AP2002002606A0 - INTERLEUKIN 8 RECEPTOR ANTAGONISTS - Google Patents

INTERLEUKIN 8 RECEPTOR ANTAGONISTS

Info

Publication number: AP2002002606A0
Authority: AP; ARIPO
Prior art keywords: receptor antagonists; chemokine; interleukin; vii; compositions
Prior art date: 2000-03-16

Application number

APAP/P/2002/002606A

Other languages

English (en)

French (fr)

Inventor

Katherine Louisa Widdowson

Qi Jin

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-16

Filing date

2001-03-16

Publication date

2002-09-30

2001-03-16 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2002-09-30 Publication of AP2002002606A0 publication Critical patent/AP2002002606A0/en

Links

102000010681 interleukin-8 receptors Human genes 0.000 title 1
108010038415 interleukin-8 receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
102000004890 Interleukin-8 Human genes 0.000 abstract 2
108090001007 Interleukin-8 Proteins 0.000 abstract 2
102000019034 Chemokines Human genes 0.000 abstract 1
108010012236 Chemokines Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 1
229940096397 interleukin-8 Drugs 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Immunology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)

APAP/P/2002/002606A 2000-03-16 2001-03-16 INTERLEUKIN 8 RECEPTOR ANTAGONISTS AP2002002606A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18984800P	2000-03-16	2000-03-16
PCT/US2001/008672 WO2001068084A1 (en)	2000-03-16	2001-03-16	Il-8 receptor antagonists

Publications (1)

Publication Number	Publication Date
AP2002002606A0 true AP2002002606A0 (en)	2002-09-30

Family

ID=22699008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/2002/002606A AP2002002606A0 (en)	2000-03-16	2001-03-16	INTERLEUKIN 8 RECEPTOR ANTAGONISTS

Country Status (23)

Country	Link
EP (1)	EP1263427A4 (pl)
JP (1)	JP2003526664A (pl)
KR (1)	KR20020091130A (pl)
CN (1)	CN1424910A (pl)
AP (1)	AP2002002606A0 (pl)
AR (1)	AR031098A1 (pl)
AU (1)	AU2001250873A1 (pl)
BG (1)	BG107013A (pl)
BR (1)	BR0108749A (pl)
CA (1)	CA2403062A1 (pl)
CO (1)	CO5280089A1 (pl)
CZ (1)	CZ20023075A3 (pl)
DZ (1)	DZ3317A1 (pl)
EA (1)	EA200200981A1 (pl)
HU (1)	HUP0300470A3 (pl)
MA (1)	MA25659A1 (pl)
MX (1)	MXPA02009094A (pl)
NO (1)	NO20024367L (pl)
OA (1)	OA12231A (pl)
PL (1)	PL366034A1 (pl)
SK (1)	SK13282002A3 (pl)
WO (1)	WO2001068084A1 (pl)
ZA (1)	ZA200207325B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR030689A1 (es) *	2000-03-14	2003-09-03	Smithkline Beecham Corp	Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas
WO2005113534A2 (en)	2004-05-12	2005-12-01	Schering Corporation	Cxcr1 and cxcr2 chemokine antagonists
AU2007240365B2 (en) *	2006-04-21	2011-12-15	Glaxosmithkline Llc	IL-8 receptor antagonists
US8097626B2 (en) *	2006-04-21	2012-01-17	Glaxosmithkline Llc	IL-8 receptor antagonists
CR20160557A (es) *	2014-05-29	2017-01-20	Glaxosmithkline Ip Dev Ltd	Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2
EP3174851A1 (en) *	2014-07-31	2017-06-07	GlaxoSmithKline Intellectual Property Management Limited	Use of cxcr2 antagonists for the prevention and/or treatment of chemotherapy induced peripheral neuropathy (cipn)
CN111727184B (zh)	2018-01-11	2022-06-28	深圳嘉科生物科技有限公司	Cxcr2拮抗剂
US12577235B2 (en)	2019-07-11	2026-03-17	Shenzhen Optimum Biological Technology Co., Ltd	Crystalline form of CXCR2 antagonist and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0809492A4 (en) *	1995-02-17	2007-01-24	Smithkline Beecham Corp	IL-8 RECEPTOR ANTAGONISTS
PL330850A1 (en) *	1996-06-27	1999-06-07	Smithkline Beecham Corp	Antagonists of il-8 receptors
US6214881B1 (en) *	1996-08-21	2001-04-10	Smithkline Beecham Corporation	IL-8 receptor antagonists
KR100642184B1 (ko) *	1998-09-23	2006-11-10	암젠 인크	아릴술폰아닐리드 우레아
UY25842A1 (es) *	1998-12-16	2001-04-30	Smithkline Beecham Corp	Antagonistas de receptores de il-8

2001
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- 2001-03-14 AR ARP010101183A patent/AR031098A1/es unknown
- 2001-03-16 BR BR0108749-5A patent/BR0108749A/pt not_active Application Discontinuation
- 2001-03-16 KR KR1020027012102A patent/KR20020091130A/ko not_active Withdrawn
- 2001-03-16 HU HU0300470A patent/HUP0300470A3/hu unknown
- 2001-03-16 SK SK1328-2002A patent/SK13282002A3/sk unknown
- 2001-03-16 EP EP01924195A patent/EP1263427A4/en not_active Withdrawn
- 2001-03-16 CA CA002403062A patent/CA2403062A1/en not_active Abandoned
- 2001-03-16 EA EA200200981A patent/EA200200981A1/ru unknown
- 2001-03-16 CN CN01806605A patent/CN1424910A/zh active Pending
- 2001-03-16 WO PCT/US2001/008672 patent/WO2001068084A1/en not_active Ceased
- 2001-03-16 JP JP2001566648A patent/JP2003526664A/ja not_active Withdrawn
- 2001-03-16 PL PL01366034A patent/PL366034A1/pl not_active Application Discontinuation
- 2001-03-16 AU AU2001250873A patent/AU2001250873A1/en not_active Abandoned
- 2001-03-16 OA OA1200200289A patent/OA12231A/en unknown
- 2001-03-16 CZ CZ20023075A patent/CZ20023075A3/cs unknown
- 2001-03-16 MX MXPA02009094A patent/MXPA02009094A/es active IP Right Grant
- 2001-03-16 AP APAP/P/2002/002606A patent/AP2002002606A0/en unknown
- 2001-03-16 DZ DZ013317A patent/DZ3317A1/fr active
2002
- 2002-08-20 BG BG107013A patent/BG107013A/bg unknown
- 2002-09-12 ZA ZA200207325A patent/ZA200207325B/en unknown
- 2002-09-12 NO NO20024367A patent/NO20024367L/no unknown
- 2002-09-12 MA MA26815A patent/MA25659A1/fr unknown

Also Published As

Publication number	Publication date
EP1263427A4 (en)	2005-08-24
CO5280089A1 (es)	2003-05-30
EA200200981A1 (ru)	2003-02-27
PL366034A1 (pl)	2005-01-24
BR0108749A (pt)	2004-06-29
CZ20023075A3 (cs)	2003-05-14
NO20024367L (no)	2002-10-22
ZA200207325B (en)	2003-10-17
MXPA02009094A (es)	2003-03-12
BG107013A (bg)	2003-05-30
SK13282002A3 (sk)	2003-02-04
DZ3317A1 (pl)	2001-09-20
HUP0300470A2 (hu)	2003-06-28
CN1424910A (zh)	2003-06-18
JP2003526664A (ja)	2003-09-09
WO2001068084A1 (en)	2001-09-20
HUP0300470A3 (en)	2005-05-30
AR031098A1 (es)	2003-09-10
EP1263427A1 (en)	2002-12-11
CA2403062A1 (en)	2001-09-20
MA25659A1 (fr)	2002-12-31
NO20024367D0 (no)	2002-09-12
AU2001250873A1 (en)	2001-09-24
KR20020091130A (ko)	2002-12-05
OA12231A (en)	2003-11-07

Publication	Publication Date	Title
BG105661A (en)	2002-02-28	Hydroxy diphenylurea sulfonamides as il-8 receptor antagonists
EP1357909A4 (en)	2006-01-04	ANTAGONISTS OF IL-8 RECEPTORS
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JO2796B1 (en)	2014-03-15	Antiallergic drugs IL-8
TR199900318T2 (xx)	1999-05-21	IL-8 resept�r antagonistleri.
WO2005000231A3 (en)	2005-05-12	Il-8 receptor antagonists
AP2002002605A0 (en)	2002-09-30	Il-8 receptor antagonists
AP1548A (en)	2006-01-16	Il-8 Receptor Antagonists.
WO2001068569A3 (en)	2002-04-18	Il-8 receptor antagonists
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MY143477A (en)	2011-05-31	Il-8 receptor antagonists
HK1045257A1 (zh)	2002-11-22	Il-8受体拮抗剂
WO2001076530A3 (en)	2002-02-28	Il-8 receptor antagonists
WO2001068033A3 (en)	2002-03-07	Il-8 receptor antagonists
BR0108749A (pt)	2004-06-29	Antagonistas de receptor il-8
WO2001064165A3 (en)	2002-03-21	Il-8 receptor antagonists
HK1045256A1 (zh)	2002-11-22	Il-8受体拮抗剂
WO2000072800A3 (en)	2001-03-08	Il-8 receptor antagonists
WO2001068570A3 (en)	2002-04-18	Il-8 receptor antagonists
HK1044475A1 (zh)	2002-10-25	Il-8受体拮抗剂
NZ515232A (en)	2004-02-27	IL-8 receptor antagonists
TR200100219T2 (tr)	2001-06-21	IL-8 Reseptörü Antagonistleri
AP2001002178A0 (en)	2001-06-15	IL-8 receptor antagonists.
ECSP003529A (es)	2002-01-25	Antagonistas del receptor de il - 8 vii
ECSP982589A (es)	1999-04-13	Antagonistas de un receptor de il- 8''