WO2019125965A1 - Synthesis of azelaic acid - Google Patents

Synthesis of azelaic acid Download PDF

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Publication number
WO2019125965A1
WO2019125965A1 PCT/US2018/065848 US2018065848W WO2019125965A1 WO 2019125965 A1 WO2019125965 A1 WO 2019125965A1 US 2018065848 W US2018065848 W US 2018065848W WO 2019125965 A1 WO2019125965 A1 WO 2019125965A1
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Prior art keywords
azelaic acid
another embodiment
base
decarboxylation
hydrolysis
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PCT/US2018/065848
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French (fr)
Inventor
Bishwabhusan Sahoo
Rajesh Shukla
Rajesh Thamatam
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Pci Synthesis Inc
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Pci Synthesis Inc
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Priority to CA3086530A priority Critical patent/CA3086530A1/en
Priority to EP18892440.1A priority patent/EP3728178A4/en
Publication of WO2019125965A1 publication Critical patent/WO2019125965A1/en
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Definitions

  • This invention concerns a method of synthesizing Azelaic Acid.
  • Azelaic acid is a saturated aliphatic dicarboxylic acid having the formula:
  • HOOC-(CH 2 )7-COOH It is also known as l,9-nonanedioic acid.
  • Azelaic acid is used as a starting material for producing industrial products including polyesters, plasticizers and lubricants.
  • Azelaic acid is also a component of hair- and skin-care products. See , R.H. Liu el al.“Azelaic acid in the treatment of papulopustular rosacea - A systematic review of randomized controlled trials,” Arch. Dermatol ., (2006) 142 (8): 1047-1052.
  • azelaic acid is produced via ozonolysis of oleic acid followed by dioxygen oxidation, as described by B. Cornils et al. in“Dicarboxylic Acids, Aliphatic: Ullmann's Encyclopedia of Industrial Chemistry,” Wiley (2010); and by E.F. Moran Jr. in “Process for making a C6 to C12 dibasic acid or azelaic acid using ozone generated from carbon dioxide,” US 2003/0010622.
  • azelaic acid syntheses include those described in E. Antonelli et al .,
  • the present invention is directed to compositions and methods for
  • the invention provides a process for manufacturing azelaic acid comprising the step of decarboxylating heptane-l,l,7,7-tetracarboxylic acid with a mild base to form azelaic acid.
  • the mild base is an organic base.
  • the mild base is triethylamine, trimethylamine, methylamine, di-isopropyl ethylamine, diethylamine, propylamine, butylamine, tripropylamine, ethylmethylamine, ethylamine, diethylmethylamine, phenylamine, alanine, aniline, ammonia, dimethylaminopyridine or pyridine.
  • the mild base is triethylamine.
  • the mild base is at a molar/molar ratio from about 0.6 to about 2.
  • the decarboxylation is performed using a solvent having a boiling temperature of at most about 200°C. In some embodiments the decarboxylation is performed at a temperature of at most about 200°C.
  • the solvent is toluene, tetrahydrofuran,
  • methyl tert-butyl ether dimethylsulfoxide, acetonitrile, l,2-dimethoxy ethane, dioxane, benzene, xylenes, methyl t-butyl ether, methylene chloride, chloroform, methyl ethyl ketone, methyl isobutyl ketone, acetone, acetonitrile, benzene, A'-di m ethyl form am i de,
  • the decarboxylation is performed in lab-scale, kilogram scale or plant-scale.
  • the azelaic acid is formed with a purity of
  • the invention also provides a process for manufacturing azelaic acid comprising the steps of: hydrolyzing tetraethyl heptane- 1,1, 7, 7-tetracarboxylate with an inorganic base to form heptane-l,l,7,7-tetracarboxylic acid; and decarboxylating the heptane- l,l,7,7-tetracarboxylic acid with a mild base thereby forming azelaic acid.
  • the heptane-l,l,7,7-tetracarboxylic acid, resulting from the hydrolysis step is isolated prior to the decarboxylating step.
  • the hydrolyzing step and the decarboxylating step are performed in situ.
  • the inorganic base is sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, cesium carbonate, potassium phosphate, sodium carbonate, sodium phosphate, sodium ethoxide, or potassium tert-butoxide.
  • the inorganic base is sodium hydroxide.
  • the inorganic base is at a molar/molar ratio from about 1 to about 4.
  • the hydrolysis is performed using a solvent having a boiling temperature of at most about l00°C. In some embodiments, the hydrolysis is performed using THF, toluene, methanol, dioxane, water, or mixtures thereof.
  • the hydrolysis is performed at ambient temperature.
  • the invention also provides a process for manufacturing azelaic acid comprising the steps of: reacting l,5-dibromopentane with diethylmalonate to form tetraethyl heptane-l,l,7,7-tetracarboxylate; hydrolyzing the tetraethyl heptane-l,l,7,7-tetracarboxylate with an inorganic base to form heptane-l,l,7,7-tetracarboxylic acid; and decarboxylating the heptane-l,l,7,7-tetracarboxylic acid with a mild base to form azelaic acid.
  • the present invention provides several advantages over prior syntheses of azelaic acid.
  • the present invention provides more mild processes for producing azelaic acid.
  • the process comprises a mild decarboxylation step.
  • the process comprises a mild hydrolysis step.
  • the decarboxylation step uses a mild base.
  • the decarboxylation step uses an organic base such as trimethylamine as a very mild base compared to the previous use of strong acids.
  • the decarboxylation step uses a mild temperature.
  • the decarboxylation step uses a solution of toluene refluxed between about l00°C and about 1 l0°C, which is much milder than other reports of very high temperature of >200°C.
  • the present invention provides a safer process.
  • the process is safer because reaction conditions such as lower temperatures (e.g., ⁇ 200°C) are less hazardous and therefore less risky. Furthermore, the milder processes of the present invention are less damaging to manufacturing equipment.
  • the present invention provides more cost-effective processes because raw-materials are inexpensive and readily available. Furthermore, the processes do not require special equipment, such as equipment for cryogenic conditions or high-pressure conditions.
  • the present invention provides an industrially viable scale up because batches can be consistently scaled to kilogram-scale (e.g., 100 kg - 200 kg) and plant-scale (e.g., ⁇ 1,000 kg).
  • kilogram-scale e.g. 100 kg - 200 kg
  • plant-scale e.g., ⁇ 1,000 kg
  • GMP Manufacturing Practice
  • GLP Good Laboratory Practice
  • the present invention provides processes for producing azelaic acid in higher yield.
  • azelaic acid shall mean l,9-nonanedioic acid, which has Chemical
  • Azelaic acid is also known as l,7-heptanedicarboxylic acid.
  • Azelaic acid has the formula: HOOC-(CH2) 7 -COOH and is illustrated by the following chemical structure (I):
  • Azelaic acid shall include, but not be limited to, salts, isoforms, isotopes, and formulations thereof.
  • Non-limiting examples of azelaic acid salts can include its disodium salt or ammonium salt.
  • Non-limiting examples of isotopes of azelaic acid may have the replacement of hydrogen by deuterium or tritium, or have the replacement of a carbon by a U C- , 13 C- or 14 C-enriched carbon.
  • Non-limiting examples of azelaic acid esters are methyl, ethyl and other alkylesters.
  • One aspect of the present invention comprises a step of decarboxylating heptane-l, l,7,7-tetracarboxylic acid (Formula III; tetraacid) to form azelaic acid (I).
  • the decarboxylation step uses any suitable base.
  • the decarboxylation step uses any suitable mild base.
  • the suitable mild base has a pKb of about 10 or less.
  • the suitable mild base has a pKb of less than 10 (pKb ⁇ 10).
  • the mild base is an organic base.
  • organic bases include but are not limited to, triethylamine (TEA,
  • Et 3 N trimethyl amine, methylamine, di-isopropyl ethylamine (DIPEA), diethylamine, propylamine, butylamine, tripropylamine, ethylmethylamine, ethylamine,
  • DIPEA di-isopropyl ethylamine
  • diethylamine diethylamine
  • propylamine propylamine
  • butylamine tripropylamine
  • ethylmethylamine ethylamine
  • the base is triethylamine.
  • the base is DIPEA.
  • the base is pyridine.
  • the step of decarboxylating the tetraacid can be performed using a
  • the decarboxylation step can be performed using any effective molar ratio of bases greater than the acid number of the tetraacid.
  • a base is added to the reaction solution at a molar/molar ratio between about 0.5 and about 4.0.
  • a base is added to the reaction solution at a molar/molar ratio between about 0.6 and about 2.0.
  • triethylamine is added to the reaction solution at a molar/molar ratio between about 0.6 and about 2.0.
  • the step of decarboxylating the tetraacid can be performed using any one or more suitable solvents.
  • suitable solvents or solutions comprising one or more suitable solvents have boiling temperatures below about 200°C. In another embodiment, suitable solvents or solutions have boiling temperatures below about l50°C.
  • the organic solvent is an aprotic solvent.
  • suitable solvents include, but are not limited to, toluene, tetrahydrofuran (THF), methyl tert- butyl ether (MTBE), dimethylsulfoxide, acetonitrile, l,2-dimethoxy ethane, dioxane, benzene, xylenes, methyl t-butyl ether, methylene chloride, chloroform, methyl ethyl ketone, methyl isobutyl ketone, acetone, acetonitrile, benzene, M, A -di m ethyl form am i de,
  • the organic solvent is toluene. In another particular embodiment, the organic solvent is THF. In another particular embodiment, the organic solvent is MTBE. In another particular embodiment, the organic solvent is xylene. In another particular embodiment, the solution comprises a combination of two or more solvents selected from THF, MTBE, and Xylene.
  • the step of decarboxylating the tetraacid can be performed using any suitable temperature.
  • a suitable temperature is a mild temperature.
  • the decarboxylation is performed at a temperature of at most about 200°C.
  • the decarboxylation is performed at a temperature of at most about l50°C.
  • the decarboxylation is performed at a temperature of at most about 1 lO°C.
  • the decarboxylation is performed at a temperature of at most about 66°C.
  • the decarboxylation is performed at a temperature of at most about 55°C.
  • the decarboxylation is performed at reflux
  • the decarboxylation is performed at the reflux temperature of a reaction solution comprising toluene, xylene, heptane, THF, or MTBE.
  • the decarboxylation is performed at a temperature ranging from about 60°C to about l00°C. In another embodiment, the decarboxylation is performed at a temperature ranging from about l00°C to about 200°C. In another
  • the decarboxylation is performed at a temperature ranging from
  • the decarboxylation is performed at a temperature ranging from about l00°C to about l20°C. In another embodiment, the decarboxylation is performed at a temperature ranging from about 80°C to about l20°C.
  • the decarboxylation is performed at about 1 l0°C. In another embodiment, the decarboxylation is performed at about 66°C. In another
  • the decarboxylation is performed at about 55°C.
  • the tetraacid decarboxylation step can be performed using any suitable effective amount of time.
  • a suitable amount of time can be any time needed for reaction completion.
  • the effective amount of time ranges from about 2 to about
  • the effective amount of time it is between about 2 and about 18 hours. In another embodiment, the effective amount of time is between about 2 and about 12 hours. In another embodiment, the effective amount of time is between about 2 and about 6 hours. In one particular embodiment, the reaction time is about 15 hours. In another particular embodiment the reaction time is about 12 hours.
  • the present invention provides processes for producing azelaic acid in high yield.
  • the invention provides processes for producing azelaic acid in high purified yield.
  • the yield of azelaic acid from the decarboxylation step ranges from about 30% to about 50%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 40% to about 60%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 50% to about 70%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 60% to about 80%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 70% to about 90%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 80% to about 100%.
  • the yield of azelaic acid from the decarboxylation step is greater than about 40%. In another embodiment the yield of azelaic acid from the decarboxylation step is greater than about 70%. In another embodiment the yield of azelaic acid from the decarboxylation step is greater than about 80%. In another embodiment the yield of azelaic acid from the decarboxylation step is greater than about 90%.
  • the yield of azelaic acid from the decarboxylation step is about 40%. In another embodiment the yield of azelaic acid from the decarboxylation step is about 70%. In another embodiment the yield of azelaic acid from the decarboxylation step is about 80%. In another embodiment the yield of azelaic acid from the decarboxylation step is about 90%.
  • Another aspect of the present invention comprises a step of hydrolyzing tetraethylheptane-l,l,7,7-tetracarboxylate (Formula II; tetraester) to form
  • the hydrolyzation step uses any suitable base.
  • the hydrolyzation step uses an inorganic base.
  • the base is sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, cesium carbonate, potassium phosphate, sodium carbonate, sodium phosphate, sodium ethoxide, or potassium tert-butoxide.
  • the base is sodium hydroxide.
  • the base is potassium hydroxide.
  • the base is sodium ethoxide.
  • the step of hydrolyzing the tetraester can be performed using a stoichiometric amount of bases with respect to esters.
  • the step of hydrolyzing the tetraester can be performed using any effective molar ratio of base to tetraester.
  • the effective molar ratio is a base molar ratio greater than one compared to the ester number.
  • the tetraester hydrolysis step can be performed using any suitable base.
  • the hydrolysis step uses a base with a molar ratio greater than about 4 with respect to the ester number.
  • the hydrolysis step uses a base with molar ratio greater than about 6 with respect to the ester number.
  • the hydrolysis step uses a base with molar ratio greater than about 8 with respect to the ester number.
  • the base is at a molar/molar ratio from about 1 to about 8.
  • the base is at a molar/molar ratio from about 1 to about 4.
  • the suitable base is sodium hydroxide with molar ratio greater than about 4 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio greater than about 6 with respect to the ester number.
  • a suitable base is sodium hydroxide with molar ratio greater than about 8 with respect to the ester number.
  • the hydrolysis step uses a base with a molar ratio of about
  • the hydrolysis step uses a base with molar ratio of about 4 to about 6 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio of about 6 to about 8 with respect to the ester number.
  • the suitable base is sodium hydroxide with molar ratio of about 4 to about 8 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 4 to about 6 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 6 to about 8 with respect to the ester number.
  • the hydrolysis step uses a base with a molar ratio of about
  • the hydrolysis step uses a base with molar ratio of about 6 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio of about 8 with respect to the ester number.
  • the suitable base is sodium hydroxide with molar ratio of about 4 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 6 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 8 with respect to the ester number.
  • the tetraester hydrolysis step can be performed using medium having any suitable pH.
  • the pH of the medium could be anything greater than about pH 8.
  • the pH of the medium could be anything greater than about pH 7.
  • pH of the medium is greater than or equal to about pH 8. In another embodiment the pH of the medium is greater than about pH 8. In another embodiment the pH of the medium is greater than about pH 8. In another
  • the pH of the medium is about pH 7 to about pH 8. In another embodiment the pH of the medium is about pH 8 to about pH 9. In another embodiment the pH of the medium is about pH 9 to about pH 10.
  • the step of hydrolyzing the tetraester can be performed using any one or more suitable solvents.
  • the hydrolysis is performed using a solvent having a boiling temperature of at most about l00°C.
  • the hydrolysis is performed using THF, toluene, methanol, dioxane, water, or mixtures thereof.
  • the hydrolysis is performed using a solution of THF and water.
  • the hydrolysis is performed using a solution of about 50% THF and about 50% water.
  • the hydrolysis is performed using a solution of about 40% THF and about 60% water.
  • the hydrolysis is performed using a solution of about 30% THF and about 70% water.
  • the hydrolysis is performed using a solution of about 20% THF and about 80% water.
  • the step of hydrolyzing the tetraester can be performed using any suitable temperature.
  • a suitable temperature is a mild temperature.
  • a suitable temperature is ambient temperature.
  • the hydrolysis is performed at a temperature of at most about l00°C. In one embodiment, the hydrolysis is performed at a temperature of at most about 65°C. In another embodiment, the hydrolysis is performed at a temperature of at most about 45°C. In another embodiment, the hydrolysis is performed at a temperature of at most about 25°C.
  • the hydrolysis is performed at a temperature ranging from about 20°C to about 25°C, about 40°C to about 45°C, about 25°C to about 65°C, or about 35°C to about 55°C.
  • the hydrolysis is performed at a temperature of about
  • the hydrolysis is performed at a temperature of about 45°C. In one particular embodiment, the hydrolysis is performed at ambient temperature. In another particular embodiment, the hydrolysis is performed at reflux temperature.
  • the step of hydrolyzing the tetraester can be performed using any suitable effective amount of time.
  • a suitable amount of time can be any amount of time needed for substantial reaction completion.
  • effective amount of time ranges from about 2 to about 24 hours. In another embodiment, between about 2 and about 18 hours. In another embodiment, the effective amount of time is between about 2 and about 12 hours. In another embodiment, the effective amount of time is between about 2 and about 6 hours. In one particular embodiment the reaction time is 15 hours. In another particular embodiment the reaction time is 12 hours.
  • the yield of tetraacid from the hydrolysis step ranges from about 30% to about 50%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 40% to about 60%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 50% to about 70%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 60% to about 80%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 70% to about 90%. In another embodiment the yield tetraacid from the hydrolysis step ranges from about 80% to about 100%.
  • the yield of tetraacid from the hydrolysis step is greater than about 40%. In another embodiment the yield of tetraacid from the hydrolysis step is greater than about 70%. In another embodiment the yield of tetraacid from the hydrolysis step is greater than about 80%. In another embodiment the yield of tetraacid from the hydrolysis step is greater than about 90%.
  • the yield of tetraacid from the hydrolysis step is about 40%. In another embodiment the yield of tetraacid from the hydrolysis step is about 70%. In another embodiment the yield of tetraacid from the hydrolysis step is about 80%. In another embodiment the yield of tetraacid from the hydrolysis step is about 90%.
  • the tetraacid as it is isolated crude and not purified prior to the decarboxylation step. In another embodiment the tetraacid is isolated crude and purified prior to the decarboxylation step.
  • azelaic acid is extracted from the crude product and purified using an organic solvent. In another aspect, azelaic acid is purified using an organic solvent. In one aspect, azelaic acid is extracted from the crude product and purified using the same organic solvent or combination of solvents.
  • crude azelaic acid is extracted from crude product from an organic solvent, a combination of organic solvents, or a combination of an organic solvent and water.
  • organic solvents include, but are not limited to, ethyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, toluene, methyl t-butyl ether (MTBE), methyl isobutyl ketone, hexane, heptane, and xylene, or 1 -propanol/water (at various ratios).
  • azelaic acid is purified by crystallization from an organic solvent, a combination of organic solvents, or a combination of an organic solvent and water.
  • organic solvents include, but are not limited to, ethyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, toluene, methyl t-butyl ether (MTBE), methyl isobutyl ketone, hexane, heptane, and xylene, or 1 -propanol/water (at various ratios).
  • crude azelaic acid is purified by chromatography.
  • the invention provides a process yielding tetra-acid with high purity. In another aspect, the invention provides a process yielding tetra-acid with high purity prior to purification from crude product. In one embodiment, the tetra-acid product has a purity of at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, or at least about 97%.
  • the tetraacid product has a purity ranging from about 40% to about 60%. In one embodiment, the tetraacid product has a purity ranging from about 60% to about 70%. In one embodiment, the tetraacid product has a purity ranging from about 70% to about 80%. In one embodiment, the tetraacid product has a purity ranging from about 80% to about 90%. In one embodiment, the tetraacid product has a purity ranging from about 90% to about 100%. In one embodiment, the tetraacid product has a purity ranging from about 95% to about 99%. In one embodiment, the tetraacid product has a purity ranging from about 97% to about 99%.
  • the tetraacid product has a purity of about 60%, about
  • the invention provides a process yielding azelaic acid with high purity. In another aspect, the invention provides a process yielding azelaic acid with high purity prior to purification from crude azelaic acid product. In one embodiment, the azelaic acid product has a purity of at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 97%, or at least about 99%. [0080] In one embodiment, the azelaic acid product has a purity ranging from about
  • the azelaic acid product has a purity ranging from about 60% to about 70%. In one embodiment, the azelaic acid product has a purity ranging from about 70% to about 80%. In one embodiment, the azelaic acid product has a purity ranging from about 80% to about 90%. In one embodiment, the azelaic acid product has a purity ranging from about 90% to about 100%. In one embodiment, the azelaic acid product has a purity ranging from about 95% to about 99%. In one embodiment, the azelaic acid product has a purity ranging from about 97% to about 99%.
  • the azelaic acid product has a purity of about 70%, about
  • the azelaic acid product has a purity of at least 99%.
  • the final azelaic acid product has a purity of at least 99.5%, at least 99.7%, or at least 99.9%.
  • the azelaic acid product has a purity of about 99.5%, about 99.7%, about 99.9%, or about 100%.
  • each individual impurity is not more than 1%. In another embodiment each individual impurity is not more than 0.5%, not more than 0.2%, not more than 0.1%, not more than 0.01%, or not more than 0.001%.
  • high purity is greater than 99% pure and each individual impurity is not more than 0.1%. In another embodiment, high purity is greater than 99% pure and each individual impurity is not more than 0.05%.
  • the process is performed at any scale.
  • the process is a large-scale process.
  • the process is a laboratory-scale process.
  • the large-scale process is a kilogram-scale process.
  • the large-scale process is a plant-scale process.
  • the process produces azelaic acid in kilogram-scale (kilo-scale).
  • azelaic acid is produced on a scale of about 0.5kg to about 10 kg.
  • azelaic acid is produced on a scale of about lkg to about 10 kg.
  • azelaic acid is produced on a scale of at least about
  • azelaic acid is produced on a scale of at least about 1 kg. In another embodiment azelaic acid is produced on a scale of at least about 5 kg.
  • the process produces azelaic acid in plant-scale.
  • azelaic acid is produced on a scale of about 10 kg to about 1000 kg.
  • azelaic acid is produced on a scale of about 10 kg to about 100 kg.
  • azelaic acid is produced on a scale of about 100 kg to about 1000 kg.
  • azelaic acid is produced on a scale of at least about
  • azelaic acid is produced on a scale of at least about 100 kg. In another embodiment azelaic acid is produced on a scale of at least about 200 kg. In another embodiment azelaic acid is produced on a scale of at least about 500 kg. In another embodiment azelaic acid is produced on a scale of at least about 1000 kg. In another embodiment azelaic acid is produced on a scale of at least about 2000 kg. In another embodiment azelaic acid is produced on a scale of at least about 5000 kg.
  • Tetraester 50g was charged to the reaction flask. THF 90g and lOOg of sodium hydroxide (50% aqueous solution, w/w) solution were then charged to the flask. The batch was stirred at 30-50°C overnight. After the reaction completion, the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH ⁇ 2, extracted with ethyl acetate to get 35g of the desired crude product. The crude tetraacid product can be purified after the distillation of the solvents under reduced pressure to get the pure product. The product was crystalized using organic ethyl acetate to yield a product having >90% purity.
  • Tetra ester 50g was charged to the reaction flask. THF 90g and lOOg of 50% sodium hydroxide solution were then charged to the flask. The batch was stirred at 30-50°C overnight. After the reaction completion, the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH ⁇ 2, extracted with ethyl acetate and or MTBE to get 35g of the desired crude product. The crude product can be purified after the distillation of the solvents under reduced pressure to get the pure product. The product was crystalized using MTBE to yield a product having >90% purity.
  • Tetra ester 7.6Kg was charged to the reactor.
  • THF l3.5Kg and l5Kg of 50% sodium hydroxide solution and water l0-20Kg were charged to the reactor and stirred at 30- 50°C overnight.
  • the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH ⁇ 2, extracted with ethyl acetate and or MTBE to get the desired crude product.
  • the crude product was purified after the distillation of the solvents under reduced pressure to get the 5.3Kg pure tetraacid product.
  • Tetraester 85Kg was charged to the reactor.
  • THF l5lKg and l68Kg of 50% sodium hydroxide solution and water 224Kg were charged to the reactor and stirred at 30- 50°C overnight.
  • the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH ⁇ 2, and extracted with ethyl acetate and or MTBE to get the desired crude product.
  • the crude product can be purified after the distillation of the solvents under reduced pressure to get 60Kg of the pure tetraacid product.
  • Tetraester (7l00Kg) is charged to the reactor.
  • THF 14000 Kg
  • a 50% sodium hydroxide (28500Kg) and water (l3200Kg) solution are then charged to the reactor.
  • the reaction is stirred at 30-50°C overnight.
  • the product is acidified with concentrated hydrochloric acid (20-36% HC1) to pH ⁇ 2, and extracted with ethyl acetate to get the desired crude product.
  • the crude product is purified after the distillation of the solvents under reduced pressure to get 5l00Kg of the pure product.
  • Tetraacid (30-40g) from example 3 was charged to the flask. Charged toluene
  • Tetraacid (55-70Kg) from Example 6 was charged to a flask. Charged toluene
  • Tetraacid 500Kg is charged to a flask. Toluene (250Kg) is added and some is distilled off to remove water from the reaction. Trimethylamine (730Kg) is added to a reactor equipped with Dean- Stark apparatus and a refluxing condenser. The mixture is stirred vigorously under nitrogen atmosphere. The reaction mixture is refluxed for 12 hours. Heating is stopped, and the reaction is allowed to cool to room temperature. Under vigorous mixing, pH of the reaction is adjusted to below 2. The reaction is cooled to 0-10 °C. The solids are filtered and washed twice with ice cold water. The solids are collected and dried in an oven at 35-45 °C until constant weight. The reaction yields 340Kg of azelaic acid.
  • Tetraacid (5000Kg) is charged to a flask. Toluene (2500Kg) is added and some is distilled off to remove water from the reaction. Trimethylamine (7320Kg) is added to a reactor equipped with Dean- Stark apparatus and a refluxing condenser. The mixture is stirred vigorously under nitrogen atmosphere. The reaction mixture is refluxed for 12 hours. Heating is stopped, and the reaction is allowed to cool to room temperature. Under vigorous mixing, pH of the reaction is adjusted to below 2. The reaction is cooled to 0-10 °C. The solids are filtered and washed twice with ice cold water. The solids are collected and dried in an oven at 35-45 °C until constant weight. The reaction yields 3406Kg of azelaic acid.
  • Ethyl acetate (l750Kg) is then charged to the reactor.
  • the batch mixture is heated to reflux temperature.
  • the hot solution is then transferred through a filter.
  • the filtrates are cooled to l0°C.
  • the solids are filtered and washed twice with MTBE.
  • the wet cake is dried under vacuum at NMT 50 °C to yield 2577kg (97% purity).

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Abstract

This invention concerns a method of synthesizing azelaic acid. Particular reference is made to providing a new synthetic process for preparing azelaic acid in large scale with high purity (e.g., >99.7% with any individual impurity not more than 0.1%), which can be used as an active pharmaceutical ingredient. Particular reference is made to a process comprising the step of decarboxylating heptane-1,1,7,7-tetracarboxylic acid with a mild base to form azelaic acid.

Description

SYNTHESIS OF AZELAIC ACID
FIELD OF THE INVENTION
[0001] This invention concerns a method of synthesizing Azelaic Acid.
BACKGROUND OF THE INVENTION
[0002] Azelaic acid is a saturated aliphatic dicarboxylic acid having the formula:
HOOC-(CH2)7-COOH. It is also known as l,9-nonanedioic acid.
[0003] Azelaic acid is used as a starting material for producing industrial products including polyesters, plasticizers and lubricants. Azelaic acid is also a component of hair- and skin-care products. See , R.H. Liu el al.“Azelaic acid in the treatment of papulopustular rosacea - A systematic review of randomized controlled trials,” Arch. Dermatol ., (2006) 142 (8): 1047-1052. For example, Finacea® (azelaic acid) Gel, 15% (Bayer HealthCare
Pharmaceuticals Inc. Whippany, NJ) is prescribed for topical treatment of mild to moderate rosacea.
[0004] Large scale synthesis of azelaic acid remains challenging.
[0005] Industrially, azelaic acid is produced via ozonolysis of oleic acid followed by dioxygen oxidation, as described by B. Cornils et al. in“Dicarboxylic Acids, Aliphatic: Ullmann's Encyclopedia of Industrial Chemistry,” Wiley (2010); and by E.F. Moran Jr. in “Process for making a C6 to C12 dibasic acid or azelaic acid using ozone generated from carbon dioxide,” US 2003/0010622.
[0006] Other azelaic acid syntheses include those described in E. Antonelli et al .,
“Efficient Oxidative Cleavage of Olefins to Carboxylic Acids with Hydrogen Peroxide Catalyzed by Methyltrioctylammonium Tetrakis(oxodiperoxotungsto) phosphate (3-) under Two-Phase Conditions. Synthetic Aspects and Investigation of the Reaction Course” J. Org. Chem. 1998, 63, 7190-7206; Lemaire et al. in“Method for Preparing Carboxylic Acids by Oxidative Cleavage of a Vicinal Diol” US 2013/0131379; P.L. Alsters,“Process for the Preparation of (Azelaic) Acid from 9-Octadecenedioic Acid,” US 2015/0183704; and S. Dantale et al.“Processes for Making Azelaic Acid and Derivatives Thereof’
US 2016/0145182. These references and all publications cited herein are incorporated by reference in their entirety. [0007] There is a need for new synthetic processes for preparing azelaic acid.
Particularly, there is a need for viable, cost-effective, efficient scale-up procedures for manufacturing high purity azelaic acid under cGMP conditions for use as an active pharmaceutical ingredient.
BRIEF SUMMARY OF THE INVENTION
[0008] The present invention is directed to compositions and methods for
synthesizing azelaic acid.
[0009] The invention provides a process for manufacturing azelaic acid comprising the step of decarboxylating heptane-l,l,7,7-tetracarboxylic acid with a mild base to form azelaic acid.
[0010] In one aspect, the mild base is an organic base. In some embodiments, the mild base is triethylamine, trimethylamine, methylamine, di-isopropyl ethylamine, diethylamine, propylamine, butylamine, tripropylamine, ethylmethylamine, ethylamine, diethylmethylamine, phenylamine, alanine, aniline, ammonia, dimethylaminopyridine or pyridine. In one embodiment the mild base is triethylamine.
[0011] In some embodiments the mild base is at a molar/molar ratio from about 0.6 to about 2.
[0012] In some embodiments the decarboxylation is performed using a solvent having a boiling temperature of at most about 200°C. In some embodiments the decarboxylation is performed at a temperature of at most about 200°C.
[0013] In certain embodiments the solvent is toluene, tetrahydrofuran,
methyl tert-butyl ether, dimethylsulfoxide, acetonitrile, l,2-dimethoxy ethane, dioxane, benzene, xylenes, methyl t-butyl ether, methylene chloride, chloroform, methyl ethyl ketone, methyl isobutyl ketone, acetone, acetonitrile, benzene, A'-di m ethyl form am i de,
/V, Af-di ethyl acetam i de, /V-methylpyrrolidinone, hexane, heptane, or xylene.
[0014] In some embodiments the decarboxylation is performed in lab-scale, kilogram scale or plant-scale.
[0015] In some embodiments the azelaic acid is formed with a purity of
at least about 90%.
[0016] The invention also provides a process for manufacturing azelaic acid comprising the steps of: hydrolyzing tetraethyl heptane- 1,1, 7, 7-tetracarboxylate with an inorganic base to form heptane-l,l,7,7-tetracarboxylic acid; and decarboxylating the heptane- l,l,7,7-tetracarboxylic acid with a mild base thereby forming azelaic acid. [0017] In some embodiments, the heptane-l,l,7,7-tetracarboxylic acid, resulting from the hydrolysis step, is isolated prior to the decarboxylating step. In some embodiments, the hydrolyzing step and the decarboxylating step are performed in situ.
[0018] In some embodiments, the inorganic base is sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, cesium carbonate, potassium phosphate, sodium carbonate, sodium phosphate, sodium ethoxide, or potassium tert-butoxide. In some embodiment, the inorganic base is sodium hydroxide. In one embodiment, the inorganic base is at a molar/molar ratio from about 1 to about 4.
[0019] In some embodiments, the hydrolysis is performed using a solvent having a boiling temperature of at most about l00°C. In some embodiments, the hydrolysis is performed using THF, toluene, methanol, dioxane, water, or mixtures thereof.
[0020] In some embodiments, the hydrolysis is performed at ambient temperature.
[0021] The invention also provides a process for manufacturing azelaic acid comprising the steps of: reacting l,5-dibromopentane with diethylmalonate to form tetraethyl heptane-l,l,7,7-tetracarboxylate; hydrolyzing the tetraethyl heptane-l,l,7,7-tetracarboxylate with an inorganic base to form heptane-l,l,7,7-tetracarboxylic acid; and decarboxylating the heptane-l,l,7,7-tetracarboxylic acid with a mild base to form azelaic acid.
DETAILED DESCRIPTION OF THE INVENTION
[0022] The present invention provides several advantages over prior syntheses of azelaic acid.
[0023] (i) The present invention provides more mild processes for producing azelaic acid. In one aspect, the process comprises a mild decarboxylation step. In another aspect, the process comprises a mild hydrolysis step. In one embodiment, the decarboxylation step uses a mild base. In one nonlimiting example, the decarboxylation step uses an organic base such as trimethylamine as a very mild base compared to the previous use of strong acids.
In another embodiment, the decarboxylation step uses a mild temperature. In one nonlimiting example, the decarboxylation step uses a solution of toluene refluxed between about l00°C and about 1 l0°C, which is much milder than other reports of very high temperature of >200°C.
[0024] (ii) The present invention provides a safer process. The process is safer because reaction conditions such as lower temperatures (e.g., <200°C) are less hazardous and therefore less risky. Furthermore, the milder processes of the present invention are less damaging to manufacturing equipment.
[0025] (iii) The present invention provides more cost-effective processes because raw-materials are inexpensive and readily available. Furthermore, the processes do not require special equipment, such as equipment for cryogenic conditions or high-pressure conditions.
[0026] (iv) The present invention provides an industrially viable scale up because batches can be consistently scaled to kilogram-scale (e.g., 100 kg - 200 kg) and plant-scale (e.g., <1,000 kg).
[0027] (v) The present invention provides processes that apply to Good
Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) conditions.
[0028] (vi) The present invention provides processes for producing azelaic acid in higher yield.
[0029] (vii) The present invention provides processes for producing azelaic acid in higher purity. [0030] The term“azelaic acid” shall mean l,9-nonanedioic acid, which has Chemical
Abstracts Service (CAS) Registry Number: 123-99-9. Azelaic acid is also known as l,7-heptanedicarboxylic acid. Azelaic acid has the formula: HOOC-(CH2)7-COOH and is illustrated by the following chemical structure (I):
Figure imgf000007_0001
[0031] Azelaic acid shall include, but not be limited to, salts, isoforms, isotopes, and formulations thereof.
[0032] Non-limiting examples of azelaic acid salts can include its disodium salt or ammonium salt. Non-limiting examples of isotopes of azelaic acid may have the replacement of hydrogen by deuterium or tritium, or have the replacement of a carbon by a UC- ,13C- or 14C-enriched carbon. Non-limiting examples of azelaic acid esters are methyl, ethyl and other alkylesters.
Decarboxylation of Tetraacid
[0033] One aspect of the present invention comprises a step of decarboxylating heptane-l, l,7,7-tetracarboxylic acid (Formula III; tetraacid) to form azelaic acid (I).
Figure imgf000007_0002
Decarboxylation Base
[0034] The decarboxylation step uses any suitable base. In some embodiments, the decarboxylation step uses any suitable mild base. In some embodiments, the suitable mild base has a pKb of about 10 or less. In some embodiments, the suitable mild base has a pKb of less than 10 (pKb <10). In some embodiments, the mild base is an organic base.
[0035] Examples of organic bases, include but are not limited to, triethylamine (TEA,
Et3N), trimethyl amine, methylamine, di-isopropyl ethylamine (DIPEA), diethylamine, propylamine, butylamine, tripropylamine, ethylmethylamine, ethylamine,
diethylmethylamine, phenylamine, alanine, aniline, ammonia, dimethylaminopyridine (DMAP) or pyridine. In one particular embodiment, the base is triethylamine. In another particular embodiment, the base is DIPEA. In another particular embodiment, the base is pyridine.
[0036] The step of decarboxylating the tetraacid can be performed using a
stoichiometric amount of bases with respect to carboxylic acids. In one embodiment, the decarboxylation step can be performed using any effective molar ratio of bases greater than the acid number of the tetraacid. In one embodiment, a base is added to the reaction solution at a molar/molar ratio between about 0.5 and about 4.0. In another embodiment, a base is added to the reaction solution at a molar/molar ratio between about 0.6 and about 2.0. In another embodiment, triethylamine is added to the reaction solution at a molar/molar ratio between about 0.6 and about 2.0.
Decarboxylation Solvent
[0037] The step of decarboxylating the tetraacid, can be performed using any one or more suitable solvents.
[0038] In one embodiment, suitable solvents or solutions comprising one or more suitable solvents, have boiling temperatures below about 200°C. In another embodiment, suitable solvents or solutions have boiling temperatures below about l50°C.
[0039] In one embodiment, the organic solvent is an aprotic solvent. Examples of suitable solvents include, but are not limited to, toluene, tetrahydrofuran (THF), methyl tert- butyl ether (MTBE), dimethylsulfoxide, acetonitrile, l,2-dimethoxy ethane, dioxane, benzene, xylenes, methyl t-butyl ether, methylene chloride, chloroform, methyl ethyl ketone, methyl isobutyl ketone, acetone, acetonitrile, benzene, M, A -di m ethyl form am i de,
A X-di ethyl acetam i de, or A - ethyl pyrrol idi none, hexane, heptane, or xylene.
[0040] In one particular embodiment, the organic solvent is toluene. In another particular embodiment, the organic solvent is THF. In another particular embodiment, the organic solvent is MTBE. In another particular embodiment, the organic solvent is xylene. In another particular embodiment, the solution comprises a combination of two or more solvents selected from THF, MTBE, and Xylene.
Decarboxylation Temperature
[0041] The step of decarboxylating the tetraacid, can be performed using any suitable temperature. In one aspect, a suitable temperature is a mild temperature. In one embodiment, the decarboxylation is performed at a temperature of at most about 200°C. In another embodiment, the decarboxylation is performed at a temperature of at most about l50°C. In another embodiment, the decarboxylation is performed at a temperature of at most about 1 lO°C. In another embodiment, the decarboxylation is performed at a temperature of at most about 66°C. In another embodiment, the decarboxylation is performed at a temperature of at most about 55°C.
[0042] In another embodiment, the decarboxylation is performed at reflux
temperature. In another embodiment, the decarboxylation is performed at the reflux temperature of a reaction solution comprising toluene, xylene, heptane, THF, or MTBE.
[0043] In another embodiment, the decarboxylation is performed at a temperature ranging from about 60°C to about l00°C. In another embodiment, the decarboxylation is performed at a temperature ranging from about l00°C to about 200°C. In another
embodiment, the decarboxylation is performed at a temperature ranging from
about 1 l0°C to about l30°C. In another embodiment, the decarboxylation is performed at a temperature ranging from about l00°C to about l20°C. In another embodiment, the decarboxylation is performed at a temperature ranging from about 80°C to about l20°C.
[0044] In another embodiment, the decarboxylation is performed at about 1 l0°C. In another embodiment, the decarboxylation is performed at about 66°C. In another
embodiment, the decarboxylation is performed at about 55°C.
Decarboxylation Time
[0045] The tetraacid decarboxylation step can be performed using any suitable effective amount of time. A suitable amount of time can be any time needed for reaction completion.
[0046] In one embodiment, the effective amount of time ranges from about 2 to about
24 hours. In another embodiment, the effective amount of time it is between about 2 and about 18 hours. In another embodiment, the effective amount of time is between about 2 and about 12 hours. In another embodiment, the effective amount of time is between about 2 and about 6 hours. In one particular embodiment, the reaction time is about 15 hours. In another particular embodiment the reaction time is about 12 hours. Decarboxylation Yield
[0047] The present invention provides processes for producing azelaic acid in high yield. In one aspect, the invention provides processes for producing azelaic acid in high purified yield.
[0048] In one embodiment the yield of azelaic acid from the decarboxylation step ranges from about 30% to about 50%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 40% to about 60%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 50% to about 70%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 60% to about 80%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 70% to about 90%. In another embodiment the yield of azelaic acid from the decarboxylation step ranges from about 80% to about 100%.
[0049] In one embodiment the yield of azelaic acid from the decarboxylation step is greater than about 40%. In another embodiment the yield of azelaic acid from the decarboxylation step is greater than about 70%. In another embodiment the yield of azelaic acid from the decarboxylation step is greater than about 80%. In another embodiment the yield of azelaic acid from the decarboxylation step is greater than about 90%.
[0050] In one embodiment the yield of azelaic acid from the decarboxylation step is about 40%. In another embodiment the yield of azelaic acid from the decarboxylation step is about 70%. In another embodiment the yield of azelaic acid from the decarboxylation step is about 80%. In another embodiment the yield of azelaic acid from the decarboxylation step is about 90%.
Hydrolysis of Tetraester
[0051] Another aspect of the present invention comprises a step of hydrolyzing tetraethylheptane-l,l,7,7-tetracarboxylate (Formula II; tetraester) to form
heptane-l,l,7,7-tetracarboxylic acid (Formula III; tetraacid).
Figure imgf000010_0001
Hydrolysis Base [0052] In some embodiments, the hydrolyzation step uses any suitable base. In some embodiments, the hydrolyzation step uses an inorganic base. In one embodiment, the base is sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, cesium carbonate, potassium phosphate, sodium carbonate, sodium phosphate, sodium ethoxide, or potassium tert-butoxide. In one particular embodiment the base is sodium hydroxide. In another particular embodiment the base is potassium hydroxide. In another particular embodiment the base is sodium ethoxide.
[0053] The step of hydrolyzing the tetraester can be performed using a stoichiometric amount of bases with respect to esters. The step of hydrolyzing the tetraester can be performed using any effective molar ratio of base to tetraester. In one embodiment the effective molar ratio is a base molar ratio greater than one compared to the ester number.
[0054] The tetraester hydrolysis step can be performed using any suitable base. In one embodiment, the hydrolysis step uses a base with a molar ratio greater than about 4 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio greater than about 6 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio greater than about 8 with respect to the ester number.
[0055] In one embodiment, the base is at a molar/molar ratio from about 1 to about 8.
In one embodiment, the base is at a molar/molar ratio from about 1 to about 4.
[0056] In one embodiment, the suitable base is sodium hydroxide with molar ratio greater than about 4 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio greater than about 6 with respect to the ester number.
In another embodiment, a suitable base is sodium hydroxide with molar ratio greater than about 8 with respect to the ester number.
[0057] In one embodiment, the hydrolysis step uses a base with a molar ratio of about
4 to about 8 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio of about 4 to about 6 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio of about 6 to about 8 with respect to the ester number.
[0058] In one embodiment, the suitable base is sodium hydroxide with molar ratio of about 4 to about 8 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 4 to about 6 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 6 to about 8 with respect to the ester number.
[0059] In one embodiment, the hydrolysis step uses a base with a molar ratio of about
4 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio of about 6 with respect to the ester number. In another embodiment, the hydrolysis step uses a base with molar ratio of about 8 with respect to the ester number.
[0060] In one embodiment, the suitable base is sodium hydroxide with molar ratio of about 4 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 6 with respect to the ester number. In another embodiment, a suitable base is sodium hydroxide with molar ratio of about 8 with respect to the ester number.
[0061] The tetraester hydrolysis step can be performed using medium having any suitable pH. In one embodiment the pH of the medium could be anything greater than about pH 8. In one embodiment the pH of the medium could be anything greater than about pH 7.
In another embodiment the pH of the medium is greater than or equal to about pH 8. In another embodiment the pH of the medium is greater than about pH 8. In another
embodiment the pH of the medium is about pH 7 to about pH 8. In another embodiment the pH of the medium is about pH 8 to about pH 9. In another embodiment the pH of the medium is about pH 9 to about pH 10.
Hydrolysis Solvent
[0062] The step of hydrolyzing the tetraester, can be performed using any one or more suitable solvents. In one embodiment, the hydrolysis is performed using a solvent having a boiling temperature of at most about l00°C. In one embodiment, the hydrolysis is performed using THF, toluene, methanol, dioxane, water, or mixtures thereof. In one embodiment, the hydrolysis is performed using a solution of THF and water. In another embodiment, the hydrolysis is performed using a solution of about 50% THF and about 50% water. In another embodiment, the hydrolysis is performed using a solution of about 40% THF and about 60% water. In another embodiment, the hydrolysis is performed using a solution of about 30% THF and about 70% water. In another, the hydrolysis is performed using a solution of about 20% THF and about 80% water. Hydrolysis Temperature
[0063] The step of hydrolyzing the tetraester, can be performed using any suitable temperature. In one aspect, a suitable temperature is a mild temperature. In another aspect, a suitable temperature is ambient temperature.
[0064] In one embodiment, the hydrolysis is performed at a temperature of at most about l00°C. In one embodiment, the hydrolysis is performed at a temperature of at most about 65°C. In another embodiment, the hydrolysis is performed at a temperature of at most about 45°C. In another embodiment, the hydrolysis is performed at a temperature of at most about 25°C.
[0065] In another embodiment, the hydrolysis is performed at a temperature ranging from about 20°C to about 25°C, about 40°C to about 45°C, about 25°C to about 65°C, or about 35°C to about 55°C.
[0066] In another embodiment, the hydrolysis is performed at a temperature of about
25°C. In another embodiment, the hydrolysis is performed at a temperature of about 45°C. In one particular embodiment, the hydrolysis is performed at ambient temperature. In another particular embodiment, the hydrolysis is performed at reflux temperature.
Hydrolysis Time
[0067] The step of hydrolyzing the tetraester, can be performed using any suitable effective amount of time. A suitable amount of time can be any amount of time needed for substantial reaction completion.
[0068] In one embodiment, effective amount of time ranges from about 2 to about 24 hours. In another embodiment, between about 2 and about 18 hours. In another embodiment, the effective amount of time is between about 2 and about 12 hours. In another embodiment, the effective amount of time is between about 2 and about 6 hours. In one particular embodiment the reaction time is 15 hours. In another particular embodiment the reaction time is 12 hours. Hydrolysis Yield
[0069] In one embodiment the yield of tetraacid from the hydrolysis step ranges from about 30% to about 50%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 40% to about 60%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 50% to about 70%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 60% to about 80%. In another embodiment the yield of tetraacid from the hydrolysis step ranges from about 70% to about 90%. In another embodiment the yield tetraacid from the hydrolysis step ranges from about 80% to about 100%.
[0070] In one embodiment the yield of tetraacid from the hydrolysis step is greater than about 40%. In another embodiment the yield of tetraacid from the hydrolysis step is greater than about 70%. In another embodiment the yield of tetraacid from the hydrolysis step is greater than about 80%. In another embodiment the yield of tetraacid from the hydrolysis step is greater than about 90%.
In one embodiment the yield of tetraacid from the hydrolysis step is about 40%. In another embodiment the yield of tetraacid from the hydrolysis step is about 70%. In another embodiment the yield of tetraacid from the hydrolysis step is about 80%. In another embodiment the yield of tetraacid from the hydrolysis step is about 90%.
Isolation of tetraacid
[0071] In one embodiment the tetraacid as it is isolated crude and not purified prior to the decarboxylation step. In another embodiment the tetraacid is isolated crude and purified prior to the decarboxylation step.
Purification
[0072] In one aspect, azelaic acid is extracted from the crude product and purified using an organic solvent. In another aspect, azelaic acid is purified using an organic solvent. In one aspect, azelaic acid is extracted from the crude product and purified using the same organic solvent or combination of solvents.
[0073] In some embodiments, crude azelaic acid is extracted from crude product from an organic solvent, a combination of organic solvents, or a combination of an organic solvent and water. Examples of organic solvents include, but are not limited to, ethyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, toluene, methyl t-butyl ether (MTBE), methyl isobutyl ketone, hexane, heptane, and xylene, or 1 -propanol/water (at various ratios).
[0074] In some embodiments, azelaic acid is purified by crystallization from an organic solvent, a combination of organic solvents, or a combination of an organic solvent and water. Examples of organic solvents include, but are not limited to, ethyl acetate, isopropyl acetate, butyl acetate, isobutyl acetate, toluene, methyl t-butyl ether (MTBE), methyl isobutyl ketone, hexane, heptane, and xylene, or 1 -propanol/water (at various ratios).
[0075] In other embodiments, crude azelaic acid is purified by chromatography.
Tetraacid Purity
[0076] In one aspect, the invention provides a process yielding tetra-acid with high purity. In another aspect, the invention provides a process yielding tetra-acid with high purity prior to purification from crude product. In one embodiment, the tetra-acid product has a purity of at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, or at least about 97%.
[0077] In one embodiment, the tetraacid product has a purity ranging from about 40% to about 60%. In one embodiment, the tetraacid product has a purity ranging from about 60% to about 70%. In one embodiment, the tetraacid product has a purity ranging from about 70% to about 80%. In one embodiment, the tetraacid product has a purity ranging from about 80% to about 90%. In one embodiment, the tetraacid product has a purity ranging from about 90% to about 100%. In one embodiment, the tetraacid product has a purity ranging from about 95% to about 99%. In one embodiment, the tetraacid product has a purity ranging from about 97% to about 99%.
[0078] In one embodiment, the tetraacid product has a purity of about 60%, about
70%, about 80%, about 90%, about 95%, about 97%, or about 99%.
Azelaic Acid Purity
[0079] In one aspect, the invention provides a process yielding azelaic acid with high purity. In another aspect, the invention provides a process yielding azelaic acid with high purity prior to purification from crude azelaic acid product. In one embodiment, the azelaic acid product has a purity of at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 97%, or at least about 99%. [0080] In one embodiment, the azelaic acid product has a purity ranging from about
40% to about 60%. In one embodiment, the azelaic acid product has a purity ranging from about 60% to about 70%. In one embodiment, the azelaic acid product has a purity ranging from about 70% to about 80%. In one embodiment, the azelaic acid product has a purity ranging from about 80% to about 90%. In one embodiment, the azelaic acid product has a purity ranging from about 90% to about 100%. In one embodiment, the azelaic acid product has a purity ranging from about 95% to about 99%. In one embodiment, the azelaic acid product has a purity ranging from about 97% to about 99%.
[0081] In one embodiment, the azelaic acid product has a purity of about 70%, about
80%, about 90%, about 95%, about 97%, or about 99%.
[0082] In another embodiment, the azelaic acid product has a purity of at least 99%.
In another embodiment, the final azelaic acid product has a purity of at least 99.5%, at least 99.7%, or at least 99.9%.
[0083] In another embodiment, the azelaic acid product has a purity of about 99.5%, about 99.7%, about 99.9%, or about 100%.
[0084] In one embodiment each individual impurity is not more than 1%. In another embodiment each individual impurity is not more than 0.5%, not more than 0.2%, not more than 0.1%, not more than 0.01%, or not more than 0.001%.
[0085] In one particular embodiment, high purity is greater than 99% pure and each individual impurity is not more than 0.1%. In another embodiment, high purity is greater than 99% pure and each individual impurity is not more than 0.05%.
Scale of Synthesis
[0086] In one aspect of the present invention, the process is performed at any scale.
In one aspect of the present invention, the process is a large-scale process. In a further aspect of the present invention, the process is a laboratory-scale process. In a further aspect of the present invention, the large-scale process is a kilogram-scale process. In a further aspect of the present invention, the large-scale process is a plant-scale process.
[0087] In some embodiments of the present invention, the process produces azelaic acid in kilogram-scale (kilo-scale). In one embodiment azelaic acid is produced on a scale of about 0.5kg to about 10 kg. In another embodiment azelaic acid is produced on a scale of about lkg to about 10 kg. [0088] In another embodiment azelaic acid is produced on a scale of at least about
0.5 kg. In another embodiment azelaic acid is produced on a scale of at least about 1 kg. In another embodiment azelaic acid is produced on a scale of at least about 5 kg.
[0089] In some embodiment of the present invention, the process produces azelaic acid in plant-scale. In one embodiment azelaic acid is produced on a scale of about 10 kg to about 1000 kg. In another embodiment azelaic acid is produced on a scale of about 10 kg to about 100 kg. In another embodiment azelaic acid is produced on a scale of about 100 kg to about 1000 kg.
[0090] In another embodiment azelaic acid is produced on a scale of at least about
10 kg. In another embodiment azelaic acid is produced on a scale of at least about 100 kg. In another embodiment azelaic acid is produced on a scale of at least about 200 kg. In another embodiment azelaic acid is produced on a scale of at least about 500 kg. In another embodiment azelaic acid is produced on a scale of at least about 1000 kg. In another embodiment azelaic acid is produced on a scale of at least about 2000 kg. In another embodiment azelaic acid is produced on a scale of at least about 5000 kg.
EXAMPLES
[0091] Examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way.
Example 1.
Synthesis of Tetraester - Kilo scale
[0092] Diethylmalonate 10.6kg was refluxed with sodium ethoxide under nitrogen atmosphere. While refluxing, l,5-dibromopentane (5kg) was added slowly and continued refluxing until the reaction completion. Reaction was quenched by adding MTBE and water and stirring the whole mixture. The organic (top) layer was separated and stored in a container. The aqueous (bottom) layer was extracted twice with MTBE. All MTBE layers were combined and washed with water. Organic MTBE (top) layer was separated and concentrated under reduced pressure until all solvents and residual diethylmalonate were distilled out to concentrated oil with quantitative yield (>95%).
Example 2.
Synthesis of Tetraester - Plant scale
[0093] Sodium ethoxide solution (740Kg) was charged to the reactor.
Diethylmalonate (520Kg) was charged to the reactor slowly over a period of 30 minutes. Heated the batch to reflux for 30 minutes. Charged l,5-dibromopentane (250Kg) slowly. The batch was stirred at reflux lhour. The reaction was cooled to ambient temperature. MTBE and purified water were added. The batch was cooled down to below l0°C and the MTBE layer was extracted. The process was repeated twice. The combined organic layers were washed with purified water and concentrated to a thick oil under reduced pressure removing the residual malonate and any solvents to get thick oil with quantitative yield (>95%). Example 3.
Hydrolysis of Tetraester - R&D scale
[0094] Tetraester 50g was charged to the reaction flask. THF 90g and lOOg of sodium hydroxide (50% aqueous solution, w/w) solution were then charged to the flask. The batch was stirred at 30-50°C overnight. After the reaction completion, the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH < 2, extracted with ethyl acetate to get 35g of the desired crude product. The crude tetraacid product can be purified after the distillation of the solvents under reduced pressure to get the pure product. The product was crystalized using organic ethyl acetate to yield a product having >90% purity.
Example 4.
Hydrolysis of Tetraester - R&D scale
[0095] Tetra ester 50g was charged to the reaction flask. THF 90g and lOOg of 50% sodium hydroxide solution were then charged to the flask. The batch was stirred at 30-50°C overnight. After the reaction completion, the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH < 2, extracted with ethyl acetate and or MTBE to get 35g of the desired crude product. The crude product can be purified after the distillation of the solvents under reduced pressure to get the pure product. The product was crystalized using MTBE to yield a product having >90% purity.
Example 5.
Hydrolysis of Tetraester - Kilo scale
[0096] Tetra ester 7.6Kg was charged to the reactor. THF l3.5Kg and l5Kg of 50% sodium hydroxide solution and water l0-20Kg were charged to the reactor and stirred at 30- 50°C overnight. After the reaction completion, the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH < 2, extracted with ethyl acetate and or MTBE to get the desired crude product. The crude product was purified after the distillation of the solvents under reduced pressure to get the 5.3Kg pure tetraacid product. Example 6.
Hydrolysis of Tetraester - Plant scale
[0097] Tetraester 85Kg was charged to the reactor. THF l5lKg and l68Kg of 50% sodium hydroxide solution and water 224Kg were charged to the reactor and stirred at 30- 50°C overnight. After the reaction completion, the product was acidified with concentrated hydrochloric acid (20-36% HC1) to pH < 2, and extracted with ethyl acetate and or MTBE to get the desired crude product. The crude product can be purified after the distillation of the solvents under reduced pressure to get 60Kg of the pure tetraacid product.
Example 7.
Hydrolysis of Tetraester, Plant scale
[0098] Tetraester (7l00Kg) is charged to the reactor. THF (14000 Kg) is added to the reactor. A 50% sodium hydroxide (28500Kg) and water (l3200Kg) solution are then charged to the reactor. The reaction is stirred at 30-50°C overnight. After the reaction completion, the product is acidified with concentrated hydrochloric acid (20-36% HC1) to pH < 2, and extracted with ethyl acetate to get the desired crude product. The crude product is purified after the distillation of the solvents under reduced pressure to get 5l00Kg of the pure product.
Example 8.
Decarboxylation of Tetraacid - Lab Scale
[0099] Tetraacid (30-40g) from example 3 was charged to the flask. Charged toluene
(420g) and distilled off some to remove water from the reaction. Adjusted toluene and charged trimethyl amine (66g) to a reactor equipped with Dean-Stark apparatus and a refluxing condenser. Stirred the mixture vigorously under nitrogen atmosphere. Refluxed the reaction mixture for at least 12 hours. Stopped heating and allowed the reaction to cool to room temperature. Under vigorous mixing, adjusted the pH of the reaction to below 2.
Allowed the reaction to cool to room temperature and then cooled the reaction to 0-10 °C. Filtered the solids and washed twice with ice cold water. Collected the solids and dry in an oven at 35-45 °C until constant weight. The reaction yielded 20g of azelaic acid. Example 9.
Decarboxylation of Tetraacid - Plant scale
[0100] Tetraacid (55-70Kg) from Example 6 was charged to a flask. Charged toluene
(370Kg) and distilled off some to remove water from the reaction. Adjusted toluene and charged trimethylamine (56Kg) to a reactor equipped with Dean-Stark apparatus and a refluxing condenser. Stirred the mixture vigorously under nitrogen atmosphere. Refluxed the reaction mixture for at least 12 hours. Stopped heating and allowed the reaction to cool to room temperature. Under vigorous mixing, adjusted the pH of the reaction to below 2.
Allowed the reaction to cool to room temperature and then cooled the reaction to 0-10 °C. Filtered the solids and washed twice with ice cold water. Collected the solids and dried the solid in an oven at 35-45 °C until constant weight. The reaction yielded 35Kg of azelaic acid.
Example 10.
Decarboxylation of Tetraacid - Plant scale
[0101] Tetraacid (500Kg) is charged to a flask. Toluene (250Kg) is added and some is distilled off to remove water from the reaction. Trimethylamine (730Kg) is added to a reactor equipped with Dean- Stark apparatus and a refluxing condenser. The mixture is stirred vigorously under nitrogen atmosphere. The reaction mixture is refluxed for 12 hours. Heating is stopped, and the reaction is allowed to cool to room temperature. Under vigorous mixing, pH of the reaction is adjusted to below 2. The reaction is cooled to 0-10 °C. The solids are filtered and washed twice with ice cold water. The solids are collected and dried in an oven at 35-45 °C until constant weight. The reaction yields 340Kg of azelaic acid.
Example 11.
Decarboxylation of Tetraacid - Plant scale
[0102] Tetraacid (5000Kg) is charged to a flask. Toluene (2500Kg) is added and some is distilled off to remove water from the reaction. Trimethylamine (7320Kg) is added to a reactor equipped with Dean- Stark apparatus and a refluxing condenser. The mixture is stirred vigorously under nitrogen atmosphere. The reaction mixture is refluxed for 12 hours. Heating is stopped, and the reaction is allowed to cool to room temperature. Under vigorous mixing, pH of the reaction is adjusted to below 2. The reaction is cooled to 0-10 °C. The solids are filtered and washed twice with ice cold water. The solids are collected and dried in an oven at 35-45 °C until constant weight. The reaction yields 3406Kg of azelaic acid.
Example 12.
Purification of Azelaic Acid - R&D lab scale
[0103] Crude Azelaic acid (32g) from example 8 and charcoal (3.2g) were charged to the reactor. Ethyl acetate (l75Kg) was charged to the reactor and the reaction mixture was heated to reflux temperature. The hot solution was transferred through a cloth or paper filter. The filtrates to 0-10 °C. The solids were filtered and washed twice with MTBE. The wet cake was dried under vacuum at NMT 50 °C to yield 29g of azelaic acid (99% purity) with not more than 0.5% of other individual impurities.
Example 13.
Purification of Azelaic Acid - Plant scale
[0104] Crude Azelaic acid (32Kg) from example 8 and charcoal (3.2Kg) were charged to the reactor. Ethyl acetate (l75Kg) was charged to the reactor and the reaction mixture was heated to reflux temperature. The hot solution was transferred through a filter. The filtrates to 0-10 °C. The solids were filtered and washed twice with MTBE. The wet cake was dried under vacuum at NMT 50 °C to yield 25kg of azelaic acid (99% purity) with not more than 0.1% individual impurities.
Example 14.
Purification of Azelaic Acid - Plant scale
[0105] Crude azelaic acid (3200Kg) and charcoal (320Kg) are charged to the reactor.
Ethyl acetate (l750Kg) is then charged to the reactor. The batch mixture is heated to reflux temperature. The hot solution is then transferred through a filter. The filtrates are cooled to l0°C. The solids are filtered and washed twice with MTBE. The wet cake is dried under vacuum at NMT 50 °C to yield 2577kg (97% purity).

Claims

CLAIMS What is claimed is:
1. A process for manufacturing azelaic acid comprising the step of:
(a) decarboxylating heptane- 1,1, 7, 7-tetracarboxylic acid with a mild base;
thereby forming azelaic acid.
2. The process of Claim 1, wherein the mild base is an organic base.
3. The process of Claim 1, wherein the mild base is triethylamine, trimethylamine, methylamine, di-isopropyl ethylamine, diethylamine, propylamine, butylamine, tripropylamine, ethylmethylamine, ethylamine, diethylmethylamine, phenylamine, alanine, aniline, ammonia, dimethylaminopyridine or pyridine.
4. The process of Claim 1, wherein the mild base is triethylamine.
5. The process of Claim 1, wherein the mild base is at a molar/molar ratio from about
0.6 to about 2.
6. The process of Claim 1, wherein the decarboxylation is performed using a solvent having a boiling temperature of at most about 200°C.
7. The process of Claim 1, wherein the solvent is toluene, tetrahydrofuran,
methyl tert-butyl ether, dimethylsulfoxide, acetonitrile, l,2-dimethoxy ethane, dioxane, benzene, xylenes, methyl t-butyl ether, methylene chloride, chloroform, methyl ethyl ketone, methyl isobutyl ketone, acetone, acetonitrile, benzene,
N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidinone, hexane, heptane, or xylene.
8. The process of Claim 1, wherein the decarboxylation is performed at a temperature of at most about 200°C.
9. The process of Claim 1, wherein decarboxylation is performed in lab-scale, kilogram scale or plant-scale.
10. The process of Claim 1, wherein the azelaic acid is formed with a purity of at least about 90%.
11. The process of Claim 1, further comprising the step of:
(b) hydrolyzing tetraethyl heptane- 1,1, 7, 7-tetracarboxylate with an inorganic base to form heptane-l,l,7,7-tetracarboxylic acid.
12. The process of claim 11, wherein the heptane-l,l,7,7-tetracarboxylic acid resulting from the hydrolyzing step (b) is isolated prior to the decarboxylating step (a).
13. The process of claim 11, wherein the hydrolyzing step (b) and the decarboxylating step (a) are performed in situ.
14. The process of Claim 11, wherein the inorganic base is sodium hydroxide, potassium hydroxide, lithium hydroxide, potassium carbonate, cesium carbonate, potassium phosphate, sodium carbonate, sodium phosphate, sodium ethoxide, or
potassium tert-butoxide.
15. The process of Claim 11, wherein the inorganic base is sodium hydroxide.
16. The process of Claim 11, wherein the inorganic base is at a molar/molar ratio from about 1 to about 4.
17. The process of Claim 11, wherein the hydrolysis is performed using a solvent having a boiling temperature of at most about l00°C.
18. The process of Claim 11, wherein the hydrolysis is performed using THF, toluene, methanol, dioxane, water, or mixtures thereof.
19. The process of Claim 11, wherein the hydrolysis is performed at ambient temperature.
20. The process of Claim 11, further comprising the step of: (c) reacting
l,5-dibromopentane with diethylmalonate to form tetraethyl heptane-l, 1,7,7- tetracarboxylate.
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