ZA914727B - Polycyclic guanine derivatives - Google Patents

Polycyclic guanine derivatives

Info

Publication number: ZA914727B
Authority: ZA; South Africa
Prior art keywords: aryl; alkyl; heteroaryl; hydrogen; pct
Prior art date: 1990-06-21

Application number

ZA914727A

Other languages

English (en)

Inventor

Bernard R Neustadt

R Neustadt Bernard

Neil A Lindo

A Lindo Neil

Brian A Mckittrick

A Mckittrick Brian

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-21

Filing date

1991-06-19

Publication date

1992-03-25

1991-06-19 Application filed by Schering Corp filed Critical Schering Corp

1992-03-25 Publication of ZA914727B publication Critical patent/ZA914727B/xx

Links

-1 Polycyclic guanine derivatives Chemical class 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 8
125000003118 aryl group Chemical group 0.000 abstract 6
125000001072 heteroaryl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004663 dialkyl amino group Chemical group 0.000 abstract 3
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005122 aminoalkylamino group Chemical group 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
230000003182 bronchodilatating effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Filtering Materials (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

ZA914727A 1990-06-21 1991-06-19 Polycyclic guanine derivatives ZA914727B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54156890A	1990-06-21	1990-06-21

Publications (1)

Publication Number	Publication Date
ZA914727B true ZA914727B (en)	1992-03-25

Family

ID=24160139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA914727A ZA914727B (en)	1990-06-21	1991-06-19	Polycyclic guanine derivatives

Country Status (21)

Country	Link
US (1)	US5393755A (fr)
EP (1)	EP0538332B1 (fr)
JP (1)	JPH0747589B2 (fr)
KR (1)	KR960004532B1 (fr)
AT (1)	ATE155786T1 (fr)
AU (1)	AU651607B2 (fr)
CA (1)	CA2085733C (fr)
CZ (1)	CZ281920B6 (fr)
DE (1)	DE69126980T2 (fr)
FI (1)	FI925731A0 (fr)
HU (1)	HUT65623A (fr)
IE (1)	IE912126A1 (fr)
IL (1)	IL98559A0 (fr)
NO (1)	NO924940D0 (fr)
NZ (1)	NZ238609A (fr)
OA (1)	OA09723A (fr)
PL (1)	PL169481B1 (fr)
RU (1)	RU2080322C1 (fr)
TW (1)	TW197441B (fr)
WO (1)	WO1991019717A1 (fr)
ZA (1)	ZA914727B (fr)

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US5824683A (en) *	1995-11-28	1998-10-20	Schering Corporation	2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
US5858694A (en) *	1997-05-30	1999-01-12	Cell Pathways, Inc.	Method for identifying compounds for inhibition of cancerous lesions
CA2238283C (fr)	1997-05-30	2002-08-20	Cell Pathways, Inc.	Methode d'identification de composes visant a inhiber les lesions neoplasiques, compositions pharmaceutiques a prtir de ces composes et compositions pour traiter les lesions neoplasiques
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US6486155B1 (en)	1998-11-24	2002-11-26	Cell Pathways Inc	Method of inhibiting neoplastic cells with isoquinoline derivatives
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ES2166270B1 (es) *	1999-07-27	2003-04-01	Almirall Prodesfarma Sa	Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
US6555547B1 (en)	2000-02-28	2003-04-29	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
US6569638B1 (en)	2000-03-03	2003-05-27	Cell Pathways, Inc	Method for screening compounds for the treatment of neoplasia
US6821978B2 (en)	2000-09-19	2004-11-23	Schering Corporation	Xanthine phosphodiesterase V inhibitors
WO2003020724A1 (fr) *	2001-08-28	2003-03-13	Schering Corporation	Inhibiteurs polycycliques de la phosphodiesterase v de la guanine
EP1790652A1 (fr) *	2001-08-28	2007-05-30	Schering Corporation	Guanines polycycliques comme inhibiteurs de la phosphodiésterase V
EP1575916B1 (fr)	2001-08-31	2013-05-22	The Rockefeller University	Activite de phosphodiesterase et regulation de la signalisation a mediation par phosphodiesterase 1-b dans le cerveau
EP1312363A1 (fr) *	2001-09-28	2003-05-21	Pfizer Products Inc.	Méthode de traitement et kit comprenant un secrétagogue d'hormone de croissance
CA2465893A1 (fr) *	2001-11-09	2003-05-22	Schering Corporation	Inhibiteurs de la phosphodiesterase v de derives polycycliques de guanine
US7342884B2 (en) *	2002-03-13	2008-03-11	Harmonic, Inc.	Method and apparatus for one directional communications in bidirectional communications channel
WO2003101992A1 (fr) *	2002-05-31	2003-12-11	Schering Corporation	Procede de preparation d'inhibiteur de la phosphodiesterase v de la xanthine
EP1719772A1 (fr)	2002-05-31	2006-11-08	Schering Corporation	Procédé de préparation d'inhibiteurs de la phosphodiesterase v de la xanthine et leur précurseurs
CA2533715A1 (fr) *	2003-07-31	2005-02-10	Schering Corporation	Metabolite de l'inhibiteur de xanthine phosphodiesterase 5 et derives de ce metabolite, utiles dans le traitement de la dyserection
EP1650206A4 (fr) *	2003-08-01	2006-12-20	Nippon Soda Co	Composes de phenylazole, leur procede de production et antioxydants
KR20060101762A (ko) *	2003-11-21	2006-09-26	쉐링 코포레이션	포스포디에스테라제 ｖ 억제제 제형
US20070004745A1 (en) *	2005-03-25	2007-01-04	Schering-Plough Corporation	Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
US8273750B2 (en) *	2005-06-06	2012-09-25	Takeda Pharmaceutical Company Limited	Organic compounds
EP1919287A4 (fr) *	2005-08-23	2010-04-28	Intra Cellular Therapies Inc	Composés organiques pour traiter un signald'activité réduit du récepteur de la dopamine
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US9006258B2 (en) *	2006-12-05	2015-04-14	Intra-Cellular Therapies, Inc.	Method of treating female sexual dysfunction with a PDE1 inhibitor
US8349858B2 (en) *	2007-06-21	2013-01-08	Merck Sharp & Dohme	Polycyclic guanine derivatives and use thereof
AU2008335811B2 (en)	2007-12-06	2012-05-17	Intra-Cellular Therapies, Inc.	Organic compounds
ES2588238T3 (es) *	2007-12-06	2016-10-31	Intra-Cellular Therapies, Inc.	Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico
AU2009322904A1 (en)	2008-12-06	2010-06-10	Intra-Cellular Therapies, Inc.	Organic compounds
WO2010065147A1 (fr)	2008-12-06	2010-06-10	Intra-Cellular Therapies, Inc.	Composés organiques
KR20110098732A (ko)	2008-12-06	2011-09-01	인트라-셀룰라 써래피스, 인코퍼레이티드.	유기 화합물
CN102231953A (zh)	2008-12-06	2011-11-02	细胞内治疗公司	有机化合物
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JP5989993B2 (ja)	2008-12-06	2016-09-07	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	有機化合物
JP2012518685A (ja)	2009-02-25	2012-08-16	イントラ−セルラー・セラピーズ・インコーポレイテッド	眼障害のためのｐｄｅ１阻害剤
JP5765239B2 (ja) *	2009-03-13	2015-08-19	アドヴィナス・セラピューティックス・リミテッド	置換縮合ピリミジン化合物
US9468637B2 (en)	2009-05-13	2016-10-18	Intra-Cellular Therapies, Inc.	Organic compounds
SG178279A1 (en)	2009-08-05	2012-03-29	Intra Cellular Therapies Inc	Novel regulatory proteins and inhibitors
WO2011081915A2 (fr) *	2009-12-15	2011-07-07	Cebix Inc.	Procédés pour traiter un dysfonctionnement érectile chez des patients souffrant de diabète insulino-dépendant
US9434730B2 (en)	2010-05-31	2016-09-06	Intra-Cellular Therapies, Inc.	PDE1 inhibitor compounds
TW201206937A (en)	2010-05-31	2012-02-16	Intra Cellular Therapies Inc	Organic compounds
WO2011153135A1 (fr)	2010-05-31	2011-12-08	Intra-Cellular Therapies, Inc.	Composés organiques
US9763948B2 (en)	2010-05-31	2017-09-19	Intra-Cellular Therapies, Inc.	PDE1 inhibitory compounds and methods
EP2717877B1 (fr)	2011-06-10	2017-11-08	Intra-Cellular Therapies, Inc.	Composés organiques
US9801882B2 (en)	2013-02-17	2017-10-31	Intra-Cellular Therapies, Inc.	Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases
CA2906640C (fr)	2013-03-15	2021-07-20	Intra-Cellular Therapies, Inc.	Composes imidazo-[1,2-a] pyrazolo[4,3-e]pyrimidin-4[5h]-one substitues et compositions pharmaceutiques et leur utilisation en tant qu'inhibiteurs de la pde-1
US9545406B2 (en)	2013-03-15	2017-01-17	Intra-Cellular Therapies, Inc.	Method of treating a CNS injury with a PDE1 inhibitor
EP3091983B1 (fr)	2014-01-08	2019-10-02	Intra-Cellular Therapies, Inc.	Compositions pharmaceutiques contenant un inhibiteur de la pde-1 et un inhibiteur de la pde-2
WO2015196186A1 (fr)	2014-06-20	2015-12-23	Intra-Cellular Therapies, Inc.	Composés organiques
WO2016022893A1 (fr)	2014-08-07	2016-02-11	Intra-Cellular Therapies, Inc.	Composés organiques
US9546175B2 (en)	2014-08-07	2017-01-17	Intra-Cellular Therapies, Inc.	Organic compounds
US10285992B2 (en)	2014-08-07	2019-05-14	Intra-Cellular Therapies, Inc.	Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
BR112017005533B1 (pt)	2014-09-17	2023-10-10	Intra-Cellular Therapies, Inc	Compostos inibidores de fosfodiesterase 1 (pde1), composição farmacêutica que compreende os ditos compostos e usos dos mesmos no tratamento de uma doença, distúrbio, e/ou lesão do snc e no tratamento e/ou na profilaxia de uma doença, distúrbio e/ou lesão do snp
CN107205993B (zh)	2014-12-06	2021-03-09	细胞内治疗公司	有机化合物
US10300064B2 (en)	2014-12-06	2019-05-28	Intra-Cellular Therapies, Inc.	Organic compounds
EP3436083A4 (fr)	2016-03-28	2019-11-27	Intra-Cellular Therapies, Inc.	Nouvelles compositions et méthodes
WO2018049417A1 (fr)	2016-09-12	2018-03-15	Intra-Cellular Therapies, Inc.	Nouvelles utilisations
JP7111720B2 (ja)	2016-12-28	2022-08-02	ダート・ニューロサイエンス・エルエルシー	Ｐｄｅ２阻害剤としての置換ピラゾロピリミジノン化合物
CA3120971A1 (fr)	2017-11-27	2019-05-31	Dart Neuroscience, Llc	Composes furanopyrimidine substitues utilises en tant qu'inhibiteurs de pde1
JP7401442B2 (ja)	2018-01-31	2023-12-19	イントラ－セルラー・セラピーズ・インコーポレイテッド	新規使用
EP4025202A4 (fr)	2019-09-03	2023-08-02	Intra-Cellular Therapies, Inc.	Nouveaux composés
US12364695B2 (en)	2020-06-02	2025-07-22	Intra-Cellular Therapies, Inc.	Methods of treating inflammatory disease

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CA1095906A (fr) *	1977-02-14	1981-02-17	Davis L. Temple, Jr.	Heterocyclopyrimidines, composes et procedes therapeutiques
BE863525A (fr) *	1977-02-14	1978-07-31	Bristol Myers Co	Heterocyclopyrimidines
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1991
- 1991-06-19 ZA ZA914727A patent/ZA914727B/xx unknown
- 1991-06-19 IL IL98559A patent/IL98559A0/xx unknown
- 1991-06-19 NZ NZ238609A patent/NZ238609A/en unknown
- 1991-06-20 CA CA002085733A patent/CA2085733C/fr not_active Expired - Fee Related
- 1991-06-20 DE DE69126980T patent/DE69126980T2/de not_active Expired - Fee Related
- 1991-06-20 EP EP91912779A patent/EP0538332B1/fr not_active Expired - Lifetime
- 1991-06-20 RU RU9192016466A patent/RU2080322C1/ru active
- 1991-06-20 AT AT91912779T patent/ATE155786T1/de not_active IP Right Cessation
- 1991-06-20 US US07/949,811 patent/US5393755A/en not_active Expired - Lifetime
- 1991-06-20 JP JP3512084A patent/JPH0747589B2/ja not_active Expired - Fee Related
- 1991-06-20 WO PCT/US1991/004154 patent/WO1991019717A1/fr not_active Ceased
- 1991-06-20 CZ CS923749A patent/CZ281920B6/cs unknown
- 1991-06-20 PL PL91297299A patent/PL169481B1/pl unknown
- 1991-06-20 KR KR1019920703316A patent/KR960004532B1/ko not_active Expired - Fee Related
- 1991-06-20 TW TW080104761A patent/TW197441B/zh active
- 1991-06-20 HU HU9204032A patent/HUT65623A/hu unknown
- 1991-06-20 IE IE212691A patent/IE912126A1/en unknown
- 1991-06-20 AU AU81992/91A patent/AU651607B2/en not_active Ceased
1992
- 1992-12-17 FI FI925731A patent/FI925731A0/fi not_active Application Discontinuation
- 1992-12-18 NO NO924940A patent/NO924940D0/no unknown
- 1992-12-21 OA OA60319A patent/OA09723A/en unknown

Also Published As

Publication number	Publication date
DE69126980D1 (de)	1997-09-04
IE912126A1 (en)	1992-01-01
HU9204032D0 (en)	1993-03-29
NO924940L (no)	1992-12-18
IL98559A0 (en)	1992-07-15
HUT65623A (en)	1994-07-28
PL169481B1 (pl)	1996-07-31
CA2085733A1 (fr)	1991-12-22
CZ281920B6 (cs)	1997-04-16
CA2085733C (fr)	1996-03-05
OA09723A (en)	1993-08-30
AU651607B2 (en)	1994-07-28
WO1991019717A1 (fr)	1991-12-26
US5393755A (en)	1995-02-28
JPH0747589B2 (ja)	1995-05-24
EP0538332B1 (fr)	1997-07-23
FI925731A7 (fi)	1992-12-17
CZ374992A3 (en)	1993-10-13
RU2080322C1 (ru)	1997-05-27
NZ238609A (en)	1993-12-23
KR960004532B1 (ko)	1996-04-06
JPH05508647A (ja)	1993-12-02
AU8199291A (en)	1992-01-07
EP0538332A1 (fr)	1993-04-28
PL297299A1 (fr)	1992-07-13
TW197441B (fr)	1993-01-01
DE69126980T2 (de)	1998-01-08
NO924940D0 (no)	1992-12-18
ATE155786T1 (de)	1997-08-15
FI925731A0 (fi)	1992-12-17

Publication	Publication Date	Title
TW197441B (fr)	1993-01-01
DE69919897D1 (en)	2004-10-07	4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel
ATE155133T1 (de)	1997-07-15	Piperazinderivate als 5-ht antagonisten
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