WO2015010026A3 - Compositions and methods for controlling leptinotarsa - Google Patents

Compositions and methods for controlling leptinotarsa Download PDF

Info

Publication number
WO2015010026A3
WO2015010026A3 PCT/US2014/047204 US2014047204W WO2015010026A3 WO 2015010026 A3 WO2015010026 A3 WO 2015010026A3 US 2014047204 W US2014047204 W US 2014047204W WO 2015010026 A3 WO2015010026 A3 WO 2015010026A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
disclosed
leptinotarsa spp
compositions
plants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/047204
Other languages
French (fr)
Other versions
WO2015010026A2 (en
Inventor
Jodi Lynn BEATTIE
Michael John CRAWFORD
Brian Donovan EADS
Lex Evan FLAGEL
Mahak KAPOOR
Christina Marie Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Technology LLC
Original Assignee
Monsanto Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Technology LLC filed Critical Monsanto Technology LLC
Priority to EP19185431.4A priority Critical patent/EP3608412A3/en
Priority to UAA201601494A priority patent/UA122662C2/en
Priority to RU2016105470A priority patent/RU2703498C2/en
Priority to JP2016527128A priority patent/JP6668236B2/en
Priority to BR112016000555-4A priority patent/BR112016000555B1/en
Priority to PL14747277T priority patent/PL3030663T3/en
Priority to CN201480051779.8A priority patent/CN105980567B/en
Priority to MX2016000741A priority patent/MX359191B/en
Priority to EP14747277.3A priority patent/EP3030663B1/en
Priority to CA2918387A priority patent/CA2918387C/en
Publication of WO2015010026A2 publication Critical patent/WO2015010026A2/en
Publication of WO2015010026A3 publication Critical patent/WO2015010026A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Insects & Arthropods (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed herein are methods of controlling insect pests, in particular Leptinotarsa spp. which infest crop plants, and methods of providing plants resistant to such pests. Also disclosed are polynucleotides and recombinant DNA molecules and constructs useful in such methods, insecticidal compositions such as topical sprays containing insecticidal double-stranded RNAs, and solanaceous plants with improved resistance to infestation by Leptinotarsa spp. Further disclosed are methods of selecting target genes for RNAi-mediated silencing and control of Leptinotarsa spp.
PCT/US2014/047204 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa Ceased WO2015010026A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP19185431.4A EP3608412A3 (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa
UAA201601494A UA122662C2 (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa
RU2016105470A RU2703498C2 (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa
JP2016527128A JP6668236B2 (en) 2013-07-19 2014-07-18 Composition for controlling LEPTINOTARSA and method therefor
BR112016000555-4A BR112016000555B1 (en) 2013-07-19 2014-07-18 METHOD FOR CONTROLLING AN INFESTATION OF THE LEPTINOTARSA SPECIES IN A PLANT, INSECTICIDAL COMPOSITION AND CONSTRUCTION OF RECOMBINANT DNA
PL14747277T PL3030663T3 (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa
CN201480051779.8A CN105980567B (en) 2013-07-19 2014-07-18 Compositions and methods for controlling Beetle
MX2016000741A MX359191B (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa.
EP14747277.3A EP3030663B1 (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa
CA2918387A CA2918387C (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361856137P 2013-07-19 2013-07-19
US61/856,137 2013-07-19
US201361899000P 2013-11-01 2013-11-01
US61/899,000 2013-11-01
US201461980800P 2014-04-17 2014-04-17
US61/980,800 2014-04-17

Publications (2)

Publication Number Publication Date
WO2015010026A2 WO2015010026A2 (en) 2015-01-22
WO2015010026A3 true WO2015010026A3 (en) 2015-04-23

Family

ID=51263577

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/047204 Ceased WO2015010026A2 (en) 2013-07-19 2014-07-18 Compositions and methods for controlling leptinotarsa

Country Status (11)

Country Link
US (5) US9777288B2 (en)
EP (2) EP3608412A3 (en)
JP (1) JP6668236B2 (en)
CN (1) CN105980567B (en)
BR (1) BR112016000555B1 (en)
CA (1) CA2918387C (en)
MX (2) MX359191B (en)
PL (1) PL3030663T3 (en)
RU (1) RU2703498C2 (en)
UA (1) UA122662C2 (en)
WO (1) WO2015010026A2 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
ES2641642T3 (en) 2010-03-08 2017-11-10 Monsanto Technology Llc Polynucleotide molecules for gene regulation in plants
US9840715B1 (en) 2011-09-13 2017-12-12 Monsanto Technology Llc Methods and compositions for delaying senescence and improving disease tolerance and yield in plants
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
MX342856B (en) 2011-09-13 2016-10-13 Monsanto Technology Llc Methods and compositions for weed control.
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
BR112014005958A2 (en) 2011-09-13 2020-10-13 Monsanto Technology Llc agricultural chemical methods and compositions for plant control, method of reducing expression of an accase gene in a plant, microbial expression cassette, method for making a polynucleotide, method of identifying polynucleotides useful in modulating expression of the accase gene and herbicidal composition
CN103974967A (en) 2011-09-13 2014-08-06 孟山都技术公司 Methods and compositions for weed control
UA116089C2 (en) 2011-09-13 2018-02-12 Монсанто Текнолоджи Ллс Methods and compositios for weed control
US9920326B1 (en) 2011-09-14 2018-03-20 Monsanto Technology Llc Methods and compositions for increasing invertase activity in plants
US10240161B2 (en) 2012-05-24 2019-03-26 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
MX364070B (en) 2012-10-18 2019-04-10 Monsanto Technology Llc Methods and compositions for plant pest control.
WO2014106837A2 (en) 2013-01-01 2014-07-10 A. B. Seeds Ltd. ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
US10000767B2 (en) 2013-01-28 2018-06-19 Monsanto Technology Llc Methods and compositions for plant pest control
EP2971185A4 (en) 2013-03-13 2017-03-08 Monsanto Technology LLC Methods and compositions for weed control
BR112015022797A2 (en) 2013-03-13 2017-11-07 Monsanto Technology Llc weed control method, herbicidal composition, microbial expression cassette and polynucleotide production method
US20140283211A1 (en) 2013-03-14 2014-09-18 Monsanto Technology Llc Methods and Compositions for Plant Pest Control
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
RU2703498C2 (en) 2013-07-19 2019-10-17 Монсанто Текнолоджи Ллс Compositions and methods for controlling leptinotarsa
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
HUE070313T2 (en) 2013-11-04 2025-05-28 Greenlight Biosciences Inc Compositions and methods for controlling arthropod parasite and pest infestations
UA119253C2 (en) 2013-12-10 2019-05-27 Біолоджикс, Інк. METHOD FOR VARROA TREATMENT AND VEGETABLES
AU2015206585A1 (en) 2014-01-15 2016-07-21 Monsanto Technology Llc Methods and compositions for weed control using EPSPS polynucleotides
BR112016022711A2 (en) 2014-04-01 2017-10-31 Monsanto Technology Llc compositions and methods for insect pest control
US10988764B2 (en) 2014-06-23 2021-04-27 Monsanto Technology Llc Compositions and methods for regulating gene expression via RNA interference
EP3161138A4 (en) 2014-06-25 2017-12-06 Monsanto Technology LLC Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
RU2021123470A (en) * 2014-07-29 2021-09-06 Монсанто Текнолоджи Ллс COMPOSITIONS AND METHODS FOR COMBATING PESTS
JP6942632B2 (en) * 2015-01-22 2021-09-29 モンサント テクノロジー エルエルシー LEPTINOTARSA control composition and its method
US20180135048A1 (en) * 2015-02-27 2018-05-17 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
US10883103B2 (en) 2015-06-02 2021-01-05 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
EP3302030A4 (en) 2015-06-03 2019-04-24 Monsanto Technology LLC METHODS AND COMPOSITIONS FOR THE INTRODUCTION OF NUCLEIC ACIDS IN PLANTS
WO2016201523A1 (en) 2015-06-19 2016-12-22 The University Of Queensland Composition
CN105274101B (en) * 2015-11-04 2018-06-05 重庆大学 The RNAi expression vector and its construction method of colorado potato bug TOR genes and application
WO2017131124A1 (en) * 2016-01-26 2017-08-03 日産化学工業株式会社 Single-stranded oligonucleotide
CN109312344A (en) * 2016-01-26 2019-02-05 孟山都技术公司 Compositions and methods for controlling insect pests
EP3342780A1 (en) * 2016-12-30 2018-07-04 Dow AgroSciences LLC Pre-mrna processing factor 8 (prp8) nucleic acid molecules to control insect pests
GB201718701D0 (en) * 2017-11-13 2017-12-27 Syngenta Participations Ag Improvements in or relating to gene silencing
CN108277220B (en) * 2018-03-08 2021-08-24 湖北大学 Application of srp54k gene and its specific dsRNA in the control of willow blue leaf beetle
EP3856908A1 (en) 2018-09-26 2021-08-04 Greenlight Biosciences, Inc. Control of coleopteran insects
WO2020081486A1 (en) * 2018-10-15 2020-04-23 Greenlight Biosciences, Inc. Control of insect infestation
US20210395738A1 (en) 2018-11-08 2021-12-23 Greenlight Biosciences, Inc. Control of insect infestation
CN109913457A (en) * 2019-03-20 2019-06-21 新疆农业科学院植物保护研究所 Application and products of dsRNA in potato beetle control
CN109913456A (en) * 2019-03-20 2019-06-21 新疆农业科学院植物保护研究所 Application and products of dsRNA in potato beetle control
CA3129553A1 (en) * 2019-03-21 2020-09-24 Lien DE SCHRIJVER Control of insect pests using rna molecules
WO2020215149A1 (en) * 2019-04-24 2020-10-29 University Of Manitoba Flea beetle-specific rnai-based pesticides
MX2023000694A (en) 2020-07-20 2023-04-18 Flagship Pioneering Inc Viroid-derived polynucleotides for modification of plants.
EP4304353A4 (en) 2021-03-08 2025-02-12 Greenlight Biosciences, Inc. RNA-BASED CONTROL OF VINE POWDERY MILDEW
CA3226284A1 (en) * 2021-07-08 2023-01-12 Temple University - Of The Commonwealth System Of Higher Education Oligonucleotides and viral untranslated region (utr) for increasing expression of target genes and proteins
WO2023077118A1 (en) 2021-11-01 2023-05-04 Flagship Pioneering Innovations Vii, Llc Polynucleotides for modifying organisms
KR20240135651A (en) 2022-01-20 2024-09-11 플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 Polynucleotides for modifying organisms
EP4705476A1 (en) 2023-05-03 2026-03-11 Flagship Pioneering Innovations VII, LLC Artificial amalgavirus satellite rnas
EP4705478A1 (en) 2023-05-03 2026-03-11 Flagship Pioneering Innovations VII, LLC Artificial martellivirales satellite rnas
AR132591A1 (en) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc SATELLITE RNA OF ARTIFICIAL SECOVIRIDAE
AR132589A1 (en) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Satellite RNA of artificial solemoviridae
CN121712897A (en) 2023-05-03 2026-03-20 旗舰创业创新第七有限责任公司 Split Virus Satellite RNA Amplification System for Plants
EP4705474A2 (en) 2023-05-03 2026-03-11 Flagship Pioneering Innovations VII, LLC Artificial tymovirales satellite rnas
AR132592A1 (en) 2023-05-03 2025-07-16 Flagship Pioneering Innovations Vii Llc Artificial Ghabviral Satellite Arn
EP4705470A1 (en) 2023-05-03 2026-03-11 Flagship Pioneering Innovations VII, LLC Artificial tombusviridae satellite rnas
CN121712898A (en) 2023-05-03 2026-03-20 旗舰创业创新第七有限责任公司 Endogenous RNA Virus Satellite RNA Amplification System for Plants

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007035650A2 (en) * 2005-09-16 2007-03-29 Monsanto Technology Llc Methods for genetic control of insect infestations in plants and compositions thereof
WO2007074405A2 (en) * 2005-09-16 2007-07-05 Devgen Nv Dsrna as insect control agent
WO2013010691A1 (en) * 2011-07-18 2013-01-24 Devgen Nv Plants resistant to insect pests

Family Cites Families (593)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE288618C (en) 1911-10-16 1915-11-10
NL154600B (en) 1971-02-10 1977-09-15 Organon Nv METHOD FOR THE DETERMINATION AND DETERMINATION OF SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES.
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
NL154598B (en) 1970-11-10 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING.
NL154599B (en) 1970-12-28 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES, AND TEST PACKAGING.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (en) 1972-05-11 1983-06-01 Akzo Nv METHOD FOR DETERMINING AND DETERMINING BITES AND TEST PACKAGING.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4476301A (en) 1982-04-29 1984-10-09 Centre National De La Recherche Scientifique Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
US4535060A (en) 1983-01-05 1985-08-13 Calgene, Inc. Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use
US5094945A (en) 1983-01-05 1992-03-10 Calgene, Inc. Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthase, production and use
JPS60179523A (en) 1983-11-10 1985-09-13 ル−ク・ラメレン・ウント・クツプルングスバウ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Torque transmitting apparatus
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
US4761373A (en) 1984-03-06 1988-08-02 Molecular Genetics, Inc. Herbicide resistance in plants
US5331107A (en) 1984-03-06 1994-07-19 Mgi Pharma, Inc. Herbicide resistance in plants
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US5550111A (en) 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4581847A (en) 1984-09-04 1986-04-15 Molecular Genetics Research And Development Tryptophan overproducer mutants of cereal crops
DE3587548T2 (en) 1984-12-28 1993-12-23 Bayer Ag Recombinant DNA that can be introduced into plant cells.
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5405938A (en) 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4940835A (en) 1985-10-29 1990-07-10 Monsanto Company Glyphosate-resistant plants
CA1313830C (en) 1985-08-07 1993-02-23 Dilip Maganlal Shah Glyphosate-resistant plants
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
ATE57390T1 (en) 1986-03-11 1990-10-15 Plant Genetic Systems Nv PLANT CELLS OBTAINED BY GENOLOGICAL TECHNOLOGY AND RESISTANT TO GLUTAMINE SYNTHETASE INHIBITORS.
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
US5273894A (en) 1986-08-23 1993-12-28 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5013659A (en) 1987-07-27 1991-05-07 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
US5378824A (en) 1986-08-26 1995-01-03 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
US5605011A (en) 1986-08-26 1997-02-25 E. I. Du Pont De Nemours And Company Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase
US5004863B2 (en) 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5264423A (en) 1987-03-25 1993-11-23 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US5276019A (en) 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
TR27832A (en) * 1987-04-29 1995-08-31 Monsanto Co Plants resistant to harmful volatile damage.
US5312910A (en) 1987-05-26 1994-05-17 Monsanto Company Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthase
US5145783A (en) 1987-05-26 1992-09-08 Monsanto Company Glyphosate-tolerant 5-endolpyruvyl-3-phosphoshikimate synthase
US4971908A (en) 1987-05-26 1990-11-20 Monsanto Company Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthase
US4924624A (en) 1987-10-22 1990-05-15 Temple University-Of The Commonwealth System Of Higher Education 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
US5188897A (en) 1987-10-22 1993-02-23 Temple University Of The Commonwealth System Of Higher Education Encapsulated 2',5'-phosphorothioate oligoadenylates
US5922602A (en) 1988-02-26 1999-07-13 Biosource Technologies, Inc. Cytoplasmic inhibition of gene expression
JPH03503894A (en) 1988-03-25 1991-08-29 ユニバーシィティ　オブ　バージニア　アランミ　パテンツ　ファウンデイション Oligonucleotide N-alkylphosphoramidate
US5278302A (en) 1988-05-26 1994-01-11 University Patents, Inc. Polynucleotide phosphorodithioates
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5258300A (en) 1988-06-09 1993-11-02 Molecular Genetics Research And Development Limited Partnership Method of inducing lysine overproduction in plants
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
GB8825402D0 (en) 1988-10-31 1988-11-30 Cambridge Advanced Tech Sulfonamide resistance genes
CA2006008C (en) 1988-12-20 2000-02-15 Donald J. Kessler Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5310667A (en) 1989-07-17 1994-05-10 Monsanto Company Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthases
US5550318A (en) 1990-04-17 1996-08-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5286634A (en) 1989-09-28 1994-02-15 Stadler Joan K Synergistic method for host cell transformation
DD288618A5 (en) 1989-10-23 1991-04-04 Adl Fz Fuer Bodenfruchtbarkeit Muenchberg,De METHOD FOR SELECTIVELY REDUCING THE PRODUCTION OF AN ISOENZYME OF GLUTAMINE SYNTHASE FROM MEDICAGO SATIVA L.
US5399676A (en) 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
US5264564A (en) 1989-10-24 1993-11-23 Gilead Sciences Oligonucleotide analogs with novel linkages
US5264562A (en) 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
US5177198A (en) 1989-11-30 1993-01-05 University Of N.C. At Chapel Hill Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
US5587361A (en) 1991-10-15 1996-12-24 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
WO1991010725A1 (en) 1990-01-22 1991-07-25 Dekalb Plant Genetics Fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
US5321131A (en) 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
US5837848A (en) 1990-03-16 1998-11-17 Zeneca Limited Root-specific promoter
US5470967A (en) 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2083948C (en) 1990-06-25 2001-05-15 Ganesh M. Kishore Glyphosate tolerant plants
US5489677A (en) 1990-07-27 1996-02-06 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
US5610289A (en) 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5541307A (en) 1990-07-27 1996-07-30 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs and solid phase synthesis thereof
US5623070A (en) 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5618704A (en) 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
US5677437A (en) 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5608046A (en) 1990-07-27 1997-03-04 Isis Pharmaceuticals, Inc. Conjugated 4'-desmethyl nucleoside analog compounds
MY107332A (en) 1990-08-03 1995-11-30 Sterling Drug Inc Compounds and methods for inhibiting gene expression.
US5177196A (en) 1990-08-16 1993-01-05 Microprobe Corporation Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
US6403865B1 (en) 1990-08-24 2002-06-11 Syngenta Investment Corp. Method of producing transgenic maize using direct transformation of commercially important genotypes
US5633435A (en) 1990-08-31 1997-05-27 Monsanto Company Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases
US5214134A (en) 1990-09-12 1993-05-25 Sterling Winthrop Inc. Process of linking nucleosides with a siloxane bridge
US5561225A (en) 1990-09-19 1996-10-01 Southern Research Institute Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
JPH06505704A (en) 1990-09-20 1994-06-30 ギリアド　サイエンシズ，インコーポレイテッド Modified internucleoside linkages
US5866775A (en) 1990-09-28 1999-02-02 Monsanto Company Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthases
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
US5767366A (en) 1991-02-19 1998-06-16 Louisiana State University Board Of Supervisors, A Governing Body Of Louisiana State University Agricultural And Mechanical College Mutant acetolactate synthase gene from Ararbidopsis thaliana for conferring imidazolinone resistance to crop plants
FR2673642B1 (en) 1991-03-05 1994-08-12 Rhone Poulenc Agrochimie CHIMERIC GENE COMPRISING A PROMOTER CAPABLE OF GIVING INCREASED TOLERANCE TO GLYPHOSATE.
FR2673643B1 (en) 1991-03-05 1993-05-21 Rhone Poulenc Agrochimie TRANSIT PEPTIDE FOR THE INSERTION OF A FOREIGN GENE INTO A PLANT GENE AND PLANTS TRANSFORMED USING THIS PEPTIDE.
USRE36449E (en) 1991-03-05 1999-12-14 Rhone-Poulenc Agro Chimeric gene for the transformation of plants
US20020123476A1 (en) 1991-03-19 2002-09-05 Emanuele R. Martin Therapeutic delivery compositions and methods of use thereof
ATE207126T1 (en) 1991-05-15 2001-11-15 Monsanto Technology Llc METHOD FOR CREATION OF A TRANSFORMED RICE PLANT
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5731180A (en) 1991-07-31 1998-03-24 American Cyanamid Company Imidazolinone resistant AHAS mutants
US5571799A (en) 1991-08-12 1996-11-05 Basco, Ltd. (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
JPH0557182A (en) 1991-09-03 1993-03-09 Central Glass Co Ltd Carbon dioxide absorbent
US5518908A (en) 1991-09-23 1996-05-21 Monsanto Company Method of controlling insects
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
FR2684354B1 (en) 1991-11-29 1995-01-20 Oreal DISPENSING DEVICE FOR A CONTAINER CONTAINING A LIQUID PASTE PRODUCT.
US5593874A (en) 1992-03-19 1997-01-14 Monsanto Company Enhanced expression in plants
US5633360A (en) 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
ATE398679T1 (en) 1992-07-07 2008-07-15 Japan Tobacco Inc METHOD FOR TRANSFORMING A MONOCOTYLEDON PLANT
CA2118698A1 (en) 1992-07-10 1994-01-20 Naosuke Moriyuki Gas generating agent and gas generator for automobile air bags
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5339107A (en) 1992-08-19 1994-08-16 Hewlett-Packard Company Color optical scanner with rotating color filter assembly
DE69323875T2 (en) 1992-12-14 1999-09-30 Sony Corp., Tokio/Tokyo FIXING COMPOSITION FOR WATER-BASED INK, WITH THIS COVERING FILM FOR THERMALLY TRANSMITTING IMAGES AND DEDICATED RECORDING MEDIUM
US5721138A (en) 1992-12-15 1998-02-24 Sandford University Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use
US5476925A (en) 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
US6414222B1 (en) 1993-02-05 2002-07-02 Regents Of The University Of Minnesota Gene combinations for herbicide tolerance in corn
GB9304618D0 (en) 1993-03-06 1993-04-21 Ciba Geigy Ag Chemical compounds
HU9501974D0 (en) 1993-03-31 1995-09-28 Sterling Winthrop Inc Oligonucleotides with amide linkages replacing phosphodiester linkages
DE4314274C2 (en) 1993-04-30 1995-11-30 Foerster Inst Dr Friedrich Method and device for automatic diameter adjustment of sensors of measuring and / or testing devices provided on a rotatingly driven test head
US5393175A (en) 1993-06-18 1995-02-28 Courville; Leo Diamond core drill
US6118047A (en) 1993-08-25 2000-09-12 Dekalb Genetic Corporation Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction
ES2146952T3 (en) 1993-09-14 2000-08-16 Lucas Industries Ltd FUEL FEED SYSTEM.
US6969782B2 (en) 1993-10-06 2005-11-29 Ajinomoto Co., Inc. Method of producing transgenic plants having improved amino acid composition
GB9403941D0 (en) 1994-03-01 1994-04-20 Sandoz Ltd Improvements in or relating to organic compounds
US5558071A (en) 1994-03-07 1996-09-24 Combustion Electromagnetics, Inc. Ignition system power converter and controller
US5625050A (en) 1994-03-31 1997-04-29 Amgen Inc. Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5939602A (en) 1995-06-06 1999-08-17 Novartis Finance Corporation DNA molecules encoding plant protoporphyrinogen oxidase and inhibitor-resistant mutants thereof
US5767373A (en) 1994-06-16 1998-06-16 Novartis Finance Corporation Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
US5392910A (en) 1994-07-21 1995-02-28 Transidyne General Corporation Package for a device having a sharp cutting edge
JPH10506269A (en) 1994-08-19 1998-06-23 モンサント・カンパニー Delivery of exogenous chemicals to plant tissue
DE4430307A1 (en) 1994-08-26 1996-02-29 Bayer Ag Method and device for the simultaneous dispersion and atomization of at least two liquids
US5631152A (en) 1994-10-26 1997-05-20 Monsanto Company Rapid and efficient regeneration of transgenic plants
US5550398A (en) 1994-10-31 1996-08-27 Texas Instruments Incorporated Hermetic packaging with optical
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5853973A (en) 1995-04-20 1998-12-29 American Cyanamid Company Structure based designed herbicide resistant products
US6576455B1 (en) 1995-04-20 2003-06-10 Basf Corporation Structure-based designed herbicide resistant products
FR2734842B1 (en) 1995-06-02 1998-02-27 Rhone Poulenc Agrochimie DNA SEQUENCE OF A HYDROXY-PHENYL PYRUVATE DIOXYGENASE GENE AND OBTAINING PLANTS CONTAINING A HYDROXY-PHENYL PYRUVATE DIOXYGENASE GENE, TOLERANT TO CERTAIN HERBICIDES
US6084155A (en) 1995-06-06 2000-07-04 Novartis Ag Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes
US5976567A (en) 1995-06-07 1999-11-02 Inex Pharmaceuticals Corp. Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
CN1137997C (en) 1995-12-27 2004-02-11 日本烟草产业株式会社 low temperature inducible promoter sequence
US5739180A (en) 1996-05-02 1998-04-14 Lucent Technologies Inc. Flat panel displays and methods and substrates therefor
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
GB9612403D0 (en) 1996-06-13 1996-08-14 Sandoz Ltd Organic compounds
EP0856060A2 (en) 1996-06-21 1998-08-05 Monsanto Company METHODS FOR THE PRODUCTION OF STABLY-TRANSFORMED, FERTILE WHEAT EMPLOYING $i(AGROBACTERIUM)-MEDIATED TRANSFORMATION AND COMPOSITIONS DERIVED THEREFROM
BR9710855A (en) 1996-06-27 1999-08-17 Du Pont Isolated nucleic acid fragment chi-rich gene plasmid vector transformed host cell transformed plant method for identifying a compound compound method for conferring tolerance to a plant method for producing Microbial method and method for overexpressing p-hydroxyphenylpyruvate dioxygenase enzyme in a plant
FR2751347B1 (en) 1996-07-16 2001-12-07 Rhone Poulenc Agrochimie CHIMERIC GENE WITH MULTIPLE HERBICIDE TOLERANCE GENES, PLANT CELL AND PLANT TOLERANT WITH MULTIPLE HERBICIDES
ATE252827T1 (en) 1996-08-16 2003-11-15 Monsanto Technology Llc SERIES METHOD FOR TREATING PLANTS WITH EXOGENOUS CHEMICALS
WO1998010080A1 (en) 1996-09-05 1998-03-12 Unilever N.V. Salt-inducible promoter derivable from a lactic acid bacterium, and its use in a lactic acid bacterium for production of a desired protein
JPH10117776A (en) 1996-10-22 1998-05-12 Japan Tobacco Inc Indicine Transformation Method
DE19652284A1 (en) 1996-12-16 1998-06-18 Hoechst Schering Agrevo Gmbh Novel genes encoding amino acid deacetylases with specificity for N-acetyl-L-phosphinothricin, their isolation and use
CA2275491A1 (en) 1997-01-20 1998-07-23 Plant Genetic Systems, N.V. Pathogen-induced plant promoters
US5981840A (en) 1997-01-24 1999-11-09 Pioneer Hi-Bred International, Inc. Methods for agrobacterium-mediated transformation
US6040497A (en) 1997-04-03 2000-03-21 Dekalb Genetics Corporation Glyphosate resistant maize lines
US7022896B1 (en) 1997-04-04 2006-04-04 Board Of Regents Of University Of Nebraska Methods and materials for making and using transgenic dicamba-degrading organisms
US7105724B2 (en) 1997-04-04 2006-09-12 Board Of Regents Of University Of Nebraska Methods and materials for making and using transgenic dicamba-degrading organisms
ZA988332B (en) 1997-09-12 1999-03-23 Performance Plants Inc In planta transformation of plants
FR2770854B1 (en) 1997-11-07 2001-11-30 Rhone Poulenc Agrochimie DNA SEQUENCE OF A GENE OF HYDROXY-PHENYL PYRUVATE DIOXYGENASE AND PRODUCTION OF PLANTS CONTAINING SUCH A GENE, HERBICIDE TOLERANT
US6245968B1 (en) 1997-11-07 2001-06-12 Aventis Cropscience S.A. Mutated hydroxyphenylpyruvate dioxygenase, DNA sequence and isolation of plants which contain such a gene and which are tolerant to herbicides
US6069115A (en) 1997-11-12 2000-05-30 Rhone-Poulenc Agrochimie Method of controlling weeds in transgenic crops
IL122270A0 (en) 1997-11-20 1998-04-05 Yeda Res & Dev DNA molecules conferring to plants resistance to a herbicide and plants transformed thereby
IL136384A0 (en) 1997-11-26 2001-06-14 Kamterter Ii Llc Solid matrix conditioning of seeds
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6421956B1 (en) 1997-12-29 2002-07-23 Van Dok Ijsbrand Method and apparatus for priming seed
US20030027173A1 (en) 1998-01-16 2003-02-06 Della-Cioppa Guy Method of determining the function of nucleotide sequences and the proteins they encode by transfecting the same into a host
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US5914451A (en) 1998-04-06 1999-06-22 Monsanto Company Efficiency soybean transformation protocol
US8598332B1 (en) 1998-04-08 2013-12-03 Bayer Cropscience N.V. Methods and means for obtaining modified phenotypes
US6906245B1 (en) 1998-04-30 2005-06-14 Sumitomo Chemical Company, Limited Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants
US6307123B1 (en) 1998-05-18 2001-10-23 Dekalb Genetics Corporation Methods and compositions for transgene identification
AR020078A1 (en) 1998-05-26 2002-04-10 Syngenta Participations Ag METHOD FOR CHANGING THE EXPRESSION OF AN OBJECTIVE GENE IN A PLANT CELL
CA2328457A1 (en) 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
WO1999067367A1 (en) 1998-06-22 1999-12-29 Regents Of The University Of Minnesota DNA ENCODING OAT ACETYL CoA CARBOXYLASE
WO1999067400A1 (en) 1998-06-24 1999-12-29 Musc Foundation For Research Development Tissue-specific and target rna-specific ribozymes
CA2333897A1 (en) 1998-07-16 2000-01-27 Stichting Centrum Voor Plantenveredelings-En Reproduktieonderzoek (Cpro- Dlo) Process to collect metabolites from modified nectar by insects
JP2000083680A (en) 1998-07-16 2000-03-28 Nippon Paper Industries Co Ltd Introduction of gene into plant utilizing adventitious bud redifferentiation gene put under control due to photoinduction type promoter as selection marker gene and vector for transduction of gene into plant used therefor
US6121513A (en) 1998-07-20 2000-09-19 Mendel Biotechnology, Inc. Sulfonamide resistance in plants
US6717034B2 (en) 2001-03-30 2004-04-06 Mendel Biotechnology, Inc. Method for modifying plant biomass
AU2037700A (en) 1998-12-03 2000-06-19 E.I. Du Pont De Nemours And Company Plant vitamin e biosynthetic enzymes
US6642435B1 (en) 1998-12-18 2003-11-04 E. I. Du Pont De Nemours And Company Plant folate biosynthetic genes
WO2000042207A2 (en) 1999-01-14 2000-07-20 Monsanto Technology Llc Soybean transformation method
IL128207A (en) 1999-01-24 2005-03-20 Bio Oz Advanced Biotechnologic Multi-barrel plant inoculation gun
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
DE19956568A1 (en) 1999-01-30 2000-08-17 Roland Kreutzer Method and medicament for inhibiting the expression of a given gene
US6232536B1 (en) 1999-02-16 2001-05-15 Dekalb Genetics Corporation Inbred corn plant F307W and seeds thereof
JP2000247810A (en) 1999-02-26 2000-09-12 Meiji Seika Kaisha Ltd Accelerator of pharmacological effect of agrochemical
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US6992237B1 (en) 1999-04-16 2006-01-31 Pioneer Hi-Bred International Inc. Regulated expression of genes in plant seeds
KR20070118315A (en) 1999-04-21 2007-12-14 와이어쓰 Compositions for Inhibiting the Function of Polynucleotide Sequences
US6232526B1 (en) 1999-05-14 2001-05-15 Dekalb Genetics Corp. Maize A3 promoter and methods for use thereof
US6194636B1 (en) 1999-05-14 2001-02-27 Dekalb Genetics Corp. Maize RS324 promoter and methods for use thereof
US6207879B1 (en) 1999-05-14 2001-03-27 Dekalb Genetics Corporation Maize RS81 promoter and methods for use thereof
US6713077B1 (en) 1999-07-28 2004-03-30 Monsanto Technology, Llc Control of shoot/foliar feeding pests with pesticide seed treatments
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
CZ20022139A3 (en) 1999-12-07 2002-10-16 Monsanto Technology Llc Sugar beet regeneration and transformation process
DE10000600A1 (en) 2000-01-10 2001-07-12 Bayer Ag New N-substituted oxazolyl-uracil and thiazolyl-uracil derivatives useful as herbicides, especially for weed control in crops
US6303374B1 (en) 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
GB0001309D0 (en) 2000-01-20 2000-03-08 Nestle Sa Valve arrangement
IL134830A0 (en) 2000-03-01 2001-05-20 Chay 13 Medical Res Group N V Peptides and immunostimulatory and anti-bacterial pharmaceutical compositions containing them
JP2001253874A (en) 2000-03-10 2001-09-18 Ishihara Sangyo Kaisha Ltd Pyrimidine compound, their manufacturing method and herbicide including them
ES2336887T5 (en) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediators of RNA interference specific to RNA sequences
US6444615B1 (en) 2000-04-18 2002-09-03 Dow Agrosciences Llc Herbicidal imidazolidinetrione and thioxo-imidazolidinediones
US6768044B1 (en) 2000-05-10 2004-07-27 Bayer Cropscience Sa Chimeric hydroxyl-phenyl pyruvate dioxygenase, DNA sequence and method for obtaining plants containing such a gene, with herbicide tolerance
AU2001261358B2 (en) 2000-05-10 2006-07-13 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Resistance to acetohydroxyacid synthase-inhibiting herbicides
JP2002080454A (en) 2000-06-26 2002-03-19 Nippon Nohyaku Co Ltd Pyridine-2,3-dicarboxylic acid diamide derivatives and herbicides
US7109393B2 (en) 2000-08-15 2006-09-19 Mendel Biotechnology, Inc. Methods of gene silencing using inverted repeat sequences
BR0003908A (en) 2000-08-18 2002-06-18 Suzano Papel & Celulose Method for genetic transformation of eucalyptus spp
US6453609B1 (en) 2000-09-06 2002-09-24 University Of Iowa Research Foundation Method for uptake of a substance into a seed
US7462481B2 (en) 2000-10-30 2008-12-09 Verdia, Inc. Glyphosate N-acetyltransferase (GAT) genes
FR2815969B1 (en) 2000-10-30 2004-12-10 Aventis Cropscience Sa TOLERANT PLANTS WITH HERBICIDES BY METABOLIC BYPASS
JP2002138075A (en) 2000-10-30 2002-05-14 Nippon Soda Co Ltd 3-aminoacrylic acid derivative and herbicide
CN1162542C (en) 2000-11-03 2004-08-18 中国科学院微生物研究所 A plant lectin gene
JP2002145707A (en) 2000-11-10 2002-05-22 Sankyo Co Ltd Herbicide comprising n-substituted dihydropyrrole derivative
AU1430302A (en) 2000-11-29 2002-06-11 Kumiai Chemical Industry Co Gene encoding acetolactic acid synthase gene
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
WO2002046387A2 (en) 2000-12-07 2002-06-13 Syngenta Limited Plant derived hydroxy phenyl pyruvate dioxygenases (hppd) resistant against triketone herbicides and transgenic plants containing these dioxygenases
JP4254236B2 (en) 2000-12-12 2009-04-15 コニカミノルタホールディングス株式会社 Thin film formation method
US7151204B2 (en) 2001-01-09 2006-12-19 Monsanto Technology Llc Maize chloroplast aldolase promoter compositions and methods for use thereof
JP2002220389A (en) 2001-01-26 2002-08-09 Hokko Chem Ind Co Ltd Pyridylbenzoxazine derivatives, herbicides and intermediates
US20050246784A1 (en) 2001-02-16 2005-11-03 Gunnar Plesch Method for identifying herbicidally active substances
ATE504573T1 (en) 2001-02-20 2011-04-15 Sagami Chem Res PYRAZOLE DERIVATIVES, THEIR INTERMEDIATE PRODUCTS, METHOD FOR THE PRODUCTION THEREOF AND HERBICIDE CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENTS
US6843985B2 (en) 2001-02-28 2005-01-18 The United States Of America As Represented By The Secretary Of Agriculture Control of parasitic mites of honey bees
EP1238586A1 (en) 2001-03-09 2002-09-11 Basf Aktiengesellschaft Herbicidal 2-alkynyl-pyri(mi)dines
DE10116399A1 (en) 2001-04-03 2002-10-10 Bayer Ag Substituted azolazine (thi) one
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
AU2002256359A1 (en) 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Antisense and anti-inflammatory based compositions to treat respiratory disorders
JP2003064059A (en) 2001-06-14 2003-03-05 Nippon Soda Co Ltd Pyrimidine compound, method for producing the same and herbicide
DE10130397A1 (en) 2001-06-23 2003-01-09 Bayer Cropscience Gmbh Herbicidally substituted pyridines, processes for their preparation and their use as herbicides and plant growth regulators
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
ES2192945B1 (en) 2001-07-06 2005-03-01 Consejo Superior De Investigaciones Cientificas A METHOD TO INTERFER WITH VIRUS INFECTION IN PLANTS.
ITMI20011497A1 (en) 2001-07-13 2003-01-13 Isagro Ricerca Srl NEW ANILINE DERIVATIVES SUBSTITUTED FOR HERBICIDE ACTIVITIES
US7612194B2 (en) 2001-07-24 2009-11-03 Monsanto Technology Llc Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof
WO2003012052A2 (en) 2001-07-30 2003-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Specific inhibition of gene expression by small double stranded rnas
AU2002319037B2 (en) 2001-08-09 2008-05-29 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
AR035087A1 (en) 2001-08-09 2004-04-14 Syngenta Participations Ag PIRIDIL-ALQUINOS AND PIRIDIL-N-OXIDO-ACTIVE HERBICIDE ALKINES, PROCEDURE FOR PREPARATION, HERBICIDE COMPOSITION AND TO INHIBIT THE GROWTH OF PLANTS, METHOD FOR CONTROLLING GROWTH OF INDESEABLE PLANTS, AND METHOD OF CREAM INHIBITION
US20040198758A1 (en) 2001-08-17 2004-10-07 Rapado Liliana Parra N-heterocyclyl substituted thienyloxy-pyrimidines used as herbicides
EP1421066A1 (en) 2001-08-28 2004-05-26 Syngenta Participations AG Sulfonylamino derivatives useful as herbicides
AU2002332795A1 (en) 2001-08-31 2003-03-18 The Dow Chemical Company Nucleic acid compositions conferring insect control in plants
US20040242456A1 (en) 2001-09-06 2004-12-02 Christoph Luthy Herbicidal n-alkysulfonamino derivatives
EP1427719B1 (en) 2001-09-07 2005-11-02 Basf Aktiengesellschaft 4-alkyl-substitute thienyloxy-pyridines
CA2459359A1 (en) 2001-09-07 2003-03-20 Basf Aktiengesellschaft Pyrazolyl-substituted thienyloxypyridines
JP2003096059A (en) 2001-09-21 2003-04-03 Otsuka Chem Co Ltd Thiazole compound and herbicidal composition containing the same
WO2003029243A2 (en) 2001-09-24 2003-04-10 Basf Aktiengesellschaft 2-aryloxy-6-pyrazolyl-pyridines
US7550578B2 (en) 2001-09-26 2009-06-23 Syngenta Participations Ag Rice promoters for regulation of plant expression
US7745418B2 (en) 2001-10-12 2010-06-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting viral replication
WO2003037085A1 (en) 2001-11-01 2003-05-08 Dongbu Hannong Chemical Co., Ltd. Optically active herbicidal (r)-phenoxypropionic acid-n-methyl-n-2-fluorophenyl amides
DE10154075A1 (en) 2001-11-02 2003-05-15 Bayer Cropscience Ag Substituted pyrimidines
US20030150017A1 (en) 2001-11-07 2003-08-07 Mesa Jose Ramon Botella Method for facilitating pathogen resistance
AU2002367564A1 (en) 2001-11-08 2003-09-29 Paradigm Genetics, Inc. Methods for the identification of herbicides and the modulation of plant growth
US6766613B2 (en) 2001-11-16 2004-07-27 University Of Florida Research Foundation, Inc. Materials and methods for controlling pests
CA2467665A1 (en) 2001-11-29 2003-06-05 Basf Aktiengesellschaft 2,w-diaminocarboxylic acid compounds
DE10256353A1 (en) 2001-12-06 2003-06-18 Syngenta Participations Ag New 4-pyridylcarbonyl-cyclohexene-dione derivatives, useful as both total and selective herbicides and effective against mono- and di-cotyledonous weeds, for use on e.g. cereals, cotton, soya, sugar beet/cane and rape
DE10256367A1 (en) 2001-12-06 2003-06-26 Syngenta Participations Ag New 4-(pyridine-3-carbonyl)-cyclohex-4-ene-1,3-dione derivatives, useful as herbicides and plant growth inhibitors, especially for selective weed control in crops such as cereals, cotton or soya
DE10256354A1 (en) 2001-12-06 2003-06-18 Syngenta Participations Ag New 5-thiol-4-pyridylcarbonyl-cyclohexene-dione derivatives, useful as herbicides and plant growth inhibitors, with improved leaching properties and selectivity
AR037754A1 (en) 2001-12-11 2004-12-01 Syngenta Participations Ag HERBICIDES
DE10161765A1 (en) 2001-12-15 2003-07-03 Bayer Cropscience Gmbh Substituted phenyl derivatives
EP1458674B1 (en) 2001-12-19 2010-02-24 Basf Se Beta-amino-alpha-cyanoacrylates and their use as herbicides
DE60235493D1 (en) 2001-12-19 2010-04-08 Basf Se Alpha-cyanoacrylate
BR0307253A (en) 2002-01-30 2004-12-14 Arborgen Llc DNA constructs, expression system, methods of suppressing expression of a target gene in a cell, transformed plant cell, transgenic plant and gene expression suppression kit
ATE556714T1 (en) 2002-02-01 2012-05-15 Life Technologies Corp DOUBLE STRANDED OLIGONUCLEOTIDES
DE10204951A1 (en) 2002-02-06 2003-08-14 Basf Ag Phenylalanine derivatives as herbicides
CA2478904A1 (en) 2002-03-14 2003-09-18 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing rna and uses thereof
WO2003076409A1 (en) 2002-03-14 2003-09-18 Syngenta Participations Ag Derivatives of 1-phenyl-3-phenylpyrazole as herbicides
WO2003078613A2 (en) 2002-03-20 2003-09-25 Basf Aktiengesellschaft Serine hydroxymethyltransferase as a target for herbicides
US7166771B2 (en) 2002-06-21 2007-01-23 Monsanto Technology Llc Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs
BRPI0308946B1 (en) 2002-03-29 2016-08-30 Kumiai Chemical Industry Co nucleic acid, protein, recombinant vector, bacterium, processes for cultivating plant presenting said nucleic acid, for cultivating plant presenting said protein, for selecting transformant cell presenting said nucleic acid and for selecting transformant cell presenting said nucleic acid protein
AR039208A1 (en) 2002-04-03 2005-02-09 Syngenta Participations Ag PHENYL AND PIRIDYL ALKIN COMPOUNDS, HERBICIDE COMPOSITION CONTAINING THEM, PROCEDURE FOR PREPARATION OF THOSE AND PROCEDURE TO COMBAT THE GROWTH OF INDENATED PLANTS
PL373888A1 (en) 2002-04-25 2005-09-19 Basf Aktiengesellschaft 3-heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides
WO2003091217A1 (en) 2002-04-26 2003-11-06 Ishihara Sangyo Kaisha, Ltd. Pyridine compounds or salts thereof and herbicides containing the same
US6645914B1 (en) 2002-05-01 2003-11-11 Ndsu-Research Foundation Surfactant-ammonium sulfate adjuvant composition for enhancing efficacy of herbicides
DE10219435A1 (en) 2002-05-02 2003-11-13 Bayer Cropscience Ag Substituted pyrazolo-pyrimidin-4-ones
JP2004051628A (en) 2002-05-28 2004-02-19 Ishihara Sangyo Kaisha Ltd Pyridine-based compound or its salt, method for producing the same, and herbicide containing the same
AR040413A1 (en) 2002-05-31 2005-04-06 Syngenta Participations Ag HETEROCICLILALQUINOS ACTIVE AS HERBICIDES
AR041181A1 (en) 2002-07-01 2005-05-04 Syngenta Participations Ag HERBICIDE TENYLALKINS AND PROCEDURE FOR PREPARING SUCH COMPOUNDS
AR041182A1 (en) 2002-07-01 2005-05-04 Syngenta Participations Ag DERIVATIVES OF PHENOXIPROPENYLPHENYL AND ITS USE AS HERBICIDES
BR0312580A (en) 2002-07-10 2006-10-10 Univ Kansas State compositions and methods for controlling parasitic nematodes
AU2003249302A1 (en) 2002-07-17 2004-02-02 Sepro Corporation Herbicide-resistant plants, and polynucleotides and methods for providing same
AU2003247962B2 (en) 2002-07-18 2008-06-12 Monsanto Technology Llc Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing
ATE395828T1 (en) 2002-07-24 2008-06-15 Basf Se SYNERGISTIC HERBICIDE MIXTURES
DE10234876A1 (en) 2002-07-25 2004-02-05 Bayer Cropscience Gmbh 4-trifluoromethylpyrazolyl substituted pyridines and pyrimidines
DE10234875A1 (en) 2002-07-25 2004-02-05 Bayer Cropscience Gmbh 4-trifluoromethylpyrazolyl substituted pyridines and pyrimidines
AU2003252259A1 (en) 2002-07-26 2004-02-16 Nihon Nohyaku Co., Ltd. Novel haloalkylsulfonanilide derivatives, herbicides and usage thereof
US20040029275A1 (en) 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
FR2844415B1 (en) 2002-09-05 2005-02-11 At & T Corp FIREWALL SYSTEM FOR INTERCONNECTING TWO IP NETWORKS MANAGED BY TWO DIFFERENT ADMINISTRATIVE ENTITIES
US20040053289A1 (en) 2002-09-09 2004-03-18 The Regents Of The University Of California Short interfering nucleic acid hybrids and methods thereof
JP2004107228A (en) 2002-09-17 2004-04-08 Nippon Nohyaku Co Ltd Bicyclic pyrimidinone derivative and herbicide containing the same as active ingredient
AR044743A1 (en) 2002-09-26 2005-10-05 Nihon Nohyaku Co Ltd HERBICIDE, METHOD OF USE, DERIVED FROM REPLACED TIENOPIRIMIDINE, INTERMEDIATE COMPOUNDS, AND PROCEDURES USED TO PRODUCE THEM,
AU2003304398A1 (en) 2002-10-16 2005-02-25 Board Of Regents, The University Of Texas System Methods and compositions for increasing the efficacy of biologically-active ingredients
WO2004035563A1 (en) 2002-10-17 2004-04-29 Syngenta Participations Ag 3-heterocyclylpyridine derivatives useful as herbicides
WO2004035564A1 (en) 2002-10-17 2004-04-29 Syngenta Participations Ag Pyridine derivatives useful as herbicides
WO2004037787A1 (en) 2002-10-18 2004-05-06 Basf Aktiengesellschaft 1-phenylpyrrolidine-2-one-3-carboxamides
WO2004035545A2 (en) 2002-10-18 2004-04-29 E.I. Du Pont De Nemours And Company Azolecarboxamide herbicides
AU2003295600A1 (en) 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
GB0228326D0 (en) 2002-12-04 2003-01-08 Syngenta Ltd Method of controlling unwanted vegitation
EP1581642B1 (en) 2002-12-18 2011-04-20 Athenix Corporation Genes conferring herbicide resistance
US20040123347A1 (en) 2002-12-20 2004-06-24 Hinchey Brendan S. Water-deficit-inducible plant promoters
US20040133944A1 (en) 2003-01-08 2004-07-08 Delta And Pine Land Company Seed oil suppression to enhance yield of commercially important macromolecules
WO2004062351A2 (en) 2003-01-09 2004-07-29 Virginia Tech Intellectual Properties, Inc. Gene encoding resistance to acetolactate synthase-inhibiting herbicides
CN1521165A (en) 2003-01-30 2004-08-18 拜尔农作物科学股份公司 Thiophene derivative
DE10303883A1 (en) 2003-01-31 2004-08-12 Bayer Cropscience Ag Substituted pyrimidines
CN101173273B (en) 2003-02-18 2013-03-20 孟山都技术有限公司 Glyphosate resistant class I 5-enolpyruvylshikimate-3-phosphate synthase(epsps)
CN1526704A (en) 2003-03-06 2004-09-08 拜尔农作物科学股份公司 Substituted triazolformamide compound
WO2005003362A2 (en) 2003-03-10 2005-01-13 Athenix Corporation Methods to confer herbicide resistance
EP1628519A2 (en) 2003-04-11 2006-03-01 Bio-Oz Biotechnologies Ltd. Liquid discharge apparatus particularly useful as a portable inoculation gun for anti-virus inoculation of plants
US7682829B2 (en) 2003-05-30 2010-03-23 Monsanto Technology Llc Methods for corn transformation
PT1633767T (en) 2003-06-02 2019-02-27 Univ Massachusetts Methods and compositions for controlling efficacy of rna silencing
US7578598B2 (en) 2006-11-13 2009-08-25 Black & Decker Inc. Battery charging work light
JP2005008583A (en) 2003-06-20 2005-01-13 Nippon Soda Co Ltd Guanidine compound, herbicide and plant growth regulator
JP2005015390A (en) 2003-06-26 2005-01-20 Bayer Cropscience Ag Azolidine derivative and herbicide
WO2005017108A2 (en) 2003-06-30 2005-02-24 United Soybean Board Soybean selection system based on aec-resistance
JP5183064B2 (en) 2003-07-02 2013-04-17 エムユーエスシー ファウンデイション フォー リサーチ デべロップメント Specific and non-specific immunity induced by dsRNA in crustaceans and other invertebrates, and biological delivery vehicles used therein
CN1208325C (en) 2003-07-04 2005-06-29 中国科学院上海有机化学研究所 2-Pyrimidinyloxy-N-ureidophenylbenzylamine compound, preparation method and use thereof
WO2005007627A1 (en) 2003-07-18 2005-01-27 Nihon Nohyaku Co., Ltd. Phenylpyridine derivative, intermediate therefor, and herbicide containing the same as active ingredient
KR100568457B1 (en) 2003-07-22 2006-04-07 학교법인 성균관대학 RNA Transfer to Plants Using Cationic Oligopeptides
US7371927B2 (en) 2003-07-28 2008-05-13 Arborgen, Llc Methods for modulating plant growth and biomass
CN1929781A (en) 2003-08-21 2007-03-14 依斯克姆公司 Automated methods and systems for plaque detection and analysis
US8090164B2 (en) 2003-08-25 2012-01-03 The University Of North Carolina At Chapel Hill Systems, methods, and computer program products for analysis of vessel attributes for diagnosis, disease staging, and surgical planning
WO2005040152A1 (en) 2003-10-20 2005-05-06 E.I. Dupont De Nemours And Company Heteroyclylphenyl-and heterocyclylpyridyl-substituted azolecarboxamides as herbicides
WO2005047233A1 (en) 2003-10-31 2005-05-26 Syngenta Participations Ag Novel herbicides
WO2005047281A1 (en) 2003-11-13 2005-05-26 Syngenta Participations Ag Novel herbicides
PL1687435T3 (en) 2003-11-17 2012-02-29 Bayer Cropscience Nv Insect resistance using inhibition of gene expression
US7687435B2 (en) 2003-12-19 2010-03-30 Basf Aktiengesellschaft Benzoyl-substituted phenylalanineamides
KR20060111582A (en) 2003-12-19 2006-10-27 바스프 악티엔게젤샤프트 Heteroaroyl-substituted phenylalanineamides for herbicides
GT200500013A (en) 2004-01-23 2005-08-10 HERBICIDE AMIDAS
US7297541B2 (en) 2004-01-26 2007-11-20 Monsanto Technology Llc Genes encoding 4-hydroxyphenylpyruvate dioxygenase (HPPD) enzymes for plant metabolic engineering
US7855323B2 (en) 2004-02-10 2010-12-21 Monsanto Technology Llc Recombinant DNA for gene suppression
US7622301B2 (en) 2004-02-24 2009-11-24 Basf Plant Science Gmbh Compositions and methods using RNA interference for control of nematodes
JP4596795B2 (en) 2004-02-27 2010-12-15 住友林業株式会社 Plant inhibitor containing piperitol or its derivatives as active ingredients
DE102004011705A1 (en) 2004-03-10 2005-09-29 Bayer Cropscience Gmbh Substituted 4- (4-trifluoromethylpyrazolyl) -pyrimidines
EA011812B1 (en) 2004-03-27 2009-06-30 Байер Кропсайенс Аг Herbicide combination
EP1729580B1 (en) 2004-03-30 2018-04-11 Monsanto Technology LLC Methods for controlling plant pathogens using n-phosphonomethylglycine
WO2005095335A1 (en) 2004-03-31 2005-10-13 Kureha Corporation Ylide compounds, process for production of the same, and use thereof as herbicide and intermediates of drugs
JP2005314407A (en) 2004-03-31 2005-11-10 Nippon Nohyaku Co Ltd Novel haloalkylsulfonanilide derivatives, herbicides, methods of use and intermediates thereof
AU2005244258B2 (en) 2004-04-09 2010-07-01 Monsanto Technology Llc Compositions and methods for control of insect infestations in plants
CN102094032B (en) 2004-04-30 2014-02-26 美国陶氏益农公司 New herbicide resistance gene
WO2005116204A1 (en) 2004-05-11 2005-12-08 Rnai Co., Ltd. Polynucleotide causing rna interfere and method of regulating gene expression with the use of the same
WO2006006569A1 (en) 2004-07-12 2006-01-19 Nihon Nohyaku Co., Ltd. Phenylpyridine derivative or salt thereof, herbicide containing the same as active ingredient, and method of use thereof
US20090075921A1 (en) 2004-08-04 2009-03-19 Riken Bone/joint disease sensitivity gene and use thereof
US8410022B2 (en) 2004-08-19 2013-04-02 Monsanto Technology Llc Glyphosate salt herbicidal composition
US7323310B2 (en) 2004-08-31 2008-01-29 Qiagen North American Holdings, Inc. Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
US20060135758A1 (en) 2004-08-31 2006-06-22 Kunsheng Wu Soybean polymorphisms and methods of genotyping
AU2005279042A1 (en) 2004-09-03 2006-03-09 Syngenta Limited Isoxazoline derivatives and their use as herbicides
KR20070058619A (en) 2004-09-16 2007-06-08 바스프 악티엔게젤샤프트 Benzoyl-substituted serine amides
PE20060721A1 (en) 2004-09-16 2006-08-24 Basf Ag SERINAMIDES REPLACED BY HETEROAROIL
EP1799028B1 (en) 2004-09-24 2015-03-04 J.R. Simplot Company Gene silencing
US20060247197A1 (en) 2004-10-04 2006-11-02 Van De Craen Marc Method for down-regulating gene expression in fungi
WO2006037945A1 (en) 2004-10-05 2006-04-13 Syngenta Limited Isoxazoline derivatives and their use as herbicides
US20100170000A9 (en) 2004-10-25 2010-07-01 Devgen Nv Rna constructs
DE102004054666A1 (en) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh New substituted pyrazol-3-carboxamide derivatives useful to combat harmful plants and for growth regulation of plants
DE102004054665A1 (en) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituted bicyclic and tricyclic pyrazole derivatives Methods for the preparation and use as herbicides and plant growth regulators
US7393812B2 (en) 2004-11-19 2008-07-01 Dow Agrosciences Llc Methylidene mevalonates and their use as herbicides
US8314290B2 (en) 2004-12-21 2012-11-20 Monsanto Technology Llc Temporal regulation of gene expression by MicroRNAs
US8404927B2 (en) 2004-12-21 2013-03-26 Monsanto Technology Llc Double-stranded RNA stabilized in planta
US20060200878A1 (en) 2004-12-21 2006-09-07 Linda Lutfiyya Recombinant DNA constructs and methods for controlling gene expression
US8030473B2 (en) 2005-01-07 2011-10-04 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Method to trigger RNA interference
JP2006232824A (en) 2005-01-27 2006-09-07 Sagami Chem Res Center Imidazole derivatives, methods for producing them, and herbicides containing them as active ingredients
WO2006082558A2 (en) 2005-02-04 2006-08-10 Koninklijke Philips Electronics N.V. System for the determination of vessel geometry and flow characteristics
FR2882062B1 (en) 2005-02-14 2007-06-15 Commissariat Energie Atomique STABLE AND LONG-TERM EXPRESSION VECTORS OF SIRNA AND THEIR APPLICATIONS
ZA200707119B (en) 2005-02-24 2009-09-30 Nihon Nohyaku Co Ltd Novel haloalkylsulfonanilide derivative, herbicide, and method of use thereof
US8088976B2 (en) 2005-02-24 2012-01-03 Monsanto Technology Llc Methods for genetic control of plant pest infestation and compositions thereof
DE102005014638A1 (en) 2005-03-31 2006-10-05 Bayer Cropscience Gmbh Substituted pyrazolyloxyphenyl derivatives as herbicides
JP2006282552A (en) 2005-03-31 2006-10-19 Nippon Nohyaku Co Ltd Phenylheteroaryls or salts thereof and herbicides containing these as active ingredients
DE102005014906A1 (en) 2005-04-02 2006-10-05 Bayer Cropscience Gmbh New pyrimidine compounds e.g. N-((4-ethyl-6((2-(trifluoromethyl) pyridine-4-yl)oxy) pyrimidine-2-yl)methyl) cyclopropane carboxamide useful for combating weeds
CN101203611B (en) 2005-04-19 2013-08-14 巴斯福植物科学有限公司 Improved methods controlling gene expression
WO2006121178A1 (en) 2005-05-09 2006-11-16 Kumiai Chemical Industry Co., Ltd. Method for transformation using mutant acetolactate synthase gene
GB0510151D0 (en) 2005-05-18 2005-06-22 Syngenta Ltd Novel herbicides
MX2007014490A (en) 2005-05-25 2008-02-11 Basf Ag Heteroaroyl-substituted serine amides.
EA013646B1 (en) 2005-05-25 2010-06-30 Басф Акциенгезельшафт Benzoyl-substituted serine amides
JPWO2006132270A1 (en) 2005-06-10 2009-01-08 国立大学法人京都大学 Herbicide resistance gene
US20070130653A1 (en) 2005-06-17 2007-06-07 Pioneer Hi-Bred International, Inc. Methods and compositions for gene silencing
RU2291613C1 (en) 2005-06-29 2007-01-20 Алексей Борисович Сохликов Composition for combating of honey bee parasitic acarines
US20070011448A1 (en) 2005-07-06 2007-01-11 Microsoft Corporation Using non 5-tuple information with IPSec
DE102005031412A1 (en) 2005-07-06 2007-01-11 Bayer Cropscience Gmbh 3- [1-Halo-1-aryl-methane-sulfonyl] and 3- [1-halo-1-heteroaryl-methanesulfonyl] -isoxazoline derivatives, processes for their preparation and use as herbicides and plant growth regulators
CA2614317A1 (en) 2005-07-07 2007-01-18 Cbd Technologies Ltd. Compositions and methods comprising stinging capsules/cells for delivering a biologically active agent into a plant cell
US7702116B2 (en) 2005-08-22 2010-04-20 Stone Christopher L Microphone bleed simulator
BRPI0615087A2 (en) 2005-08-24 2011-05-03 Pioneer Hi Bred Int methods and compositions for the expression of a polynucleotide of interest
US7671254B2 (en) 2005-08-25 2010-03-02 The Board Of Trustees Of The University Of Illinois Herbicide resistance gene, compositions and methods
US7842856B2 (en) 2005-08-25 2010-11-30 The Board Of Trustees Of The University Of Illinois Herbicide resistance gene, compositions and methods
WO2007026834A1 (en) 2005-09-01 2007-03-08 Kumiai Chemical Industry Co., Ltd. Pyrazole derivatives and herbicides for agricultural and horticultural use
CA2622671C (en) 2005-09-16 2020-12-22 Devgen Nv Methods for controlling pests using rnai
WO2007039454A1 (en) 2005-09-20 2007-04-12 Basf Plant Science Gmbh Methods for controlling gene expression using ta-siran
WO2007038788A2 (en) 2005-09-29 2007-04-05 The Cleveland Clinic Foundation Small interfering rnas as non-specific drugs
EA023885B1 (en) 2005-10-13 2016-07-29 МОНСАНТО ТЕКНОЛОДЖИ, ЭлЭлСи Recombinant dna construct for inducing sterility in a transgenic plant, sterile transgenic plants and methods for producing hybrid seed
WO2007050715A2 (en) 2005-10-26 2007-05-03 Integrated Plant Genetics, Inc. Compositions and methods for safe delivery of biologically-active plant transformation agents using non-fibrous silicon carbide powder
EP1948196B1 (en) 2005-11-03 2012-12-26 Zoser B. Salama Use of tetraorganosilicon compounds
JP2007161701A (en) 2005-11-15 2007-06-28 Hokko Chem Ind Co Ltd Aryloxy-N- (oxyiminoalkyl) alkanoic acid amide derivatives and uses
EP1951736A4 (en) 2005-11-21 2009-12-16 Johnson & Johnson Res Pty Ltd Multitargeting interfering rnas and methods of their use and design
JP2007153847A (en) 2005-12-08 2007-06-21 Hokko Chem Ind Co Ltd Phenoxyalkanoic acid amide derivative and herbicide
WO2007070389A2 (en) 2005-12-12 2007-06-21 Syngenta Participations Ag Control of parasitic weeds
WO2007069301A1 (en) 2005-12-13 2007-06-21 Japan Tobacco Inc. Method of elevating transforming efficiency by using powder
GB0526044D0 (en) 2005-12-21 2006-02-01 Syngenta Ltd Novel herbicides
KR20080081979A (en) 2005-12-23 2008-09-10 바스프 에스이 Inhibition method of aquatic weeds
KR100755027B1 (en) 2005-12-28 2007-09-06 한국과학기술연구원 Method for preparing feed for bee mite
AR058408A1 (en) 2006-01-02 2008-01-30 Basf Ag PIPERAZINE COMPOUNDS WITH HERBICITY ACTION
PL1971581T3 (en) 2006-01-05 2010-09-30 Basf Se Piperazine compounds with a herbicidal action
JP2007182404A (en) 2006-01-10 2007-07-19 Hokko Chem Ind Co Ltd Aryloxy-N- (alkoxyalkyl) alkanoic acid amide derivatives and herbicides
CA2627795C (en) 2006-01-12 2019-01-22 Devgen N.V. Dsrna as insect control agent
US8906876B2 (en) 2006-01-12 2014-12-09 Devgen Nv Methods for controlling pests using RNAi
EP2348115A3 (en) 2006-01-12 2012-01-18 deVGen N.V. Transgenic plant-based methods for plant pests using RNAi
WO2008063203A2 (en) 2006-01-27 2008-05-29 Whitehead Institute For Biomedical Research Compositions and methods for efficient gene silencing in plants
US20080022423A1 (en) 2006-02-03 2008-01-24 Monsanto Technology Llc IN PLANTA RNAi CONTROL OF FUNGI
WO2007095469A2 (en) 2006-02-10 2007-08-23 Monsanto Technology Llc Identification and use of target genes for control of plant parasitic nematodes
CN105385679B (en) 2006-02-13 2020-05-26 孟山都技术有限公司 Selecting and stabilizing dsRNA constructs
EP1987015A2 (en) 2006-02-16 2008-11-05 Basf Se Benzoyl-substituted alanines
US20090054240A1 (en) 2006-02-16 2009-02-26 Basf Se Heteroaroyl-substituted Alanines
GB0603891D0 (en) 2006-02-27 2006-04-05 Syngenta Ltd Novel herbicides
US20070214515A1 (en) 2006-03-09 2007-09-13 E.I.Du Pont De Nemours And Company Polynucleotide encoding a maize herbicide resistance gene and methods for use
US20100068172A1 (en) 2006-03-16 2010-03-18 Devgen N.V. Nematode Control
TWI375669B (en) 2006-03-17 2012-11-01 Sumitomo Chemical Co Pyridazinone compound and use thereof
US7767234B2 (en) 2006-03-31 2010-08-03 John I. Haas, Inc. Compositions and methods for controlling a honey bee parasitic mite
US20070281900A1 (en) 2006-05-05 2007-12-06 Nastech Pharmaceutical Company Inc. COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
WO2008015692A2 (en) 2006-05-09 2008-02-07 Reliance Life Sciences Pvt Ltd MOLECULAR CLONING AND SEQUENCING OF ACETYL CoA CARBOXYLASE (ACCase) GENE FROM JATROPHA CURCAS
WO2007134971A1 (en) 2006-05-19 2007-11-29 Basf Se Benzoyl-substituted alanines
JP2009537480A (en) 2006-05-19 2009-10-29 ビーエーエスエフ ソシエタス・ヨーロピア Heteroaroyl-substituted alanine with herbicidal activity
US7884262B2 (en) 2006-06-06 2011-02-08 Monsanto Technology Llc Modified DMO enzyme and methods of its use
EP2436769B1 (en) 2006-06-07 2015-04-01 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Plant expression constructs and methods of utilizing same
WO2007146767A2 (en) 2006-06-08 2007-12-21 Athenix Corporation Bacterial glutamine synthetases and methods of use
GB0613901D0 (en) 2006-07-13 2006-08-23 Univ Lancaster Improvements in and relating to plant protection
GB0614471D0 (en) 2006-07-20 2006-08-30 Syngenta Ltd Herbicidal Compounds
JP2008074840A (en) 2006-08-23 2008-04-03 Nippon Nohyaku Co Ltd Novel haloalkylsulfonanilide derivatives, herbicides and methods of use thereof
JP2008074841A (en) 2006-08-23 2008-04-03 Nippon Nohyaku Co Ltd Novel haloalkylsulfonanilide derivatives, herbicides and methods of use thereof
GB0617575D0 (en) 2006-09-06 2006-10-18 Syngenta Ltd Herbicidal compounds and compositions
US20090306181A1 (en) 2006-09-29 2009-12-10 Children's Medical Center Corporation Compositions and methods for evaluating and treating heart failure
US7897846B2 (en) 2006-10-30 2011-03-01 Pioneer Hi-Bred Int'l, Inc. Maize event DP-098140-6 and compositions and methods for the identification and/or detection thereof
TW200829171A (en) 2006-11-17 2008-07-16 Nihon Nohyaku Co Ltd Haloalkyl sulfonanilide derivatives or salts thereof, herbicide using it as effective constituent and use-method thereof
JP2008133218A (en) 2006-11-28 2008-06-12 Hokko Chem Ind Co Ltd Phenoxybutyric acid amide derivatives and herbicides
JP2008133207A (en) 2006-11-28 2008-06-12 Hokko Chem Ind Co Ltd Oxazolinone derivative, production method thereof and herbicide
US8053223B2 (en) 2006-11-30 2011-11-08 The United States Of America As Represented By The Secretary Of Agriculture Biocontrol of Varroa mites
GB0624760D0 (en) 2006-12-12 2007-01-17 Syngenta Ltd Herbicidal compounds
GB0625598D0 (en) 2006-12-21 2007-01-31 Syngenta Ltd Novel herbicides
JP2008169121A (en) 2007-01-09 2008-07-24 Bayer Cropscience Ag Jasmonic acid derivative, herbicide and herbicidal effect-reinforcing agent
DE502008001391D1 (en) 2007-01-11 2010-11-04 Basf Se HETEROAROYL SUBSTITUTED SERIN AMIDE
CL2008000376A1 (en) 2007-02-09 2008-08-18 Du Pont COMPOUNDS DERIVED FROM PIRIDINE N-OXIDES; HERBICIDE COMPOSITION; AND METHOD TO CONTROL THE GROWTH OF INDESEATED VEGETATION.
JPWO2008102908A1 (en) 2007-02-23 2010-05-27 日産化学工業株式会社 Haloalkylsulfonanilide derivatives
US8781193B2 (en) 2007-03-08 2014-07-15 Sync-Rx, Ltd. Automatic quantitative vessel analysis
DE102007012168A1 (en) 2007-03-12 2008-09-18 Bayer Cropscience Ag New thiazole derivatives useful as herbicides and plant growth regulators
RU2337529C1 (en) * 2007-03-26 2008-11-10 Центр "Биоинженерия" Ран RECOMBINANT POLYNUCLEOTIDE SEQUENCE MARKING UNIQUE TRANSFORMATION ACTION BETWEEN GENETIC MAKER INCLUDING GENE cryIIIA AND GENOMIC DNA OF LUGOVSKOY POTATO; ITS APPLICATION; CELL, TRANSGENIC PLANT, AND ITS PROGENY CONTAINING THIS SEQUENCE
CN101279951B (en) 2007-04-06 2010-09-01 中国中化股份有限公司 2-Pyrimidinyloxy (thio) benzoic acid enoate compounds and their application
CN101279950B (en) 2007-04-06 2010-08-11 中国中化股份有限公司 2-pyrimidinyloxy (thio) benzoyl acetamide compounds and their application
GB0709710D0 (en) 2007-05-21 2007-06-27 Syngenta Ltd Herbicidal compositions
EP1997381A1 (en) 2007-06-01 2008-12-03 Commissariat à l'Energie Atomique Use of a compound having a monogalactosyldiacylglycerol synthase inhibitory activity as herbicide or algaecide, herbicide and algaecide compositions
RU2485180C2 (en) 2007-06-07 2013-06-20 Эгрикалча Энд Эгри-Фуд Кэнэда Method of transfection and transduction of plant cells
TW200906806A (en) 2007-06-12 2009-02-16 Basf Se Piperazine compounds having herbicidal action
PT2054394E (en) 2007-06-12 2009-12-30 Basf Se Piperazine compounds with a herbicidal action
US8420891B2 (en) 2007-06-21 2013-04-16 National University Corporation Nagoya University Method for introducing foreign substance into cell having cell wall
EP2061770A1 (en) 2007-06-22 2009-05-27 Basf Se Piperazine compounds with herbicidal action
NL2000719C2 (en) 2007-06-22 2008-12-23 Synthesis B V Method and device for treating vegetable seeds.
KR100884933B1 (en) 2007-07-03 2009-02-23 주식회사경농 Photoactive (R) -allyloxypropionic acid amide compound and herbicide composition comprising the same
US20130084243A1 (en) 2010-01-27 2013-04-04 Liliane Goetsch Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders
CN101139607A (en) 2007-08-07 2008-03-12 西南大学 Bombyx mori microsporidia polar filament protein PTP1 gene
DE602008004666D1 (en) 2007-08-14 2011-03-03 Dsm Ip Assets Bv DEVULACANIZATION OF RUBBER
NZ599997A (en) 2007-08-16 2013-08-30 Basf Se Seed treatment compositions and methods
EP3889261A1 (en) 2007-08-27 2021-10-06 1Globe Health Institute LLC Compositions of asymmetric interfering rna and uses thereof
JP2009067739A (en) 2007-09-14 2009-04-02 Sumitomo Chemical Co Ltd Herbicidal composition
CL2008002703A1 (en) 2007-09-14 2009-11-20 Sumitomo Chemical Co Compounds derived from 1,4-dihydro-2h-pyridazin-3-one; herbicidal composition comprising said compounds; weed control method; use of said compounds for weed control; and intermediate compounds.
EP2193202A2 (en) 2007-09-21 2010-06-09 BASF Plant Science GmbH Plants with increased yield
EP2195438B1 (en) 2007-10-05 2013-01-23 Dow AgroSciences LLC Methods for transferring molecular substances into plant cells
US20110015084A1 (en) 2007-10-25 2011-01-20 Monsanto Technology Llc Methods for Identifying Genetic Linkage
WO2009060124A2 (en) 2007-11-05 2009-05-14 Baltic Technology Development, Ltd. Use of oligonucleotides with modified bases in hybridization of nucleic acids
JP5710977B2 (en) 2007-11-05 2015-04-30 バルティック テクノロジー デヴェロプメント，リミテッド Use of oligonucleotides containing modified bases as antiviral agents
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
JP2009114128A (en) 2007-11-07 2009-05-28 Hokko Chem Ind Co Ltd Amino acid amide derivatives and herbicides
GB0722472D0 (en) 2007-11-15 2007-12-27 Syngenta Ltd Herbicidal compounds
JP2009126792A (en) 2007-11-20 2009-06-11 Sagami Chem Res Center 5-Substituted phenyl-2-trifluoromethylpyrimidin-6 (1H) -one derivative, method for producing the same, and herbicide containing the derivative as an active ingredient
EP2065373A1 (en) 2007-11-30 2009-06-03 Bayer CropScience AG Chiral 3-(benzylsulfinyl)-5,5-dimethyl-4,5-dihydroisoxazole and 5,5-dimethyl-3-[(1H-pyrazol-4-ylmethyl) sulfinyl]-4,5-dihydroisoxazole derivatives, methods for their preparation and their use as herbicides and plant growth regulators
EP2065374A1 (en) 2007-11-30 2009-06-03 Bayer CropScience AG 2-(benzyl- and 1H-pyrazol-4-ylmethyl)sulfinyl-thiazol-derivatives as herbicides and plant growth regulators
JP2009137851A (en) 2007-12-04 2009-06-25 Sagami Chem Res Center 2-Trifluoromethylpyrimidin-6 (1H) -one derivative, method for producing the same, and herbicide containing the derivative as an active ingredient
WO2009085982A1 (en) 2007-12-19 2009-07-09 Monsanto Technology Llc Method to enhance yield and purity of hybrid crops
CL2008003785A1 (en) 2007-12-21 2009-10-09 Du Pont Pyridazine derived compounds; herbicidal compositions comprising said compounds; and method of controlling the growth of unwanted vegetation.
US20090188008A1 (en) 2008-01-17 2009-07-23 Pioneer Hi-Bred International, Inc. Compositions and methods for the suppression of target polynucleotides
US8847013B2 (en) 2008-01-17 2014-09-30 Pioneer Hi Bred International Inc Compositions and methods for the suppression of target polynucleotides from lepidoptera
GB0800856D0 (en) 2008-01-17 2008-02-27 Syngenta Ltd Herbicidal compounds
GB0800855D0 (en) 2008-01-17 2008-02-27 Syngenta Ltd Herbicidal compounds
EA018281B1 (en) 2008-02-20 2013-06-28 Зингента Партисипейшнс Аг Herbicide formulation
CA2714460C (en) 2008-03-03 2016-05-17 Ms Technologies Llc Antibodies immunoreactive with mutant 5-enolpyruvylshikimate-3-phosphate synthase
WO2009116151A1 (en) 2008-03-19 2009-09-24 アグロカネショウ株式会社 1-phenyl-5-difluoromethylpyrazole-4-carboxamide derivatives and herbicides containing the derivatives as the active ingredient
GB0805318D0 (en) 2008-03-20 2008-04-30 Syngenta Ltd Herbicidal compounds
US8802923B2 (en) 2008-04-10 2014-08-12 A.B. Seeds Ltd. Compositions and methods for enhancing oil content in plants
WO2009144079A1 (en) 2008-04-14 2009-12-03 Bayer Bioscience N.V. New mutated hydroxyphenylpyruvate dioxygenase, dna sequence and isolation of plants which are tolerant to hppd inhibitor herbicides
US8271857B2 (en) 2008-05-13 2012-09-18 International Business Machines Corporation Correcting errors in longitudinal position (LPOS) words
US20110053226A1 (en) 2008-06-13 2011-03-03 Riboxx Gmbh Method for enzymatic synthesis of chemically modified rna
EP2135865A1 (en) 2008-06-17 2009-12-23 Bayer CropScience AG Substituted 1-(diazinyl)pyrazol-4-yl acetic acids, method for their production and their use as herbicides and plant growth regulators
GR1006569B (en) 2008-06-20 2009-10-13 ΚΑΤΕΡΙΝΟΠΟΥΛΟΣ (κατά ποσοστό 25%) ΧΑΡΑΛΑΜΠΟΣ Use of costic acid and other components derived from dittrichia viscosa plant and related sub-species thereof for fighting the varroa destructor's activity
WO2009158258A1 (en) 2008-06-25 2009-12-30 E. I. Du Pont De Nemours And Company Herbicidal dihydro oxo six-membered azinyl isoxazolines
AU2009267007B2 (en) 2008-07-01 2016-02-25 Monsanto Technology, Llc Recombinant DNA constructs and methods for modulating expression of a target gene
TWI455944B (en) 2008-07-01 2014-10-11 Daiichi Sankyo Co Ltd Double-stranded polynucleotides
NZ591057A (en) 2008-07-10 2012-11-30 Az Univ Amsterdam Complement antagonists and uses thereof
EP2147919A1 (en) 2008-07-24 2010-01-27 Bayer CropScience Aktiengesellschaft Heterocyclic substituted amides, method for their manufacture and their use as herbicides
KR20110036633A (en) 2008-07-29 2011-04-07 바스프 에스이 Piperazine Compounds with Herbicidal Effect
CN102186820B (en) 2008-08-15 2013-08-28 乔治城大学 Fluorescent regulators of rassf1a expression and human cancer cell proliferation
WO2010018003A2 (en) 2008-08-15 2010-02-18 Salama Zoser B Carrier system for biological agents containing organosilicon compounds and uses thereof
CN102137841B (en) 2008-09-02 2014-05-14 日产化学工业株式会社 Ortho-substituted haloalkylsulfonanilide derivative and herbicide
WO2010034153A1 (en) 2008-09-25 2010-04-01 沈阳化工研究院 New 2-pyrimidinyloxy (sulfo) benzoxy olefin acid ester compounds and uses thereof
CA2735899A1 (en) 2008-09-25 2010-04-01 Cephalon, Inc. Liquid formulations of bendamustine
CN102187379A (en) 2008-09-25 2011-09-14 Cae医疗保健有限公司 Simulation of medical imaging
CA2738170C (en) 2008-09-30 2016-05-03 Basf Se Composition for improving the efficacy of herbicides
US20100099561A1 (en) 2008-10-15 2010-04-22 E.I. Du Pont De Nemours And Company Heterobicyclic alkylthio-bridged isoxazolines
US8338337B2 (en) 2008-10-29 2012-12-25 Basf Se Substituted pyridines having a herbicidal effect
CA2741006A1 (en) 2008-10-30 2010-05-20 Pioneer Hi-Bred International, Inc. Manipulation of glutamine synthetases (gs) to improve nitrogen use efficiency and grain yield in higher plants
BRPI0914348A2 (en) 2008-10-31 2015-08-11 Basf Se Method for improving the health of a cultivated plant, uses at least one compost, fruit and seed.
RU2011121521A (en) 2008-10-31 2012-12-10 Басф Се METHOD FOR IMPROVING PLANT VIABILITY
JP2012506889A (en) 2008-10-31 2012-03-22 ビーエーエスエフ ソシエタス・ヨーロピア Piperazine compounds with herbicidal effect
EP2194052A1 (en) 2008-12-06 2010-06-09 Bayer CropScience AG Substituted 1.(1-thiazolyl)- and 1-(isothiazolyl)pyrazol-4-yl acetic acids, method for their production and their use as herbicides and plant growth regulators
DE102008063561A1 (en) 2008-12-18 2010-08-19 Bayer Cropscience Ag Hydrazides, process for their preparation and their use as herbicides and insecticides
WO2010069802A1 (en) 2008-12-18 2010-06-24 Basf Se Heterocyclic diketone derivatives with herbicidal action
US20100249214A1 (en) 2009-02-11 2010-09-30 Dicerna Pharmaceuticals Multiplex dicer substrate rna interference molecules having joining sequences
EP2204366A1 (en) 2008-12-19 2010-07-07 Bayer CropScience AG Herbicidal and insecticidal phenyl-substituted pyridazinones
WO2010099016A1 (en) 2009-02-25 2010-09-02 Worcester Polytechnic Institute Automatic vascular model generation based on fluid-structure interactions (fsi)
WO2010101660A2 (en) 2009-03-06 2010-09-10 Bio-Tree Sytems, Inc. Vascular analysis methods and apparatus
JP2010235603A (en) 2009-03-13 2010-10-21 Sumitomo Chemical Co Ltd Pyridazinone compounds and uses thereof
EP2229813A1 (en) 2009-03-21 2010-09-22 Bayer CropScience AG Pyrimidine-4-ylpropandinitrile derivatives, method for their manufacture and their use as herbicides and plant growth regulators
GB0905441D0 (en) 2009-03-30 2009-05-13 Syngenta Ltd Herbicidal compounds
EP2756845B1 (en) 2009-04-03 2017-03-15 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
BRPI1016044B1 (en) 2009-04-06 2021-03-09 Syngenta Limited herbicidal compounds, agronomically acceptable salt of the compound, herbicidal composition, method of selectively controlling pests at a site comprising crop plants and pests, method of producing said compound and use of the same
BRPI1015525A2 (en) 2009-04-14 2015-09-01 Nissan Chemical Ind Ltd Haloalkylsulfonanilide derivatives, their uses, their intermediates and their method of use, as well as agrochemical and herbicide
WO2010121956A1 (en) 2009-04-21 2010-10-28 Basf Plant Science Company Gmbh Rna-mediated induction of gene expression in plants
EP2427180B1 (en) 2009-05-05 2016-04-13 Beeologics Inc. Prevention and treatment of nosema disease in bees
GB0908293D0 (en) 2009-05-14 2009-06-24 Syngenta Ltd Herbicidal compounds
MX2012000271A (en) 2009-06-30 2012-09-07 Yissum Res Dev Co Introducing dna into plant cells.
WO2011003776A2 (en) 2009-07-09 2011-01-13 Basf Se Substituted cyanobutyrates having a herbicidal effect
CA2806295A1 (en) 2009-08-03 2011-02-10 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating insects
US20110028412A1 (en) 2009-08-03 2011-02-03 Cappellos, Inc. Herbal enhanced analgesic formulations
MX2012002189A (en) 2009-08-21 2012-03-16 Beeologics Inc Preventing and curing beneficial insect diseases via plant transcribed molecules.
PL2480539T3 (en) 2009-09-25 2013-11-29 Bayer Cropscience Ag N-(1,2,5-oxadiazol-3-yl)benzamides and their use as herbicides
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
EP3272869B1 (en) 2009-10-14 2020-06-24 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Compositions for controlling varroa mites in bees
DE102010042866A1 (en) 2009-10-30 2011-05-05 Basf Se New thioamide compounds, useful for controlling undesirable plant growth or weeds in cultural plants e.g. Arachis hypogaea, Allium cepa, Elaeis guineensis and Gossypium herbaceum
US8329619B2 (en) 2009-11-03 2012-12-11 Basf Se Substituted quinolinones having herbicidal action
US8926626B2 (en) 2009-11-10 2015-01-06 Wake Forest University Health Sciences Tissue tensioning devices and related methods
US9145562B2 (en) 2009-11-20 2015-09-29 Alberta Innovates—Technology Futures Variegation in plants
WO2011062904A1 (en) 2009-11-23 2011-05-26 Monsanto Technology Llc Transgenic maize event mon 87427 and the relative development scale
JP2011195561A (en) 2009-11-24 2011-10-06 Sumitomo Chemical Co Ltd Ketone compound, and herbicide comprising the same
WO2011067745A2 (en) 2009-12-06 2011-06-09 Rosetta Green Ltd. Compositions and methods for enhancing plants resistance to abiotic stress
EA201290559A1 (en) 2009-12-23 2013-01-30 Байер Интеллектуэль Проперти Гмбх PLANTS RESISTANT TO HERBICIDES - HPPD INHIBITORS
AU2010337936B2 (en) 2009-12-28 2016-06-23 Evogene Ltd. Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency
CA2788198C (en) 2010-01-26 2021-01-19 Pioneer Hi-Bred International, Inc. Hppd-inhibitor herbicide tolerance
US20110203013A1 (en) 2010-02-17 2011-08-18 Pioneer Hi Bred International Inc Delivering compositions of interest to plant cells
ES2641642T3 (en) 2010-03-08 2017-11-10 Monsanto Technology Llc Polynucleotide molecules for gene regulation in plants
EP2385129A1 (en) 2010-05-03 2011-11-09 BASF Plant Science Company GmbH Enhanced methods for gene regulation in plants
AU2011273004A1 (en) 2010-06-30 2015-11-19 Basf Plant Science Company Gmbh Novel microRNA precursor and use thereof in regulation of target gene expression
CN101892247B (en) 2010-07-21 2012-12-12 河北大学 Herbicide resistance gene and application thereof
EP2418283A1 (en) 2010-08-07 2012-02-15 Nomad Bioscience GmbH Process of transfecting plants
CN101914540A (en) 2010-08-09 2010-12-15 大连大学 A method of introducing RNA interference into plants
WO2012056401A1 (en) 2010-10-25 2012-05-03 Rosetta Green Ltd. ISOLATED POLYNUCLEOTIDES EXPRESSING OR MODULATING MICRORNAs OR TARGETS OF SAME, TRANSGENIC PLANTS COMPRISING SAME AND USES THEREOF IN IMPROVING NITROGEN USE EFFICIENCY, ABIOTIC STRESS TOLERANCE, BIOMASS, VIGOR OR YIELD OF A PLANT
EP2633049B1 (en) 2010-10-27 2018-10-10 Harrisvaccines Inc Methods and compositions to protect aquatic invertebrates from disease
EP2633048B1 (en) * 2010-10-27 2019-07-31 Devgen NV Down-regulating gene expression in insect pests
JP5932832B2 (en) 2010-12-17 2016-06-08 モンサント テクノロジー エルエルシー Methods for improving plant cell eligibility
US9068191B2 (en) 2010-12-29 2015-06-30 Syngenta Participations Ag Methods and compositions for a soybean in-planta transient expression system
US8987552B2 (en) 2010-12-30 2015-03-24 Dow Agrosciences, Llc. Nucleic acid molecules that target the vacuolar ATPase H subunit and confer resistance to coleopteran pests
CN102154364A (en) 2010-12-31 2011-08-17 广西作物遗传改良生物技术重点开放实验室 Method for agrobacterium tumefaciens-mediated genetic transformation of sugarcane
CN103562394B (en) * 2011-04-20 2019-09-03 德福根有限公司 Downregulation of gene expression in insect pests
US20140135281A1 (en) 2011-05-18 2014-05-15 Syngenta Participations Ag Methods for controlling varroa mites
US8871969B2 (en) 2011-05-30 2014-10-28 Basf Se Process for the production of polyisocyanates
EP2530159A1 (en) 2011-06-03 2012-12-05 Sandoz Ag Transcription terminator sequences
KR101873734B1 (en) 2011-07-19 2018-07-03 엘지전자 주식회사 Mobile terminal and Method for controlling display thereof
BR112014003367A2 (en) 2011-08-16 2017-03-01 Syngenta Participations Ag methods and compositions for introducing exogenous dsrna into plant cells
US9974508B2 (en) 2011-09-01 2018-05-22 Ghassan S. Kassab Non-invasive systems and methods for determining fractional flow reserve
CA2848669A1 (en) 2011-09-13 2013-03-21 Monsanto Technology Llc Methods and compositions for weed control targeting epsps
WO2013040005A1 (en) 2011-09-13 2013-03-21 Monsanto Technology Llc Methods and compositions for weed control
MX342856B (en) 2011-09-13 2016-10-13 Monsanto Technology Llc Methods and compositions for weed control.
EP3434779A1 (en) 2011-09-13 2019-01-30 Monsanto Technology LLC Methods and compositions for weed control
AU2012308753B2 (en) 2011-09-13 2018-05-17 Monsanto Technology Llc Methods and compositions for weed control
CN103974967A (en) 2011-09-13 2014-08-06 孟山都技术公司 Methods and compositions for weed control
BR112014005958A2 (en) 2011-09-13 2020-10-13 Monsanto Technology Llc agricultural chemical methods and compositions for plant control, method of reducing expression of an accase gene in a plant, microbial expression cassette, method for making a polynucleotide, method of identifying polynucleotides useful in modulating expression of the accase gene and herbicidal composition
UA116089C2 (en) 2011-09-13 2018-02-12 Монсанто Текнолоджи Ллс Methods and compositios for weed control
US8571612B2 (en) 2011-12-08 2013-10-29 Vocollect, Inc. Mobile voice management of devices
US10034614B2 (en) 2012-02-29 2018-07-31 General Electric Company Fractional flow reserve estimation
US8548778B1 (en) 2012-05-14 2013-10-01 Heartflow, Inc. Method and system for providing information from a patient-specific model of blood flow
US10240161B2 (en) * 2012-05-24 2019-03-26 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
US20130324842A1 (en) 2012-05-29 2013-12-05 The Johns Hopkins University Method for Estimating Pressure Gradients and Fractional Flow Reserve from Computed Tomography Angiography: Transluminal Attenuation Flow Encoding
AU2013296321B2 (en) 2012-08-03 2019-05-16 Alnylam Pharmaceuticals, Inc. Modified RNAi agents
WO2014106837A2 (en) 2013-01-01 2014-07-10 A. B. Seeds Ltd. ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
BR112015022797A2 (en) 2013-03-13 2017-11-07 Monsanto Technology Llc weed control method, herbicidal composition, microbial expression cassette and polynucleotide production method
EP2971185A4 (en) 2013-03-13 2017-03-08 Monsanto Technology LLC Methods and compositions for weed control
US9920316B2 (en) 2013-03-14 2018-03-20 Pioneer Hi-Bred International, Inc. Compositions and methods to control insect pests
US9445603B2 (en) 2013-03-15 2016-09-20 Monsanto Technology Llc Compositions and methods for the production and delivery of double stranded RNA
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
RU2703498C2 (en) 2013-07-19 2019-10-17 Монсанто Текнолоджи Ллс Compositions and methods for controlling leptinotarsa
HUE070313T2 (en) 2013-11-04 2025-05-28 Greenlight Biosciences Inc Compositions and methods for controlling arthropod parasite and pest infestations
UA119253C2 (en) 2013-12-10 2019-05-27 Біолоджикс, Інк. METHOD FOR VARROA TREATMENT AND VEGETABLES
BR112016022711A2 (en) 2014-04-01 2017-10-31 Monsanto Technology Llc compositions and methods for insect pest control
EP3161138A4 (en) 2014-06-25 2017-12-06 Monsanto Technology LLC Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
RU2021123470A (en) 2014-07-29 2021-09-06 Монсанто Текнолоджи Ллс COMPOSITIONS AND METHODS FOR COMBATING PESTS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007035650A2 (en) * 2005-09-16 2007-03-29 Monsanto Technology Llc Methods for genetic control of insect infestations in plants and compositions thereof
WO2007074405A2 (en) * 2005-09-16 2007-07-05 Devgen Nv Dsrna as insect control agent
WO2013010691A1 (en) * 2011-07-18 2013-01-24 Devgen Nv Plants resistant to insect pests

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 27 February 2008 (2008-02-27), "CBIB7954.fwd CBIB_Daphnia_pulex_Chosen_One_Library_2 Daphnia pulex cDNA clone CBIB7954 5', mRNA sequence.", XP002732239, retrieved from EBI accession no. EM_EST:FE348695 Database accession no. FE348695 *
J. K. COLBOURNE ET AL: "The Ecoresponsive Genome of Daphnia pulex", SCIENCE, vol. 331, no. 6017, 3 February 2011 (2011-02-03), pages 555 - 561, XP055151455, ISSN: 0036-8075, DOI: 10.1126/science.1197761 *

Also Published As

Publication number Publication date
WO2015010026A2 (en) 2015-01-22
MX2018011342A (en) 2022-01-25
US20150143580A1 (en) 2015-05-21
CA2918387A1 (en) 2015-01-22
US9777288B2 (en) 2017-10-03
MX2016000741A (en) 2016-08-11
US9856495B2 (en) 2018-01-02
RU2703498C2 (en) 2019-10-17
US11377667B2 (en) 2022-07-05
US20180066278A1 (en) 2018-03-08
US20150203867A1 (en) 2015-07-23
BR112016000555A2 (en) 2017-12-12
RU2016105470A (en) 2017-08-24
US20230035621A1 (en) 2023-02-02
EP3030663B1 (en) 2019-09-04
CN105980567B (en) 2021-04-16
MX359191B (en) 2018-09-18
EP3608412A3 (en) 2020-04-08
JP2016532440A (en) 2016-10-20
PL3030663T3 (en) 2020-04-30
CN105980567A (en) 2016-09-28
US20200165627A1 (en) 2020-05-28
CA2918387C (en) 2021-11-02
RU2016105470A3 (en) 2018-03-06
BR112016000555B1 (en) 2022-12-27
JP6668236B2 (en) 2020-03-18
US10597676B2 (en) 2020-03-24
EP3608412A2 (en) 2020-02-12
EP3030663A2 (en) 2016-06-15
UA122662C2 (en) 2020-12-28

Similar Documents

Publication Publication Date Title
WO2015010026A3 (en) Compositions and methods for controlling leptinotarsa
WO2015153339A3 (en) Compositions and methods for controlling insect pests
MX395326B (en) COMPOSITIONS AND METHODS FOR CONTROLLING LEPTINOTARSA.
WO2012055982A3 (en) Down-regulating gene expression in insect pests
WO2012143543A3 (en) Plants resistant to insect pests
MX2014015403A (en) Biological control of coleopteran pests.
PH12013502638A1 (en) Plants resistant to insect pests
PH12012502367A1 (en) Control of coleopteran insect pests
PH12012501425A1 (en) Insecticidal protein combinations for controlling fall armyworm and european corn borer, and methods for insect resistance management
WO2014153254A3 (en) Compositions and methods to control insect pests
MX390727B (en) COLEOPTERAN PEST CONTROL USING RIBONUCLEIC ACID (RNA) MOLECULES.
MX2019001445A (en) Control of coleopteran pests using rna molecules.
MX2017007904A (en) Biological control of coleopteran pests.
MX2019001444A (en) Control of coleopteran pests using rna molecules.
WO2014100878A8 (en) Genetic control method and compositions against insect pests in cotton plants by the siliencing of genes of the laccase family
WO2014100879A3 (en) Method and compositions for the genetic control of insect pests in cotton plants by chitin synthase gene silencing
TH156188A (en) The collective fraction of the insecticidal protein for the control of fall-army worms. And European corn borer and methods for managing insect resistance.
TH158348A (en) Decreased Control of Gene Expression in Insect Pests

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14747277

Country of ref document: EP

Kind code of ref document: A2

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2014747277

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2918387

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2016527128

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: MX/A/2016/000741

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112016000555

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 2016105470

Country of ref document: RU

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01E

Ref document number: 112016000555

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112016000555

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20160111

WWE Wipo information: entry into national phase

Ref document number: MX/A/2018/011342

Country of ref document: MX