WO2021104258A1 - 一种组织处理设备 - Google Patents
一种组织处理设备 Download PDFInfo
- Publication number
- WO2021104258A1 WO2021104258A1 PCT/CN2020/131122 CN2020131122W WO2021104258A1 WO 2021104258 A1 WO2021104258 A1 WO 2021104258A1 CN 2020131122 W CN2020131122 W CN 2020131122W WO 2021104258 A1 WO2021104258 A1 WO 2021104258A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- box
- elastic
- tissue processing
- processing device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N2001/315—Basket-type carriers for tissues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00425—Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
Definitions
- Fig. 1 is a perspective view of a tissue processing device according to an embodiment of the present disclosure
- the tissue processing device 100 according to an embodiment of the present disclosure will be described below according to FIGS. 1 to 3.
- the tissue processing apparatus 100 includes: a box body for carrying tissue; a box body container 10, the box body is received in the box body container 10; a workbench 20 ,
- the workbench 20 has an upper side and a lower side that are relatively disposed, and the box container 10 is movably disposed on the upper side of the workbench 20; and the elastic container 30 is disposed on the lower side of the workbench 20, wherein the workbench 20 defines a through hole 22, the box container 10 can communicate with the elastic container 30 through the through hole 22, and the elastic container 30 is configured to squeeze the reagent contained in the elastic container 30 into the box container 10 when the elastic container 30 is deformed, When the elastic container 30 is restored, the reagent in the cassette container 10 is sucked into the elastic container 30.
- the box container 10 is formed with an opening at the lower part, and the opening of the box container 10 can be aligned with the through hole 22 of the workbench 20.
- the elastic container 10 can communicate with the box container 10 through the through hole 22 of the workbench 20 and the opening of the box container 10.
- the top of the box container 10 has an opening 12, and the reagent is filled into the elastic container 30 and the box container 10 through the opening 12.
- the tissue processing device 100 further includes a container cover 40 that is detachably mounted to the box container 10 to seal the opening 12, so that the box container 10, the elastic container 30, and the container
- the cover 40 may form a sealed cavity.
- the tissue processing apparatus 100 further includes a suction device or a pressurizing device.
- the suction device or pressurizing device is operably disposed above the cassette container 10 and is configured to operatively pump The gas in the sealed cavity is sucked or inflated into the sealed cavity, thereby establishing a vacuum or pressure in the sealed cavity.
- the tissue can be more fully immersed in the reagent, and the quality of the tissue can be improved.
- the tissue processing apparatus 100 further includes a dispensing nozzle 50, which is operably disposed above the box container 10 and configured to face the box container 10 and the elastic container Fill 30 with reagents.
- a dispensing nozzle 50 which is operably disposed above the box container 10 and configured to face the box container 10 and the elastic container Fill 30 with reagents.
- a suction device or a pressurizing device is integrated with the dispensing nozzle 50.
- an air pump can be selectively connected to the dispensing nozzle 50, so as to draw air from or into the sealed cavity through the dispensing nozzle 50 to establish a vacuum or pressure in the sealed cavity.
- the container cap 40 is fixedly connected to the dispensing nozzle 50.
- the container cover 40 can be detachably mounted to the box container 10 by manipulating the dispensing nozzle 50.
- dispensing nozzle 50 moves up and down to approach or move away from the box container 10 so that the container cover 40 fixedly connected to the dispensing nozzle 50 can seal or release the opening 12 of the box container 10.
- the tip of the dispensing nozzle 50 extends toward the box container 10 and passes through the container cover 40, so that the dispensing nozzle 50 can selectively fill the box container 10 and the elastic container 30 with reagents, or selectively The pressure or vacuum is established in the sealed cavity, which is beneficial to improve the quality of the tissue.
- the discharge nozzle 60 is arranged above the box container 10 means that the discharge nozzle 60 can be moved above the box container 10 or removed from above the box container 10.
- the discharge nozzle 60 is movable in the up and down direction above the box container 10, that is, moves closer to or away from the box container 10 in the up and down direction.
- the arrangement of the top rod 70 above the box container 10 means that the top rod 70 can be moved below the box container 10 or removed from below the box container 10.
- the top rod 70 is movable in the up and down direction under the box container 10, that is, moves closer to or away from the box container 10 in the up and down direction.
- a heating device may be provided at the top rod 70 so that the heat generated by the heating device can be transferred to the elastic container 30 through the top rod 70. Therefore, it is beneficial to maintain the temperature of the reagent and improve the quality of the tissue.
- the heating device may be provided in the ejector rod 70, thereby simplifying the structure of the tissue processing device 100.
- the tissue processing apparatus 100 further includes a conveying device 80, the cassette container 10 is fixedly mounted to the conveying device 80, and the conveying device 80 is configured to drive the cassette container 10 to move relative to the workbench 20 .
- the box container 10 can be moved relative to the workbench 20 to facilitate subsequent processing of the tissue.
- the workbench 20 may be provided with a first working position and a second working position, the first working position is provided with a through hole 22 and an elastic container 30, a dispensing nozzle 50 is provided above the first working position, and the first working position A jack 70 is arranged below the working position; a through hole 22 and an elastic container 30 are arranged at the second working position, and a discharge nozzle 60 is arranged above the second working position.
- the box container 10 is conveyed to the first working position by the conveyor belt 82 of the conveying device 80, and the opening of the box container 10 is aligned with the through hole 22 of the working table 20 at the first position, so that the working table 20 is at the first position.
- the elastic container 30 is in communication with the box container 10.
- the dispensing nozzle 50 fills the cartridge container 10 and the elastic container 30 with reagents.
- the ejector rod 70 is lifted upward so that the tissue is immersed in the reagent.
- the tissue processing device is a one-piece flow processing device, a unique solution for processing a single tissue can prevent cross-contamination, and can provide pressure, vacuum and heating functions for tissue processing to improve tissue quality; Track and integrate with the previous or next processing step.
- the terms “installed”, “connected”, “connected”, “fixed” and other terms should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection. , Or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two components or the interaction relationship between two components.
- installed may be a fixed connection or a detachable connection. , Or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two components or the interaction relationship between two components.
- the first feature “on” or “under” the second feature may be in direct contact with the first and second features, or the first and second features may be indirectly through an intermediary. contact.
- the "above”, “above” and “above” of the first feature on the second feature may mean that the first feature is directly above or diagonally above the second feature, or it simply means that the level of the first feature is higher than the second feature.
- the “below”, “below” and “below” of the second feature of the first feature may mean that the first feature is directly below or obliquely below the second feature, or it simply means that the level of the first feature is smaller than the second feature.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
Claims (12)
- 一种组织处理设备,其特征在于,所述组织处理设备包括:盒体,所述盒体用于承载组织;盒体容器,所述盒体接收在所述盒体容器中;工作台,所述工作台具有相对设置的上侧和下侧,所述盒体容器可移动地设置在所述工作台的上侧;以及弹性容器,所述弹性容器设置在所述工作台的下侧,其中所述工作台限定有通孔,所述盒体容器能够通过所述通孔与所述弹性容器连通,并且所述弹性容器构造成在所述弹性容器变形时将容纳在所述弹性容器中的试剂挤入所述盒体容器,在所述弹性容器恢复时将所述盒体容器中的试剂吸入所述弹性容器。
- 根据权利要求1所述的组织处理设备,其特征在于,所述盒体容器的顶部具有开口,所述试剂通过所述开口填充到所述弹性容器和所述盒体容器。
- 根据权利要求2所述的组织处理设备,其特征在于,所述组织处理设备还包括容器盖,所述容器盖可拆卸地安装到所述盒体容器以密封所述开口,从而所述容器盖、所述盒体容器、所述弹性容器形成密封腔体。
- 根据权利要求3所述的组织处理设备,其特征在于,所述组织处理设备还包括抽吸装置或加压装置,所述抽吸装置或所述加压装置可操作地设置在所述盒体容器上方,并构造成操作地抽吸所述密封腔体中的气体或向所述密封腔体中充气,从而在所述密封腔体内建立真空或压力。
- 根据权利要求4所述的组织处理设备,其特征在于,所述组织处理设备还包括分配喷嘴,所述分配喷嘴可操作地设置在所述盒体容器上方,并构造成向所述盒体容器和所述弹性容器中填充试剂。
- 根据权利要求5所述的组织处理设备,其特征在于,所述抽吸装置或加压装置与所述分配喷嘴集成在一起。
- 根据权利要求5或6所述的组织处理设备,其特征在于,所述容器盖固定地连接到所述分配喷嘴。
- 根据权利要求2至6中任一项所述的组织处理设备,其特征在于,所述组织处理设备还包括排放喷嘴,所述排放喷嘴可操作地设置在所述盒体容器上方,并且构造成能够伸入所述弹性容器中并将所述盒体容器中的试剂抽吸到所述弹性容器中。
- 根据权利要求1至6中任一项所述的组织处理设备,其特征在于,所述组织处理设备还包括顶杆,所述顶杆设置在所述弹性容器下方,并且所述顶杆构造成操作性地压紧或 释放所述弹性容器,从而使得所述弹性容器变形或恢复。
- 根据权利要求9所述的组织处理设备,其特征在于,所述顶杆处设置有加热装置,使得加热装置产生的热量能够通过所述顶杆传递到所述弹性容器。
- 根据权利要求1至6中任一项所述的组织处理设备,其特征在于,所述组织处理设备还包括传送装置,所述盒体容器固定地安装到所述传送装置,所述传送装置构造成驱动所述盒体容器相对于所述工作台移动。
- 根据权利要求11所述的组织处理设备,其特征在于,所述传送装置包括平行设置的两条传送带,两条传送带限定有至少一对相对设置的安装槽,所述盒体容器形成有成对的相对设置的安装凸耳,所述成对的相对设置的安装凸耳适于配合在所述至少一对相对设置的安装槽中。
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022530891A JP2023504246A (ja) | 2019-11-26 | 2020-11-24 | 組織処理装置 |
| US17/779,687 US20230020209A1 (en) | 2019-11-26 | 2020-11-24 | Tissue treatment device |
| EP20893578.3A EP4067859A4 (en) | 2019-11-26 | 2020-11-24 | Tissue treatment device |
| CN202080081451.6A CN114793445A (zh) | 2019-11-26 | 2020-11-24 | 一种组织处理设备 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922063022.3 | 2019-11-26 | ||
| CN201922063022.3U CN211235173U (zh) | 2019-11-26 | 2019-11-26 | 一种组织处理设备 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021104258A1 true WO2021104258A1 (zh) | 2021-06-03 |
Family
ID=71921124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2020/131122 Ceased WO2021104258A1 (zh) | 2019-11-26 | 2020-11-24 | 一种组织处理设备 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230020209A1 (zh) |
| EP (1) | EP4067859A4 (zh) |
| JP (1) | JP2023504246A (zh) |
| CN (2) | CN211235173U (zh) |
| WO (1) | WO2021104258A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN211235173U (zh) * | 2019-11-26 | 2020-08-11 | 莱卡生物系统努斯洛赫有限责任公司 | 一种组织处理设备 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH09236598A (ja) * | 1995-12-28 | 1997-09-09 | Aloka Co Ltd | 生物組織の処理装置 |
| US20050124028A1 (en) * | 2001-10-01 | 2005-06-09 | Windeyer Victor C. | Histological tissue specimen treatment |
| CN101228429A (zh) * | 2005-05-24 | 2008-07-23 | 利·H·安格罗斯 | 原位热诱发的抗原修复及染色设备和方法 |
| US20090074624A1 (en) * | 2007-09-19 | 2009-03-19 | Don Liang | Liquid transfer device |
| CN103293034A (zh) * | 2012-02-24 | 2013-09-11 | 奚金华 | 全自动病理组织制片系统 |
| CN107356738A (zh) * | 2014-03-11 | 2017-11-17 | Emd密理博公司 | Ihc、组织载片流体交换可置换件和系统 |
| CN211235173U (zh) * | 2019-11-26 | 2020-08-11 | 莱卡生物系统努斯洛赫有限责任公司 | 一种组织处理设备 |
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| DE29505652U1 (de) * | 1995-04-01 | 1996-04-25 | Boehringer Mannheim Gmbh, 68305 Mannheim | Gefäß zur kontaminationsreduzierten Behandlung von Flüssigkeiten |
| US6183693B1 (en) * | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
| DE60144160D1 (de) * | 2000-12-18 | 2011-04-14 | Protedyne Corp | Extrudieren von gel für gel elektrophorese |
| US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
| US20050065470A1 (en) * | 2003-09-19 | 2005-03-24 | Reed Pamela S. | Collection reservoir for an ambulatory pain pump system |
| EP2615160A1 (en) * | 2004-10-06 | 2013-07-17 | Universal Bio Research Co., Ltd. | Reaction vessel and reaction controller |
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| US10048175B2 (en) * | 2011-02-27 | 2018-08-14 | Bioventures, Llc | Apparatus, system, and method of processing biopsy specimens |
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| US10012664B2 (en) * | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
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| DE102013204646B4 (de) * | 2013-03-15 | 2018-04-05 | Leica Biosystems Nussloch Gmbh | Gerät zum Bearbeiten von histologischen Proben |
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-
2019
- 2019-11-26 CN CN201922063022.3U patent/CN211235173U/zh active Active
-
2020
- 2020-11-24 EP EP20893578.3A patent/EP4067859A4/en not_active Withdrawn
- 2020-11-24 JP JP2022530891A patent/JP2023504246A/ja not_active Ceased
- 2020-11-24 US US17/779,687 patent/US20230020209A1/en not_active Abandoned
- 2020-11-24 WO PCT/CN2020/131122 patent/WO2021104258A1/zh not_active Ceased
- 2020-11-24 CN CN202080081451.6A patent/CN114793445A/zh active Pending
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| JPH09236598A (ja) * | 1995-12-28 | 1997-09-09 | Aloka Co Ltd | 生物組織の処理装置 |
| US20050124028A1 (en) * | 2001-10-01 | 2005-06-09 | Windeyer Victor C. | Histological tissue specimen treatment |
| CN101228429A (zh) * | 2005-05-24 | 2008-07-23 | 利·H·安格罗斯 | 原位热诱发的抗原修复及染色设备和方法 |
| US20090074624A1 (en) * | 2007-09-19 | 2009-03-19 | Don Liang | Liquid transfer device |
| CN103293034A (zh) * | 2012-02-24 | 2013-09-11 | 奚金华 | 全自动病理组织制片系统 |
| CN107356738A (zh) * | 2014-03-11 | 2017-11-17 | Emd密理博公司 | Ihc、组织载片流体交换可置换件和系统 |
| CN211235173U (zh) * | 2019-11-26 | 2020-08-11 | 莱卡生物系统努斯洛赫有限责任公司 | 一种组织处理设备 |
Non-Patent Citations (1)
| Title |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2023504246A (ja) | 2023-02-02 |
| EP4067859A1 (en) | 2022-10-05 |
| CN211235173U (zh) | 2020-08-11 |
| EP4067859A4 (en) | 2023-12-27 |
| CN114793445A (zh) | 2022-07-26 |
| US20230020209A1 (en) | 2023-01-19 |
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