AP1882A - Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-Benzothiazole. - Google Patents

Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-Benzothiazole.

Info

Publication number
AP1882A
AP1882A AP2005003306A AP2005003306A AP1882A AP 1882 A AP1882 A AP 1882A AP 2005003306 A AP2005003306 A AP 2005003306A AP 2005003306 A AP2005003306 A AP 2005003306A AP 1882 A AP1882 A AP 1882A
Authority
AP
ARIPO
Prior art keywords
benzothiazole
diamino
tetrahydro
preparing
Prior art date
Application number
AP2005003306A
Other languages
English (en)
Other versions
AP2005003306A0 (en
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of AP2005003306A0 publication Critical patent/AP2005003306A0/xx
Application granted granted Critical
Publication of AP1882A publication Critical patent/AP1882A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AP2005003306A 2002-11-04 2003-11-03 Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-Benzothiazole. AP1882A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0225701A GB2394951A (en) 2002-11-04 2002-11-04 One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
PCT/GB2003/004734 WO2004041797A1 (en) 2002-11-04 2003-11-03 Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole

Publications (2)

Publication Number Publication Date
AP2005003306A0 AP2005003306A0 (en) 2005-06-30
AP1882A true AP1882A (en) 2008-08-21

Family

ID=9947186

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2005003306A AP1882A (en) 2002-11-04 2003-11-03 Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-Benzothiazole.

Country Status (25)

Country Link
US (1) US7285669B2 (xx)
EP (1) EP1562921B1 (xx)
JP (1) JP4708792B2 (xx)
KR (1) KR101086844B1 (xx)
CN (1) CN100551918C (xx)
AP (1) AP1882A (xx)
AT (1) ATE396180T1 (xx)
AU (1) AU2003278396B2 (xx)
BR (1) BR0315919A (xx)
CA (1) CA2505179C (xx)
DE (1) DE60321208D1 (xx)
EC (1) ECSP055835A (xx)
GB (1) GB2394951A (xx)
HR (1) HRPK20050403B3 (xx)
IS (1) IS7882A (xx)
MA (1) MA27534A1 (xx)
MX (1) MXPA05004815A (xx)
NO (1) NO20052189L (xx)
NZ (1) NZ539953A (xx)
PL (1) PL376543A1 (xx)
PT (1) PT1562921E (xx)
RU (1) RU2305097C2 (xx)
TN (1) TNSN05125A1 (xx)
WO (1) WO2004041797A1 (xx)
ZA (1) ZA200503548B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
WO2006012277A2 (en) * 2004-06-30 2006-02-02 Amr Technology, Inc. Biocatalytic process for preparing enantiomerically enriched pramipexole
EP1761511A1 (en) * 2004-12-06 2007-03-14 Alembic Limited Improved process for the preparation of biologically active tetrahydrobenzthiazole derivative
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
ES2379117T3 (es) 2006-05-16 2012-04-20 Knopp Neurosciences, Inc. Composiciones de R(+) y S(-) pramipexol y métodos de utilización de las mismas
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
SI22446A (sl) * 2007-02-07 2008-08-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli
WO2008104847A2 (en) * 2007-02-26 2008-09-04 Wockhardt Research Centre Processes for the preparation of pramipexole and salts thereof
CA2681110A1 (en) 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
CN101429173B (zh) * 2007-11-09 2012-12-05 重庆医药工业研究院有限责任公司 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢-苯并噻唑的制备方法
KR20110071064A (ko) 2008-08-19 2011-06-28 크놉 뉴로사이언시스 인코포레이티드 (ｒ)-프라미펙솔을 사용하는 조성물 및 방법
WO2011021214A2 (en) * 2009-08-07 2011-02-24 Msn Laboratories Limited Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
EP3838271B1 (en) 2013-07-12 2025-09-03 Areteia Therapeutics, Inc. Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
CA2921381A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
CN104311507A (zh) * 2013-10-09 2015-01-28 安徽万邦医药科技有限公司 (6s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法
CN103613562B (zh) * 2013-11-25 2015-09-30 浙江美诺华药物化学有限公司 一种普拉克索的制备方法
CN107573301B (zh) * 2017-11-08 2020-08-11 江苏长青农化股份有限公司 一种三环唑中间体的制备方法
CN109232471B (zh) * 2018-10-31 2022-05-10 安徽省庆云医药股份有限公司 一种盐酸普拉克索的制备方法
CN111362884A (zh) * 2018-12-26 2020-07-03 江苏神龙药业股份有限公司 一种2,6-二氨基-4,5,6,7-四氢-苯并噻唑的工业化制备方法
CN110734413A (zh) * 2019-12-02 2020-01-31 山东铂源药业有限公司 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186087A1 (de) * 1984-12-22 1986-07-02 Dr. Karl Thomae GmbH Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447075A1 (de) * 1984-12-22 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
DE4241013A1 (de) * 1992-12-05 1994-06-09 Boehringer Ingelheim Kg Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung
ES2187249B1 (es) * 2000-09-18 2004-09-16 Synthon Bv Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186087A1 (de) * 1984-12-22 1986-07-02 Dr. Karl Thomae GmbH Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 2, 1958, pages 64-74 *

Also Published As

Publication number Publication date
ATE396180T1 (de) 2008-06-15
JP4708792B2 (ja) 2011-06-22
RU2005117364A (ru) 2006-02-27
DE60321208D1 (de) 2008-07-03
NO20052189L (no) 2005-06-03
TNSN05125A1 (en) 2007-05-14
MXPA05004815A (es) 2005-08-18
CN100551918C (zh) 2009-10-21
CA2505179A1 (en) 2004-05-21
BR0315919A (pt) 2005-09-20
HRPK20050403B3 (en) 2007-05-31
KR20050072474A (ko) 2005-07-11
ZA200503548B (en) 2006-12-27
EP1562921A1 (en) 2005-08-17
PT1562921E (pt) 2008-06-11
GB0225701D0 (en) 2002-12-11
ECSP055835A (es) 2005-11-22
CN1735604A (zh) 2006-02-15
GB2394951A (en) 2004-05-12
EP1562921B1 (en) 2008-05-21
US7285669B2 (en) 2007-10-23
WO2004041797A1 (en) 2004-05-21
CA2505179C (en) 2012-10-16
US20060100256A1 (en) 2006-05-11
NZ539953A (en) 2007-11-30
PL376543A1 (pl) 2006-01-09
JP2006506412A (ja) 2006-02-23
HRP20050403A2 (en) 2005-12-31
AU2003278396B2 (en) 2010-04-01
IS7882A (is) 2005-06-02
AU2003278396A1 (en) 2004-06-07
AP2005003306A0 (en) 2005-06-30
RU2305097C2 (ru) 2007-08-27
MA27534A1 (fr) 2005-09-01
KR101086844B1 (ko) 2011-11-24

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