ZA876749B - New phenyl,pyrrolidin-2-yl substituted 5-ring heterocycles having antipsychotic properties - Google Patents

New phenyl,pyrrolidin-2-yl substituted 5-ring heterocycles having antipsychotic properties

Info

Publication number: ZA876749B
Authority: ZA; South Africa
Prior art keywords: pyrrolidin; substituted; ring; antipsychotic properties; ring heterocycles
Prior art date: 1986-09-12

Application number

ZA876749A

Other languages

English (en)

Inventor

Van Wijngaarden Ineke

G. Kruse Cornelis

Van Hes Roelof

A.M. Van Der Heyden Johannes

Original Assignee

Duphar International Research B.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-12

Filing date

1987-09-09

Publication date

1988-03-14

1987-09-09 Application filed by Duphar International Research B.V. filed Critical Duphar International Research B.V.

1988-03-14 Publication of ZA876749B publication Critical patent/ZA876749B/xx

Links

230000000561 anti-psychotic effect Effects 0.000 title abstract 2
125000000623 heterocyclic group Chemical group 0.000 title 1
-1 phenyl,pyrrolidin-2-yl Chemical group 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA876749A 1986-09-12 1987-09-09 New phenyl,pyrrolidin-2-yl substituted 5-ring heterocycles having antipsychotic properties ZA876749B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8602305		1986-09-12

Publications (1)

Publication Number	Publication Date
ZA876749B true ZA876749B (en)	1988-03-14

Family

ID=19848538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA876749A ZA876749B (en)	1986-09-12	1987-09-09	New phenyl,pyrrolidin-2-yl substituted 5-ring heterocycles having antipsychotic properties

Country Status (14)

Country	Link
US (1)	US4791132A (de)
EP (1)	EP0259930B1 (de)
JP (1)	JPH0794432B2 (de)
AT (1)	ATE72435T1 (de)
AU (1)	AU609415B2 (de)
DE (1)	DE3776611D1 (de)
DK (1)	DK166275C (de)
ES (1)	ES2033297T3 (de)
GR (1)	GR3004436T3 (de)
IE (1)	IE60294B1 (de)
IL (1)	IL83841A (de)
NZ (1)	NZ221731A (de)
PH (1)	PH23898A (de)
ZA (1)	ZA876749B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4992441A (en) *	1987-10-14	1991-02-12	Mcneilab, Inc.	1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
JPH07509705A (ja) *	1992-08-06	1995-10-26	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	ドーパミンｄ３レセプター拮抗薬用５−（２−オキシフェニル）−ピロール誘導体
GB9307400D0 (en) *	1993-04-08	1993-06-02	Smithkline Beecham Plc	Compounds
GB9309573D0 (en) *	1993-05-10	1993-06-23	Merck Sharp & Dohme	Therapeutic agents
DE69408674T2 (de) *	1993-06-25	1998-09-10	Smithkline Beecham Plc	Phenylpyrrol-derivate und ihre verwendung als dopamin d3 antagonisten
GB9315800D0 (en) *	1993-07-30	1993-09-15	Smithkline Beecham Plc	Compounds
GB9315801D0 (en) *	1993-07-30	1993-09-15	Smithkline Beecham Plc	Compounds
GB9320855D0 (en) *	1993-10-09	1993-12-01	Smithkline Beecham Plc	Compounds
GB9402197D0 (en) *	1994-02-04	1994-03-30	Smithkline Beecham Plc	Compounds
GB9403199D0 (en) *	1994-02-19	1994-04-13	Smithkline Beecham Plc	Compounds
GB9512129D0 (en) *	1995-06-15	1995-08-16	Smithkline Beecham Plc	Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4219560A (en) *	1978-04-17	1980-08-26	Sandoz, Inc.	Piperidine and pyrrolidine alcohols
DE2835439A1 (de) *	1978-08-12	1980-02-28	Basf Ag	2-(o-hydroxyphenyl)-pyrrol
US4321385A (en) *	1980-02-04	1982-03-23	Hoechst Roussel Pharmaceuticals Inc.	[(Aryl-1-pyrryl) methyl]-piperidinols and pyrrolidinols
US4539332A (en) *	1983-11-14	1985-09-03	Merck & Co., Inc.	2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists

1987
- 1987-09-08 PH PH35780A patent/PH23898A/en unknown
- 1987-09-09 AT AT87201706T patent/ATE72435T1/de not_active IP Right Cessation
- 1987-09-09 IL IL83841A patent/IL83841A/xx not_active IP Right Cessation
- 1987-09-09 DK DK470687A patent/DK166275C/da active
- 1987-09-09 EP EP87201706A patent/EP0259930B1/de not_active Expired - Lifetime
- 1987-09-09 AU AU78191/87A patent/AU609415B2/en not_active Ceased
- 1987-09-09 ES ES198787201706T patent/ES2033297T3/es not_active Expired - Lifetime
- 1987-09-09 NZ NZ221731A patent/NZ221731A/xx unknown
- 1987-09-09 DE DE8787201706T patent/DE3776611D1/de not_active Expired - Fee Related
- 1987-09-09 ZA ZA876749A patent/ZA876749B/xx unknown
- 1987-09-09 IE IE240987A patent/IE60294B1/en not_active IP Right Cessation
- 1987-09-09 US US07/094,746 patent/US4791132A/en not_active Expired - Fee Related
- 1987-09-10 JP JP62225427A patent/JPH0794432B2/ja not_active Expired - Lifetime
1992
- 1992-04-22 GR GR920400808T patent/GR3004436T3/el unknown

Also Published As

Publication number	Publication date
DK166275B (da)	1993-03-29
IE872409L (en)	1988-03-12
DK470687D0 (da)	1987-09-09
GR3004436T3 (de)	1993-03-31
DK166275C (da)	1993-08-23
JPH0794432B2 (ja)	1995-10-11
DE3776611D1 (de)	1992-03-19
EP0259930A1 (de)	1988-03-16
NZ221731A (en)	1990-07-26
DK470687A (da)	1988-03-13
US4791132A (en)	1988-12-13
ES2033297T3 (es)	1993-03-16
IE60294B1 (en)	1994-06-29
JPS6377856A (ja)	1988-04-08
IL83841A0 (en)	1988-02-29
AU609415B2 (en)	1991-05-02
PH23898A (en)	1989-12-18
EP0259930B1 (de)	1992-02-05
AU7819187A (en)	1988-03-17
ATE72435T1 (de)	1992-02-15
IL83841A (en)	1991-11-21

Publication	Publication Date	Title
GR3005072T3 (de)	1993-05-24
ID17851A (id)	1998-01-29	Persenyawaan heterosiklis, produksi dan pemakaiannya
IE781619L (en)	1979-02-11	Phosphonoacyl proline compounds.
EP0675187A3 (de)	1996-04-17	Flüssigkristallverbindungen und diese enthaltende Flüssigkristallzusammensetzung.
PH31278A (en)	1998-07-06	Spiro compound.
FI915116A0 (fi)	1991-10-30	1-arylimidazol-insekticider.
ZA876749B (en)	1988-03-14	New phenyl,pyrrolidin-2-yl substituted 5-ring heterocycles having antipsychotic properties
GR3004139T3 (de)	1993-03-31
NZ218243A (en)	1990-03-27	B-carboline derivatives and pharmaceutical compositions
ZA894102B (en)	1990-03-28	Butenoic or propenoic acid derivative
IE780182L (en)	1978-07-28	N-9,10-DIHYDROLYSERGYL-m-AMINOBENZOIC ACID AMIDES.
ZA895623B (en)	1990-05-30	Tetracyclic antidepressants
NO875357L (no)	1988-06-23	Kjemiske sammensetninger og deres bruk som brennstoffadditiver.
GR3004091T3 (de)	1993-03-31
DE3175327D1 (en)	1986-10-23	Antihypertensive lactams
EP0574271A3 (de)	1994-04-06
ATE10629T1 (de)	1984-12-15	Benzotriazole, ihre herstellung und ihre verwendung als fungizide.
YU189290A (sh)	1993-05-28	Fungicidi
IL86665A0 (en)	1988-11-30	Mitomycin analogs
IE832885L (en)	1984-06-10	Substituted tropyl and pseudotropyl benzoates.
ES2077697T3 (es)	1995-12-01	Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
ES2015297B3 (es)	1990-08-16	Herbicidas de fenilurea.