WO2026050252A1 - Dispositifs médicaux implantables (dmi) multiples et/ou tissus cibles multiples pour le traitement de troubles respiratoires du sommeil (trs) - Google Patents

Dispositifs médicaux implantables (dmi) multiples et/ou tissus cibles multiples pour le traitement de troubles respiratoires du sommeil (trs)

Info

Publication number
WO2026050252A1
WO2026050252A1 PCT/US2025/043538 US2025043538W WO2026050252A1 WO 2026050252 A1 WO2026050252 A1 WO 2026050252A1 US 2025043538 W US2025043538 W US 2025043538W WO 2026050252 A1 WO2026050252 A1 WO 2026050252A1
Authority
WO
WIPO (PCT)
Prior art keywords
imd
sensing
target tissue
examples
activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/043538
Other languages
English (en)
Inventor
Jesse FINE
David DIEKEN
Wondimeneh Tesfayesus
Philip Ebeling
Kevin VERZAL
Mehmet Arcan Erturk
Simeng Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inspire Medical Systems Inc
Original Assignee
Inspire Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspire Medical Systems Inc filed Critical Inspire Medical Systems Inc
Publication of WO2026050252A1 publication Critical patent/WO2026050252A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4806—Sleep evaluation
    • A61B5/4818—Sleep apnoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/3611—Respiration control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37205—Microstimulators, e.g. implantable through a cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
    • A61N1/37288—Communication to several implantable medical devices within one patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/0826—Detecting or evaluating apnoea events
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/113—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0548—Oral electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36078—Inducing or controlling sleep or relaxation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/3614—Control systems using physiological parameters based on impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36182—Direction of the electrical field, e.g. with sleeve around stimulating electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3756—Casings with electrodes thereon, e.g. leadless stimulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Prostheses (AREA)

Abstract

Une méthode de traitement de troubles respiratoires du sommeil (TRS) consiste à mettre en œuvre sélectivement un premier dispositif médical implantable (DMI) par rapport à un premier tissu cible et/ou à mettre en œuvre sélectivement un second dispositif médical implantable (DMI) par rapport à un second tissu cible. Un dispositif comprenant un premier dispositif médical implantable (DMI) est agencé par rapport à un premier tissu cible et configuré pour être mis en œuvre sélectivement; et/ou un second DMI est agencé par rapport à un second tissu cible et configuré pour être mis en œuvre sélectivement; le dispositif comprend une partie de commande configurée pour : mettre en œuvre sélectivement le premier DMI par rapport au premier tissu cible et/ou au second tissu cible; ou à mettre en œuvre sélectivement le second DMI par rapport au premier tissu cible et/ou au second tissu cible.
PCT/US2025/043538 2024-08-26 2025-08-26 Dispositifs médicaux implantables (dmi) multiples et/ou tissus cibles multiples pour le traitement de troubles respiratoires du sommeil (trs) Pending WO2026050252A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202463687062P 2024-08-26 2024-08-26
US63/687,062 2024-08-26
US202563811256P 2025-05-23 2025-05-23
US63/811,256 2025-05-23

Publications (1)

Publication Number Publication Date
WO2026050252A1 true WO2026050252A1 (fr) 2026-03-05

Family

ID=97268793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/043538 Pending WO2026050252A1 (fr) 2024-08-26 2025-08-26 Dispositifs médicaux implantables (dmi) multiples et/ou tissus cibles multiples pour le traitement de troubles respiratoires du sommeil (trs)

Country Status (1)

Country Link
WO (1) WO2026050252A1 (fr)

Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5522862A (en) 1994-09-21 1996-06-04 Medtronic, Inc. Method and apparatus for treating obstructive sleep apnea
US5944680A (en) 1996-06-26 1999-08-31 Medtronic, Inc. Respiratory effort detection method and apparatus
US20010053926A1 (en) * 2000-06-20 2001-12-20 Whitehurst Todd K. Combined frequency-domain time-domain multiplexing of radio frequency communications with multiple implanted devices
US6770022B2 (en) 1997-10-17 2004-08-03 Respironics, Inc. Muscle stimulating device and method for diagnosing and treating a breathing disorder
US20070239229A1 (en) * 2006-03-31 2007-10-11 Javaid Masoud Multichannel Communication for Implantable Medical Device Applications
US20100114200A1 (en) * 2008-10-31 2010-05-06 Medtronic, Inc. Implantable medical device crosstalk evaluation and mitigation
US8938299B2 (en) 2008-11-19 2015-01-20 Inspire Medical Systems, Inc. System for treating sleep disordered breathing
US20150196758A1 (en) * 2014-01-10 2015-07-16 Cardiac Pacemakers, Inc. Systems and methods for detecting cardiac arrhythmias
US20180117316A1 (en) 2015-03-19 2018-05-03 Inspire Medical Systems, Inc. Stimulation for treating sleep disordered breathing
US10583297B2 (en) 2011-08-11 2020-03-10 Inspire Medical Systems, Inc. Method and system for applying stimulation in treating sleep disordered breathing
US20200147376A1 (en) * 2018-11-13 2020-05-14 Inspire Medical Systems, Inc. Multiple type sleep apnea
WO2021016562A1 (fr) 2019-07-25 2021-01-28 Inspire Medical Systems, Inc. Détection de respiration
US11324950B2 (en) 2016-04-19 2022-05-10 Inspire Medical Systems, Inc. Accelerometer-based sensing for sleep disordered breathing (SDB) care
WO2022246320A1 (fr) 2021-05-21 2022-11-24 Inspire Medical Systems, Inc. Thérapie de stimulation cible multiple pour troubles respiratoires du sommeil
WO2022261311A1 (fr) 2021-06-10 2022-12-15 Inspire Medical Systems, Inc. Détection de respiration
US20230095780A1 (en) 2019-07-25 2023-03-30 Inspire Medical Systems, Inc. Sleep detection for sleep disordered breathing (sdb) care
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US20230172479A1 (en) 2020-05-23 2023-06-08 Inspire Medical Systems, Inc. Single or multiple nerve stimulation to treat sleep disordered breathing
US20230177121A1 (en) 2021-12-02 2023-06-08 Zendrive, Inc. System and/or method for personalized driver classifications
WO2023150158A1 (fr) 2022-02-02 2023-08-10 Inspire Medical Systems, Inc. Éléments de stimulation implantables et procédés de soins de troubles respiratoires du sommeil (sdb)
WO2023230131A1 (fr) 2022-05-24 2023-11-30 Inspire Medical Systems, Inc. Détection et application d'une stimulation dans une relation temporisée
WO2024144516A1 (fr) 2022-12-29 2024-07-04 T.C. Ankara Universitesi Rektorlugu Nid d'ange thérapeutique portatif
WO2024145251A1 (fr) 2022-12-29 2024-07-04 Inspire Medical Systems, Inc. Stimulation d'un tissu associé à un muscle infra-hyoïdien
US20240216692A1 (en) 2022-12-29 2024-07-04 Inspire Medical Systems, Inc. Stimulating a glossopharyngeal-related tissue for upper airway patency
US20240216163A1 (en) 2022-12-29 2024-07-04 Inspire Medical Systems, Inc. Mechanically promoting upper airway patency
US20240275279A1 (en) 2021-11-01 2024-08-15 Halo Microelectronics International Switched Capacitor Converter and Control Method
WO2024206680A1 (fr) 2023-03-31 2024-10-03 Inspire Medical Systems, Inc. Mise en prise de tissu biologique cible
WO2024233290A1 (fr) 2023-05-05 2024-11-14 Inspire Medical Systems, Inc. Détection de respiration
WO2024243537A1 (fr) 2023-05-24 2024-11-28 Inspire Medical Systems, Inc. Détection et/ou stimulation d'un tissu cible comprenant un tissu associé au diaphragme et/ou un tissu associé à la perméabilité des voies respiratoires supérieures
WO2025101932A2 (fr) 2023-11-08 2025-05-15 Inspire Medical Systems, Inc. Stimulation transveineuse pour favoriser la perméabilité des voies respiratoires supérieures

Patent Citations (34)

* Cited by examiner, † Cited by third party
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US20250108218A1 (en) 2022-02-02 2025-04-03 Inspire Medical Systems, Inc. Implantable stimulation elements and methods for sleep disordered breathing (sdb) care
WO2023230131A1 (fr) 2022-05-24 2023-11-30 Inspire Medical Systems, Inc. Détection et application d'une stimulation dans une relation temporisée
WO2024144516A1 (fr) 2022-12-29 2024-07-04 T.C. Ankara Universitesi Rektorlugu Nid d'ange thérapeutique portatif
WO2024145251A1 (fr) 2022-12-29 2024-07-04 Inspire Medical Systems, Inc. Stimulation d'un tissu associé à un muscle infra-hyoïdien
US20240216692A1 (en) 2022-12-29 2024-07-04 Inspire Medical Systems, Inc. Stimulating a glossopharyngeal-related tissue for upper airway patency
US20240216163A1 (en) 2022-12-29 2024-07-04 Inspire Medical Systems, Inc. Mechanically promoting upper airway patency
WO2024206680A1 (fr) 2023-03-31 2024-10-03 Inspire Medical Systems, Inc. Mise en prise de tissu biologique cible
WO2024233290A1 (fr) 2023-05-05 2024-11-14 Inspire Medical Systems, Inc. Détection de respiration
WO2024243537A1 (fr) 2023-05-24 2024-11-28 Inspire Medical Systems, Inc. Détection et/ou stimulation d'un tissu cible comprenant un tissu associé au diaphragme et/ou un tissu associé à la perméabilité des voies respiratoires supérieures
WO2025101932A2 (fr) 2023-11-08 2025-05-15 Inspire Medical Systems, Inc. Stimulation transveineuse pour favoriser la perméabilité des voies respiratoires supérieures

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* Cited by examiner, † Cited by third party
Title
CULJAK: "Wireless Body Sensor Communication Systems Based on UWB and IBC Technologies: State-of-the-Art and Open Challenges", SENSORS, vol. 20, 2020, pages 3587
VIZZIELLO: "Intra-body communications for nervous system applications: Current technologies and future directions", COMPUTER NETWORKS, vol. 227, 17 March 2023 (2023-03-17), pages 109718, XP087293358, Retrieved from the Internet <URL:https://doi.org/10.1016/j.comnet.2023.109718> DOI: 10.1016/j.comnet.2023.109718

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