ZA200303372B - Radioactive member for use in brachytherapy and method of making. - Google Patents

Radioactive member for use in brachytherapy and method of making. Download PDF

Info

Publication number: ZA200303372B
Authority: ZA; South Africa
Prior art keywords: radioactive; bioabsorbable carrier; carrier; mold; sources
Prior art date: 2000-11-01

Application number

ZA200303372A

Other languages

English (en)

Inventor

Michael A Rapach

Charles E Shanks

Kevin M Helle

Jay C Reed

Original Assignee

Medi Physics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-01

Filing date

2003-04-30

Publication date

2004-07-30

2003-04-30 Application filed by Medi Physics Inc filed Critical Medi Physics Inc

2004-07-30 Publication of ZA200303372B publication Critical patent/ZA200303372B/en

Links

230000002285 radioactive effect Effects 0.000 title claims abstract description 191
238000002725 brachytherapy Methods 0.000 title claims abstract description 21
238000004519 manufacturing process Methods 0.000 title claims abstract description 15
239000012876 carrier material Substances 0.000 claims abstract description 77
238000000034 method Methods 0.000 claims abstract description 48
238000011282 treatment Methods 0.000 claims abstract description 24
239000000463 material Substances 0.000 claims description 35
-1 poly(glycolic acid) Polymers 0.000 claims description 25
239000007788 liquid Substances 0.000 claims description 23
229920000954 Polyglycolide Polymers 0.000 claims description 20
229920001432 poly(L-lactide) Polymers 0.000 claims description 18
206010028980 Neoplasm Diseases 0.000 claims description 15
JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims description 11
229920006149 polyester-amide block copolymer Polymers 0.000 claims description 9
239000004604 Blowing Agent Substances 0.000 claims description 8
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 7
201000011510 cancer Diseases 0.000 claims description 7
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 5
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 5
235000014655 lactic acid Nutrition 0.000 claims description 5
239000008247 solid mixture Substances 0.000 claims description 5
238000001959 radiotherapy Methods 0.000 claims description 4
238000013022 venting Methods 0.000 claims description 2
206010060862 Prostate cancer Diseases 0.000 abstract description 9
208000000236 Prostatic Neoplasms Diseases 0.000 abstract description 9
229920000642 polymer Polymers 0.000 description 52
238000002347 injection Methods 0.000 description 19
239000007924 injection Substances 0.000 description 19
239000007789 gas Substances 0.000 description 18
239000000203 mixture Substances 0.000 description 16
238000000465 moulding Methods 0.000 description 13
229920003023 plastic Polymers 0.000 description 11
239000004033 plastic Substances 0.000 description 11
230000005855 radiation Effects 0.000 description 10
238000002513 implantation Methods 0.000 description 8
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230000008569 process Effects 0.000 description 7
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238000002604 ultrasonography Methods 0.000 description 7
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
229920001577 copolymer Polymers 0.000 description 6
239000000945 filler Substances 0.000 description 6
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 6
239000002245 particle Substances 0.000 description 6
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 5
239000003570 air Substances 0.000 description 5
238000001816 cooling Methods 0.000 description 5
238000010438 heat treatment Methods 0.000 description 5
238000001746 injection moulding Methods 0.000 description 5
238000004659 sterilization and disinfection Methods 0.000 description 5
239000010936 titanium Substances 0.000 description 5
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
230000008901 benefit Effects 0.000 description 4
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238000013461 design Methods 0.000 description 4
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229940044173 iodine-125 Drugs 0.000 description 4
ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical compound [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 description 4
238000002844 melting Methods 0.000 description 4
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210000001519 tissue Anatomy 0.000 description 4
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JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 3
208000003174 Brain Neoplasms Diseases 0.000 description 3
VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 description 3
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239000011521 glass Substances 0.000 description 3
239000007943 implant Substances 0.000 description 3
238000003780 insertion Methods 0.000 description 3
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KDLHZDBZIXYQEI-OIOBTWANSA-N palladium-103 Chemical compound [103Pd] KDLHZDBZIXYQEI-OIOBTWANSA-N 0.000 description 3
235000017557 sodium bicarbonate Nutrition 0.000 description 3
229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
125000006850 spacer group Chemical group 0.000 description 3
VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
210000001124 body fluid Anatomy 0.000 description 2
239000010839 body fluid Substances 0.000 description 2
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239000000969 carrier Substances 0.000 description 2
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239000012050 conventional carrier Substances 0.000 description 2
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239000004005 microsphere Substances 0.000 description 2
238000013508 migration Methods 0.000 description 2
230000005012 migration Effects 0.000 description 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
238000012285 ultrasound imaging Methods 0.000 description 2
SJDLIJNQXLJBBE-UHFFFAOYSA-N 1,4-dioxepan-2-one Chemical compound O=C1COCCCO1 SJDLIJNQXLJBBE-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
108010002156 Depsipeptides Proteins 0.000 description 1
229910001200 Ferrotitanium Inorganic materials 0.000 description 1
AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 description 1
241001326189 Gyrodactylus prostae Species 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
206010033128 Ovarian cancer Diseases 0.000 description 1
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OAICVXFJPJFONN-OUBTZVSYSA-N Phosphorus-32 Chemical compound [32P] OAICVXFJPJFONN-OUBTZVSYSA-N 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
229920006328 Styrofoam Polymers 0.000 description 1
NINIDFKCEFEMDL-AKLPVKDBSA-N Sulfur-35 Chemical compound [35S] NINIDFKCEFEMDL-AKLPVKDBSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000004411 aluminium Substances 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229920005578 aromatic polyanhydride Polymers 0.000 description 1
RQNWIZPPADIBDY-YPZZEJLDSA-N arsenic-73 Chemical compound [73As] RQNWIZPPADIBDY-YPZZEJLDSA-N 0.000 description 1
239000011324 bead Substances 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
150000001558 benzoic acid derivatives Chemical class 0.000 description 1
239000000560 biocompatible material Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
210000003850 cellular structure Anatomy 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
TVFDJXOCXUVLDH-YPZZEJLDSA-N cesium-131 Chemical compound [131Cs] TVFDJXOCXUVLDH-YPZZEJLDSA-N 0.000 description 1
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239000013043 chemical agent Substances 0.000 description 1
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000010894 electron beam technology Methods 0.000 description 1
238000002710 external beam radiation therapy Methods 0.000 description 1
239000006260 foam Substances 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
PCHJSUWPFVWCPO-OUBTZVSYSA-N gold-198 Chemical compound [198Au] PCHJSUWPFVWCPO-OUBTZVSYSA-N 0.000 description 1
229910002804 graphite Inorganic materials 0.000 description 1
239000010439 graphite Substances 0.000 description 1
229920006158 high molecular weight polymer Polymers 0.000 description 1
238000001794 hormone therapy Methods 0.000 description 1
238000011221 initial treatment Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
GKOZUEZYRPOHIO-IGMARMGPSA-N iridium-192 Chemical compound [192Ir] GKOZUEZYRPOHIO-IGMARMGPSA-N 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000011344 liquid material Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
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208000014018 liver neoplasm Diseases 0.000 description 1
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239000003094 microcapsule Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
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JMRZMIFDYMSZCB-UHFFFAOYSA-N morpholine-2,5-dione Chemical class O=C1COC(=O)CN1 JMRZMIFDYMSZCB-UHFFFAOYSA-N 0.000 description 1
QVRVXSZKCXFBTE-UHFFFAOYSA-N n-[4-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)butyl]-2-(2-fluoroethoxy)-5-methylbenzamide Chemical compound C1C=2C=C(OC)C(OC)=CC=2CCN1CCCCNC(=O)C1=CC(C)=CC=C1OCCF QVRVXSZKCXFBTE-UHFFFAOYSA-N 0.000 description 1
210000001640 nerve ending Anatomy 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
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229940097886 phosphorus 32 Drugs 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920000117 poly(dioxanone) Polymers 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
239000000622 polydioxanone Substances 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
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OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 description 1
238000007788 roughening Methods 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
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238000004513 sizing Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
CIOAGBVUUVVLOB-OUBTZVSYSA-N strontium-89 Chemical compound [89Sr] CIOAGBVUUVVLOB-OUBTZVSYSA-N 0.000 description 1
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239000008261 styrofoam Substances 0.000 description 1
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FRNOGLGSGLTDKL-OUBTZVSYSA-N thulium-170 Chemical compound [170Tm] FRNOGLGSGLTDKL-OUBTZVSYSA-N 0.000 description 1
238000011277 treatment modality Methods 0.000 description 1
229920000428 triblock copolymer Polymers 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
238000010792 warming Methods 0.000 description 1
PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1023—Means for creating a row of seeds, e.g. spacers

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pathology (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Radiology & Medical Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Radiation-Therapy Devices (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200303372A 2000-11-01 2003-04-30 Radioactive member for use in brachytherapy and method of making. ZA200303372B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24504600P	2000-11-01	2000-11-01

Publications (1)

Publication Number	Publication Date
ZA200303372B true ZA200303372B (en)	2004-07-30

Family

ID=22925077

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200303372A ZA200303372B (en)	2000-11-01	2003-04-30	Radioactive member for use in brachytherapy and method of making.

Country Status (18)

Country	Link
US (3)	US6905455B2 (da)
EP (1)	EP1330292B1 (da)
AT (1)	ATE305809T1 (da)
AU (5)	AU2002231227B2 (da)
BR (1)	BR0115087B1 (da)
CA (1)	CA2427837C (da)
CZ (1)	CZ20031217A3 (da)
DE (1)	DE60113871T2 (da)
DK (1)	DK1330292T3 (da)
ES (1)	ES2253446T3 (da)
IL (1)	IL155382A0 (da)
MX (1)	MXPA03003852A (da)
NO (1)	NO20031803L (da)
NZ (2)	NZ543165A (da)
PL (1)	PL203978B1 (da)
RU (1)	RU2277953C2 (da)
WO (1)	WO2002036199A2 (da)
ZA (1)	ZA200303372B (da)

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* Cited by examiner, † Cited by third party
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US8088060B2 (en)	2000-03-15	2012-01-03	Orbusneich Medical, Inc.	Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en)	2000-03-15	2016-12-20	Orbusneich Medical, Inc.	Medical device with coating for capturing genetically-altered cells and methods for using same
US6949064B2 (en)	2000-10-20	2005-09-27	Bard Brachytherapy, Inc.	Brachytherapy seed deployment system
AU2003267309A1 (en)	2000-11-16	2004-04-08	Microspherix Llc	Flexible and/or elastic brachytherapy seed or strand
EP2428174B1 (en)	2001-09-24	2014-01-08	Applied Medical Resources Corporation	Bladeless obturator
US6761680B2 (en)	2001-11-02	2004-07-13	Richard A. Terwilliger	Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing
US7074291B2 (en) *	2001-11-02	2006-07-11	Worldwide Medical Technologies, L.L.C.	Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6786858B2 (en) *	2001-11-02	2004-09-07	Ideamatrix, Inc.	Delivery system and method for interstitial radiotherapy using hollow seeds
US7094198B2 (en) *	2001-11-02	2006-08-22	Worldwide Medical Technologies, Llc	Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations
US7060020B2 (en) *	2001-11-02	2006-06-13	Ideamatrix, Inc.	Delivery system and method for interstitial radiation therapy
IL147898A (en) *	2002-01-30	2007-05-15	Yuval Golan	A method of treating cancer based on the Ugar effect
DE10204818C2 (de) *	2002-02-06	2003-11-27	Eurotope Entwicklungsgesellsch	Gerät und Verfahren zur Beladung von Implantationshohlnadeln mit Strahlungsquellen aus Strahlungsquellenketten zur interstitiellen Brachytherapie von Gewebe
CA2485481A1 (en)	2002-05-16	2003-11-27	Applied Medical Resources Corporation	Cone tip obturator
US6932758B1 (en) *	2003-02-12	2005-08-23	Bruno Schmidt	Coupled seed train
US7322928B2 (en)	2003-03-17	2008-01-29	Medi-Physics, Inc.	Products and methods for brachytherapy
US6997862B2 (en) *	2003-05-13	2006-02-14	Ideamatrix, Inc.	Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing
EP1670349B9 (en)	2003-10-03	2014-01-15	Applied Medical Resources Corporation	Bladeless optical obturator
US20050080314A1 (en) *	2003-10-09	2005-04-14	Terwilliger Richard A.	Shielded transport for multiple brachytheapy implants with integrated measuring and cutting board
EP3431026B1 (en)	2004-06-29	2020-09-23	Applied Medical Resources Corporation	Insufflating optical surgical instrument
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2001
- 2001-11-01 IL IL15538201A patent/IL155382A0/xx unknown
- 2001-11-01 BR BRPI0115087-1A patent/BR0115087B1/pt not_active IP Right Cessation
- 2001-11-01 PL PL366252A patent/PL203978B1/pl not_active IP Right Cessation
- 2001-11-01 NZ NZ543165A patent/NZ543165A/en not_active IP Right Cessation
- 2001-11-01 AU AU2002231227A patent/AU2002231227B2/en not_active Ceased
- 2001-11-01 WO PCT/US2001/049879 patent/WO2002036199A2/en not_active Ceased
- 2001-11-01 NZ NZ525361A patent/NZ525361A/en not_active IP Right Cessation
- 2001-11-01 AT AT01991503T patent/ATE305809T1/de not_active IP Right Cessation
- 2001-11-01 US US10/415,715 patent/US6905455B2/en not_active Expired - Lifetime
- 2001-11-01 CZ CZ20031217A patent/CZ20031217A3/cs unknown
- 2001-11-01 ES ES01991503T patent/ES2253446T3/es not_active Expired - Lifetime
- 2001-11-01 MX MXPA03003852A patent/MXPA03003852A/es active IP Right Grant
- 2001-11-01 DE DE60113871T patent/DE60113871T2/de not_active Expired - Lifetime
- 2001-11-01 CA CA2427837A patent/CA2427837C/en not_active Expired - Fee Related
- 2001-11-01 EP EP01991503A patent/EP1330292B1/en not_active Expired - Lifetime
- 2001-11-01 DK DK01991503T patent/DK1330292T3/da active
- 2001-11-01 AU AU3122702A patent/AU3122702A/xx active Pending
- 2001-11-01 RU RU2003112010/14A patent/RU2277953C2/ru not_active IP Right Cessation
2003
- 2003-04-23 NO NO20031803A patent/NO20031803L/no not_active Application Discontinuation
- 2003-04-30 ZA ZA200303372A patent/ZA200303372B/en unknown
2005
- 2005-04-05 US US11/099,238 patent/US7547274B2/en not_active Expired - Fee Related
2007
- 2007-05-23 AU AU2007202344A patent/AU2007202344A1/en not_active Abandoned
- 2007-09-06 AU AU2007216652A patent/AU2007216652B2/en not_active Ceased
2009
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- 2009-10-22 AU AU2009227914A patent/AU2009227914B2/en not_active Ceased

Also Published As

Publication number	Publication date
NO20031803L (no)	2003-06-30
AU2009227914A1 (en)	2009-11-12
ES2253446T3 (es)	2006-06-01
DK1330292T3 (da)	2006-02-13
DE60113871T2 (de)	2006-07-27
NO20031803D0 (no)	2003-04-23
BR0115087A (pt)	2003-09-16
US7547274B2 (en)	2009-06-16
US20090253950A1 (en)	2009-10-08
WO2002036199A3 (en)	2002-08-29
CA2427837A1 (en)	2002-05-10
NZ525361A (en)	2005-12-23
EP1330292B1 (en)	2005-10-05
MXPA03003852A (es)	2004-10-15
EP1330292A2 (en)	2003-07-30
BR0115087B1 (pt)	2011-12-27
US20060058570A1 (en)	2006-03-16
CA2427837C (en)	2010-07-13
RU2277953C2 (ru)	2006-06-20
US8033981B2 (en)	2011-10-11
AU2002231227B2 (en)	2007-06-07
AU2007216652A1 (en)	2007-09-27
US6905455B2 (en)	2005-06-14
ATE305809T1 (de)	2005-10-15
WO2002036199A9 (en)	2003-08-14
AU2007216652B2 (en)	2009-11-12
AU3122702A (en)	2002-05-15
IL155382A0 (en)	2003-11-23
CZ20031217A3 (en)	2004-04-14
PL366252A1 (en)	2005-01-24
WO2002036199A2 (en)	2002-05-10
NZ543165A (en)	2007-06-29
DE60113871D1 (de)	2005-11-10
AU2009227914B2 (en)	2011-08-25
AU2007202344A1 (en)	2007-06-14
US20040015037A1 (en)	2004-01-22
PL203978B1 (pl)	2009-11-30

Publication	Publication Date	Title
US6905455B2 (en)	2005-06-14	Radioactive member and method of making
AU2002231227A1 (en)	2002-07-18	Radioactive member for use in brachytherapy and method of making
EP1173252B1 (en)	2007-12-05	Products for brachytherapy and methods for their production
JP4846565B2 (ja)	2011-12-28	近接照射療法用の製品及び方法
EP1450891A2 (en)	2004-09-01	Delivery system and method for interstitial radiation therapy