AP1703A - Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same. - Google Patents

Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.

Info

Publication number
AP1703A
AP1703A APAP/P/2003/002744A AP2003002744A AP1703A AP 1703 A AP1703 A AP 1703A AP 2003002744 A AP2003002744 A AP 2003002744A AP 1703 A AP1703 A AP 1703A
Authority
AP
ARIPO
Prior art keywords
heparin
preparation
pharmaceutical compositions
compositions containing
containing same
Prior art date
Application number
APAP/P/2003/002744A
Other versions
AP2003002744A0 (en
Inventor
Jacques Diaz
Christelle Pecquet
Elisabeth Perrin
Christian Viskov
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP1703(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP2003002744A0 publication Critical patent/AP2003002744A0/en
Application granted granted Critical
Publication of AP1703A publication Critical patent/AP1703A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention concerns heparin-derived polysaccharide mixtures, their preparation method and pharmaceutical compositions containing them.
APAP/P/2003/002744A 2000-07-21 2001-07-18 Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same. AP1703A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0009572A FR2811992B1 (en) 2000-07-21 2000-07-21 MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR2001/002332 WO2002008295A1 (en) 2000-07-21 2001-07-18 Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same

Publications (2)

Publication Number Publication Date
AP2003002744A0 AP2003002744A0 (en) 2003-03-31
AP1703A true AP1703A (en) 2007-02-26

Family

ID=8852768

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2003/002744A AP1703A (en) 2000-07-21 2001-07-18 Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.

Country Status (35)

Country Link
EP (1) EP1307491B2 (en)
JP (1) JP5279160B2 (en)
KR (1) KR100853585B1 (en)
CN (1) CN1230449C (en)
AP (1) AP1703A (en)
AR (1) AR029865A1 (en)
AT (1) ATE470679T1 (en)
AU (2) AU7760201A (en)
BR (1) BR0112612B1 (en)
CA (1) CA2416673C (en)
CL (1) CL2004001154A1 (en)
CY (1) CY1110774T1 (en)
DE (1) DE60142340D1 (en)
DK (1) DK1307491T3 (en)
DZ (1) DZ3411A1 (en)
EA (1) EA005995B1 (en)
EC (1) ECSP034442A (en)
ES (1) ES2347134T5 (en)
FR (1) FR2811992B1 (en)
HR (1) HRP20030019A2 (en)
HU (1) HUP0300755A3 (en)
IL (2) IL153922A0 (en)
MA (1) MA26928A1 (en)
MX (1) MXPA03000579A (en)
NO (1) NO20030296L (en)
NZ (1) NZ524028A (en)
OA (1) OA12340A (en)
PL (1) PL202471B1 (en)
PT (1) PT1307491E (en)
SI (1) SI1307491T1 (en)
TW (1) TWI307278B (en)
UA (1) UA74836C2 (en)
WO (1) WO2002008295A1 (en)
YU (1) YU2903A (en)
ZA (1) ZA200300898B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
EP1375524B1 (en) * 2002-06-20 2007-03-07 CHEMI S.p.A. Process for the preparation of esters of heparin
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
AR041555A1 (en) 2002-10-10 2005-05-18 Aventis Pharma Sa MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2845686B1 (en) 2002-10-10 2013-08-30 Aventis Pharma Sa MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
FR2857971B1 (en) * 2003-07-24 2005-08-26 Aventis Pharma Sa MIXTURES OF HEPARIN DERIVED OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE102004059134B4 (en) 2004-12-08 2011-12-15 Siemens Ag Expansion device for an X-ray machine and X-ray source
FR2889078B1 (en) * 2005-07-27 2007-11-02 Aventis Pharma Sa NOVEL CHROMATOGRAPHY METHOD OF AFFINITY OF ANTITHROMBIN III
EP2447285A3 (en) * 2006-05-25 2013-01-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
CN101824099B (en) * 2010-02-12 2011-11-30 淮安麦德森化学有限公司 Method for purifying crude product heparin sodium
CN101824446B (en) * 2010-02-24 2012-12-12 淮安麦德森化学有限公司 Method for producing chondroitin sulfate by reverse precipitation
EP2399590A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2399592A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399591A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery
EP2399593A1 (en) 2010-06-28 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile
CN102399379B (en) * 2010-09-09 2016-08-31 上海喜恩医药科技发展有限公司 Polysaccharide mixture of a kind of heparin derivative and preparation method thereof and pharmaceutical composition
KR102082276B1 (en) * 2010-09-14 2020-02-27 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 High purity heparin and production method therefor
EP2446891A1 (en) 2010-10-28 2012-05-02 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings
WO2012055843A1 (en) 2010-10-28 2012-05-03 Aventis Pharma S.A. Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery
EP2548561A1 (en) 2011-07-22 2013-01-23 Aventis Pharma S.A. Semuloparin for improving the survival of patients with locally advanced cancer
ES2445494B1 (en) * 2012-08-02 2015-03-06 Rovi Lab Farmaceut Sa Procedure for obtaining low and very low molecular weight heparins
CN103175925B (en) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 Method for detecting esterification rate of heparin benzyl ester in production process of enoxaparin sodium
FR3016632A1 (en) * 2014-01-21 2015-07-24 IFP Energies Nouvelles PROCESS FOR TRANSFORMING POLYSACCHARIDES TO OXYGENIC MOLECULES IN THE PRESENCE OF NEUTRAL ORGANIC SUPERBASES
CZ306662B6 (en) * 2015-06-26 2017-04-26 Contipro A.S. Sulphated polysaccharides derivatives, the method of their preparation, the method of their modification and the use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027089A1 (en) * 1979-10-05 1981-04-15 Choay S.A. Oligosaccharide fractions and oligosaccharides with biological properties, process for their preparation and their uses as medicines
EP0040144A1 (en) * 1980-05-14 1981-11-18 Pharmuka Laboratoires Sulfated polysaccharides, process for their preparation and their use as medicines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (en) * 1980-03-20 1981-09-25 Choay Sa MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
ES2077533B1 (en) * 1994-02-28 1996-07-01 Bioiberica PROCEDURE FOR OBTAINING OLIGOSACCHARIDE FRACTIONS BY CHEMICAL DEPOLYMERIZATION OF HEPARIN.
ES2161615B1 (en) 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT.
JP4897991B2 (en) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ Ultra low molecular weight heparin composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027089A1 (en) * 1979-10-05 1981-04-15 Choay S.A. Oligosaccharide fractions and oligosaccharides with biological properties, process for their preparation and their uses as medicines
EP0040144A1 (en) * 1980-05-14 1981-11-18 Pharmuka Laboratoires Sulfated polysaccharides, process for their preparation and their use as medicines

Also Published As

Publication number Publication date
ZA200300898B (en) 2004-04-30
HUP0300755A3 (en) 2004-03-01
PT1307491E (en) 2010-09-10
NZ524028A (en) 2004-12-24
ES2347134T3 (en) 2010-10-26
WO2002008295A1 (en) 2002-01-31
CN1447820A (en) 2003-10-08
SI1307491T1 (en) 2010-10-29
NO20030296D0 (en) 2003-01-20
EP1307491B1 (en) 2010-06-09
EP1307491B2 (en) 2014-05-07
AU7760201A (en) 2002-02-05
NO20030296L (en) 2003-01-20
PL202471B1 (en) 2009-06-30
IL153922A0 (en) 2003-07-31
EP1307491A1 (en) 2003-05-07
AU2001277602B2 (en) 2007-07-19
MA26928A1 (en) 2004-12-20
CL2004001154A1 (en) 2005-05-27
CN1230449C (en) 2005-12-07
EA200300178A1 (en) 2003-06-26
HRP20030019A2 (en) 2005-10-31
JP2004504451A (en) 2004-02-12
FR2811992A1 (en) 2002-01-25
IL153922A (en) 2010-05-17
CA2416673A1 (en) 2002-01-31
CY1110774T1 (en) 2015-06-10
HUP0300755A2 (en) 2003-12-29
PL365561A1 (en) 2005-01-10
UA74836C2 (en) 2006-02-15
TWI307278B (en) 2009-03-11
KR20030040364A (en) 2003-05-22
MXPA03000579A (en) 2003-06-06
ATE470679T1 (en) 2010-06-15
DZ3411A1 (en) 2002-01-31
FR2811992B1 (en) 2003-07-04
CA2416673C (en) 2011-06-14
DK1307491T3 (en) 2010-10-11
ES2347134T5 (en) 2014-06-24
ECSP034442A (en) 2003-03-10
OA12340A (en) 2006-05-15
HK1059273A1 (en) 2004-06-25
EA005995B1 (en) 2005-08-25
JP5279160B2 (en) 2013-09-04
BR0112612A (en) 2003-07-29
BR0112612B1 (en) 2011-07-12
YU2903A (en) 2006-03-03
KR100853585B1 (en) 2008-08-21
AP2003002744A0 (en) 2003-03-31
DE60142340D1 (en) 2010-07-22
AR029865A1 (en) 2003-07-16

Similar Documents

Publication Publication Date Title
AP1703A (en) Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.
DE69905170D1 (en) Thiazolopyrimidinderivate
ZA200206905B (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same.
AP2001002225A0 (en) 1-heterocycle substituted diarylamines.
IL138280A0 (en) 20-KETO-11β-ARYLSTERIODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THE PREPARATION THEREOF
WO1999054286A3 (en) Btk inhibitors and methods for their identification and use
ATE289640T1 (en) AMIDOFUNCTIONAL AMINOPOLYDIORGANOSILOXANES
HUP0301573A3 (en) Substituted arylpyrazines, pharmaceutical compositions containing them and their use
HUP0204514A3 (en) Pyridinylimidazoles, pharmaceutical compositions containing them and their use
HUP0200312A3 (en) Substituted 2-phenylbenzimidazoles, pharmaceutical compositions containing them, the production thereof and their use
CY1112687T1 (en) METHOD FOR USING DICTIONARIES AND COMPOSITIONS THAT INCLUDE
TR200100054T2 (en) Paroxetine methanesulfonate
AU2001277602A1 (en) Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
HUP0401638A3 (en) Thiopene-amides, thiazolesulfonamides as antineoplastic agents, and pharmaceutical composition containing the same
HUP0400967A3 (en) Substituted 2-anilino-benzimidazoles, their use and pharmaceutical compositions containing them
HUP0102215A3 (en) Benzoylpyridazines, pharmaceutical compositions containing the same and process for their preparation
ZA99355B (en) Synthetic polysaccharides, process for their preparation and pharmaceutical compositions containing them.
AU5892399A (en) 1, 2, 4-triazole-3-thione compounds
HUP0302515A3 (en) Sulfanidothienopyrimidines, process for their preparation and pharmaceutical compositions containing them
IL139531A0 (en) Human antithrombin iii, methods for the production thereof and pharmaceutical compositions containing the same
IL154986A0 (en) Triazolo-epothilone derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
ZA200002546B (en) Sorbate-preserved compositions, method for the manufacture thereof and their use.
IL154414A0 (en) Pharmaceutical compositions containing an indolinyl-2,2-dimethylpropanamide
HUP0103006A3 (en) Substituted betha-diketones, pharmaceutical compositions containing them and their use
MXPA03008636A (en) Isoquinuclidine derivative, process for producing the same, and medicinal composition containing the same.