0.368 g of calcium dihydrate per liter of solution.
  • the A solution is commonly used in the world as a test for measuring the hygroscopicity (absorbability) and wet strength of the dressing.
  • Solution A The ratio of calcium to sodium in the solution is very similar to that in wound secretions.
  • This fiber has a strong ability to absorb the above liquid, and generally absorbs 6 grams or more of liquid per gram of the fiber material.
  • the sol fibers of the present invention are selected from the group consisting of alginate fibers, modified cellulose fibers or modified chitosan fibers or mixtures thereof.
  • the alginate fiber is calcium alginate/sodium fiber or calcium alginate fiber, and its hygroscopicity generally absorbs 10 grams of liquid per gram of fiber material, and the material has good moisture absorption and moisturizing properties. It can also contribute calcium ions to the wound and help the wound heal.
  • the modified cellulose fiber is a carboxymethyl cellulose fiber or a water-insoluble solvent-spun cellulose sulfonate sulfonate fiber. These fibers are based on cellulose fibers (such as viscose fiber and lyocell fiber). By chemical modification, a large water-absorbing group is added to the molecular structure, which greatly improves the hygroscopicity and formation of the fiber. Gelatinous. The degree of substitution of such fibers for use in wound dressings is generally between 0.05 and 0.4.
  • the modified chitosan fiber is a carboxymethyl chitosan fiber or an acylated chitosan fiber. These fibers also add a large water-absorbing group to the molecular chain of the chitosan fiber, which greatly improves the hygroscopicity and gelation of the fiber.
  • the degree of substitution of such fibers for use in wound dressings is generally between 0.10 and 0.4.
  • the non-solifying fibers are selected from the group consisting of polyester filaments or yarns, nylon filaments or yarns, vinylon filaments or yarns, viscose filaments or yarns, Lyocdl filaments or yarns, Non-solar chitosan filaments or yarns, spandex filaments or yarns, polypropylene filaments or yarns, silk, cotton yarns, other non-sol chemical or natural filaments or yarns, or filaments or yarns as described above a mixture of wires.
  • some or all of the sol fibers and/or some or all of the non-sol fibers contain an antibacterial agent.
  • Typical antibacterial agents for sol fibers are silver, iodine, honey or PHMB.
  • a typical antibacterial agent for non-sol fibers is, for example, a silver-containing mixture of the trade name Alphasan, which can be incorporated into a spinning dope to impart antibacterial properties to the fibers or filaments.
  • Antibacterial agents such as metallic silver particles (or nanoscale) can also be added directly to the surface or surface of the fibrous structure.
  • Dressings prepared from sol-containing fibers and non-sol-containing fibers containing antibacterial agents can be used to treat wounds that have a bacterial infection or infection tendency, and can effectively eliminate infection or prevent infection. In general, such anti-infective dressings can be used continuously for 7 days without the need to change dressings, greatly reducing the pain and burden of the patient.
  • the sol fibers are interwoven on the base fabric by the underlying fabric loop structure, and the sol fibers can be woven on the bottom layer at one or both ends.
  • the density of the bottom layer can be controlled by the thickness of the needle and the fineness of the filament or yarn.
  • the fineness of the bottom filament or yarn is generally about 167 dtex, and it may be single or double, and the density of the bottom layer is generally about 20 mesh/inch.
  • the pile layer may be formed of two or more kinds of sol fibers.
  • the dressing of the present invention can be prepared by a plush circular knitting machine.
  • the non-sol fibers used to form the bottom layer are fed to the knitting machine by a yarn guiding mechanism, and the sol fibers for forming the pile layer are fed into the knitting machine in the form of tops by a carding device.
  • a typical plush model is
  • the device has two types of weaving, positive blowing and back blowing, the positive blowing method is to hold one end of the pile in the loop, and the back blowing type is to hold both ends of the pile in the loop.
  • the average free pile length of the positive blow type is longer, up to 20 mm or even longer.
  • the average free pile length of the backflush type is generally short, typically between 3 and 10 mm.
  • the average free pile length of the pile layer can also be controlled by means of cut pile, which can be as short as 1-5 mm.
  • the dry or wet strength of wound dressings is directional, ie longitudinal (MD) and transverse (CD).
  • the longitudinal strength refers to the strength along the direction of movement of the material during production
  • the transverse strength is the strength in the direction of 90 degrees from the longitudinal direction.
  • the strength of the material in the longitudinal direction is lower than in the transverse direction.
  • rupture occurs in the weakest direction during the removal of the wound dressing.
  • the invention utilizes the weaving technology to reasonably combine the non-solar fiber and the sol fiber, and fully utilizes their respective advantages, and the prepared dressing has the high moisture absorption, high moisturizing property and non-sol fiber of the sol fiber.
  • the reduced hygroscopic strength provides the dressing of the present invention with high moisture absorption properties and high wet strength properties not found in other modern fiber-based dressings.
  • the bottom layer of the dressing of the present invention is formed by interlacing non-solile fiber filaments or yarns.
  • This structure has good elasticity and strength. Since the strength of the filaments or yarns does not decrease significantly after the dressing absorbs moisture, the underlying structure will provide the dressing with an overall strength that does not significantly decrease after moisture absorption, allowing the dressing to be removed as a whole during replacement.
  • the present invention relates to a method of preparing the above wound dressing having high hygroscopicity, the method comprising:
  • the tops can be fed to all the feeding mechanisms, for example, 18 tops can be fed at the same time, or only the partial feeding mechanism can be fed, for example, only 6 or 9 or 12 can be fed.
  • the linear density of the fed top may be between 4 and 18 g/m, preferably between 6 and 12 g/m.
  • the stitch length (transverse density) of the loom is usually 6-18 needles/inch, and the bottom layer (longitudinal) density is usually 12-42 mesh/inch.
  • the free pile length varies with the blowing method.
  • the free pile length in the case of blowing is long, and the free pile length in the case of back blowing is short, generally can be controlled between 5-10 mm, after the shearing process , free plush length can reach 1-2 mm.
  • the invention further relates to the use of the wound dressing for the treatment of chronic wounds such as venous stasis, pressure ulcers, diabetic foot ulcers and other chronic ulcer wounds, and for the treatment of cavernous or depressed ulcer wounds.
  • Figure 1 is a schematic illustration of a highly hygroscopic wound dressing woven on one end of a sol fiber.
  • Figure 2 is a schematic illustration of a highly hygroscopic wound dressing woven on both ends of a sol fiber. detailed description
  • the plush circular knitting machine WHCW-S18C-24B-1056 was fed with 2xl83dte X lyocell filaments as non-solar fibers, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a base fabric density of 18 mesh/inch.
  • a calcium alginate fiber top having a linear density of 6.7 g/m as a sol fiber was fed, and the calcium alginate fiber had a fineness of 2.65 dtex and a feed number of 18.
  • Hair blowing method blowing.
  • the resulting fabric had a basis weight of 410 g/m 2 .
  • the average free pile length of the fabric pile layer is 40 mm.
  • the fabric was tested for hygroscopicity of 45 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 150 N/cm, an elongation of 90%, a wet strength of 145 N/cm, an elongation of 93%, a transverse dry strength of the fabric of 41 N/cm, an elongation of 266%, and a wet strength.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with 2xl67dte X low-elastic polyester filaments as non-solar fibers, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a backing density of 20 mesh/inch.
  • the calcium alginate/sodium fiber tops having a linear density of 6.7 g/m as a sol fiber were fed, and the calcium alginate/sodium fiber fineness was 2.65 dtex, and the number of feeds was 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 320 g/m 2 .
  • the average free pile length of the fabric pile layer is 12 mm.
  • the fabric was tested for hygroscopicity of 32 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 109 N/cm, an elongation of 128%, a wet strength of 100 N/cm, an elongation of 115%, a transverse dry strength of the fabric of 44 N/cm, an elongation of 192%, and a wet strength.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with 2xl67dte X low-elastic polyester filaments as non-solar fibers, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a backing density of 20 mesh/inch.
  • the carboxymethylcellulose tops having a linear density of 6 g/m as a sol fiber were fed, and the fineness of the carboxymethylcellulose fibers was 2.1 dtex, and the number of feeds was 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 300 g/m 2 .
  • the average free pile length of the fabric pile layer is 8 mm.
  • the fabric was tested for hygroscopicity of 33 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 105 N/cm, an elongation of 120%, a wet strength of 95 N/cm, an elongation of 105%, a transverse dry strength of the fabric of 42 N/cm, an elongation of 182%, and a wet strength. It is 39 N/cm and the elongation is 165%.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with a 2xl67dtex low-elastic polyester filament as a non-sol fiber, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a bottom layer density of 20 mesh/inch.
  • the acylated chitosan fiber tops having a linear density of 6 g/m as a sol fiber were fed, and the acylated chitosan fiber had a fineness of 2.2 dtex and a feed number of 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 290 g/m 2 .
  • the average free pile length of the fabric pile layer is 5 mm.
  • the fabric was tested for hygroscopicity of 32 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 101 N/cm, an elongation of 128%, a wet strength of 92 N/cm, an elongation of 112%, a transverse dry strength of the fabric of 39 N/cm, an elongation of 180%, and a wet strength. It is 40 N/cm and the elongation is 176%.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with a 2xl67dtex low-elastic polyester filament as a non-sol fiber, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a bottom layer density of 20 mesh/inch.
  • a calcium alginate fiber top having a linear density of 6.7 g/m as a sol fiber was fed, and the calcium alginate fiber had a fineness of 2.65 dtex and a feed number of 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 300 g/m 2 .
  • the average free pile length of the fabric pile layer is 8 mm.
  • the fabric was tested for hygroscopicity of 30 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 106 N/cm, an elongation of 116%, a wet strength of 197 N/cm, an elongation of 103%, a transverse dry strength of the fabric of 41 N/cm, an elongation of 180%, and a wet strength. It is 37 N/cm and has an elongation of 159%.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with a 2xl67dtex low-elastic polyester filament as a non-sol fiber, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a bottom layer density of 20 mesh/inch.
  • a silver-containing alginate fiber bristles having a linear density of 6.7 g/m as a sol fiber were fed, and the fine silver-containing alginate fibers had a fineness of 2.75 dtex and a feed number of 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 320 g/m 2 .
  • the average free pile length of the fabric pile layer is 12 mm.
  • the fabric was tested for hygroscopicity of 31 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 110 N/cm, an elongation of 120%, a wet strength of 105 N/cm, an elongation of 113%, a transverse dry strength of the fabric of 39 N/cm, an elongation of 190%, and a wet strength. It is 42 N/cm and has an elongation of 170%.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with 2xl67dtex low-elastic polyester filaments as non-sol fibers, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a base fabric density of 20 mesh/inch.
  • a PHMB-containing calcium alginate fiber top yarn having a linear density of 6.7 g/m as a sol fiber was fed, and the PHMB calcium alginate fiber had a fineness of 2.75 dtex and a feed number of 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 320 g/m 2 .
  • the average free pile length of the fabric pile layer is 12 mm.
  • the fabric was tested for hygroscopicity of 31 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 101 N/cm, an elongation of 124%, a wet strength of 98 N/cm, an elongation of 114%, a transverse dry strength of the fabric of 45 N/cm, an elongation of 188%, and a wet strength. It is 40 N/cm and has an elongation of 166%.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with 2xl67dte X low-elastic polyester filaments as non-solar fibers, and the bottom layer was prepared at a stitch length of 14 needles/inch and a bottom layer density of 20 mesh/inch.
  • a silver-containing carboxymethyl cellulose fiber top having a linear density of 6 g/m as a sol fiber was fed, and the fineness of the silver-containing carboxymethyl cellulose fiber was 2.2 dtex, and the number of feeds was 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 300 g/m 2 .
  • the average free pile length of the fabric pile layer is 8 mm.
  • the fabric was tested for hygroscopicity of 32 g/100 cm 2 according to the method of EN 13726-1 :2002 /AC:2003.
  • the fabric has a longitudinal dry strength of 103 N/cm, an elongation of 118%, a wet strength of 96 N/cm, an elongation of 104%, a transverse dry strength of the fabric of 38 N/cm, an elongation of 176%, and a wet strength. It is 35 N/cm and has an elongation of 143%.
  • the plush circular knitting machine WHCW-S18C-27A-1176 was fed with 2xl67dte X low-elastic polyester filaments as non-solar fibers, and the bottom layer was prepared at a stitch length of 14 stitches/inch and a base fabric density of 20 mesh/inch.
  • a silver-containing chitosan fiber top having a linear density of 6 g/m as a sol fiber was fed, and the silver-containing chitosan fiber had a fineness of 2.3 dtex and a feed number of 9.
  • Hair blowing method Back blowing.
  • the resulting fabric had a basis weight of 300 g/m 2 .
  • the average free pile length of the fabric pile layer is 5 mm.
  • the hygroscopicity of the fabric tested according to EN 13726-1 :2002 /AC:2003 is 31 g/lOOcm ⁇
  • the fabric has a longitudinal dry strength of 98 N/cm, an elongation of 125%, a wet strength of 90 N/cm, an elongation of 117%, a transverse dry strength of the fabric of 38 N/cm, an elongation of 185%, and a wet strength of 44 N. /cm, elongation is 186%.

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Abstract

一种具有高吸湿性的伤口敷料，所述伤口敷料包括由非溶胶性纤维形成的底层和由溶胶性纤维形成的毛绒层，所述溶胶性纤维通过编织的方式织在底层上且具有1-100mm的自由毛绒长度。该伤口敷料可用于护理慢性伤口，如静脉淤血性溃疡、压迫性溃疡、糖尿病足部溃疡以及其它慢性溃疡伤口。该伤口敷料的制备方法也被提及。

Description

具有高吸湿性的伤口敷料及其制备方法和用途 技术领域
本发明涉及一种具有高吸湿性的伤口敷料及其制备方法和用途。 背景技术
众所周知， 在护理溃疡性伤口时都希望使用具有高吸湿的现代伤 口敷料， 特别是具有溶胶性能的纤维类伤口敷料， 例如海藻酸钙伤口 敷料、 壳聚糖伤口敷料、 改性的纤维素伤口敷料等。 这些敷料的特点 是高吸湿性和高保湿性， 从而可以为伤口愈合提供一个相对湿润的环 境。 但是这类敷料的显著缺点是敷料的强度较低， 特别是湿强度较低。 湿强度低的伤口敷料在去除过程中易破损而加大伤口护理工作的难 度， 更有可能引起伤口或周边皮肤感染。
一般伤口在愈合过程中会产生大量渗出液， 有的伤口可在 24小时 内渗出高达 50ml的渗出液。因此临床上需要具有高吸湿性的溶胶性纤 维伤口敷料将这些渗出液吸收， 但也希望有办法可以提高敷料的湿强 度， 使得敷料在吸收饱和后仍具有一定强度可以整片去除。 以海藻酸 钙伤口敷料为例，这种敷料可吸收的渗出液可达自身重量的 20倍之多。 最常见的较大的伤口敷料（10x20cm)的重量一般为 2-3g， 在充分吸收 后， 这种敷料可以重达 60g或更多。 这就需要伤口敷料的湿强度达到 60g ( 0.6 N)或以上， 以防止换药时伤口敷料可能会因湿强度低而破 损而造成敷料更换困难。
WO 2009/0287130在这方面做了一些尝试， 其在羧甲基纤维素敷 料 （Aquacd) 的基础上用针刺的方式将一些缝纫线交织在敷料上。 敷 料在充分吸湿之后， 这些交织的缝纫线就会像钢筋混凝土中的 "钢筋" 一样为敷料提供强度， 保持敷料的整片去除性能。 但该敷料同时也将 非溶胶性的缝纫线暴露于伤口， 削弱了溶胶性纤维不与伤口粘连的优 点。 发明内容
本发明提供了一种具有高吸湿性的伤口敷料， 所述伤口敷料包括 由非溶胶性纤维形成的底层和由溶胶性纤维形成的毛绒层， 所述溶胶 性纤维通过编织的方式织在底层上且具有 1-100 mm, 优选 5-50 mm的 自由毛绒长度。 在本发明中， 术语 "自由毛绒长度"是指未编织入底 层时的单根溶胶性纤维的平均长度。
根据本发明的伤口敷料具有按照 EN 13726-1:2002 /AC :2003方法 测试的 6 g/100 cm2或更高的吸湿性。 当这种敷料被用于护理溃疡性伤 口时， 由溶胶性纤维形成的毛绒层与伤口接触， 吸收伤口分泌液， 而 由非溶胶性纤维形成的底层由于其不溶胶性而不会因敷料吸湿而强度 变弱， 从而使得整个敷料保持其基本强度而可以整片去除。
此外， 当沿本发明的伤口敷料的底层横向剪切时， 本发明的伤口 敷料能够自然卷曲成底层在内、 毛绒层在外的圆筒状， 这将是非常理 想的洞穴型伤口的填充敷料。 当这种敷料被用来填充洞穴型伤口时， 圆筒状敷料外部的溶胶性纤维吸收伤口分泌液， 而内部的底层仍然保 持其强度， 使敷料在充分吸湿后仍然可以在去除时不断裂而可以整片 去除。
根据本发明， 所述溶胶性纤维的细度为 1-10 dtex, 优选 2-5 dtex。 根据本发明， 所述溶胶性纤维的长度为 10-120 mm, 优选 10-75 mm。
根据本发明，所述非溶胶性纤维的细度为 50-500 dtex,优选 50-200 dtexo
所谓溶胶性纤维是指在吸收液态水 （或者含有钙钠离子的 A溶液 (英国药典 1993， 95年增补)或者含有钠离子的生理盐水）后形成胶体 状态的纤维。 （A溶液是指每升溶液中含有 8.298克的氯化钠和 0.368 克的二水氯化钙的溶液。 国际上普遍使用 A溶液作为在测量敷料吸湿 性 （吸收性） 和湿强度时的试验溶液。 A 溶液中的钙和钠离子的比例 与伤口分泌物中的很相似）。 这种纤维吸收上述液体的能力很强， 一般 为每克纤维材料吸收 6克或更多的液体。 而且这种纤维一般在吸收液 体后横向剧烈膨胀， 膨胀后的直径达到原来纤维直径的数倍甚至数十 倍。 有的溶胶性纤维横向膨胀后几乎丧失了原来的纤维状结构， 变成 无定型的胶体。 本发明的溶胶性纤维选自海藻酸盐纤维、 改性纤维素 纤维或改性壳聚糖纤维或其混合物。 所述海藻酸盐纤维为海藻酸钙 /钠纤维或海藻酸钙纤维， 其吸湿性 一般为每克纤维材料吸收 10克液体，这种材料除了有很好的吸湿保湿、 吸水成胶的性能外， 还可以为伤口贡献钙离子， 帮助伤口愈合。
所述改性纤维素纤维为羧甲基纤维素纤维或不溶于水的溶剂纺纤 维素垸基磺酸盐纤维。 这些纤维是在纤维素纤维 （如黏胶纤维和莱赛 尔纤维） 的基础上， 通过化学改性在其分子结构上加上一个很大的吸 水基团， 大大提高了纤维的吸湿性和成胶性。 用在伤口敷料方面的这 种纤维的取代度一般在 0.05和 0.4之间。
所述改性壳聚糖纤维为羧甲基壳聚糖纤维或酰化壳聚糖纤维。 这 些纤维也是在壳聚糖纤维的分子链上加上一个很大的吸水基团， 大大 提高了纤维的吸湿性和成胶性。 用在伤口敷料方面的这种纤维的取代 度一般在 0.10和 0.4之间。
所述非溶胶性纤维选自涤纶长丝或纱线、 尼纶长丝或纱线、 维纶 长丝或纱线、 黏胶长丝或纱线、 莱赛尔 （Lyocdl) 长丝或纱线、 非溶 胶性壳聚糖长丝或纱线、 氨纶长丝或纱线、 丙纶长丝或纱线、 蚕丝、 棉纱线、 其它非溶胶性化学或天然长丝或纱线， 或上述长丝或纱线的 混合物。
根据本发明， 部分或全部所述溶胶性纤维和 /或部分或全部所述非 溶胶性纤维含有抗菌剂。 用于溶胶性纤维的典型的抗菌剂为银、 碘、 蜂蜜或 PHMB。 用于非溶胶性纤维的典型的抗菌剂为例如商品名为 Alphasan 的含银混合物， 可以将所述含银混合物掺入纺丝原液从而使 纤维或长丝具有抗菌性。 也可以直接将抗菌剂如金属银粒子 （或纳米 级） 加到纤维结构之内或表面。 用含有抗菌剂的溶胶性纤维和非溶胶 性纤维制备的敷料可以用于护理那些有细菌感染或者有感染倾向的伤 口， 可以有效地消除感染或预防感染。 一般来说这类抗感染敷料可以 一次连续使用 7天而不需更换敷料， 大大减轻了患者的痛苦和负担。
根据本发明， 溶胶性纤维通过底层织物毛圈组织交织在底层织物 上， 所述溶胶性纤维可以一端或两端织在所述底层上。 底层密度可以 由织针的粗细和长丝或纱线的细度来控制。 底层长丝或纱线的细度一 般在 167dtex左右， 可以是单根的， 也可以是双根的， 底层密度一般在 20目 /英寸左右。 根据本发明， 所述毛绒层可以由两种或两种以上的溶胶性纤维形 成。
本发明的敷料可以通过长毛绒针织圆机制备。 用于形成底层的非 溶胶性纤维通过导纱机构喂入针织机， 而用于形成毛绒层的溶胶性纤 维以毛条形式通过梳理装置喂入针织机。 典型的长毛绒机型为
WHCW-T/S18C-27A-1176。 这种设备有正吹和反吹两种织造形式， 正吹 式是将毛绒的一端握持在毛圈里， 而反吹式是将毛绒的两端都握持在 毛圈里。 正吹式的平均自由毛绒长度较长， 可达到 20毫米甚至更长。 反吹式的平均自由毛绒长度一般较短， 一般在 3-10毫米之间。 毛绒层 的平均自由毛绒长度也可以通过割绒的方式来控制， 最短可以达到 1-5 毫米。
众所周知， 伤口敷料的干强度或湿强度是具有方向性的， 即纵向 (MD) 和横向 （CD)。 所述纵向强度是指沿生产过程中材料的运动方 向的强度， 横向强度是与纵向成 90度的方向的强度。 一般情况下， 对 于通过针刺工艺制备的敷料来说， 材料在纵向受力的强度比横向低。 一般来说， 在伤口敷料的去除过程中会在强度最弱的方向上发生破裂。
本发明利用编织技术将非溶胶性纤维与溶胶性纤维合理地组合在 一起， 充分利用了各自的优势， 制备成的敷料既有溶胶性纤维的高吸 湿、 高保湿性能， 又有非溶胶性纤维吸湿强度减少不多的性能， 使得 本发明的敷料有着其它现代纤维类敷料所不具有的高吸湿性能和高湿 强度性能。
本发明的敷料的底层是由非溶胶性纤维长丝或纱线交织而成。 这 种结构有着较好的弹性和强度。 由于长丝或纱线的强度在敷料吸湿后 不会有很大的降低， 所述底层结构将为敷料提供在吸湿后不会显著降 低的整体强度， 使得敷料可以在更换时整片去除。
此外， 本发明还涉及一种制备上述具有高吸湿性的伤口敷料的方 法， 所述方法包括：
1 )给长毛绒针织圆机喂入非溶胶性纤维形式的底纱或长丝， 从而 形成底层；
2) 给长毛绒针织圆机喂入溶胶性纤维形式的毛条；
3 )进行正吹或反吹， 从而将所述溶胶性纤维的一端或两端织在所 述底层上；
4) 进行剪毛、 烫光、 后剪切处理；
5 )进行包装、 灭菌， 所述灭菌采用辐照、 环氧乙垸或高温的方式 进行。
在上述步骤 2) 中， 可以向所有喂毛机构都喂入毛条， 例如 18个 毛条同时喂入， 也可以只给部分喂毛机构喂入毛条， 比如只喂入 6条 或 9条或 12条。喂入毛条的线密度可以在 4-18 g/m之间，优选 6-12 g/m。
在上述步骤 1 )中， 织机的针距（横向密度）通常为 6-18针 /英寸， 底层 （纵向） 密度通常为 12-42目 /英寸。
自由毛绒长度随吹风方式的不同而不同， 正吹情况下的自由毛绒 长度较长， 反吹情况下的自由毛绒长度较短， 一般可以控制在 5-10毫 米之间， 经过剪毛工序， 自由毛绒长度可以达到 1-2毫米。
本发明还涉及所述伤口敷料用于护理慢性伤口， 如静脉瘀血性溃 疡、 压迫性溃疡、 糖尿病足部溃疡以及其它慢性溃疡伤口的用途， 以 及用于护理洞穴型或凹陷型溃疡伤口的用途。 附图说明
图 1 是溶胶性纤维一端织在底层上的具有高吸湿性的伤口敷料示 意图。
图 2是溶胶性纤维两端织在底层上的具有高吸湿性的伤口敷料示 意图。 具体实施方式
实施例 1
给长毛绒针织圆机 WHCW-S18C-24B-1056 喂入作为非溶胶性纤维 的 2xl83dteX的莱赛尔长丝， 以 14针 /英寸的针距、 18目 /英寸的底布 密度制备底层。
喂入作为溶胶性纤维的线密度为 6.7 g/m的海藻酸钙纤维毛条， 其 海藻酸钙纤维细度为 2.65dtex， 喂入头数为 18。
吹风方式： 正吹。
所得织物克重为 410 g/m2。 织物毛绒层的平均自由毛绒长度为 40 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 45 g/100cm2。
织物的纵向干强度为 150 N/cm，伸长为 90%,湿强度为 145 N/cm， 伸长为 93%, 织物的横向干强度为 41 N/cm， 伸长为 266%, 湿强度为
40 N/cm, 伸长为 240%。 实施例 2
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dteX的低弹涤纶长丝， 以 14针 /英寸的针距、 20目 /英寸的底 布密度制备底层。
喂入作为溶胶性纤维的线密度为 6.7 g/m的海藻酸钙 /钠纤维毛条， 其海藻酸钙 /钠纤维细度为 2.65dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 320 g/m2。
织物毛绒层的平均自由毛绒长度为 12 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 32 g/100cm2。
织物的纵向干强度为 109 N/cm，伸长为 128% ,湿强度为 100 N/cm， 伸长为 115%, 织物的横向干强度为 44 N/cm， 伸长为 192%, 湿强度为
41 N/cm, 伸长为 168%。
实施例 3
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dteX的低弹涤纶长丝， 以 14针 /英寸的针距、 20目 /英寸的底 布密度制备底层。
喂入作为溶胶性纤维的线密度为 6 g/m的羧甲基纤维素毛条，其羧 甲基纤维素纤维细度为 2.1dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 300 g/m2。 织物毛绒层的平均自由毛绒长度为 8 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 33 g/100cm2。
织物的纵向干强度为 105 N/cm，伸长为 120% ,湿强度为 95 N/cm， 伸长为 105%, 织物的横向干强度为 42 N/cm， 伸长为 182%, 湿强度 为 39 N/cm， 伸长为 165%。
实施例 4
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤 维的 2xl67dtex的低弹涤纶长丝， 以 14针 /英寸的针距、 20 目 /英寸的 底层密度制备底层。
喂入作为溶胶性纤维的线密度为 6 g/m的酰化壳聚糖纤维毛条，其 酰化壳聚糖纤维细度为 2.2dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 290 g/m2。
织物毛绒层的平均自由毛绒长度为 5 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 32 g/100cm2。
织物的纵向干强度为 101 N/cm，伸长为 128% ,湿强度为 92 N/cm， 伸长为 112%, 织物的横向干强度为 39 N/cm， 伸长为 180%, 湿强度为 40 N/cm, 伸长为 176%。 实施例 5
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dtex的低弹涤纶长丝， 以 14针 /英寸的针距、 20 目 /英寸的底 层密度制备底层。
喂入作为溶胶性纤维的线密度为 6.7 g/m的海藻酸钙纤维毛条， 其 海藻酸钙纤维细度为 2.65dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 300 g/m2。 织物毛绒层的平均自由毛绒长度为 8 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 30 g/100cm2。
织物的纵向干强度为 106 N/cm，伸长为 116% ,湿强度为 197 N/cm， 伸长为 103%, 织物的横向干强度为 41 N/cm， 伸长为 180%, 湿强度 为 37 N/cm， 伸长为 159%。 实施例 6
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dtex的低弹涤纶长丝， 以 14针 /英寸的针距、 20 目 /英寸的底 层密度制备底层。
喂入作为溶胶性纤维的线密度为 6.7 g/m 的含银海藻酸钙纤维毛 条， 其含银海藻酸钙纤维细度为 2.75dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 320 g/m2。
织物毛绒层的平均自由毛绒长度为 12 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 31 g/100cm2。
织物的纵向干强度为 110 N/cm，伸长为 120% ,湿强度为 105 N/cm， 伸长为 113% , 织物的横向干强度为 39 N/cm， 伸长为 190%, 湿强度为 42 N/cm, 伸长为 170%。 实施例 7
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dtex的低弹涤纶长丝， 以 14针 /英寸的针距、 20 目 /英寸的底 布密度制备底层。
喂入作为溶胶性纤维的线密度为 6.7 g/m的含 PHMB海藻酸钙纤 维毛条， 其含 PHMB海藻酸钙纤维细度为 2.75dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 320 g/m2。
织物毛绒层的平均自由毛绒长度为 12 mm。 织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 31 g/100cm2。
织物的纵向干强度为 101 N/cm，伸长为 124% ,湿强度为 98 N/cm， 伸长为 114%, 织物的横向干强度为 45 N/cm， 伸长为 188%, 湿强度为 40 N/cm, 伸长为 166%。 实施例 8
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dteX的低弹涤纶长丝， 以 14针 /英寸的针距、 20 目 /英寸的底 层密度制备底层。
喂入作为溶胶性纤维的线密度为 6 g/m的含银羧甲基纤维素纤维 毛条， 其含银羧甲基纤维素纤维细度为 2.2dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 300 g/m2。
织物毛绒层的平均自由毛绒长度为 8 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 32 g/100cm2。
织物的纵向干强度为 103 N/cm，伸长为 118%,湿强度为 96 N/cm， 伸长为 104%, 织物的横向干强度为 38 N/cm, 伸长为 176%, 湿强度 为 35 N/cm， 伸长为 143%。 实施例 9
给长毛绒针织圆机 WHCW-S18C-27A-1176 喂入作为非溶胶性纤维 的 2xl67dteX的低弹涤纶长丝， 以 14针 /英寸的针距、 20 目 /英寸的底 布密度制备底层。
喂入作为溶胶性纤维的线密度为 6 g/m的含银酰化壳聚糖纤维毛 条， 其含银酰化壳聚糖纤维细度为 2.3dtex， 喂入头数为 9。
吹风方式： 反吹。
所得织物克重为 300 g/m2。
织物毛绒层的平均自由毛绒长度为 5 mm。
织物按照 EN 13726-1 :2002 /AC:2003 方法测试的吸湿性为 31 g/lOOcm^
织物的纵向干强度为 98N/cm， 伸长为 125%, 湿强度为 90N/cm， 伸长为 117%, 织物的横向干强度为 38N/cm， 伸长为 185%, 湿强度为 44 N/cm, 伸长为 186%。

Claims

权利要求书:
1、 一种具有高吸湿性的伤口敷料， 其特征在于， 所述伤口敷料包 括由非溶胶性纤维形成的底层和由溶胶性纤维形成的毛绒层， 所述溶 胶性纤维通过编织的方式织在底层上且具有 1-100 mm, 优选 5-50 mm 的自由毛绒长度。
2、根据权利要求 1所述的具有高吸湿性的伤口敷料，其特征在于， 所述伤口敷料具有按照 EN 13726-1 :2002 /AC:2003方法测试的 6 g/100 cm2或更高的吸湿性。
3、根据权利要求 1所述的具有高吸湿性的伤口敷料，其特征在于， 所述伤口敷料当沿所述底层横向剪切时能够自然卷曲成底层在内、 毛 绒层在外的圆筒状。
4、根据权利要求 1所述的具有高吸湿性的伤口敷料，其特征在于， 所述溶胶性纤维的细度为 1-10 dtex, 优选 2-5 dtex o
5、根据权利要求 1所述的具有高吸湿性的伤口敷料，其特征在于， 所述溶胶性纤维的长度为 10-120 mm, 优选 10-75 mm。
6、根据权利要求 1所述的具有高吸湿性的伤口敷料，其特征在于， 所述非溶胶性纤维的细度为 50-500 dtex, 优选 50-200 dtex。
7、 根据权利要求 1至 6任一项所述的具有高吸湿性的伤口敷料， 其特征在于， 所述溶胶性纤维选自海藻酸盐纤维、 改性纤维素纤维或 改性壳聚糖纤维或其混合物。
8、根据权利要求 7所述的具有高吸湿性的伤口敷料，其特征在于， 所述海藻酸盐纤维为海藻酸钙 /钠纤维或海藻酸钙纤维。
9、根据权利要求 7所述的具有高吸湿性的伤口敷料，其特征在于， 所述改性纤维素纤维为羧甲基纤维素纤维或不溶于水的溶剂纺纤维素 垸基磺酸盐纤维。
10、 根据权利要求 7所述的具有高吸湿性的伤口敷料， 其特征在 于， 所述改性壳聚糖纤维为羧甲基壳聚糖纤维或酰化壳聚糖纤维。
11、 根据权利要求 1至 6任一项所述的具有高吸湿性的伤口敷料， 其特征在于， 所述非溶胶性纤维选自涤纶长丝或纱线、 尼纶长丝或纱 线、 维纶长丝或纱线、 黏胶长丝或纱线、 莱赛尔 （Lyocdl ) 长丝或纱 线、 非溶胶性壳聚糖长丝或纱线、 氨纶长丝或纱线、 丙纶长丝或纱线、 蚕丝、 棉纱线、 其它非溶胶性化学或天然长丝或纱线， 或上述长丝或 纱线的混合物。
12、 根据权利要求 1至 6任一项所述的具有高吸湿性的伤口敷料， 其特征在于， 部分或全部所述溶胶性纤维和 /或部分或全部所述非溶胶 性纤维含有抗菌剂。
13、 根据权利要求 1至 6任一项所述的具有高吸湿性的伤口敷料， 其特征在于， 所述溶胶性纤维的一端或两端织在所述底层上。
14、 根据权利要求 1至 6任一项所述的具有高吸湿性的伤口敷料， 其特征在于， 所述毛绒层由两种或两种以上的溶胶性纤维形成。
15、 一种制备根据权利要求 1至 14任一项所述的具有高吸湿性的 伤口敷料的方法， 其特征在于：
1 )给长毛绒针织圆机喂入非溶胶性纤维形式的底纱或长丝， 从而 形成底层；
2) 给长毛绒针织圆机喂入溶胶性纤维形式的毛条；
3 )进行正吹或反吹， 从而将所述溶胶性纤维的一端或两端织在所 述底层上；
4) 进行剪毛、 烫光、 后剪切处理；
5 )进行包装、 灭菌， 所述灭菌采用辐照、 环氧乙垸或高温的方式 进行。
16、 根据权利要求 1至 14任一项所述的具有高吸湿性的伤口敷料 用于护理慢性伤口， 如静脉瘀血性溃疡、 压迫性溃疡、 糖尿病足部溃 疡以及其它慢性溃疡伤口的用途。
17、 根据权利要求 1至 14任一项所述的具有高吸湿性的伤口敷料 用于护理洞穴型或凹陷型溃疡伤口的用途。
PCT/CN2013/082801 2012-10-29 2013-09-02 具有高吸湿性的伤口敷料及其制备方法和用途 Ceased WO2014067342A1 (zh)

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