WO2025209934A1 - Procédé de réduction de la quantité d'utilisation d'acides organiques dans l'alimentation animale - Google Patents

Procédé de réduction de la quantité d'utilisation d'acides organiques dans l'alimentation animale

Info

Publication number
WO2025209934A1
WO2025209934A1 PCT/EP2025/058521 EP2025058521W WO2025209934A1 WO 2025209934 A1 WO2025209934 A1 WO 2025209934A1 EP 2025058521 W EP2025058521 W EP 2025058521W WO 2025209934 A1 WO2025209934 A1 WO 2025209934A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
salt
benzoate
animal
additional organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/058521
Other languages
English (en)
Inventor
Wen REN
Mathias SPIEGELHOFER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of WO2025209934A1 publication Critical patent/WO2025209934A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings

Definitions

  • the present invention relates to a method for reducing usage amount of organic acids in an animal feed.
  • Acidifier products including organic acids are wildly used to maintain food and feed.
  • Organic acids e.g. formic acid, propionic acid or acetic acid as described in EP 2 642 874 may be used to control microbial growth in foodstuff, food or feed with the aim to minimize the risk for foodborne diseases.
  • acidifier products may be used to achieve a reduced growth of potentially pathogenic microorganisms in the gastrointestinal tract, but also to improve feed conversion rate and weight gain upon ingestion. There is a constant need to improve said acidifier products, e.g. by improving the efficiency of the employed acids and reducing the dosage of expensive acids such as benzoic acid.
  • benzoic acid and/or at least one salt thereof can be used in a reduced amount while maintaining or improving its effect in animals.
  • the present invention provides a method for reducing usage dosage of benzoic acid and/or at least one salt thereof for improving growth performance of an animal, comprising administering to the animal a feed composition comprising a) benzoic acid and/or at least one salt thereof, and b) at least one additional organic acid and/or at least one salt thereof.
  • Animals refers to any animal except human. Examples of the animals include but are not limited to pigs or swine such as piglets, growing pigs and sows; poultry such as turkeys, ducks, quail, guinea fowl, geese, pigeons (including squabs) and chicken (including but not limited to broilers, chicks and layers); pets such as cats and dogs; horses; crustaceans such as shrimps and prawns; fish such as amberjack, arapaima, barb, bass, bluefish, bocachico, bream, bullhead, cachama, carp, catfish, catla, chanos, char, cichlid, cobia, cod, crappie, dorada, drum, eel, goby, goldfish, gourami, grouper, guapote, halibut, java, labeo, lai, loach, mackerel, milk
  • the animal is selected from the group consisting of pigs or swine (including but not limited to piglets, growing-finishing pigs and sows); poultry such as turkeys, ducks, quail, guinea fowl, geese, pigeons (including squabs) and chicken (including but not limited to broilers, chicks, layers); and pets such as cats and dogs.
  • pigs or swine including but not limited to piglets, growing-finishing pigs and sows
  • poultry such as turkeys, ducks, quail, guinea fowl, geese, pigeons (including squabs) and chicken (including but not limited to broilers, chicks, layers)
  • pets such as cats and dogs.
  • Animal Feed refers to any compound, preparation, or mixture suitable for or intended for intake by an animal and capable of maintaining life and/or promoting production of the animal without any additional substance being consumed except water.
  • Animal Feed Additive refers to an ingredient or combination of ingredients added to the animal feed, usually used in micro quantities and requires careful handling and mixing.
  • ingredient includes but is not limited to vitamins, amino acids, minerals, enzymes, eubiotics, colouring agents, growth improving additives and aroma compounds/flavourings, polyunsaturated fatty acids (PUFAs); reactive oxygen generating species, antioxidants, anti-microbial peptides, anti-fungal polypeptides and mycotoxin management compounds etc.
  • benzoic acid and/or at least one salt thereof can be administered to an animal in a reduced amount while maintaining or even improving its effect in growth performance of the animal.
  • the present invention provides a method for reducing usage dosage of benzoic acid and/or at least one salt thereof for improving growth performance of an animal, wherein the benzoic acid and/or at least one salt thereof is contained in combination with at least one additional organic acid and/or at least one salt thereof in an feed composition administered to the animal.
  • the at least one salt of benzoic acid may be selected from the group consisting of sodium benzoate, magnesium benzoate, manganese benzoate, potassium hypophosphite, aluminium benzoate, calcium benzoate and ferric benzoate, preferably sodium benzoate, magnesium benzoate, manganese benzoate and potassium benzoate, and more preferably sodium benzoate.
  • the at least one additional organic acid is any organic acid other than benzoic acid, which may be selected from the group consisting of short monocarboxylic acids having between 1 and 6 carbon atom(s), saturated dicarboxylic acids, unsaturated dicarboxylic acids, unsaturated carboxylic acids, saturated carboxylic acids, hydroxycarboxylic acids, aromatic carboxylic acids, and/or keto carboxylic acids.
  • examples of the short monocarboxylic acids having between 1 and 6 carbon atom(s) are formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, 3-methylbutyric acid, 2-methylbutyric acid, 2-ethylbutyric acid, valeric acid and hexanoic acid.
  • Examples of the saturated dicarboxylic acids are adipic acid and succinic acid.
  • An example of the unsaturated dicarboxylic acid is fumaric acid.
  • examples of the unsaturated carboxylic acids are sorbic acid and oleic acid.
  • Examples of the saturated carboxylic acids are stearic acid, octanoic acid (also referred to as caprylic acid), decanoic acid (also referred to as capric acid) and dodecanoic acid (also referred to as lauric acid).
  • Examples of the hydroxycarboxylic acids are lactic acid, malic acid (D-, or L-, or D/L-malic acid), citric acid and tartaric acid.
  • An example of the aromatic carboxylic acids is cinnamic acid.
  • An example of the keto carboxylic acid is pyruvic acid.
  • the at least one additional organic acid is selected from the group consisting of formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, 3-methylbutyric acid, 2-metylbutyric acid, 2-ethylbutyric acid, valeric acid, hexanoic acid, adipic acid, succinic acid, fumaric acid, sorbic acid, oleic acid, stearic acid, octanoic (caprylic) acid, decanoic (capric) acid, dodecanoic (lauric) acid, lactic acid, malic acid, citric acid, tartaric acid, cinnamic acid, pyruvic acid, gluconic acid, suberic acid, malonic acid, tannic acid, caffeic acid, ellagic acid, perillic acid and gallic acid.
  • formic acid acetic acid, propionic acid, butyric acid, isobutyric acid, 3-methylbutyric acid
  • the at least one additional organic acid is selected from formic acid, acetic acid, propionic acid, butyric acid, isobutyric acid, 3-methylbutyric acid, 2-metylbutyric acid, 2-ethylbutyric acid, valeric acid, hexanoic acid, adipic acid, succinic acid, fumaric acid, sorbic acid, oleic acid, stearic acid, octanoic (caprylic) acid, decanoic (capric) acid, dodecanoic (lauric) acid, lactic acid, malic acid, citric acid, tartaric acid, cinnamic acid and pyruvic acid, or at least one salt thereof.
  • the at least one additional organic acid is selected from formic acid, acetic acid, propionic acid, fumaric acid and succinic acid.
  • the most preferably, the at least one additional organic acid is selected from fumaric acid and succinic acid.
  • the at least one salt of the additional organic acid may be any one of metal salts such as potassium, sodium or calcium salts, and ammonium salts.
  • salts of the organic acid include but are not limited to ammonium formate, potassium diformate, sodium diacetate, calcium acetate, ammonium propionate, sodium propionate, calcium propionate, calcium lactate, potassium sorbate, sodium formate, calcium formate, sodium butyrate, sodium sorbate, potassium citrate, sodium citrate and calcium citrate.
  • the composition according to the invention may comprise benzoic acid and/or at least one salt thereof in combination with more than one additional organic acid and/or at least one salt thereof.
  • such a composition may comprise benzoic acid and/or at least one salt thereof in combination with two, three, four, five or even more additional organic acids.
  • the composition comprises benzoic acid and/or a salt of benzoic acid and at least three additional organic acids, especially formic acid, acetic acid and propionic acid, wherein the salt of benzoic acid is selected from the group consisting of sodium benzoate, manganese benzoate, magnesium benzoate and potassium benzoate, preferably sodium benzoate or manganese benzoate, more preferably sodium benzoate.
  • the composition according to the invention comprises benzoic acid and/or a salt of benzoic acid and at least four additional organic acids, especially formic acid, acetic acid, propionic acid and fumaric acid, wherein the salt of benzoic acid is selected from the group consisting of sodium benzoate, manganese benzoate, magnesium benzoate and potassium benzoate, preferably sodium benzoate or manganese benzoate, more preferably sodium benzoate.
  • the composition according to the invention comprises benzoic acid and/or a salt of benzoic acid and at least five additional organic acids, especially formic acid, acetic acid, propionic acid, fumaric acid and succinic acid, wherein the salt of benzoic acid is selected from the group consisting of sodium benzoate, manganese benzoate, magnesium benzoate and potassium benzoate, preferably sodium benzoate or manganese benzoate, more preferably sodium benzoate.
  • said feed composition may be provided in a particular manner, wherein the molar ratio of the at least one additional organic acid and/or the at least one salt thereof to benzoic acid and/or the at least one salt thereof is from 0.001 :1 to 500:1 , preferably from 0.005:1 to 300:1 , more preferably from 0.01 :1 to 200:1 , such as from 0.01 :1 to 0.15:1 , from 0.02:1 to 0.1 :1 , from 0.04:1 to 100:1 , from 0.05:1 to 100:1 , , from 0.1 :1 to 100:1 , from 1 :1 to 100:1 , from 10:1 to 80:1 and from 20:1 to 40:1.
  • the molar ratio of the at least one additional organic acid and/or the at least one salt thereof to benzoic acid and/or the at least one salt thereof is in the range of from 0.001 :1 to 0.15:1.
  • a feed composition according to the present invention may be provided in a form wherein one or more or all of the components is/are provided in solid form (e.g. salt, powder, granulate, pellet etc.) or in liquid form (e.g. aqueous, gel, viscous). It is also considered that the feed composition may be provided in a manner, wherein one component (e.g. benzoic acid) is provided in liquid form and a second component is provided in solid form (e.g. one or more organic acid(s)), and the composition is formed by combining the two components in a mixture or in a separate form.
  • one component e.g. benzoic acid
  • micro-ingredients include but are not limited to aroma compounds; antimicrobial peptides; polyunsaturated fatty acids (PUFAs); reactive oxygen generating species; at least one enzyme, and fat- and water-soluble vitamins, as well as minerals.
  • aroma compounds include but are not limited to aroma compounds; antimicrobial peptides; polyunsaturated fatty acids (PUFAs); reactive oxygen generating species; at least one enzyme, and fat- and water-soluble vitamins, as well as minerals.
  • PUFAs polyunsaturated fatty acids
  • reactive oxygen generating species at least one enzyme
  • fat- and water-soluble vitamins as well as minerals.
  • fat-soluble vitamins include but are not limited to vitamin A, vitamin D3, and vitamin K, e.g. vitamin K3.
  • water-soluble vitamins include but are not limited to vitamin B12, biotin and choline, vitamin Bi, vitamin B2, vitamin Be, niacin, folic acid and panthothenate, e.g. Ca-D-panthothenate.
  • minerals include but are not limited to calcium, phosphorus, sodium, potassium, magnesium, chlorine, iodine, iron, manganese, copper, molybdenum, cobalt and zinc.
  • Common mineral supplements in feed include but are not limited to limestone, Bone meal, oyster shell, sodium chloride, dicalcium phosphate, manganese sulphate, potassium iodide, and superphosphate.
  • Sources of minerals include meat scraps, fish meal, milk products, ground limestone (calcium), ground oyster shells (calcium), dicalcium phosphate (calcium, phosphorus), defluorinated rock phosphate (phosphorus, calcium), steamed bone meal (phosphorus, calcium), salt (sodium, chlorine, iodine), manganese sulfate (manganese), manganese oxide (manganese), zinc carbonate (zinc), zinc oxide (zinc).
  • suitable types of proteins include, but are not limited to, meat scraps (lysine), fish meal (lysine, methionine), poultry by-product meal (tryptophan, lysine), blood meal, liver and glandular meal, feather meal (hydrolyzed), animal tankage, milk products, cottonseed meal, peanut meal, soybean meal, sesame meal, sunflower seed meal.
  • feed ingredients (maize, barley, safflower, milo, wheat, rice, bran, etc.) contain approximately 2- 5% fat and linoleic acid.
  • Sources of fats include animal tallow (beef), lard, corn oil, and other vegetable oils.
  • benzoic acid and/or at least one salt thereof may be provided at a concentration of from 0.001 % to 10%, preferably from 0.01% to 5%, more preferably from 0.05% to 1 % by weight such as 0.05%, 0.1%, 0.2%, 0.3%, 0.4% and 0.5% by weight of the animal feed.
  • the at least one additional organic acid and/or at least one salt thereof may be provided at a concentration of from 0.0005% to 1%, preferably from 0.001 % to 0.5%, more preferably from 0.002% to 0.2%, even more preferably 0.0025% to 0.1 % by weight such as 0.0025%, 0.003%, 0.004%, 0.005%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.04%, 0.05%, 0.06%, 0.08% and 0.1% by weight of the animal feed.
  • the usage amount of benzoic acid can be reduced by at least 10%, at least 20%, at least 30%, and preferably at least 40%, and more preferably at least 50% in the animal feed.
  • the usage amount of benzoic acid in animal feed is reduced from 5000 ppm or above into 4000 ppm or less or 3000 ppm or less, from 3000 ppm or above into 2000 ppm or less or 1000 ppm or less.
  • a 2-phase feeding plan (0-14d and 14-38d) was used, the duration of the experimental period was 38 days, distributed in 4 periods: 0-7d, 7-14d, 14-21d and 21-38d.
  • piglets were weighted (individually dO, d7, d14, d21 and d38), and the total feed consumption recorded in order to subsequently calculate the main productive parameters (growth rate, average daily feed consumption and feed conversion rate).
  • the experimental diets for each of the study phases were formulated using BRILL Software (linear programming method) and FEDNA 2019 composition tables. Same nutrient and ingredient restrictions were used with the only exception of the inclusion of the test products (VEVOVITALL® (DSM Nutritional Products, Switzerland) and BIOTRONIC® TOP 3 (DSM Nutritional Products, Austria)). The inclusion levels of the test products as well as the ingredient of the experimental diets are shown in Tables 1 and 2.
  • Table 1 0-14d diet composition (%, as fed basis) 1
  • Rovimap CP70 vegetal protein concentrate (70% crude protein)
  • Table 2 14-38d diet composition (%, as fed basis) 1 Rovimap CP70: vegetal protein concentrate (70% crude protein)
  • ADWG Average daily weight gain
  • ADFI Average daily feed intake
  • the average daily weight gain and average daily feed intake were increased in the BIO group which was supplemented with VevoVitall® and BIOTRONIC® TOP 3.
  • the BIO group provided much lower mortality ratio of piglets.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)

Abstract

La présente invention concerne un procédé de réduction du dosage d'utilisation d'acide benzoïque et/ou d'au moins un sel de celui-ci pour améliorer les performances de croissance d'un animal, ledit procédé consistant à administrer à l'animal une composition alimentaire contenant a) de l'acide benzoïque et/ou au moins un sel de celui-ci, et b) au moins un acide organique supplémentaire et/ou au moins un sel de celui-ci.
PCT/EP2025/058521 2024-04-03 2025-03-27 Procédé de réduction de la quantité d'utilisation d'acides organiques dans l'alimentation animale Pending WO2025209934A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2024085991 2024-04-03
CNPCT/CN2024/085991 2024-04-03

Publications (1)

Publication Number Publication Date
WO2025209934A1 true WO2025209934A1 (fr) 2025-10-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2025/058521 Pending WO2025209934A1 (fr) 2024-04-03 2025-03-27 Procédé de réduction de la quantité d'utilisation d'acides organiques dans l'alimentation animale

Country Status (1)

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WO (1) WO2025209934A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2642874A1 (fr) 2010-11-26 2013-10-02 Erber Aktiengesellschaft Additif pour produits alimentaires pour animaux

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2642874A1 (fr) 2010-11-26 2013-10-02 Erber Aktiengesellschaft Additif pour produits alimentaires pour animaux

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Feedinfo - Biomin Finds Home With Like-Minded Peer in DSM- INDUSTRY PERSPECTIVES", 25 October 2021 (2021-10-25), XP093281592, Retrieved from the Internet <URL:https://www.feedinfo.com/our-content/biomin-finds-home-with-like-minded-peer-in-dsm-industry-perspectives/257278> [retrieved on 20250527] *
MENANTEAU-LEDOUBLE SIMON ET AL: "Antimicrobial effect of the Biotronic Top3 supplement and efficacy in protecting rainbow trout (Oncorhynchus mykiss) from infection byAeromonas salmonicidasubsp.salmonicida", RESEARCH IN VETERINARY SCIENCE, BRITISH VETERINARY ASSOCIATION, LONDON, GB, vol. 114, 18 March 2017 (2017-03-18), pages 95 - 100, XP085223392, ISSN: 0034-5288, DOI: 10.1016/J.RVSC.2017.03.010 *
PEH ELISA ET AL: "Antimicrobial activity of organic acids against Campylobacter spp. and development of combinations-A synergistic effect?", PLOS ONE, vol. 15, no. 9, 17 September 2020 (2020-09-17) - 27 May 2025 (2025-05-27), pages e0239312, XP055915925, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497993/pdf/pone.0239312.pdf> DOI: 10.1371/journal.pone.0239312 *
RYCHEN GUIDO ET AL: "Safety and efficacy of VevoVitall (benzoic acid) as feed additive for minor porcine species", EFSA JOURNAL, 1 October 2017 (2017-10-01), Parma, Italy, XP093281552, ISSN: 1831-4732, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.2903/j.efsa.2017.5026> [retrieved on 20250527], DOI: 10.2903/j.efsa.2017.5026 *
TACCONI A. ET AL: "Tacconi and Kovacs: Saving space in feed formulations for piglets: reduce the inclusion level of organic acids", 1 January 2017 (2017-01-01), XP093281469, Retrieved from the Internet <URL:https://boku.ac.at/fileadmin/data/H03000/H97000/H97600/Symptagungsbaende/BOKU_Symposium_2017.pdf> [retrieved on 20250527] *

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