WO2015176628A1 - 电化学感应试片及其制造方法 - Google Patents

电化学感应试片及其制造方法 Download PDF

Info

Publication number
WO2015176628A1
WO2015176628A1 PCT/CN2015/079158 CN2015079158W WO2015176628A1 WO 2015176628 A1 WO2015176628 A1 WO 2015176628A1 CN 2015079158 W CN2015079158 W CN 2015079158W WO 2015176628 A1 WO2015176628 A1 WO 2015176628A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrochemical
substrate
conductive electrode
electrochemical sensing
cover plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/079158
Other languages
English (en)
French (fr)
Inventor
江振丰
江荣泉
江文德
江建颖
江建毅
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuang Hong Precision Co Ltd
Original Assignee
Kuang Hong Precision Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuang Hong Precision Co Ltd filed Critical Kuang Hong Precision Co Ltd
Priority to EP15796328.1A priority Critical patent/EP3147657A4/en
Priority to JP2016568870A priority patent/JP2017516995A/ja
Publication of WO2015176628A1 publication Critical patent/WO2015176628A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/307—Disposable laminated or multilayered electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C18/00—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating
    • C23C18/16—Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coating; Contact plating by reduction or substitution, e.g. electroless plating
    • C23C18/1601—Process or apparatus
    • C23C18/1633—Process of electroless plating
    • C23C18/1635—Composition of the substrate
    • C23C18/1639—Substrates other than metallic, e.g. inorganic or organic or non-conductive
    • C23C18/1641—Organic substrates, e.g. resin, plastic

Definitions

  • the invention relates to an electrochemical induction test piece and a manufacturing method thereof, in particular to a structure and a manufacturing method of a disposable induction test piece.
  • a metal electrode is suitable for testing a liquid sample such as blood to test blood sugar, uric acid, cholesterol in the sample through the instrument.
  • Disposable inductive test pieces such as concentration or concentration of heavy metals and pesticides in sewage, etc., have gradually developed into widely used and important detection tools.
  • the principle of electrochemical detection has been matured in recent years for the detection of various liquid samples. However, it is mainly based on the structure disclosed in the invention patent "Electrochemical Sensing Test Sheet Structure and Process" of Taiwan Case No. I245119.
  • the through hole is disposed on the upper hole, and then the at least one solid electrode needs to be fixed in the through hole in an implanted manner, so that the problem of excellent detection efficiency can be achieved by eliminating the need for structural combination of the layers as in the prior art. .
  • the inventors of the present invention have conceived and designed an electrochemical sensing test piece and a manufacturing method thereof in order to improve the lack of the prior art, thereby enhancing the industrial use and utilization.
  • the object of the present invention is to design an electrochemical sensing test piece having novelties, advancement and industrial utilization, and a manufacturing method thereof, in order to overcome the difficulties of the prior art. .
  • the technical means adopted by the present invention is to design an electrochemical sensing test piece comprising: a substrate made of a non-surface-metallized polymer plastic, the substrate being further on one side of the front side
  • the recess is provided with at least one inspection slot; at least one conductive electrode portion is a conductive object disposed on the substrate, and a portion thereof extends into the inspection slot; at least one electrochemical sensing portion is correspondingly disposed on a chemical sensing layer of the inspection tank, the electrochemical sensing portion may generate a chemical reaction to generate an electrical signal after contacting the liquid sample to be detected; and a cover plate which is a thin plate covering the substrate corresponding to the The inspection tank is further formed, so that the inspection tank forms a detection opening at the outer end thereof, and the liquid sample to be detected can be dropped from the detection opening, and the cover plate at least shields the conductive electrode portion and the a junction of the electrochemical sensing portion; and a portion of the conductive electrode portion extends out of the cover plate without being
  • At least one perforation is further disposed on the substrate adjacent to the inner side of the inspection slot, the number corresponding to the conductive electrode portion, and the conductive electrode portion extends out of the cover plate without being covered by the cover
  • the shaded portion of the panel passes through the perforations and thereby extends to the surface at the back of the substrate.
  • the perforations are circular holes.
  • the substrate is a polymer plastic without pre-doped catalyst.
  • the substrate is an elongated plate.
  • the inspection groove is a long straight groove structure.
  • the electrochemical sensing portion further comprises a hydrophilic layer and a biochemical reaction layer or both Mixed hydrophilic biochemical reaction layer.
  • the cover plate is transparent.
  • cover plate or the substrate is provided with at least one air hole at the cover of the cover plate.
  • the technical means further disclosed by the present invention is to design a method for manufacturing an electrochemical induction test piece, which comprises the following steps: A. A two-material molding step, which simultaneously ejects a non-surface metallized polymer in a mold. Forming a substrate, the substrate further recessing at one side of the front surface with at least one inspection groove, and forming an entity of at least one conductive electrode portion on the substrate by second-shot metallizable polymer plastic a portion extending into the inspection tank; B. a surface metallization step of surface metallizing the conductive electrode portion to have electrical conductivity; C.
  • an electrochemical reaction layer coating step Forming an electrochemical sensing portion by coating, dripping or dispersing a chemical reagent in the inspection tank, the electrochemical sensing portion may generate a chemical reaction to generate an electrical signal after contacting the liquid sample to be detected;
  • an electrochemical reaction layer a drying step of actively drying the electrochemical sensing portion or passively waiting for the electrochemical sensing portion to dry; and
  • E. masking the inspection tank step which will Covering the cover plate on the substrate corresponding to the inspection groove, so that the inspection groove forms a detection opening at the outer end thereof, and the liquid sample to be detected can be dropped from the detection opening; A portion of the conductive electrode portion extends out of the cover plate without being shielded by the cover plate.
  • the non-surface metallized polymer plastic is a polymer plastic without pre-doped catalyst.
  • the polymer plastic which can be surface-metallized comprises a polymer plastic without a pre-doped catalyst and a polymer plastic pre-doped with a catalyst.
  • the metal formed by the surface metallization step is one of copper, nickel, silver, gold, tin, titanium, platinum, palladium, rhodium, ruthenium, iridium, chromium, iron, aluminum, or at least Two metal combinations.
  • the electrochemical sensing portion further comprises a hydrophilic layer and a biochemical reaction layer or a hydrophilic biochemical reaction layer mixed with the two.
  • the present invention further discloses a technical means for designing a method for manufacturing an electrochemical induction test piece, which comprises the following steps: A. A second injection molding step, which firstly emits a high surface metallization in a first time. Molecular plastic to form an entity of at least one conductive electrode portion, and then to activate the entity of the conductive electrode portion, and to form a second non-surface metallizable polymer on the lower side of the conductive electrode portion to form a second a substrate, the substrate is further recessed at one side of the front surface to be provided with at least one inspection groove, and a solid portion of the conductive electrode portion extends into the inspection groove; B.
  • a surface metallization step which is Performing surface metallization of the body of the conductive electrode portion to make it electrically conductive
  • the shielding inspection groove step which covers the cover plate on the substrate corresponding to the inspection groove, thereby causing the inspection groove to be
  • a detection opening is formed at the outer end, and a liquid sample to be detected may be dropped from the detection opening; and a portion of the conductive electrode portion extends out of the cover without being shielded by the cover.
  • the non-surface metallized polymer plastic is a polymer plastic without pre-doped catalyst.
  • the surface-metallizable polymer plastic comprises a polymer plastic without pre-doped catalyst and a polymer plastic pre-doped with a catalyst.
  • the metal formed by the surface metallization step is one of copper, nickel, silver, gold, tin, titanium, platinum, palladium, rhodium, ruthenium, iridium, chromium, iron, aluminum, or at least Two metal combinations.
  • the electrochemical sensing portion further comprises a hydrophilic layer and a biochemical reaction layer or a hydrophilic biochemical reaction layer mixed with the two.
  • the electrochemical induction test piece and the manufacturing method thereof of the invention provide a convenient method for designing the process without cumbersome and high precision, and can effectively reduce the manufacturing cost, and further,
  • there is no problem in the prior art that it is necessary to implant a conductor inside. Therefore, it is only necessary to dissolve the surface metallized metal to recover the material, and it has high application convenience and the like, and is expected to be popularized and applied.
  • Fig. 1 is an external view of an electrochemical induction test piece of the present invention.
  • Fig. 2 is an exploded perspective view showing the electrochemical sensing test piece of the present invention.
  • Fig. 3 is a perspective view showing the back side of the electrochemical sensing test piece of the present invention.
  • FIG. 4 is a flow chart showing a method of fabricating the electrochemical sensing test strip of the present invention.
  • Fig. 5 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • Fig. 6 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • Fig. 7 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • Fig. 8 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • Fig. 9 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • Fig. 10 is a flow chart showing the manufacturing method of the electrochemical induction test strip manufacturing method of the present invention.
  • Fig. 11 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • Fig. 12 is a view showing an embodiment of a manufacturing flow of a method for producing an electrochemical induction test strip of the present invention.
  • the present invention provides an electrochemical sensing test strip and a manufacturing method thereof.
  • the electrochemical sensing test strip may include: a substrate 10 and at least one conductive electrode. The portion 20, the at least one electrochemical sensing portion 30, and the cover plate 40.
  • the substrate 10 described above may be an elongated plate made of a polymer plastic that is not surface-metallized.
  • Surface metalization generally refers to a method of forming a metal layer on a surface of a material such as electroplating or electroless plating, for example, PC or the like.
  • the polymer material of the catalyst is pre-doped, and further recessed at one side of the front surface is provided with at least one inspection groove 11 which may be a long straight groove structure and adjacent to the inspection groove on the substrate 10 Further, at least one of the through holes 12 is provided at the inner side of the hole 11, and the through hole 12 may be a circular hole.
  • the conductive electrode portion 20 is a conductive member disposed on the substrate 10, the number of which corresponds to the through hole 12, and a portion thereof extends into the inspection groove 11 and another portion thereof passes through the through hole 12, It extends to the surface at the back of the substrate 10 for transmission of electrical signals.
  • the electrochemical sensing portion 30 is a chemical sensing layer disposed in the inspection tank 11, which can react with the liquid sample to be detected to generate a chemical reaction to generate an electrical signal, and the electrochemical sensing portion 30 further comprises a hydrophilic layer and a biochemical reaction.
  • the cover plate 40 is a thin plate piece, which can be transparent, and covers the substrate 10 corresponding to the inspection groove 11, so that the inspection groove 11 forms a detection opening at the outer end thereof, and can be dripped from the detection opening.
  • the liquid sample to be inspected is placed, and the cover plate 40 is at least shielded at the intersection of the conductive electrode portion 20 and the electrochemical sensing portion 30, and at least one air hole is provided on the cover plate 40 or on the substrate 10 covered by the cover plate 40. 41; and for convenience of use, an auxiliary indicator such as an observation window and a mark can be printed on the cover 40.
  • the present invention further discloses a method for manufacturing an electrochemical induction test piece, which is used for manufacturing the aforementioned electrochemical induction test piece, in a preferred embodiment. The following steps can be included:
  • a two-material molding step is to simultaneously form a non-surface-metallized polymer plastic (for example, PC) in the mold to form the substrate 10 (please further cooperate with reference to FIG. 5), and to eject the surface at a second time.
  • a metallized polymer plastic for example, ABS
  • surface metallization step is to surface metalize the body of the conductive electrode portion 20, and the metal formed may be copper, nickel, silver, gold, tin, titanium, One or a combination of at least two metals of platinum, palladium, rhodium, ruthenium, osmium, chromium, iron, aluminum, and the like.
  • the foregoing C. electrochemical reaction layer coating step is to form the electrochemical sensing portion 30 by coating, dropping or dispersing a chemical reagent in the inspection tank 11 , and the electrochemical sensing portion 30 can further a hydrophilic biochemical reaction layer containing a hydrophilic layer and a biochemical reaction layer or a mixture of the two Layer structure.
  • the aforementioned D. electrochemical reaction layer drying step comprises an active dry electrochemical sensing portion 30 or a passive waiting electrochemical sensing portion 30 for drying.
  • the E. masking inspection slot step covers the cover plate 40 on the substrate 10 corresponding to the inspection slot 11, so that the inspection slot 11 forms a detection opening at the outer end thereof.
  • the liquid sample to be detected is dropped into the detection opening, and the cover 40 is at least shielded at the intersection of the conductive electrode portion 20 and the electrochemical sensing portion 30.
  • FIG. 10 wherein the present invention further discloses a method for manufacturing an electrochemical induction test piece, which is used for manufacturing the aforementioned electrochemical induction test piece, in a
  • a preferred embodiment may include the following steps:
  • secondary injection molding step firstly ejects a surface-metallizable polymer plastic (for example, ABS) to form an entity of the conductive electrode portion 20, and then the conductive electrode.
  • the entity of the portion 20 is catalytically catalyzed; further, as shown in FIG. 12, the substrate 10 is formed on the lower side of the conductive electrode portion 20 by ejecting a polymer plastic (for example, PC) which is not surface-metallizable for the second time.
  • a surface-metallizable polymer plastic for example, ABS
  • PC polymer plastic
  • the foregoing B. surface metallization step performs surface metallization of the body of the conductive electrode portion 20, and the metal formed may be copper, nickel, silver, gold, tin, titanium, platinum, One of a metal such as palladium, rhodium, ruthenium, iridium, chromium, iron, aluminum, or a combination of at least two of them.
  • electrochemical reaction layer coating step is performed by coating, dropping or dispersing a chemical reagent in the inspection tank 11 to form the electrochemical sensing portion 30, and the electrochemical sensing portion 30 may further comprise The hydrophilic layer and the biochemical reaction layer or a hydrophilic biochemical reaction layer mixed with the two layers.
  • the aforementioned D. electrochemical reaction layer drying step comprises an active dry electrochemical sensing portion 30 or a passive waiting electrochemical sensing portion 30 for drying.
  • the E. masking inspection slot step covers the cover plate 40 on the substrate 10 corresponding to the inspection slot 11, so that the inspection slot 11 forms a detection opening at the outer end thereof.
  • the liquid sample to be detected is dropped into the detection opening, and the cover 40 is at least shielded at the intersection of the conductive electrode portion 20 and the electrochemical sensing portion 30.
  • the inductive change in the design of the electrochemical sensing test piece and the manufacturing method thereof of the present invention provides a convenient way of making the process without complicated and high precision of production, and can effectively reduce the manufacturing cost.
  • There is no problem in the prior art that it is necessary to implant a conductor inside. Therefore, it is only necessary to dissolve the metal after surface metallization to recover the material, and it has high application convenience and the like, and is expected to be popularized and applied. What can not be achieved by the prior art, so that the beneficial effects can be seen.
  • the present invention has achieved the desired effect under the breakthrough of the prior art, and is not easily conceivable by those skilled in the art, and has the progressiveness and practicability, and has been patent-compliant. Apply for the requirements, so file a patent application with a view to obtaining corresponding protection.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

一种电化学感应试片及其制造方法。该电化学感应试片包含：基板（10），其为不可表面金属化的高分子塑料所制，基板（10）在正面上的一侧处进一步凹入设有检验槽（11）；导电电极部（20），其为设于基板（10）上的导电物件，且导电电极部（20）部分延伸进入检验槽（11）之中；电化学感应部（30），其为对应设于检验槽（11）的化学感应层，其与待检测的液态检体接触后产生化学反应产生电信号；以及盖板（40），其为薄板片，且覆盖于基板（10）上对应于检验槽（11）上，进而使检验槽（11）在其外侧端处形成检测开口，自检测开口处滴入待检测的液态检体，且盖板（40）至少遮蔽在导电电极部（20）与电化学感应部（30）的交接处；且导电电极部（20）的一部分延伸出盖板（40）而未受盖板（40）的遮蔽。该电化学感应试片制作简单，且精准度高。

Description

电化学感应试片及其制造方法 技术领域
本发明涉及一种电化学感应试片及其制造方法，特别涉及一种抛弃式感应试片的结构与制造方法。
背景技术
随着医学的进步以及相关用品器材的加工工艺过程的技术提升，一种具有金属电极而适用于测试如血液等液态检体，以通过仪器测试检体中的如血液中的血糖、尿酸、胆固醇浓度或者是污水中的重金属与农药等物质的浓度等等的抛弃式感应试片逐渐的发展为受到广泛运用，且具有重要地位的检测工具。
电化学检测原理近年来已被成熟应用于各种液态检体的检测，然而其如台湾案号第I245119的发明专利“电化学式感测试片的结构与制程”所公开的架构下，主要在本体上配置有贯孔，而后需要将至少一个实体电极以植入的方式固定在贯孔内，而可免去如现有技术中需要通过层层的结构组合，才可达到优良的检测功效的问题。
而如前所述的现有技术中，其成品的加工实际上不易，且有需要多道工法而才可完成成品的工艺过程繁复问题，且同时更需要有高度精密的装置才得以完成此工法，而这将导致制作成本拉高，而难以令价位降低，恐有普及化不易的困扰存在，不利于推广应用。
此外现有技术中通过导电柱植入方式的抛弃式检测试片在使用过后要回收时，亦会产生回收不易的问题，亦即须先行将植于其中的导电柱取出后，方可将其本体做材料的回收，实有其缺失之处。
故综观前所述，本发明的发明人思索并设计一种电化学感应试片及其制造方法，以期针对现有技术的缺失加以改善，进而增进产业上的实施利用。
发明内容
有鉴于前述的现有技术的不足点，本发明的目的在于设计一种具备新颖性、进步性及产业利用性等专利要件的电化学感应试片及其制造方法，以期克服现有技术的难点。
为达到上述目的，本发明所采用的技术手段为设计一种电化学感应试片，其包含：基板，其为不可表面金属化的高分子塑料所制，该基板在正面上的一侧处进一步凹入设有至少一个检验槽；至少一个导电电极部，其为设于所述基板上的导电物件，且其部分延伸进入所述检验槽之中；至少一个电化学感应部，其对应设于所述检验槽的化学感应层，该电化学感应部可与待检测的液态检体接触后产生化学反应产生电信号；以及盖板，其为薄板片，其覆盖于所述基板上对应于所述检验槽上，进而使所述检验槽在其外侧端处形成检测开口，而可自该检测开口处滴入待检测的液态检体，且所述盖板至少遮蔽所述导电电极部与所述电化学感应部的交接处；且所述导电电极部的部分延伸出所述盖板而未受所述盖板的遮蔽。
其中，在所述基板上邻近于所述检验槽内侧处进一步设有至少一个穿孔，其数量对应于所述导电电极部，且所述导电电极部延伸出所述盖板而未受所述盖板的遮蔽的部分穿过所述穿孔，进而延伸至所述基板的背面处的表面上。
其中，所述穿孔为圆形孔。
其中，所述基板为无预先掺杂触媒的高分子塑料。
其中，所述基板为长形板片。
其中，所述检验槽为长直凹槽结构。
其中，所述电化学感应部进一步包含亲水层与生化反应层或者是其两者 混合的亲水生化反应层。
其中，所述盖板为透明的。
其中，所述盖板上或者是所述基板上受所述盖板覆盖处设有至少一个气孔。
此外，本发明进一步公开的技术手段为设计一种电化学感应试片的制造方法，其包含下列步骤：A.双料成型步骤，其为同时在模具中以一次射出不可表面金属化的高分子塑料以形成基板，所述基板在正面上的一侧处进一步凹入设有至少一个检验槽，并且以二次射出可表面金属化的高分子塑料在所述基板上形成至少一个导电电极部的实体，其部分延伸进入所述检验槽之中；B.表面金属化步骤，其为将所述导电电极部的实体进行表面金属化，以使其具备导电性；C.电化反应层涂布步骤，其通过涂覆、滴落或散布化学试剂在所述检验槽以形成电化学感应部，该电化学感应部可与待检测的液态检体接触后产生化学反应产生电信号；D.电化反应层干燥步骤，其为主动式干燥所述电化学感应部或者是被动式等待所述电化学感应部干燥；以及E.遮蔽检验槽步骤，其将盖板覆盖于所述基板上对应于所述检验槽上，进而使所述检验槽在其外侧端处形成检测开口，而可自该检测开口处滴入待检测的液态检体；且所述导电电极部的一部分延伸出所述盖板而未受所述盖板的遮蔽。
其中，所述不可表面金属化的高分子塑料为无预先掺杂触媒的高分子塑料。
其中，所述可以表面金属化的高分子塑料包含无预先掺杂触媒的高分子塑料以及预先掺杂触媒的高分子塑料。
其中，所述B.表面金属化步骤所形成的金属为铜、镍、银、金、锡、钛、白金、钯、铑、钌、铱、铬、铁、铝等金属中的一种或者至少两种的金属组合。
其中，所述电化学感应部进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层。
此外，本发明又进一步公开一种技术手段为设计一种电化学感应试片的制造方法，其包含下列步骤：A.二次射出成型步骤，其首先以第一次射出可表面金属化的高分子塑料以形成至少一个导电电极部的实体，而后对所述导电电极部的实体进行触媒化，并且以第二次射出不可表面金属化的高分子塑料在所述导电电极部的下侧以形成基板，所述基板在正面上的一侧处进一步凹入设有至少一个检验槽，而所述导电电极部的实体的部分延伸进入所述检验槽之中；B.表面金属化步骤，其为将所述导电电极部的实体进行表面金属化，以使其具备导电性；C.电化反应层涂布步骤，其通过涂覆、滴落或散布化学试剂在所述检验槽以形成电化学感应部，该电化学感应部可与待检测的液态检体接触后产生化学反应产生电信号；D.电化反应层干燥步骤，其为主动式干燥所述电化学感应部或者是被动式等待所述电化学感应部干燥；以及E.遮蔽检验槽步骤，其为将盖板覆盖于所述基板上对应于所述检验槽上，进而使所述检验槽在其外侧端处形成检测开口，而可自该检测开口处滴入待检测的液态检体；且所述导电电极部的一部分延伸出所述盖板而未受所述盖板的遮蔽。
其中，所述不可表面金属化的高分子塑料为无预先掺杂触媒的高分子塑料。
其中，所述可表面金属化的高分子塑料包含无预先掺杂触媒的高分子塑料以及预先掺杂触媒的高分子塑料。
其中，所述B.表面金属化步骤所形成的金属为铜、镍、银、金、锡、钛、白金、钯、铑、钌、铱、铬、铁、铝等金属中的一种或者至少两种的金属组合。
其中，所述电化学感应部进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层。
本发明的电化学感应试片及其制造方法在设计上提供一种制作上工艺过程不繁复，且制作精准度高的便利方式，可有效地降低制作的成本，此外， 且无如现有技术中需要在内部植入导体的问题存在，因此仅需将表面金属化的金属溶去即可进行材质的回收，具有高度应用便利性等特征，可望推广应用。
而为了让上述目的、技术特征以及实际实施后的有益效果更为明显易懂，在下文中将以优选的实施范例配以对应相关的附图来进行更详细的说明。
附图说明
图1为本发明的电化学感应试片的外观图。
图2为本发明的电化学感应试片的外观分解图。
图3为本发明的电化学感应试片的背侧视角外观图。
图4为本发明的电化学感应试片制造方法的制作方法流程图。
图5为本发明的电化学感应试片制造方法的制作流程实施例图。
图6为本发明的电化学感应试片制造方法的制作流程实施例图。
图7为本发明的电化学感应试片制造方法的制作流程实施例图。
图8为本发明的电化学感应试片制造方法的制作流程实施例图。
图9为本发明的电化学感应试片制造方法的制作流程实施例图。
图10为本发明的电化学感应试片制造方法的制作方法流程图。
图11为本发明的电化学感应试片制造方法的制作流程实施例图。
图12为本发明的电化学感应试片制造方法的制作流程实施例图。
符号说明：
基板-10，检验槽-11，穿孔-12，导电电极部-20，电化学感应部-30，盖板-40，气孔-41。
具体实施方式
为了解本发明的发明特征、内容与优点及其所能达成的功效，将本发明配合附图，并以实施例的表达形式详细说明如下，而其中所使用的附图，其主旨仅为示意及辅助说明书之用，未必为本发明实施后的真实比例与精准配置，故不应就附图的比例与配置关系解读、局限本发明在实际实施上的权利范围。
本发明的优点、特征以及达到的技术方法将参照例示性实施例及附图进行更详细地描述而更容易理解，且本发明可以不同形式来实现，故不应被理解仅限于此处所陈述的实施例，相反地，对所属技术领域具有通常知识者而言，所提供的实施例将使本案更加透彻与全面且完整地传达本发明的范畴，且本发明将仅为权利要求书所定义。
而除非另外定义，所有使用于后文的术语(包含科技及科学术语)与专有名词，在实质上与本发明所属领域的技术人士一般所理解的意思相同，而例如在一般所使用的字典所定义的那些术语应被理解为具有与相关领域的内容一致的意思，且除非明显地定义于后文，将不以过度理想化或过度正式的意思理解，合先叙明。
请配合参看图1至图3所示，本发明提出一种电化学感应试片及其制造方法，所述电化学感应试片在一优选的实施方式中可包含：基板10、至少一个导电电极部20、至少一个电化学感应部30以及盖板40。
前述的基板10可为长形板片，其为不可表面金属化的高分子塑料所制，表面金属化泛指电镀以及化学镀等可在物质表面形成金属层的作业方式，例如为PC等无预先掺杂触媒的高分子塑料材质，且其在正面上的一侧处进一步凹入设有至少一个检验槽11，检验槽11可为长直凹槽结构，且在基板10上邻近于检验槽11内侧处进一步设有至少一个穿孔12，穿孔12可为圆形孔。
前述的导电电极部20为设于所述基板10上的导电物件，其数量对应于穿孔12，且其部分延伸进入检验槽11之中，且其另一部分对应穿过穿孔12， 进而延伸至基板10的背面处的表面上，以供接电信号的传输。
前述的电化学感应部30为设于检验槽11的化学感应层，其可与待检测的液态检体接触后产生化学反应产生电信号，且电化学感应部30进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层等层结构。
前述的盖板40为薄板片，可为透明的，其覆盖于基板10上对应于所述检验槽11上，进而使检验槽11在其外侧端处形成检测开口，而可自检测开口处滴入待检测的液态检体，且盖板40至少遮蔽在导电电极部20与电化学感应部30的交接处，且盖板40上或者是基板10上受盖板40覆盖处设有至少一个气孔41；且为了使用的便利性，盖板40上可印刷观察视窗及标示等等辅助性指示物。
请进一步配合参看图4所示，其中本发明进一步公开电化学感应试片的制造方法，所述电化学感应试片的制造方法用于制作前述的电化学感应试片，在一优选的实施方式中可包含下列步骤:
A.双料成型步骤；B.表面金属化步骤；C.电化反应层涂布步骤；D.电化反应层干燥步骤；以及E.遮蔽检验槽步骤。
前述的A.双料成型步骤为同时在模具中以一次射出不可表面金属化的高分子塑料(例如:PC)以形成基板10(请进一步配合参看图5所示)，并且以二次射出可表面金属化的高分子塑料(例如:ABS)在基板10上形成导电电极部20的实体(请进一步配合参看图6所示)。
请进一步配合参看图7所示，前述的B.表面金属化步骤为将导电电极部20的实体进行表面金属化，其所形成的金属或可为铜、镍、银、金、锡、钛、白金、钯、铑、钌、铱、铬、铁、铝等金属中的一种或者至少两种的金属组合。
请进一步配合参看图8所示，前述的C.电化反应层涂布步骤为通过涂覆、滴落或散布化学试剂在检验槽11以形成电化学感应部30，而电化学感应部30可进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层等 层结构。
前述的D.电化反应层干燥步骤包含主动式干燥电化学感应部30或者是被动式等待电化学感应部30干燥。
请进一步配合参看图9所示，前述的E.遮蔽检验槽步骤将盖板40覆盖于基板10上对应于检验槽11上，进而使检验槽11在其外侧端处形成检测开口，而可自检测开口处滴入待检测的液态检体，且盖板40至少遮蔽在导电电极部20与电化学感应部30的交接处。
请进一步配合参看图10所示，其中本发明进一步公开了另一种电化学感应试片的制造方法，所述电化学感应试片的制造方法用于制作前述的电化学感应试片，在一优选的实施方式可包含下列步骤:
A.二次射出成型步骤；B.表面金属化步骤；C.电化反应层涂布步骤；D.电化反应层干燥步骤；以及E.遮蔽检验槽步骤。
请进一步配合参看图11所示，前述的A.二次射出成型步骤首先以第一次射出可表面金属化的高分子塑料(例如:ABS)以形成导电电极部20的实体，而后对导电电极部20的实体进行触媒化；再请配合参看图12所示，并且以第二次射出不可表面金属化的高分子塑料(例如:PC)而在导电电极部20的下侧形成基板10。
请进一步配合参看图7所示，前述的B.表面金属化步骤将导电电极部20的实体进行表面金属化，其所形成的金属可为铜、镍、银、金、锡、钛、白金、钯、铑、钌、铱、铬、铁、铝等金属中的一种或者其中至少两种金属的组合。
请进一步配合参看图8所示，前述的C.电化反应层涂布步骤通过涂覆、滴落或散布化学试剂在检验槽11以形成电化学感应部30，而电化学感应部30可进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层等层结构。
前述的D.电化反应层干燥步骤包含主动式干燥电化学感应部30或者是被动式等待电化学感应部30干燥。
请进一步配合参看图9所示，前述的E.遮蔽检验槽步骤将盖板40覆盖于基板10上对应于检验槽11上，进而使检验槽11在其外侧端处形成检测开口，而可自检测开口处滴入待检测的液态检体，且盖板40至少遮蔽在导电电极部20与电化学感应部30的交接处。
通过本发明的电化学感应试片及其制造方法在设计上的巧思变化，其提供一种制作上工艺过程不繁复，且制作精准度高的便利方式，可有效地降低制作的成本，此外，无如现有技术中需要在内部植入导体的问题存在，因此仅需将表面金属化后的金属溶去即可进行材质的回收，具有高度应用便利性等特征，可望推广应用，为现有技术所不能及者，故可见其有益效果所在。
以上所述的实施例仅为说明本发明的技术思想及特点，其目的在使本领域技术人员能够了解本发明的内容并据以实施，不能以之限定本发明的专利范围，即凡是依本发明所公开的精神所作的均等变化或修饰，仍应涵盖在本发明的专利范围内。
综观上述，可见本发明在突破现有的技术下，确实已达到所欲增进的功效，且也非本领域技术人员所容易想到的，其所具有的进步性、实用性，显已符合专利的申请要件，因此提出专利申请，以期得到相应的保护。

Claims (20)

  1. 一种电化学感应试片，其特征在于，所述电化学感应试片包含：
    基板，其为不可表面金属化的高分子塑料所制，所述基板在正面上的一侧处进一步凹入设有至少一个检验槽；
    至少一个导电电极部，其为设于所述基板上的导电物件，且所述导电电极部部分延伸进入所述检验槽之中；
    至少一个电化学感应部，其为对应设于所述检验槽的化学感应层，所述电化学感应部与待检测的液态检体接触后产生化学反应产生电信号；以及
    盖板，其为薄板片，所述盖板覆盖于所述基板上对应于所述检验槽上，进而使所述检验槽在其外侧端处形成检测开口，自所述检测开口处滴入待检测的液态检体，且所述盖板至少遮蔽在所述导电电极部与所述电化学感应部的交接处；且其中所述导电电极部的一部分延伸出所述盖板而未受所述盖板的遮蔽。
  2. 如权利要求1所述的电化学感应试片，其特征在于，在所述基板上邻近于所述检验槽内侧处进一步设有至少一个穿孔，其数量对应于所述导电电极部，且所述导电电极部延伸出所述盖板而未受所述盖板的遮蔽的部分穿过所述穿孔，进而延伸至所述基板的背面处的表面上。
  3. 如权利要求2所述的电化学感应试片，其特征在于，所述穿孔为圆形孔。
  4. 如权利要求1所述的电化学感应试片，其特征在于，所述基板为无预先掺杂触媒的高分子塑料。
  5. 如权利要求1所述的电化学感应试片，其特征在于，所述基板为长形板片。
  6. 如权利要求1所述的电化学感应试片，其特征在于，所述检验槽为长直凹槽结构。
  7. 如权利要求1所述的电化学感应试片，其特征在于，所述电化学感应部进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层。
  8. 如权利要求1所述的电化学感应试片，其特征在于，所述盖板为透明的。
  9. 如权利要求1所述的电化学感应试片，其特征在于，所述盖板上或者是所述基板上受所述盖板覆盖处设有至少一个气孔。
  10. 如权利要求1所述的电化学感应试片，其特征在于，所述导电电极部为在表面电镀或化学镀有一层导电金属的高分子塑料，所述高分子塑料包含无预先掺杂触媒的高分子塑料以及预先掺杂触媒的高分子塑料。
  11. 一种电化学感应试片的制造方法，其特征在于，所述电化学感应试片的制造方法包含下列步骤：
    A.双料成型步骤，其为同时在模具中一次射出不可表面金属化的高分子塑料以形成基板，所述基板在正面上的一侧处进一步凹入设有至少一个检验槽，并且二次射出可表面金属化的高分子塑料在所述基板上形成至少一个导电电极部的实体，其部分延伸进入所述检验槽之中；
    B.表面金属化步骤，其为将所述导电电极部的实体进行表面金属化，以使其具备导电性；
    C.电化反应层涂布步骤，其通过涂覆、滴落或散布化学试剂在所述检验槽以形成电化学感应部，所述电化学感应部与待检测的液态检体接触后产生化学反应产生电信号；
    D.电化反应层干燥步骤，其为主动式干燥所述电化学感应部或者是被动式等待所述电化学感应部干燥；以及
    E.遮蔽检验槽步骤，其为将盖板覆盖于所述基板上对应于所述检验槽上，进而使所述检验槽在其外侧端处形成检测开口，自所述检测开口滴入待检测的液态检体；且所述导电电极部的一部分延伸出所述盖板而未受所述盖板的遮蔽。
  12. 如权利要求11所述的电化学感应试片的制造方法，其特征在于，所述不可表面金属化的高分子塑料为无预先掺杂触媒的高分子塑料。
  13. 如权利要求11所述的电化学感应试片的制造方法，其特征在于，所述可表面金属化的高分子塑料包含无预先掺杂触媒的高分子塑料以及预先掺杂触媒的高分子塑料。
  14. 如权利要求11所述的电化学感应试片的制造方法，其特征在于，所述B.表面金属化步骤所形成的金属为铜、镍、银、金、锡、钛、白金、钯、铑、钌、铱、铬、铁、铝等金属中的一种或者至少两种的金属组合。
  15. 如权利要求11所述的电化学感应试片的制造方法，其特征在于，所述电化学感应部进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层。
  16. 一种电化学感应试片的制造方法，其特征在于，其包含下列步骤：
    A.二次射出成型步骤，其为首先以第一次射出可表面金属化的高分子塑料以形成至少一个导电电极部的实体，而后对所述导电电极部的实体进行触媒化，并且以第二次射出不可表面金属化的高分子塑料在所述导电电极部的下侧形成基板，所述基板在正面上的一侧处进一步凹入设有至少一个检验槽，而所述导电电极部的实体的部分延伸进入所述检验槽之中；
    B.表面金属化步骤，其为将所述导电电极部的实体进行表面金属化，以使其具备导电性；
    C.电化反应层涂布步骤，其通过涂覆、滴落或散布化学试剂在所述检验槽以形成电化学感应部，所述电化学感应部与待检测的液态检体接触后产生化学反应产生电信号；
    D.电化反应层干燥步骤，其为主动式干燥所述电化学感应部或者是被动式等待所述电化学感应部干燥；以及
    E.遮蔽检验槽步骤，其将盖板覆盖于所述基板上对应于所述检验槽上，进而使所述检验槽在其外侧端处形成检测开口，而自所述检测开口滴入待检测的液态检体；且所述导电电极部的一部分延伸出所述盖板而未受所述盖板的 遮蔽。
  17. 如权利要求16所述的电化学感应试片的制造方法，其特征在于，所述不可表面金属化的高分子塑料为无预先掺杂触媒的高分子塑料。
  18. 如权利要求16所述的电化学感应试片的制造方法，其特征在于，所述可表面金属化的高分子塑料包含无预先掺杂触媒的高分子塑料以及预先掺杂触媒的高分子塑料。
  19. 如权利要求16所述的电化学感应试片的制造方法，其特征在于，所述B.表面金属化步骤所形成的金属为铜、镍、银、金、锡、钛、白金、钯、铑、钌、铱、铬、铁、铝等金属中的一种或者至少两种的金属组合。
  20. 如权利要求16所述的电化学感应试片的制造方法，其特征在于，所述电化学感应部进一步包含亲水层与生化反应层或者是其两者混合的亲水生化反应层。
PCT/CN2015/079158 2014-05-20 2015-05-18 电化学感应试片及其制造方法 Ceased WO2015176628A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP15796328.1A EP3147657A4 (en) 2014-05-20 2015-05-18 Electrochemical sensitive test piece and manufacturing method therefor
JP2016568870A JP2017516995A (ja) 2014-05-20 2015-05-18 電気化学試験片及びその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410213510.7 2014-05-20
CN201410213510.7A CN105092662B (zh) 2014-05-20 2014-05-20 电化学感应试片及其制造方法

Publications (1)

Publication Number Publication Date
WO2015176628A1 true WO2015176628A1 (zh) 2015-11-26

Family

ID=54553414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/079158 Ceased WO2015176628A1 (zh) 2014-05-20 2015-05-18 电化学感应试片及其制造方法

Country Status (5)

Country Link
US (1) US20150338366A1 (zh)
EP (1) EP3147657A4 (zh)
JP (1) JP2017516995A (zh)
CN (1) CN105092662B (zh)
WO (1) WO2015176628A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105277597B (zh) * 2014-07-17 2017-09-15 光宏精密股份有限公司 电化学感测试片导电件设置方法
US9933386B2 (en) * 2015-06-29 2018-04-03 Kuang Hong Precision Co., Ltd. Setting method for conductive object of electrochemical test strip
CN107271504B (zh) * 2016-04-06 2020-08-14 江振丰 电化学感测试片导电件设置方法
CN107037208B (zh) * 2016-11-18 2019-03-29 百奥森（江苏）食品安全科技有限公司 一种多功能荧光免疫层析快速定量检测卡
CN109557156A (zh) * 2018-08-31 2019-04-02 国竤工业有限公司 微流控电化学生物传感器及其制作方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101520428A (zh) * 2008-02-25 2009-09-02 华广生技股份有限公司 电化学式感测方法与试片
CN102387669A (zh) * 2010-08-31 2012-03-21 光宏精密股份有限公司 立体电路元件及其制作方法
TW201219779A (en) * 2010-11-10 2012-05-16 Eps Bio Technology Corp Biochemical test strip and method for making the same
CN203811568U (zh) * 2014-05-20 2014-09-03 光宏精密股份有限公司 电化学感应试片

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2191739A5 (en) * 1972-06-26 1974-02-01 Comp Generale Electricite Rapid corrosion measurement - for use in situ on workpieces corroded by any aqs soln
GB2171355B (en) * 1985-02-22 1989-11-22 Kollmorgen Tech Corp Molded articles suitable for adherent metallization, molded metallized articles and processes for making the same
US5407622A (en) * 1985-02-22 1995-04-18 Smith Corona Corporation Process for making metallized plastic articles
JPH0483877A (ja) * 1990-07-25 1992-03-17 Hitachi Cable Ltd プラスチック２ショット成形品
US6071391A (en) * 1997-09-12 2000-06-06 Nok Corporation Enzyme electrode structure
US5997817A (en) * 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
KR100340174B1 (ko) * 1999-04-06 2002-06-12 이동준 전기화학적 바이오센서 테스트 스트립, 그 제조방법 및 전기화학적 바이오센서
US20020139668A1 (en) * 1999-11-03 2002-10-03 Raghbir Singh Bhullar Embedded metallic deposits
CN1349096A (zh) * 2000-10-13 2002-05-15 聿新科技股份有限公司 电化学电极试片及其制造方法
US6755949B1 (en) * 2001-10-09 2004-06-29 Roche Diagnostics Corporation Biosensor
US20070023283A1 (en) * 2003-01-30 2007-02-01 Chun-Mu Huang Method for manufacturing electrochemical sensor and structure thereof
US20040251132A1 (en) * 2003-06-06 2004-12-16 Leach Christopher Philip Reduced volume strip
AU2003267970A1 (en) * 2003-06-17 2005-01-28 Huang, Alice, Y. Structure and manufacturing method of disposable electrochemical sensor strip
CN2632674Y (zh) * 2003-06-27 2004-08-11 茂晶生技股份有限公司 厚膜电极式生化感测试片
CN1614404A (zh) * 2003-11-07 2005-05-11 华广生技股份有限公司 电化学式感测装置
JP4421338B2 (ja) * 2004-03-16 2010-02-24 タイコエレクトロニクスジャパン合同会社 基板スルーホール加工方法
US7556724B2 (en) * 2005-02-10 2009-07-07 Bionime Corporation Electrochemical sensor strip and manufacturing method thereof
WO2006085876A1 (en) * 2005-02-10 2006-08-17 Bionime Corporation Electrochemical sensor strip and manufacturing method thereof
CN1858592A (zh) * 2005-04-30 2006-11-08 北京怡成生物电子技术有限公司 一种试片
US7316766B2 (en) * 2005-05-27 2008-01-08 Taidoc Technology Corporation Electrochemical biosensor strip
US7955856B2 (en) * 2005-07-15 2011-06-07 Nipro Diagnostics, Inc. Method of making a diagnostic test strip having a coding system
CN200975990Y (zh) * 2006-11-27 2007-11-14 厚美德生物科技股份有限公司 液体检测试片
CN101191781B (zh) * 2006-11-29 2012-03-21 合世生医科技股份有限公司 非酵素式尿酸试剂的感测装置、感测试片及其制作方法
JP2008290295A (ja) * 2007-05-23 2008-12-04 Taisei Plas Co Ltd 樹脂メッキ製品とその製造方法
TWI388823B (zh) * 2009-04-09 2013-03-11 Bionime Corp 一種判斷樣品佈滿狀況的偵測方法
CN101894824B (zh) * 2009-05-18 2014-02-19 光宏精密股份有限公司 电子元件的承载结构及其制备方法
CN201611341U (zh) * 2010-02-05 2010-10-20 凯健企业股份有限公司 电化学感测试片
CN103575773A (zh) * 2012-08-07 2014-02-12 达尔生技股份有限公司 生物检测试片及其系统
TWI512287B (zh) * 2014-03-31 2015-12-11 Taidoc Technology Corp 具有樣品偵測功能的電化學生物感測器裝置、系統以及偵測方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101520428A (zh) * 2008-02-25 2009-09-02 华广生技股份有限公司 电化学式感测方法与试片
CN102387669A (zh) * 2010-08-31 2012-03-21 光宏精密股份有限公司 立体电路元件及其制作方法
TW201219779A (en) * 2010-11-10 2012-05-16 Eps Bio Technology Corp Biochemical test strip and method for making the same
CN203811568U (zh) * 2014-05-20 2014-09-03 光宏精密股份有限公司 电化学感应试片

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3147657A4 *

Also Published As

Publication number Publication date
CN105092662B (zh) 2019-01-22
CN105092662A (zh) 2015-11-25
EP3147657A4 (en) 2017-11-01
US20150338366A1 (en) 2015-11-26
EP3147657A1 (en) 2017-03-29
JP2017516995A (ja) 2017-06-22

Similar Documents

Publication Publication Date Title
WO2015176628A1 (zh) 电化学感应试片及其制造方法
CA2833669C (en) Electrochemical sensors with carrier field
US20130206595A1 (en) Biosensor with three-dimensional structure and manufacturing method thereof
TWI531790B (zh) 電化學試片、測量系統及判斷電化學試片反應區的樣品容量的方法
CN203811568U (zh) 电化学感应试片
US9678033B2 (en) Electrochemical biosensor and method for producing the same
TWI525319B (zh) Electrochemical sensing test piece and its manufacturing method
US20120183679A1 (en) Method for making an electrochemical sensor strip
US20140284304A1 (en) Method of fabricating test strip of biological fluid
WO2016008333A1 (zh) 电化学感测试片导电件设置方法
TWI525320B (zh) Method of setting conductive parts for electrochemical sensing test pieces
US20160377570A1 (en) Setting method for conductive object of electrochemical test strip
US20140102894A1 (en) Test strip for measuring biological fluid
CN107271504B (zh) 电化学感测试片导电件设置方法
CN105755445B (zh) 一种具有复合靶材的卷对卷溅镀制程与其制成品
CN216247770U (zh) 一种插卡式微电极集成传感芯片
CN105259221B (zh) 电化学感测试片的导电件设置方法
Islam et al. Effects of Miniaturization on the Quality of Metallized Plastic Parts
CN107251662A (zh) 电路片及电路片的制造方法
US20180200932A1 (en) Method of manufacturing an electrochemical test strip
KR101753133B1 (ko) 평면식 생물학 테스트 스트립의 제조방법 및 그 완제품
CN101395277A (zh) 生产用于检验传感器的电极的方法
TW201736841A (zh) 電化學感測試片導電件設置方法及其電化學感測試片
JP5432575B2 (ja) バイオセンサ及びその製造方法
TW201608237A (zh) 用於生物檢測試片之電極與其製造方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15796328

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2016568870

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2015796328

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2015796328

Country of ref document: EP