WO2016004255A3 - Holey capsid platform - Google Patents

Holey capsid platform Download PDF

Info

Publication number
WO2016004255A3
WO2016004255A3 PCT/US2015/038907 US2015038907W WO2016004255A3 WO 2016004255 A3 WO2016004255 A3 WO 2016004255A3 US 2015038907 W US2015038907 W US 2015038907W WO 2016004255 A3 WO2016004255 A3 WO 2016004255A3
Authority
WO
WIPO (PCT)
Prior art keywords
capsid
holey
platform
modifying
create
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/038907
Other languages
French (fr)
Other versions
WO2016004255A2 (en
Inventor
Adam Zlotnick
Lye Siang LEE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of WO2016004255A2 publication Critical patent/WO2016004255A2/en
Publication of WO2016004255A3 publication Critical patent/WO2016004255A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10123—Virus like particles [VLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A self-assembling protein capsid including removable sub-units is disclosed along with a method for modifying a capsid to create a holey capsid.
PCT/US2015/038907 2014-07-01 2015-07-01 Holey capsid platform Ceased WO2016004255A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462019719P 2014-07-01 2014-07-01
US62/019,719 2014-07-01

Publications (2)

Publication Number Publication Date
WO2016004255A2 WO2016004255A2 (en) 2016-01-07
WO2016004255A3 true WO2016004255A3 (en) 2016-02-25

Family

ID=55020099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/038907 Ceased WO2016004255A2 (en) 2014-07-01 2015-07-01 Holey capsid platform

Country Status (1)

Country Link
WO (1) WO2016004255A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103588A1 (en) * 2020-02-13 2022-12-21 The Trustees of Indiana University Hepadnavirus capsid protein heterodimers and virus-like particles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120121713A1 (en) * 2009-04-14 2012-05-17 De Los Rios Miguel Chimeric therapeutics, compositions, and methods for using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120121713A1 (en) * 2009-04-14 2012-05-17 De Los Rios Miguel Chimeric therapeutics, compositions, and methods for using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NEWCOMB ET AL.: "Cell -free assembly of the herpes simplex virus capsid.", J VIROL, vol. 68, no. 9, September 1994 (1994-09-01), pages 6059 - 6063, XP002923911 *
SZCZEPANIAK ET AL.: "Disulfide bond formation contributes to herpes simplex virus capsid stability and retention of pentons.", J VIROL, vol. 85, no. 17, September 2011 (2011-09-01), pages 8625 - 8634 *

Also Published As

Publication number Publication date
WO2016004255A2 (en) 2016-01-07

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