YU63496A - Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje - Google Patents
Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanjeInfo
- Publication number
- YU63496A YU63496A YU63496A YU63496A YU63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A YU 63496 A YU63496 A YU 63496A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hydrogen
- optionally substituted
- alkyl
- denotes
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 14
- 239000001257 hydrogen Substances 0.000 abstract 14
- 150000002431 hydrogen Chemical class 0.000 abstract 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 4
- -1 C2-14 acyl Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 2
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 2
- QBBADXPVZMYLKN-UHFFFAOYSA-N 3-amino-1h-quinoxalin-2-one Chemical class C1=CC=C2NC(=O)C(N)=NC2=C1 QBBADXPVZMYLKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/54—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Pronalazak se odnosi na nove 3-amino-hinoksalin-2-on derivate opste formule I, na njihove soli, tautomerne oblike i N-okside, na farmaceutske preparate koji sadrze ova jedinjenja i na postupak za njihovo dobijanje, gde Z1 oznacava vodonik, hidroksi, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil, COOC1-4 alkil, C2-14 acil, C1-4 alkilsulfonil, trifluorometil-sulfonil, po izboru supstituisanu benzoil, i po izboru supstituisanu fenil-sulfonil grupu; Y1 oznacava vodonik ili po izboru supstituisanu amino grupu ili Y1 i Z1 grade zajedno -CO-O- grupu gde Y2 i Z2 oznacavaju zajedno valentnu vezu ili Y1 i Y2 oznacavaju zajedno valentnu vezu, i u isto vreme Z2 oznacava vodonik, hidroksi, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil, COOC1-4 alkil, C2-14 acil, C1-4 alkilsulfonil, trifluorometil-sulfonil, po izboru supstituisanu benzoil, i po izboru supstituisanu fenil-sulfonil grupu; X1 i X2 oznacavaju zajedno =O ili =S ili X1 oznacava vodonik, -NHR4 ili -WR5 grupe i u isto vreme X2 oznacava vodonik ili X2 i X3 zajedno grade valentnu vezu; X3 oznacava vodonik, C1-4 alkil, C7-9 fenilalkil, po izboru supstituisanu fenil grupu; R1 i R2 oznacavaju vodonik, halogen, C1-4 alkil, trifluorometil, cijano, merkapto ili sulfonilamido grupu; R3 oznacava vodonik ili nitro grupu; R4 oznacava vodonik ili hidroksi grupu; R5 oznacava vodonik, C1-4 alkil, C7-9 fenilalkil grupu; W oznacava kiseonik ili sumpor, uz pretpostavku, da a) ako bar jedan od supstituenata R1, R2 i R3 nije vodonik ili b) ako znacenja Z1 i Z2 su vodonik, tada R1 je 6-hloro, R3 je vodonik, R2 nije 7-hloro ili R1 je 6-metil, R3 je vodonik, R2 nije 7-metil, jedinjenja opste formule I pokazuju znacajnu aktivnost na glicin vezujuce mesto NMDA receptora i stoga se mogu koristiti kao aktivni sastojci farmaceutskih preparata.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9503422A HUT76302A (en) | 1995-11-30 | 1995-11-30 | Quinoxaline derivatives, pharmaceutical compositions containing them and process for producing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU63496A true YU63496A (sh) | 1999-03-04 |
Family
ID=10987414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU63496A YU63496A (sh) | 1995-11-30 | 1996-11-28 | Nova jedinjenja, farmaceutski preparati koji ih sadrže i postupak za njihovo dobijanje |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU7705396A (sh) |
| HR (1) | HRP960564A2 (sh) |
| HU (1) | HUT76302A (sh) |
| WO (1) | WO1997019934A1 (sh) |
| YU (1) | YU63496A (sh) |
| ZA (1) | ZA9610002B (sh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910859A (pt) * | 1998-06-01 | 2001-03-13 | Shionogi & Co | Derivados de cianoiminoquinoxalina |
| OA11749A (en) | 1999-01-11 | 2005-07-19 | Agouron Pharma | Tricyclic inhibitors of poly(adp-ribose)polymerases. |
| US6927214B1 (en) * | 1999-01-15 | 2005-08-09 | Novo Nordisk A/S | Non-peptide GLP-1 agonists |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| US7365209B2 (en) | 2003-02-11 | 2008-04-29 | Pharmacopeia, Inc. | Nitrogen heterocycle biaryls for osteoporosis and other diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3446809A (en) * | 1966-01-19 | 1969-05-27 | Eastman Kodak Co | Process for the preparation of 2-amino-3-hydroxyquinoxalines |
| EP0030795A3 (en) * | 1979-12-06 | 1981-09-09 | Imperial Chemical Industries Plc | Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives |
| US5597922A (en) * | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
-
1995
- 1995-11-30 HU HU9503422A patent/HUT76302A/hu unknown
-
1996
- 1996-11-27 HR HRP960564 patent/HRP960564A2/hr not_active Application Discontinuation
- 1996-11-28 ZA ZA9610002A patent/ZA9610002B/xx unknown
- 1996-11-28 AU AU77053/96A patent/AU7705396A/en not_active Abandoned
- 1996-11-28 YU YU63496A patent/YU63496A/sh unknown
- 1996-11-28 WO PCT/HU1996/000072 patent/WO1997019934A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU7705396A (en) | 1997-06-19 |
| WO1997019934A1 (en) | 1997-06-05 |
| HU9503422D0 (en) | 1996-01-29 |
| ZA9610002B (en) | 1997-06-13 |
| HRP960564A2 (en) | 1998-02-28 |
| HUT76302A (en) | 1997-07-28 |
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