WO2014141034A3 - A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids - Google Patents

A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids Download PDF

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Publication number
WO2014141034A3
WO2014141034A3 PCT/IB2014/059581 IB2014059581W WO2014141034A3 WO 2014141034 A3 WO2014141034 A3 WO 2014141034A3 IB 2014059581 W IB2014059581 W IB 2014059581W WO 2014141034 A3 WO2014141034 A3 WO 2014141034A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
body fluids
chemical entities
methods
soluble chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2014/059581
Other languages
French (fr)
Other versions
WO2014141034A2 (en
Inventor
Richard Harry Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2905564A priority Critical patent/CA2905564A1/en
Application filed by Individual filed Critical Individual
Priority to CN201480027187.2A priority patent/CN105492887A/en
Priority to EP14765063.4A priority patent/EP2973408A4/en
Priority to AU2014229420A priority patent/AU2014229420A1/en
Priority to EA201591800A priority patent/EA201591800A1/en
Priority to SG11201506786VA priority patent/SG11201506786VA/en
Priority to JP2015562467A priority patent/JP2016522880A/en
Priority to US14/776,555 priority patent/US10032270B2/en
Priority to BR112015023081A priority patent/BR112015023081A2/en
Publication of WO2014141034A2 publication Critical patent/WO2014141034A2/en
Anticipated expiration legal-status Critical
Publication of WO2014141034A3 publication Critical patent/WO2014141034A3/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/088—Condensers for both incident illumination and transillumination
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G06T7/73—Determining position or orientation of objects or cameras using feature-based methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10141—Special mode during image acquisition
    • G06T2207/10152—Varying illumination
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Processing (AREA)

Abstract

A system and methods for detecting particles and soluble chemical entities in body fluids consists of a system consisting of a microscopic apparatus, a sample chamber and reagents and methods used to detect, classify and enumerate particles and chemical entities in body fluids. Body fluids containing particles combined with reagents sediment to the bottom of a viewing chamber bringing them into the focal place of a digital microscopic detector. Particles identified as areas within a captured digital image that absorb or emit electromagnetic radiation can be further classified based on additional absorbed or emitted electromagnetic radiation within the predefined areas of the first digital image.
PCT/IB2014/059581 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids Ceased WO2014141034A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US14/776,555 US10032270B2 (en) 2013-03-15 2014-03-10 System and methods for the in vitro detection of particles and soluble chemical entities in body fluids
CN201480027187.2A CN105492887A (en) 2013-03-15 2014-03-10 Systems and methods for in vitro detection of particulate and soluble chemical entities in bodily fluids
EP14765063.4A EP2973408A4 (en) 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids
AU2014229420A AU2014229420A1 (en) 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids
EA201591800A EA201591800A1 (en) 2013-03-15 2014-03-10 SYSTEM AND METHODS OF DETECTION OF PARTICLES AND SOLUBLE CHEMICAL STRUCTURAL ELEMENTS OF IN VITRO IN PHYSIOLOGICAL REFLECTIVE MEDIA
CA2905564A CA2905564A1 (en) 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids
JP2015562467A JP2016522880A (en) 2013-03-15 2014-03-10 System and method for in vitro detection of particles and soluble chemicals in body fluids
SG11201506786VA SG11201506786VA (en) 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids
BR112015023081A BR112015023081A2 (en) 2013-03-15 2014-03-10 microscopic method for classifying particles as two-dimensional objects in a field of view, microscopic measuring apparatus, sample chamber, and methods for performing immunoassays and assays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361790764P 2013-03-15 2013-03-15
US61/790,764 2013-03-15

Publications (2)

Publication Number Publication Date
WO2014141034A2 WO2014141034A2 (en) 2014-09-18
WO2014141034A3 true WO2014141034A3 (en) 2015-12-17

Family

ID=51538221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/059581 Ceased WO2014141034A2 (en) 2013-03-15 2014-03-10 A system and methods for the in vitro detection of particles and soluble chemical entities in body fluids

Country Status (10)

Country Link
US (1) US10032270B2 (en)
EP (1) EP2973408A4 (en)
JP (1) JP2016522880A (en)
CN (1) CN105492887A (en)
AU (1) AU2014229420A1 (en)
BR (1) BR112015023081A2 (en)
CA (1) CA2905564A1 (en)
EA (1) EA201591800A1 (en)
SG (2) SG10201707599WA (en)
WO (1) WO2014141034A2 (en)

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Also Published As

Publication number Publication date
EA201591800A1 (en) 2016-04-29
EP2973408A2 (en) 2016-01-20
CA2905564A1 (en) 2014-09-18
SG10201707599WA (en) 2017-10-30
BR112015023081A2 (en) 2017-07-18
EP2973408A4 (en) 2017-06-14
US20160042507A1 (en) 2016-02-11
WO2014141034A2 (en) 2014-09-18
SG11201506786VA (en) 2015-09-29
AU2014229420A1 (en) 2015-09-24
JP2016522880A (en) 2016-08-04
US10032270B2 (en) 2018-07-24
CN105492887A (en) 2016-04-13

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