ZA988230B - Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists - Google Patents

Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists

Info

Publication number
ZA988230B
ZA988230B ZA988230A ZA988230A ZA988230B ZA 988230 B ZA988230 B ZA 988230B ZA 988230 A ZA988230 A ZA 988230A ZA 988230 A ZA988230 A ZA 988230A ZA 988230 B ZA988230 B ZA 988230B
Authority
ZA
South Africa
Prior art keywords
agonists
aromatic
substituted tetrahydro
prostaglandins useful
tetrahydro prostaglandins
Prior art date
Application number
ZA988230A
Other languages
English (en)
Inventor
John August Wos
Mitchell Anthony Delong
Jack S Amburgey
Biswanath De
Hayiyan George Dai
Yili Wang
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of ZA988230B publication Critical patent/ZA988230B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA988230A 1997-09-09 1998-09-09 Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists ZA988230B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5821797P 1997-09-09 1997-09-09

Publications (1)

Publication Number Publication Date
ZA988230B true ZA988230B (en) 1999-03-09

Family

ID=22015427

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA988230A ZA988230B (en) 1997-09-09 1998-09-09 Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists

Country Status (24)

Country Link
US (1) US5977173A (de)
EP (1) EP1012136B1 (de)
JP (1) JP2001515882A (de)
KR (1) KR20010023839A (de)
CN (1) CN1269786A (de)
AR (1) AR013477A1 (de)
AT (1) ATE270660T1 (de)
AU (1) AU731153B2 (de)
BR (1) BR9811774A (de)
CA (1) CA2303764C (de)
CO (1) CO4970731A1 (de)
DE (1) DE69824966T2 (de)
ES (1) ES2223141T3 (de)
HU (1) HUP0100638A3 (de)
ID (1) ID23971A (de)
IL (1) IL134839A0 (de)
NO (1) NO20001141L (de)
NZ (1) NZ503735A (de)
PE (1) PE115499A1 (de)
PL (1) PL339212A1 (de)
SK (1) SK3372000A3 (de)
TR (1) TR200000671T2 (de)
WO (1) WO1999012895A1 (de)
ZA (1) ZA988230B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4834224B2 (ja) * 1999-03-05 2011-12-14 デューク ユニバーシティ Ｃ１６不飽和ｆｐ−選択的プロスタグランジン類縁体
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
ES2202156T3 (es) 1999-08-04 2004-04-01 Procter & Gamble Nuevos analogos de 2-descarboxi-2-fosfinico prostaglandina f.
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
KR100437873B1 (ko) * 2001-05-08 2004-06-26 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
WO2006047466A2 (en) * 2004-10-21 2006-05-04 Duke University Ophthamological drugs
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
EP2214482A4 (de) 2007-10-31 2011-08-24 Pamela Lipkin Prostaglandinanalog-zusammensetzungen und verfahren zur behandlung von epithelerkrankungen
US20100074857A1 (en) * 2008-09-23 2010-03-25 Pamela Lipkin Compositions and methods to treat epithelial-related conditions
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
WO2010096123A2 (en) 2008-10-29 2010-08-26 Aerie Pharmaceuticals, Inc. Amino acid salts of prostaglandins
US8637558B2 (en) 2008-12-30 2014-01-28 Industry-Academic Cooperation Foundation, Chosun University Thiazolidinedione derivative and use thereof
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
EP3053913B1 (de) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
PH12012500928A1 (en) 2009-11-09 2012-11-26 Allergan Inc Compositions and methods for stimulating hair growth
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
DK3811943T3 (da) 2013-03-15 2023-04-03 Aerie Pharmaceuticals Inc Forbindelse til anvendelse til behandling af øjenlidelser
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102568079B1 (ko) 2016-08-31 2023-08-17 에어리 파마슈티컬즈, 인코포레이티드 안과용 조성물
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776938A (en) * 1958-05-28 1973-12-04 S Bergstrom Dihydro-pge1
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
US4024179A (en) * 1972-11-08 1977-05-17 Pfizer Inc. Substituted ω-pentanorprostaglandins
IL43571A (en) * 1972-11-08 1977-08-31 Pfizer Omega-pentanorprostaglandins and their preparation
JPS5720305B2 (de) * 1973-02-28 1982-04-27
DE2365101A1 (de) * 1973-12-21 1975-07-10 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
DE2460990A1 (de) * 1974-12-21 1976-07-01 Hoechst Ag Neue prostaglandin-analoga und verfahren zu ihrer herstellung
GB1507211A (en) * 1975-02-14 1978-04-12 Ono Pharmaceutical Co Prostaglandin analogues
GB1506816A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
DE2517771A1 (de) * 1975-04-18 1976-10-28 Schering Ag Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung
US4051238A (en) * 1976-06-03 1977-09-27 The Upjohn Company Treatment of genital tract diseases of domestic animals with prostaglandins
DE2737808A1 (de) * 1976-08-27 1978-03-16 Pfizer 2-substituierte aryl-heterocyclische omega-pentanorprostaglandine
US4206151A (en) * 1978-12-21 1980-06-03 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl or cyclopropyl prostan-1-ols of the E, A and F series
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
US5166178B1 (en) * 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
DE1300150T1 (de) * 1988-09-06 2003-09-18 Pharmacia Ab, Stockholm Prostaglandin-Derivate zur Behandlung von Glaukom oder Augenüberdruck
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
TW224942B (de) * 1990-04-04 1994-06-11 Adka Ueno Kk
US5302617A (en) * 1990-04-27 1994-04-12 Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5332730A (en) * 1992-10-16 1994-07-26 Allergan, Inc. Azido derivatives of cyclopentane heptanoic or heptenoic acid
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
AU7672096A (en) * 1995-06-07 1998-06-03 Alcon Laboratories, Inc. Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
AU7680096A (en) * 1995-12-22 1997-07-17 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
US5741810A (en) * 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
WO1997047595A1 (en) * 1996-06-10 1997-12-18 R-Tech Ueno, Ltd. Endothelin antagonist
ATE221048T1 (de) * 1996-09-17 2002-08-15 Asahi Glass Co Ltd Fluorierte prostaglandinderivate und medikamente
WO1998020881A1 (en) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension
US6353000B1 (en) * 1996-11-12 2002-03-05 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
WO1998050024A1 (en) * 1997-05-09 1998-11-12 The Mount Sinai School Of Medicine Of The City University Of New York 8-iso-prostaglandins for glaucoma therapy

Also Published As

Publication number Publication date
AR013477A1 (es) 2000-12-27
WO1999012895A1 (en) 1999-03-18
TR200000671T2 (tr) 2000-07-21
DE69824966D1 (de) 2004-08-12
NO20001141L (no) 2000-05-04
NO20001141D0 (no) 2000-03-06
US5977173A (en) 1999-11-02
DE69824966T2 (de) 2005-04-07
CA2303764C (en) 2005-02-15
AU731153B2 (en) 2001-03-22
HUP0100638A3 (en) 2002-12-28
KR20010023839A (ko) 2001-03-26
ES2223141T3 (es) 2005-02-16
IL134839A0 (en) 2001-05-20
NZ503735A (en) 2001-05-25
CO4970731A1 (es) 2000-11-07
EP1012136A1 (de) 2000-06-28
PL339212A1 (en) 2000-12-04
JP2001515882A (ja) 2001-09-25
EP1012136B1 (de) 2004-07-07
BR9811774A (pt) 2000-08-29
ATE270660T1 (de) 2004-07-15
SK3372000A3 (en) 2000-10-09
HUP0100638A2 (hu) 2001-07-30
AU9219398A (en) 1999-03-29
CA2303764A1 (en) 1999-03-18
CN1269786A (zh) 2000-10-11
ID23971A (id) 2000-06-14
PE115499A1 (es) 2000-02-03

Similar Documents

Publication Publication Date Title
IL134839A0 (en) Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
HUP0004436A3 (en) Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
IL134840A0 (en) Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
AP9801356A0 (en) Prostaglandin agonists
DE69941083D1 (en) 12,13-cyclopropan-epothilonderivate
ZA989537B (en) Lubricating composition
IL134108A0 (en) Substituted 1,2,3,4-tetrahydronaphthalene derivatives
GB2345916B (en) Alkaline solid block composition
ZA974359B (en) Microencapsulated compositions.
PL339219A1 (en) Substituted 2-pyrolydinones as pkc activators
ZA9811502B (en) Novel composition.
ZA200006118B (en) Novel composition.
PL338017A1 (en) Novel composition
GB9800912D0 (en) New composition
GB9701031D0 (en) Composition
ZA9710576B (en) 2-imidazolinylaminoindazole compounds useful as alpha-2-adrenoceptor agonists
ZA200000192B (en) Novel composition.
GB9801583D0 (en) Anti-snore gargle composition
HK1028976A (en) Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ZA981739B (en) Composition.
EG23068A (en) Pesticidale composition
ZA991829B (en) Novel composition.
GB9611276D0 (en) Self indicating composition
GB9813561D0 (en) Novel composition
GB9806685D0 (en) Novel composition