WO2015104373A3 - Duocarmycin adcs for use in treatment of endometrial cancer - Google Patents

Duocarmycin adcs for use in treatment of endometrial cancer Download PDF

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Publication number
WO2015104373A3
WO2015104373A3 PCT/EP2015/050332 EP2015050332W WO2015104373A3 WO 2015104373 A3 WO2015104373 A3 WO 2015104373A3 EP 2015050332 W EP2015050332 W EP 2015050332W WO 2015104373 A3 WO2015104373 A3 WO 2015104373A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
endometrial cancer
duocarmycin
adcs
her2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2015/050332
Other languages
French (fr)
Other versions
WO2015104373A2 (en
Inventor
Alessandro Davide SANTIN
Peter Johannes GOEDINGS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Byondis BV
Yale University
Original Assignee
Synthon Biopharmaceuticals BV
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2016563255A priority Critical patent/JP6224268B2/en
Priority to AU2015205588A priority patent/AU2015205588B2/en
Priority to CA2935430A priority patent/CA2935430C/en
Priority to MX2016009069A priority patent/MX368234B/en
Priority to RU2016132635A priority patent/RU2686085C2/en
Priority to SG11201605597VA priority patent/SG11201605597VA/en
Priority to CN201580004140.9A priority patent/CN105899237B/en
Priority to KR1020167021532A priority patent/KR20160099725A/en
Priority to EP15700211.4A priority patent/EP2948183B1/en
Priority to ES15700211.4T priority patent/ES2578831T3/en
Priority to MYPI2016001213A priority patent/MY189713A/en
Application filed by Synthon Biopharmaceuticals BV, Yale University filed Critical Synthon Biopharmaceuticals BV
Priority to KR1020227010636A priority patent/KR20220045075A/en
Priority to DK15700211.4T priority patent/DK2948183T3/en
Priority to HRP20160797TT priority patent/HRP20160797T1/en
Publication of WO2015104373A2 publication Critical patent/WO2015104373A2/en
Publication of WO2015104373A3 publication Critical patent/WO2015104373A3/en
Priority to US14/859,221 priority patent/US9427480B2/en
Priority to CY20161100612T priority patent/CY1117712T1/en
Anticipated expiration legal-status Critical
Priority to US15/216,366 priority patent/US10092659B2/en
Ceased legal-status Critical Current

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Abstract

The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours expressing HER2, wherein the human solid tumour expressing HER2 is endometrial cancer, in particular uterine serous carcinoma (USC). In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of endometrial cancer, notably USC, with HER2 IHC 2+ or 1+ and HER2 FISH negative tumour tissue status.
PCT/EP2015/050332 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer Ceased WO2015104373A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
MYPI2016001213A MY189713A (en) 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer
CA2935430A CA2935430C (en) 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer
MX2016009069A MX368234B (en) 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer.
RU2016132635A RU2686085C2 (en) 2014-01-10 2015-01-09 Antibody-drug conjugates (adc) with duocarmicin used for treating endometrial cancer
SG11201605597VA SG11201605597VA (en) 2014-01-10 2015-01-09 Duocarmycin adcs for use in treatment of endometrial cancer
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