ZA864582B - Derivatives of indole carboxamide,their salts,process and intermediates for preparation,use as medicaments and compositions containing them - Google Patents

Derivatives of indole carboxamide,their salts,process and intermediates for preparation,use as medicaments and compositions containing them

Info

Publication number: ZA864582B
Authority: ZA; South Africa
Prior art keywords: carbon atoms; group; hydrogen; alkyl; image
Prior art date: 1985-07-11

Application number

ZA864582A

Other languages

English (en)

Inventor

Francois Clemence

Jacques Guillaume

Gilles Hamon

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-11

Filing date

1986-06-19

Publication date

1987-08-26

1986-06-19 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1987-08-26 Publication of ZA864582B publication Critical patent/ZA864582B/xx

Links

-1 of indole carboxamide Chemical class 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 11
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
VFHUJFBEFDVZPJ-UHFFFAOYSA-N 1h-indole-2-carboxamide Chemical class C1=CC=C2NC(C(=O)N)=CC2=C1 VFHUJFBEFDVZPJ-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000002653 sulfanylmethyl group Chemical group [H]SC([H])([H])[*] 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ZA864582A 1985-07-11 1986-06-19 Derivatives of indole carboxamide,their salts,process and intermediates for preparation,use as medicaments and compositions containing them ZA864582B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8510648A FR2584713B1 (fr)	1985-07-11	1985-07-11	Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant

Publications (1)

Publication Number	Publication Date
ZA864582B true ZA864582B (en)	1987-08-26

Family

ID=9321209

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA864582A ZA864582B (en)	1985-07-11	1986-06-19	Derivatives of indole carboxamide,their salts,process and intermediates for preparation,use as medicaments and compositions containing them

Country Status (13)

Country	Link
US (1)	US4791109A (de)
EP (1)	EP0213984B1 (de)
JP (1)	JPH0680040B2 (de)
KR (1)	KR930009815B1 (de)
AT (1)	ATE59844T1 (de)
AU (1)	AU601687B2 (de)
DE (1)	DE3676763D1 (de)
DK (1)	DK167973B1 (de)
FI (1)	FI85015C (de)
FR (1)	FR2584713B1 (de)
HU (1)	HU196177B (de)
IE (1)	IE59153B1 (de)
ZA (1)	ZA864582B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8426474D0 (en) *	1984-10-19	1984-11-28	Ici America Inc	Heterocyclic amides
FR2609464B1 (fr) *	1987-01-09	1990-12-07	Roussel Uclaf	Nouveaux derives du n-(1h-indol 4-yl) benzamide ainsi que leurs sels, leur application a titre de medicaments, et les compositions les renfermant
US4908367A (en) *	1985-07-11	1990-03-13	Roussel Uclaf	N-(1H-indole-4-yl)-benzamides
DE3529994A1 (de) *	1985-08-22	1987-02-26	Hoechst Ag	Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
DE3818830A1 (de) *	1988-06-03	1989-12-14	Boehringer Mannheim Gmbh	Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
FR2646349B1 (fr) *	1989-04-28	1994-04-01	Roussel Uclaf	Derives du 4-phenylmethyl lh-indole, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
DE3934436A1 (de) *	1989-06-01	1991-04-18	Thomae Gmbh Dr K	2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4119611A1 (de) *	1991-06-14	1992-12-17	Bayer Ag	Mittel zur bekaempfung von schaedlingen auf basis substituierter oxazolidinone, neue substituierte oxazolidinone, deren herstellung und verwendung
WO2002070478A1 (en)	2001-03-06	2002-09-12	Astrazeneca Ab	Indolone derivatives having vascular-damaging activity
CN102175694A (zh)	2006-05-23	2011-09-07	麒麟工程技术系统公司	表面检查设备
UA110112C2 (uk)	2010-05-07	2015-11-25	Глаксосмітклайн Ллс	Індоли
BR112014010803A2 (pt)	2011-11-04	2017-04-25	Glaxosmithkline Intellectual Property (No 2) Ltd	método de tratamento
JP6648438B2 (ja) *	2014-08-27	2020-02-14	Jnc株式会社	液晶性化合物、液晶組成物およびその重合体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4313947A (en) *	1974-06-24	1982-02-02	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
US4333951A (en) *	1977-11-15	1982-06-08	A. H. Robins Company, Inc.	2-Amino-6-biphenylacetic acids
EP0089426B1 (de) *	1979-07-12	1986-06-11	A.H. Robins Company, Incorporated	2-Amino-6-biphenylessigsäuren
EP0025111B1 (de) *	1979-08-10	1984-07-25	Sandoz Ag	3-Aminopropoxyaryl-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CA1156661A (en) *	1980-02-25	1983-11-08	Hoffmann-La Roche Limited	Phenoxy-aminopropanol derivatives
FR2528043A1 (fr) *	1982-06-03	1983-12-09	Roussel Uclaf	Nouveaux derives de la 1,3-dihydro 4-/1-hydroxy-2-amino-ethyl/2h-indol-2-one, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
JPS60142981A (ja) *	1983-12-28	1985-07-29	Yoshitomi Pharmaceut Ind Ltd	３−インド−ルカルボキサミド誘導体
US4853408A (en) *	1985-04-23	1989-08-01	Roussel Uclaf	4-phenylpropyl-indoles having antiarythmic activity
FR2584070B1 (fr) *	1985-06-27	1987-08-28	Roussel Uclaf	Nouveaux derives de l'hydroxy alkoxy 4-phenyl propyl indole, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant.
DE3788207T2 (de) *	1986-12-19	1994-03-31	Roussel Uclaf	Indol-Carboxamid-Derivate und ihre Salze, Verfahren und Zwischenprodukte zur Herstellung, Anwendung als Heilmittel und Zusammenstellungen, die sie enthalten.

1985
- 1985-07-11 FR FR8510648A patent/FR2584713B1/fr not_active Expired
1986
- 1986-06-19 IE IE163386A patent/IE59153B1/en not_active IP Right Cessation
- 1986-06-19 ZA ZA864582A patent/ZA864582B/xx unknown
- 1986-07-09 JP JP61159899A patent/JPH0680040B2/ja not_active Expired - Lifetime
- 1986-07-09 DE DE8686401528T patent/DE3676763D1/de not_active Expired - Fee Related
- 1986-07-09 AT AT86401528T patent/ATE59844T1/de not_active IP Right Cessation
- 1986-07-09 EP EP86401528A patent/EP0213984B1/de not_active Expired - Lifetime
- 1986-07-10 DK DK327286A patent/DK167973B1/da not_active IP Right Cessation
- 1986-07-10 FI FI862909A patent/FI85015C/fi not_active IP Right Cessation
- 1986-07-10 HU HU862863A patent/HU196177B/hu not_active IP Right Cessation
- 1986-07-10 AU AU60032/86A patent/AU601687B2/en not_active Ceased
- 1986-07-10 US US06/883,915 patent/US4791109A/en not_active Expired - Fee Related
- 1986-07-11 KR KR1019860005590A patent/KR930009815B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR930009815B1 (ko)	1993-10-11
IE861633L (en)	1987-01-11
FR2584713A1 (fr)	1987-01-16
FR2584713B1 (fr)	1988-09-09
AU6003286A (en)	1987-01-15
DK327286A (da)	1987-01-12
EP0213984A1 (de)	1987-03-11
DE3676763D1 (de)	1991-02-14
KR870001162A (ko)	1987-03-11
HUT42440A (en)	1987-07-28
JPH0680040B2 (ja)	1994-10-12
EP0213984B1 (de)	1991-01-09
US4791109A (en)	1988-12-13
AU601687B2 (en)	1990-09-20
FI862909A0 (fi)	1986-07-10
HU196177B (en)	1988-10-28
FI862909A7 (fi)	1987-01-12
IE59153B1 (en)	1994-01-12
JPS6216460A (ja)	1987-01-24
DK327286D0 (da)	1986-07-10
FI85015B (fi)	1991-11-15
FI85015C (fi)	1992-02-25
ATE59844T1 (de)	1991-01-15
DK167973B1 (da)	1994-01-10

Publication	Publication Date	Title
AU601687B2 (en)	1990-09-20	New derivatives of carboxamide indole, their salts, process and intermediates for preparation, use as medicaments and compositions containing them
EP0233793A3 (en)	1989-04-19	Decahydroquinoline derivatives, process for their preparation, intermediates for their preparation, their use as medicaments and compositions containing them
ES8304567A1 (es)	1983-03-01	"un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida".
SE8403801D0 (sv)	1984-07-20	Nya bensotiazepiner med kardiovaskuler anvendbarhet, forfarande for framstellning derav och farmaceutiska kompositioner som innehaller dem
DE3273377D1 (en)	1986-10-23	Pyrimido quinoxalines and their salts, their preparation, their use as medicaments and compositions containing them
DE3562774D1 (en)	1988-06-23	Indole-ethylphenol derivatives, their salts, process for their peparation, their uses as medicines and compositions containing them
EP0287468A3 (en)	1990-05-02	17-aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them
DK470888D0 (da)	1988-08-23	Imidazobenzodiazepinderivater, deres fresmtilling samt laegemidler med indholdd deraf
DE3569376D1 (en)	1989-05-18	1,2,4-thiadiazines and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
ZA864292B (en)	1987-08-26	Derivatives of hydroxyalkoxy-4-phenylpropyl indole,their salts,process and intermediates for preparation,use as medicaments and compositions containing them
ES500108A0 (es)	1982-06-01	Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
IL70103A0 (en)	1984-02-29	Semicarbazides,their preparation and pharmaceutical compositions containing them