ZA891623B - 6-substituted purinyl piperazine derivatives - Google Patents

6-substituted purinyl piperazine derivatives

Info

Publication number: ZA891623B
Authority: ZA; South Africa
Prior art keywords: piperazine derivatives; substituted purinyl; purinyl piperazine; derivatives; substituted
Prior art date: 1988-03-03

Application number

ZA891623A

Other languages

English (en)

Inventor

Zoltan G Hajos

G Hajos Zoltan

Ramesh M Kanojia

M Kanojia Ramesh

Jeffrey B Press

B Press Jeffrey

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-03

Filing date

1989-03-02

Publication date

1990-11-28

1989-03-02 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1990-11-28 Publication of ZA891623B publication Critical patent/ZA891623B/xx

Links

-1 6-substituted purinyl piperazine Chemical class 0.000 title abstract 2
229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
239000003416 antiarrhythmic agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000000496 cardiotonic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA891623A 1988-03-03 1989-03-02 6-substituted purinyl piperazine derivatives ZA891623B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/163,487 US4876257A (en)	1988-03-03	1988-03-03	6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

Publications (1)

Publication Number	Publication Date
ZA891623B true ZA891623B (en)	1990-11-28

Family

ID=22590215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA891623A ZA891623B (en)	1988-03-03	1989-03-02	6-substituted purinyl piperazine derivatives

Country Status (20)

Country	Link
US (1)	US4876257A (da)
EP (1)	EP0331511B1 (da)
JP (1)	JPH0826019B2 (da)
KR (1)	KR940002822B1 (da)
CN (1)	CN1031056C (da)
AT (1)	ATE92067T1 (da)
AU (1)	AU614583B2 (da)
DE (1)	DE68907750T2 (da)
DK (1)	DK101589A (da)
ES (1)	ES2059724T3 (da)
FI (1)	FI92587C (da)
HU (1)	HU205760B (da)
IE (1)	IE63457B1 (da)
IL (1)	IL89458A (da)
MY (1)	MY104959A (da)
NO (1)	NO171500C (da)
NZ (1)	NZ228167A (da)
PH (1)	PH26971A (da)
PT (1)	PT89903B (da)
ZA (1)	ZA891623B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5057517A (en) *	1987-07-20	1991-10-15	Merck & Co., Inc.	Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5021574A (en) *	1988-03-03	1991-06-04	Ortho Pharmaceutical Corporation	6-substituted purinyl piperazine derivatives
US5164390A (en) *	1988-03-03	1992-11-17	Ortho Pharmaceutical Corporation	6-substituted purinyl piperazine derivatives
US4885300A (en) *	1988-03-03	1989-12-05	Ortho Pharmaceutical Corporation	4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
NZ237766A (en)	1990-04-23	1993-03-26	Ortho Pharma Corp	Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates
US5215987A (en) *	1990-04-23	1993-06-01	Ortho Pharmaceutical Corporation	Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
AU648070B2 (en) *	1990-04-23	1994-04-14	Ortho Pharmaceutical Corporation	Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
US5252569A (en) *	1990-05-23	1993-10-12	Ortho Pharmaceutical Corporation	6-substituted purinyl piperazine derivatives
NZ238122A (en) *	1990-05-23	1994-01-26	Ortho Pharma Corp	6-substituted purinyl piperazine derivatives and pharmaceutical
WO1993016081A1 (en) *	1992-02-13	1993-08-19	Merrell Dow Pharmaceuticals Inc.	Piperidinyl thiacyclic derivatives
EP0603404B1 (en) *	1992-05-15	1999-03-17	Mitsui Chemicals, Inc.	Process for producing glycide derivative
ZA9610736B (en)	1995-12-22	1997-06-27	Warner Lambert Co	2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
US6087512A (en) *	1996-09-18	2000-07-11	Daiso Co., Ltd.	Process for preparation of glycidyl ether
ATE222231T1 (de) *	1996-09-18	2002-08-15	Daiso Co Ltd	Verfahren zur herstellung von 3-amino-2-hydroxy-1-propylethern
AU744986B2 (en) *	1997-07-12	2002-03-07	Cancer Research Technology Limited	Cyclin dependent kinase inhibiting purine derivatives
KR20030025153A (ko) *	2001-09-19	2003-03-28	이보섭	지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
NZ541306A (en) *	2003-01-17	2008-07-31	Cv Therapeutics Inc	Substituted piperazine and piperidine derivatives useful in the treatment of cardiovascular diseases
EP4092013A1 (en)	2017-06-20	2022-11-23	Imbria Pharmaceuticals, Inc.	Compositions and methods for increasing efficiency of cardiac metabolism
WO2020081361A1 (en)	2018-10-17	2020-04-23	Imbria Pharmaceuticals, Inc.	Methods of treating rheumatic diseases using trimetazidine-based compounds
WO2020243120A1 (en)	2019-05-31	2020-12-03	Imbria Pharmaceuticals, Inc.	Methods of treating fibrosis using compounds that promote glucose oxidation
US11530184B2 (en)	2020-06-30	2022-12-20	Imbria Pharmaceuticals, Inc.	Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en)	2020-06-30	2023-10-10	Imbria Pharmaceuticals, Inc.	Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en)	2021-05-03	2024-01-30	Imbria Pharmaceuticals, Inc.	Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3238207A (en) *	1960-03-01	1966-03-01	Burroughs Wellcome Co	6-oxyorganopurines and method of preparing them
US3232937A (en) *	1962-08-02	1966-02-01	Burroughs Wellcome Co	6-benzylmercaptopurines
US3135754A (en) *	1962-08-09	1964-06-02	Burroughs Wellcome Co	Purine derivatives
GB1133989A (en) *	1964-12-08	1968-11-20	Chugai Pharmaceutical Co Ltd	Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) *	1966-11-25	1970-02-26	Troponwerke Dinklage & Co	Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
GB1289287A (da) *	1969-03-28	1972-09-13
DE2334009A1 (de) *	1973-07-04	1975-01-23	Boehringer Mannheim Gmbh	Purin-derivate sowie verfahren zu ihrer herstellung
US4189579A (en) *	1977-05-20	1980-02-19	The Dow Chemical Company	Aminoalkylthiopurines
US4426383A (en) *	1980-09-04	1984-01-17	Eisai Co., Ltd.	Theophylline and theobromine derivatives
DE3200304A1 (de) *	1981-01-16	1982-08-26	Sandoz-Patent-GmbH, 7850 Lörrach	3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3307395A1 (de) *	1982-03-02	1983-09-08	Eisai Co., Ltd., Tokyo	Arzneimittel zur behandlung von schmerzen, fieber, gewebe- und/oder knochen- und gelenkentzuendungen mit einem gehalt an theobromin- oder theophyllinderivaten als aktivem bestandteil
DK157135C (da) *	1982-04-07	1990-04-02	Pfizer	Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DE3703633A1 (de) *	1986-02-14	1987-08-20	Sandoz Ag	Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4710572A (en) *	1986-07-30	1987-12-01	American Home Products Corporation	Histamine H1 antagonists

1988
- 1988-03-03 US US07/163,487 patent/US4876257A/en not_active Expired - Fee Related
1989
- 1989-02-28 NZ NZ228167A patent/NZ228167A/xx unknown
- 1989-03-01 AU AU30882/89A patent/AU614583B2/en not_active Ceased
- 1989-03-02 FI FI891003A patent/FI92587C/fi not_active IP Right Cessation
- 1989-03-02 IL IL89458A patent/IL89458A/xx not_active IP Right Cessation
- 1989-03-02 DK DK101589A patent/DK101589A/da unknown
- 1989-03-02 ZA ZA891623A patent/ZA891623B/xx unknown
- 1989-03-02 MY MYPI89000259A patent/MY104959A/en unknown
- 1989-03-02 IE IE68489A patent/IE63457B1/en not_active IP Right Cessation
- 1989-03-02 NO NO890893A patent/NO171500C/no unknown
- 1989-03-03 ES ES89302141T patent/ES2059724T3/es not_active Expired - Lifetime
- 1989-03-03 JP JP1051804A patent/JPH0826019B2/ja not_active Expired - Lifetime
- 1989-03-03 CN CN89102516A patent/CN1031056C/zh not_active Expired - Fee Related
- 1989-03-03 PT PT89903A patent/PT89903B/pt not_active IP Right Cessation
- 1989-03-03 EP EP89302141A patent/EP0331511B1/en not_active Expired - Lifetime
- 1989-03-03 AT AT89302141T patent/ATE92067T1/de not_active IP Right Cessation
- 1989-03-03 KR KR1019890002603A patent/KR940002822B1/ko not_active Expired - Fee Related
- 1989-03-03 PH PH38279A patent/PH26971A/en unknown
- 1989-03-03 HU HU891033A patent/HU205760B/hu not_active IP Right Cessation
- 1989-03-03 DE DE89302141T patent/DE68907750T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE68907750D1 (de)	1993-09-02
CN1036765A (zh)	1989-11-01
FI92587B (fi)	1994-08-31
DK101589D0 (da)	1989-03-02
ATE92067T1 (de)	1993-08-15
FI891003A0 (fi)	1989-03-02
PT89903A (pt)	1989-11-10
AU3088289A (en)	1989-09-07
NZ228167A (en)	1991-08-27
FI891003A7 (fi)	1989-09-04
IE63457B1 (en)	1995-04-19
EP0331511A1 (en)	1989-09-06
NO890893L (no)	1989-09-04
HU205760B (en)	1992-06-29
IE890684L (en)	1989-09-03
IL89458A0 (en)	1989-09-10
KR890014538A (ko)	1989-10-24
CN1031056C (zh)	1996-02-21
MY104959A (en)	1994-07-30
US4876257A (en)	1989-10-24
EP0331511B1 (en)	1993-07-28
JPH0826019B2 (ja)	1996-03-13
ES2059724T3 (es)	1994-11-16
JPH01279887A (ja)	1989-11-10
NO171500B (no)	1992-12-14
IL89458A (en)	1993-07-08
PT89903B (pt)	1994-05-31
PH26971A (en)	1992-12-28
HUT49352A (en)	1989-09-28
AU614583B2 (en)	1991-09-05
KR940002822B1 (ko)	1994-04-04
NO171500C (no)	1993-03-24
NO890893D0 (no)	1989-03-02
FI92587C (fi)	1994-12-12
DK101589A (da)	1989-09-04
DE68907750T2 (de)	1994-01-05

Publication	Publication Date	Title
ZA891623B (en)	1990-11-28	6-substituted purinyl piperazine derivatives
HU911771D0 (en)	1991-12-30	Process for producing substituted and heterocyclic phthalides
DE3468878D1 (en)	1988-02-25	7-amino-azoloû1,5-a¨pyrimidines and fungicides containing them
HUT50330A (en)	1990-01-29	Process for producing heterocyclic piperazinyl derivatives
GB2161981B (en)	1989-05-17	Folded co2 laser
HUT62278A (en)	1993-04-28	Process for producing piperazine derivatives
HU9401331D0 (en)	1994-08-29	Substituted piperazine derivatives and process for producing them
GB2223753B (en)	1992-01-02	Piperazine derivatives
DE3568987D1 (en)	1989-04-27	Derivatives of dihydro-1h-pyrrolo(1,2-c)imidazol-3,5-dione as cognition activators
MY106167A (en)	1995-03-31	6-substituted purinyl piperazine derivatives.
GB8316779D0 (en)	1983-07-27	Process
MY104804A (en)	1994-05-31	Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
GB2144116B (en)	1987-11-25	N-hydroxyalkyl piperazine derivatives; catalysts for producing polyurethane
GB2224027B (en)	1992-01-15	Piperazine derivatives
BG44193A1 (en)	1988-10-14	Feeding source for multielemental co below 2 laser
HUT51053A (en)	1990-03-28	Circuit arrangement for the bias of a class a amplifier of sliding work point
IE881113L (en)	1988-10-14	Piperazine derivatives
IE880991L (en)	1988-10-03	Piperazine derivatives
MY104960A (en)	1994-07-30	4-substituted pyrazolo (3,4-d) pyrimidine derivatives.
GB8924323D0 (en)	1989-12-13	Piperazine derivatives