ZA907079B - Novel peptidase and isomerase inhibitors - Google Patents

Novel peptidase and isomerase inhibitors

Info

Publication number: ZA907079B
Authority: ZA; South Africa
Prior art keywords: isomerase inhibitors; novel peptidase; useful; peptidase; novel
Prior art date: 1989-09-11

Application number

ZA907079A

Other languages

English (en)

Inventor

Gary Alan Flynn

Alan Flynn Gary

Philippe Bey

Bey Philippe

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-11

Filing date

1990-09-05

Publication date

1991-07-31

1990-09-05 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-07-31 Publication of ZA907079B publication Critical patent/ZA907079B/xx

Links

102000035195 Peptidases Human genes 0.000 title abstract 2
108091005804 Peptidases Proteins 0.000 title abstract 2
235000019833 protease Nutrition 0.000 title abstract 2
239000003394 isomerase inhibitor Substances 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
230000002797 proteolythic effect Effects 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Crystallography & Structural Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA907079A 1989-09-11 1990-09-05 Novel peptidase and isomerase inhibitors ZA907079B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40549189A	1989-09-11	1989-09-11

Publications (1)

Publication Number	Publication Date
ZA907079B true ZA907079B (en)	1991-07-31

Family

ID=23603927

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA907079A ZA907079B (en)	1989-09-11	1990-09-05	Novel peptidase and isomerase inhibitors

Country Status (15)

Country	Link
EP (1)	EP0417721B1 (ja)
JP (1)	JPH03118357A (ja)
KR (1)	KR910006324A (ja)
CN (1)	CN1050198A (ja)
AT (1)	ATE127474T1 (ja)
AU (1)	AU635961B2 (ja)
CA (1)	CA2024661A1 (ja)
DD (1)	DD299309A5 (ja)
DE (1)	DE69022150D1 (ja)
FI (1)	FI904450A7 (ja)
HU (1)	HUT55347A (ja)
NO (1)	NO903944L (ja)
NZ (1)	NZ235155A (ja)
PT (1)	PT95264A (ja)
ZA (1)	ZA907079B (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5874424A (en) *	1995-12-20	1999-02-23	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6008217A (en) *	1995-12-20	1999-12-28	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en)	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
AU661270B2 (en) *	1990-03-05	1995-07-20	Cephalon, Inc.	Chymotrypsin-like proteases and their inhibitors
US6060462A (en) *	1993-10-20	2000-05-09	Dupont Pharmaceuticals Company	Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
US5756466A (en) *	1994-06-17	1998-05-26	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US5847135A (en) *	1994-06-17	1998-12-08	Vertex Pharmaceuticals, Incorporated	Inhibitors of interleukin-1β converting enzyme
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en)	1995-06-05	2002-07-16	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β converting enzyme
US6211154B1 (en)	1995-06-07	2001-04-03	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US6022861A (en) *	1995-06-07	2000-02-08	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US5919765A (en) *	1995-06-07	1999-07-06	Cor Therapeutics, Inc.	Inhibitors of factor XA
US6069130A (en) *	1995-06-07	2000-05-30	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US5721214A (en) *	1995-06-07	1998-02-24	Cor Therapeutics, Inc.	Inhibitors of factor Xa
US6046169A (en) *	1995-06-07	2000-04-04	Cor Therapeutics, Inc.	Inhibitors of factor XA
US5843904A (en) *	1995-12-20	1998-12-01	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1βconverting enzyme
US6245743B1 (en)	1996-06-05	2001-06-12	Cor Therapeutics, Inc.	Inhibitors of factor Xa
AP1019A (en)	1996-10-18	2001-10-16	Vertex Pharma	Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease.
DE69925581T2 (de)	1998-03-09	2006-04-27	Vertex Pharmaceuticals Inc., Cambridge	1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
DK1064298T3 (da)	1998-03-19	2009-01-19	Vertex Pharma	Inhibitorer af caspaser
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
SV2003000617A (es)	2000-08-31	2003-01-13	Lilly Co Eli	Inhibidores de la proteasa peptidomimetica ref. x-14912m
US7067148B2 (en)	2001-02-15	2006-06-27	King Pharmaceutical Research & Development, Inc.	Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
DE60228954D1 (en) *	2001-05-03	2008-10-30	Galileo Lab Inc	Pyruvatderivate
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
EP1636208B1 (en) *	2003-04-11	2012-02-29	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
UY28500A1 (es)	2003-09-05	2005-04-29	Vertex Pharma	Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
CA2567080A1 (en)	2004-05-27	2005-12-15	Vertex Pharmaceuticals Incorporated	Ice inhibitors for the treatment of autoinflammatory diseases
AR055395A1 (es)	2005-08-26	2007-08-22	Vertex Pharma	Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en)	2005-08-26	2011-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
AU2007217355B2 (en)	2006-02-27	2012-06-21	Vertex Pharmaceuticals Incorporated	Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same
WO2007109080A2 (en)	2006-03-16	2007-09-27	Vertex Pharmaceuticals Incorporated	Deuterated hepatitis c protease inhibitors
WO2008106058A2 (en)	2007-02-27	2008-09-04	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases
HRP20120330T1 (hr)	2007-02-27	2012-05-31	Vertex Pharmaceuticals Incorporated	Sukristali i farmaceutski pripravci koji ih sadrže
NZ583699A (en)	2007-08-30	2012-04-27	Vertex Pharma	Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
US20120128684A1 (en) *	2008-08-25	2012-05-24	Burnham Institute For Medical Research	Conserved Hemagglutinin Epitope, Antibodies to the Epitope and Methods of Use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA86746B (en) *	1985-02-04	1986-09-24	Merrell Dow Pharma	Novel peptidase inhibitors
GB8711748D0 (en) *	1986-06-05	1987-06-24	Ici America Inc	Difluoro keto compounds

1990
- 1990-09-03 NZ NZ235155A patent/NZ235155A/xx unknown
- 1990-09-05 AU AU62231/90A patent/AU635961B2/en not_active Ceased
- 1990-09-05 ZA ZA907079A patent/ZA907079B/xx unknown
- 1990-09-05 CA CA002024661A patent/CA2024661A1/en not_active Abandoned
- 1990-09-10 PT PT95264A patent/PT95264A/pt not_active Application Discontinuation
- 1990-09-10 NO NO90903944A patent/NO903944L/no unknown
- 1990-09-10 JP JP2237275A patent/JPH03118357A/ja active Pending
- 1990-09-10 HU HU905854A patent/HUT55347A/hu unknown
- 1990-09-10 DD DD90343918A patent/DD299309A5/de not_active IP Right Cessation
- 1990-09-10 FI FI904450A patent/FI904450A7/fi not_active Application Discontinuation
- 1990-09-11 EP EP90117461A patent/EP0417721B1/en not_active Expired - Lifetime
- 1990-09-11 CN CN90107621A patent/CN1050198A/zh active Pending
- 1990-09-11 DE DE69022150T patent/DE69022150D1/de not_active Expired - Lifetime
- 1990-09-11 AT AT90117461T patent/ATE127474T1/de not_active IP Right Cessation
- 1990-09-11 KR KR1019900014615A patent/KR910006324A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
KR910006324A (ko)	1991-04-29
EP0417721A3 (en)	1992-01-08
HU905854D0 (en)	1991-03-28
NZ235155A (en)	1993-04-28
HUT55347A (en)	1991-05-28
EP0417721B1 (en)	1995-09-06
DD299309A5 (de)	1992-04-09
DE69022150D1 (de)	1995-10-12
CA2024661A1 (en)	1991-03-12
PT95264A (pt)	1991-05-22
AU635961B2 (en)	1993-04-08
AU6223190A (en)	1991-03-14
EP0417721A2 (en)	1991-03-20
NO903944L (no)	1991-03-12
ATE127474T1 (de)	1995-09-15
FI904450A7 (fi)	1991-03-12
JPH03118357A (ja)	1991-05-20
NO903944D0 (no)	1990-09-10
FI904450A0 (fi)	1990-09-10
CN1050198A (zh)	1991-03-27

Publication	Publication Date	Title
EP0417721A3 (en)	1992-01-08	Novel peptidase and isomerase inhibitors
ES8800050A1 (es)	1987-10-16	Un procedimiento para la preparacion de derivados de cetona electrofilicos activados de sustratos de peptidasa, utiles en la inhibicion de enzimas proteasas
IL85105A0 (en)	1988-06-30	Novel peptidase inhibitors
NO884925L (no)	1989-05-08	Renininhibitorer.
ZA905737B (en)	1991-05-29	Novel peptidase inhibitors
CA2000342A1 (en)	1990-04-07	Novel peptidase inhibitors
NZ504026A (en)	2002-12-20	Methods for treating hypercoagulable states or acquired protein C deficiency using human-activated protein C
FI900101A7 (fi)	1990-01-09	Proteas-inhibitorer.
DE69201400D1 (de)	1995-03-23	Vorrichtung zum Wiederherstellen von gerissenem Gewebe.
DE68907909D1 (de)	1993-09-02	Praeparat zur behandlung von erektionsstoerungen.
DE58900119D1 (de)	1991-06-27	Chirurgisches instrument zum einsetzen von hueftpfannen-prothesen.
WO1999005096A3 (en)	1999-06-03	Urokinase inhibitors
DE3882775D1 (de)	1993-09-09	Zusammensetzung zur behandlung von parodontaler krankheit.
EP0651639A4 (en)	1996-06-26	METHODS OF USING CISAPRIDE (+) FOR THE TREATMENT OF GASTROSOPHAGIC REFLUX AND OTHER DISORDERS.
ZA885090B (en)	1989-04-26	Proteinase inhibitors for treatment of gastrointestinal ulcer disease
DE3869590D1 (de)	1992-04-30	Mischung zur behandlung von hypercholesterolemie.
NO883582L (no)	1989-02-14	Katodisk elektrodeponerbart belegningspreparat.
DE68911776D1 (de)	1994-02-10	Konjugierte Oxybutenolide zur Behandlung von Ulcera.
ATE109153T1 (de)	1994-08-15	Alpha-glukosidase-inhibitoren.
DE3875016D1 (de)	1992-11-05	Therapeutikum zur behandlung von aids.
AU2299592A (en)	1993-02-11	Treatment of periodontal disease with protease inhibitors
IL130500A (en)	2003-02-12	Use of comt inhibitors for the manufacture of a medicament for the prevention of diabetic vascular dysfunctions
ZA8892B (en)	1988-11-30	Dopamine-beta-hydroxylase inhibitors
ZA898553B (en)	1990-08-29	The use of ethylenediaminetetraacetic acid as inhibitor of calcium/calmodulin-dependent protein kinase ii or of protein kinase c
ID20165A (id)	1998-10-15	Penggunaan asam 2-(3,4-dimetoksisinamoil)aminobenzoat untuk pembuatan obat untuk pengobatan atau pencegahan restenosis