ZA200100983B - Substituted oxazoles and thiazoles derivatives as hPPAR gamma and hPPAR alpha activators. - Google Patents

Substituted oxazoles and thiazoles derivatives as hPPAR gamma and hPPAR alpha activators. Download PDF

Info

Publication number: ZA200100983B
Authority: ZA; South Africa
Prior art keywords: phenyl; methyl; propanoic acid; oxazol; oxo
Prior art date: 1998-08-07

Application number

ZA200100983A

Other languages

English (en)

Inventor

Jon Loren Collins

Milana Dezube

Jeffrey Alan Oplinger

Timothy Mark Wilson

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-07

Filing date

2001-02-05

Publication date

2002-03-05

2001-02-05 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2002-03-05 Publication of ZA200100983B publication Critical patent/ZA200100983B/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200100983A 1998-08-07 2001-02-05 Substituted oxazoles and thiazoles derivatives as hPPAR gamma and hPPAR alpha activators. ZA200100983B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9817118.4A GB9817118D0 (en)	1998-08-07	1998-08-07	Pharmaceutical compounds

Publications (1)

Publication Number	Publication Date
ZA200100983B true ZA200100983B (en)	2002-03-05

Family

ID=10836805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200100983A ZA200100983B (en)	1998-08-07	2001-02-05	Substituted oxazoles and thiazoles derivatives as hPPAR gamma and hPPAR alpha activators.

Country Status (31)

Country	Link
US (1)	US6498174B1 (fr)
EP (1)	EP1102757B1 (fr)
JP (1)	JP2002522426A (fr)
KR (1)	KR20010085340A (fr)
CN (1)	CN1321152A (fr)
AP (1)	AP2001002066A0 (fr)
AR (1)	AR020001A1 (fr)
AT (1)	ATE264313T1 (fr)
AU (1)	AU5731099A (fr)
BR (1)	BR9912866A (fr)
CA (1)	CA2339773A1 (fr)
CO (1)	CO5070570A1 (fr)
CZ (1)	CZ2001490A3 (fr)
DE (1)	DE69916457T2 (fr)
EA (1)	EA200100105A1 (fr)
EE (1)	EE200100074A (fr)
ES (1)	ES2220110T3 (fr)
GB (1)	GB9817118D0 (fr)
HR (1)	HRP20010095A2 (fr)
HU (1)	HUP0103469A3 (fr)
ID (1)	ID29543A (fr)
IL (1)	IL141248A0 (fr)
IS (1)	IS5840A (fr)
MA (1)	MA26668A1 (fr)
NO (1)	NO20010628L (fr)
PE (1)	PE20000947A1 (fr)
PL (1)	PL345882A1 (fr)
SK (1)	SK1962001A3 (fr)
TR (1)	TR200100372T2 (fr)
WO (1)	WO2000008002A1 (fr)
ZA (1)	ZA200100983B (fr)

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DE60005973T2 (de)	1999-08-27	2004-05-13	Eli Lilly And Co., Indianapolis	Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren
EP1939188A1 (fr) *	1999-09-22	2008-07-02	Bristol-Myers Squibb Company	Dérivés d'oxa et thiazole utiles en tant qu'agents antidiabétiques et anti-obésité
TWI302149B (en)	1999-09-22	2008-10-21	Bristol Myers Squibb Co	Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
US6414002B1 (en)	1999-09-22	2002-07-02	Bristol-Myers Squibb Company	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
GB0002667D0 (en) *	2000-02-04	2000-03-29	Glaxo Group Ltd	medicamesnts
GB0031103D0 (en) *	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
US20040072838A1 (en)	2000-12-20	2004-04-15	Pierette Banker	Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
EP1394154A4 (fr) *	2001-03-23	2005-05-18	Takeda Pharmaceutical	Derive heterocyclique a cinq membres d'acide alcanoique
GB0111523D0 (en) *	2001-05-11	2001-07-04	Glaxo Group Ltd	Chemical compounds
AU2002342244B2 (en) *	2001-05-15	2005-06-16	F. Hoffmann-La Roche Ag	Carboxylic acid substituted oxazole derivatives for use as PPAR-alpha and -gamma activators in the treatment of diabetes
CZ20033450A3 (cs) *	2001-05-29	2004-05-12	Kyotoápharmaceuticaláindustriesźáltd	Heterocyklická sloučenina a její lékařské použití
CA2448639A1 (fr) *	2001-05-29	2002-12-05	Kyoto Pharmaceutical Industries, Ltd.	Nouveaux derives heterocycliques et utilisation medicale de ces derives
US6861440B2 (en)	2001-10-26	2005-03-01	Hoffmann-La Roche Inc.	DPP IV inhibitors
TW200300681A (en)	2001-11-12	2003-06-16	Ono Pharmaceutical Co	Carboxylic acid derivative compound and medicament containing same as active ingredient
WO2003059895A1 (fr) *	2002-01-17	2003-07-24	Toaeiyo Ltd.	Derives d'acide halogenobenzylaminopropionique
US6716842B2 (en)	2002-04-05	2004-04-06	Warner-Lambert Company, Llc	Antidiabetic agents
US20050119314A1 (en) *	2002-04-05	2005-06-02	Sankyo Company, Limited	Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
KR100474202B1 (ko) *	2002-05-04	2005-03-08	강헌중	티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체
ES2291688T3 (es)	2002-07-03	2008-03-01	F. Hoffmann-La Roche Ag	Derivados de oxazol y su empleo como sensibilizadores a la insulina.
AU2003259131A1 (en)	2002-07-09	2004-01-23	Bristol-Myers Squibb Company	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
ES2350340T3 (es) *	2002-08-30	2011-01-21	F. Hoffmann-La Roche Ag	Nuevos compuestos de 2-aril-tiazol como agonistas de pparalfa y ppargamma.
NZ537979A (en)	2002-09-12	2007-08-31	Hoffmann La Roche	N-substituted-1H-indol-5-propionic acid compounds as PPAR agonists useful for the treatment of diabetes
AR041481A1 (es) *	2002-10-07	2005-05-18	Hoffmann La Roche	Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
ATE405560T1 (de)	2002-11-25	2008-09-15	Hoffmann La Roche	Indolderivaten
RU2342362C2 (ru) *	2002-11-26	2008-12-27	Шэньчжэнь Чипскрин Байосайенсиз Лтд.	Замещенные производные арилалкановой кислоты как пан агонисты рапп с высокой антигипергликемической и антигиперлипидемической активностью
US7192970B2 (en)	2002-11-26	2007-03-20	Chipscreen Biosciences, Ltd.	Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
US7268157B2 (en) *	2002-11-26	2007-09-11	Shenzhen Chipscreen Biosciences, Ltd.	Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity
ES2355105T3 (es)	2003-06-20	2011-03-22	F. Hoffmann-La Roche Ag	Pirido(2,1-a)isoquinolina como inhibidores de la dpp-iv.
RU2339636C2 (ru)	2003-06-20	2008-11-27	Ф.Хоффманн-Ля Рош Аг	Гексагидропиридоизохинолины в качестве ингибиторов дипептидилпептидазы iv (dpp-iv)
WO2005108347A2 (fr)	2004-05-06	2005-11-17	The Regents Of The University Of California	Enaminones substitues, leurs derives et leur utilisation
CN100467456C (zh) *	2004-05-24	2009-03-11	北京摩力克科技有限公司	作为hPPARα和/或hPPARγ激活剂的α-哌嗪取代的苯丙酸衍生物
CN100344618C (zh) *	2004-05-24	2007-10-24	北京摩力克科技有限公司	作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物
CN100436430C (zh) *	2004-05-24	2008-11-26	北京摩力克科技有限公司	作为hPPARα和hPPARγ激动剂的烷酰基取代的酪氨酸衍生物
CN1896069B (zh) *	2005-07-15	2011-10-05	中国科学院上海药物研究所	一类取代噻唑-4酮化合物、制备方法和用途
CN101007790B (zh) *	2006-01-27	2011-03-30	北京摩力克科技有限公司	草氨酸衍生物、其制备方法和医药用途
KR101130380B1 (ko) *	2006-06-13	2012-04-23	상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈	헤테로시클릭 비뉴클레오시드 화합물, 그의 제조방법, 약학적 조성물 및 항바이러스성 약제로서의 용도
GB0719180D0 (en)	2007-10-02	2007-11-14	Cambrex Karlskoga Ab	New process
EP2135865A1 (fr)	2008-06-17	2009-12-23	Bayer CropScience AG	Acides de vinaigre substitués 1-(diazinyle)pyrazole-4-yl, leur procédé de fabrication et d'utilisation en tant qu'herbicides et régulateurs de croissance de plantes
EP2194052A1 (fr)	2008-12-06	2010-06-09	Bayer CropScience AG	Acides de vinaigre 1-(thiazolyl) et 1-(Isothiazolyl)pyrazole-4-yl substitués, leur procédé de fabrication et d'utilisation en tant qu'herbicides et régulateurs de croissance des plantes
WO2011073098A1 (fr)	2009-12-15	2011-06-23	Bayer Cropscience Ag	Acides 1-(hétéroaryl)-pyrazol-4-yl-acétiques, procédés de production et utilisation desdits acides comme herbicides et régulateurs de la croissance des plantes
US20120094959A1 (en)	2010-10-19	2012-04-19	Bonnie Blazer-Yost	Treatment of cystic diseases
WO2022052982A1 (fr) *	2020-09-14	2022-03-17	昭明泽康（北京）生物医药科技有限公司	UTILISATION DE LIGAND PPARα (RÉCEPTEUR ACTIVÉ PAR LE PROLIFÉRATEUR DE PEROXYSOME α) DANS LA PRÉPARATION DE MÉDICAMENTS

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1998
- 1998-08-07 GB GBGB9817118.4A patent/GB9817118D0/en not_active Ceased
1999
- 1999-08-04 CO CO99049333A patent/CO5070570A1/es unknown
- 1999-08-04 AR ARP990103874A patent/AR020001A1/es not_active Application Discontinuation
- 1999-08-05 MA MA25716A patent/MA26668A1/fr unknown
- 1999-08-05 HU HU0103469A patent/HUP0103469A3/hu unknown
- 1999-08-05 CN CN99811640A patent/CN1321152A/zh active Pending
- 1999-08-05 EP EP99944335A patent/EP1102757B1/fr not_active Expired - Lifetime
- 1999-08-05 PE PE1999000790A patent/PE20000947A1/es not_active Application Discontinuation
- 1999-08-05 ID IDW20010541A patent/ID29543A/id unknown
- 1999-08-05 DE DE69916457T patent/DE69916457T2/de not_active Expired - Lifetime
- 1999-08-05 BR BR9912866-7A patent/BR9912866A/pt not_active Application Discontinuation
- 1999-08-05 CZ CZ2001490A patent/CZ2001490A3/cs unknown
- 1999-08-05 AP APAP/P/2001/002066A patent/AP2001002066A0/en unknown
- 1999-08-05 JP JP2000563635A patent/JP2002522426A/ja active Pending
- 1999-08-05 TR TR2001/00372T patent/TR200100372T2/xx unknown
- 1999-08-05 US US09/762,445 patent/US6498174B1/en not_active Expired - Fee Related
- 1999-08-05 ES ES99944335T patent/ES2220110T3/es not_active Expired - Lifetime
- 1999-08-05 AU AU57310/99A patent/AU5731099A/en not_active Abandoned
- 1999-08-05 KR KR1020017001617A patent/KR20010085340A/ko not_active Withdrawn
- 1999-08-05 EE EEP200100074A patent/EE200100074A/xx unknown
- 1999-08-05 CA CA002339773A patent/CA2339773A1/fr not_active Abandoned
- 1999-08-05 WO PCT/EP1999/005666 patent/WO2000008002A1/fr not_active Ceased
- 1999-08-05 EA EA200100105A patent/EA200100105A1/ru unknown
- 1999-08-05 PL PL99345882A patent/PL345882A1/xx not_active Application Discontinuation
- 1999-08-05 AT AT99944335T patent/ATE264313T1/de not_active IP Right Cessation
- 1999-08-05 SK SK196-2001A patent/SK1962001A3/sk unknown
- 1999-08-05 HR HR20010095A patent/HRP20010095A2/hr not_active Application Discontinuation
- 1999-08-05 IL IL14124899A patent/IL141248A0/xx unknown
2001
- 2001-02-05 ZA ZA200100983A patent/ZA200100983B/en unknown
- 2001-02-05 IS IS5840A patent/IS5840A/is unknown
- 2001-02-06 NO NO20010628A patent/NO20010628L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0103469A3 (en)	2002-08-28
JP2002522426A (ja)	2002-07-23
AR020001A1 (es)	2002-03-27
HRP20010095A2 (en)	2002-02-28
IL141248A0 (en)	2002-03-10
PL345882A1 (en)	2002-01-14
NO20010628L (no)	2001-04-06
CA2339773A1 (fr)	2000-02-17
EA200100105A1 (ru)	2001-08-27
GB9817118D0 (en)	1998-10-07
DE69916457D1 (de)	2004-05-19
DE69916457T2 (de)	2005-04-14
WO2000008002A1 (fr)	2000-02-17
EP1102757B1 (fr)	2004-04-14
EP1102757A1 (fr)	2001-05-30
PE20000947A1 (es)	2000-09-22
HUP0103469A2 (hu)	2002-01-28
AP2001002066A0 (en)	2001-03-31
BR9912866A (pt)	2001-10-30
CN1321152A (zh)	2001-11-07
EE200100074A (et)	2002-06-17
ATE264313T1 (de)	2004-04-15
MA26668A1 (fr)	2004-12-20
CZ2001490A3 (cs)	2001-08-15
NO20010628D0 (no)	2001-02-06
TR200100372T2 (tr)	2001-09-21
SK1962001A3 (en)	2001-11-06
IS5840A (is)	2001-02-05
CO5070570A1 (es)	2001-08-28
KR20010085340A (ko)	2001-09-07
ES2220110T3 (es)	2004-12-01
AU5731099A (en)	2000-02-28
US6498174B1 (en)	2002-12-24
ID29543A (id)	2001-09-06

Publication	Publication Date	Title
ZA200100983B (en)	2002-03-05	Substituted oxazoles and thiazoles derivatives as hPPAR gamma and hPPAR alpha activators.
ZA200308352B (en)	2005-01-27	Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors.
KR20010034586A (ko)	2001-04-25	카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제
JP3490704B2 (ja)	2004-01-26	チアゾールおよびオキサゾール誘導体ならびにそれらの医薬的使用
JP5261383B2 (ja)	2013-08-14	ヒトプロテインチロシンホスファターゼ阻害剤および使用法
US6545009B1 (en)	2003-04-08	Retinoid-related receptor function regulating agent
IL98447A (en)	1995-12-31	3-aryl-2- hydroxypropionic acid derivatives their preparation and pharmaceutical compositions containing them useful as hypoglycemic agents
JP2005502600A5 (fr)	2006-01-05
RU2004114875A (ru)	2005-09-10	Производные дикарбоновых кислот, их получение и терапевтическое применение
KR20040007633A (ko)	2004-01-24	심혈관 질환 및 이와 관련된 질환의 치료에 유용한 티아졸또는 옥사졸 유도체
DE60319080T2 (de)	2009-01-29	Phenyloxyalkansäure-derivate als hppar aktivatore
EP0695183B1 (fr)	2003-07-23	Utilisation de thiazolidinediones pour le traitement de l'atherosclerose et des desordres de l'alimentation
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