AP2005003248A0 - 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as reverse transcriptase modulators in the treatment of I. A. HIV. - Google Patents
4-(3,5-dicyanophenoxy) pyrazole derivatives for use as reverse transcriptase modulators in the treatment of I. A. HIV.Info
- Publication number
- AP2005003248A0 AP2005003248A0 AP2005003248A AP2005003248A AP2005003248A0 AP 2005003248 A0 AP2005003248 A0 AP 2005003248A0 AP 2005003248 A AP2005003248 A AP 2005003248A AP 2005003248 A AP2005003248 A AP 2005003248A AP 2005003248 A0 AP2005003248 A0 AP 2005003248A0
- Authority
- AP
- ARIPO
- Prior art keywords
- dicyanophenoxy
- hiv
- treatment
- reverse transcriptase
- pyrazole derivatives
- Prior art date
Links
- QBKFBPAFNXUTDK-UHFFFAOYSA-N 5-(1h-pyrazol-4-yloxy)benzene-1,3-dicarbonitrile Chemical class N#CC1=CC(C#N)=CC(OC2=CNN=C2)=C1 QBKFBPAFNXUTDK-UHFFFAOYSA-N 0.000 title 1
- 102100034343 Integrase Human genes 0.000 title 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/29—Saturated compounds containing keto groups bound to rings
- C07C49/293—Saturated compounds containing keto groups bound to rings to a three- or four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/29—Saturated compounds containing keto groups bound to rings
- C07C49/327—Saturated compounds containing keto groups bound to rings containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221477.3A GB0221477D0 (en) | 2002-09-16 | 2002-09-16 | Chemical compounds |
| GBGB0223354.2A GB0223354D0 (en) | 2002-09-16 | 2002-10-08 | Chemical compounds |
| PCT/IB2003/003946 WO2004024147A1 (en) | 2002-09-16 | 2003-09-08 | 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as transcriptase modulators in the treatment of i.a. hiv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AP2005003248A0 true AP2005003248A0 (en) | 2005-03-31 |
Family
ID=31995706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2005003248A AP2005003248A0 (en) | 2002-09-16 | 2003-09-08 | 4-(3,5-dicyanophenoxy) pyrazole derivatives for use as reverse transcriptase modulators in the treatment of I. A. HIV. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1542679B1 (pl) |
| JP (1) | JP2006504792A (pl) |
| KR (1) | KR20050043962A (pl) |
| CN (1) | CN1681494A (pl) |
| AP (1) | AP2005003248A0 (pl) |
| AU (1) | AU2003263422A1 (pl) |
| BR (1) | BR0314243A (pl) |
| CA (1) | CA2496315A1 (pl) |
| DE (1) | DE60311284T2 (pl) |
| EA (1) | EA200500287A1 (pl) |
| EC (1) | ECSP055673A (pl) |
| GB (2) | GB0221477D0 (pl) |
| HR (1) | HRP20050222A2 (pl) |
| IS (1) | IS7705A (pl) |
| MA (1) | MA27435A1 (pl) |
| MX (1) | MXPA05002963A (pl) |
| NO (1) | NO20051833L (pl) |
| OA (1) | OA12920A (pl) |
| PL (1) | PL375976A1 (pl) |
| WO (1) | WO2004024147A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080132549A1 (en) * | 2004-04-14 | 2008-06-05 | Pfizer Inc. | Sulphur-Linked Imidazone Compounds for the Treatment of Hiv/Aids |
| DE102008015033A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3303200A (en) * | 1963-11-05 | 1967-02-07 | American Home Prod | Pyrazole-1-ethanol derivatives |
| GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| EE05400B1 (et) * | 2001-04-10 | 2011-04-15 | Pfizer Inc. | Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks |
-
2002
- 2002-09-16 GB GBGB0221477.3A patent/GB0221477D0/en not_active Ceased
- 2002-10-08 GB GBGB0223354.2A patent/GB0223354D0/en not_active Ceased
-
2003
- 2003-09-08 OA OA1200500067A patent/OA12920A/en unknown
- 2003-09-08 DE DE60311284T patent/DE60311284T2/de not_active Expired - Fee Related
- 2003-09-08 AU AU2003263422A patent/AU2003263422A1/en not_active Abandoned
- 2003-09-08 EA EA200500287A patent/EA200500287A1/ru unknown
- 2003-09-08 HR HR20050222A patent/HRP20050222A2/hr not_active Application Discontinuation
- 2003-09-08 CN CNA038219603A patent/CN1681494A/zh active Pending
- 2003-09-08 PL PL03375976A patent/PL375976A1/pl not_active Application Discontinuation
- 2003-09-08 MX MXPA05002963A patent/MXPA05002963A/es unknown
- 2003-09-08 BR BR0314243-4A patent/BR0314243A/pt not_active IP Right Cessation
- 2003-09-08 AP AP2005003248A patent/AP2005003248A0/xx unknown
- 2003-09-08 JP JP2004571926A patent/JP2006504792A/ja not_active Withdrawn
- 2003-09-08 EP EP03795160A patent/EP1542679B1/en not_active Expired - Lifetime
- 2003-09-08 WO PCT/IB2003/003946 patent/WO2004024147A1/en not_active Ceased
- 2003-09-08 KR KR1020057004426A patent/KR20050043962A/ko not_active Ceased
- 2003-09-08 CA CA002496315A patent/CA2496315A1/en not_active Abandoned
-
2005
- 2005-02-21 IS IS7705A patent/IS7705A/is unknown
- 2005-03-14 EC EC2005005673A patent/ECSP055673A/es unknown
- 2005-03-16 MA MA28148A patent/MA27435A1/fr unknown
- 2005-04-15 NO NO20051833A patent/NO20051833L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0221477D0 (en) | 2002-10-23 |
| EP1542679B1 (en) | 2007-01-17 |
| MA27435A1 (fr) | 2005-07-01 |
| BR0314243A (pt) | 2005-07-26 |
| DE60311284T2 (de) | 2007-06-21 |
| WO2004024147A1 (en) | 2004-03-25 |
| JP2006504792A (ja) | 2006-02-09 |
| CN1681494A (zh) | 2005-10-12 |
| PL375976A1 (pl) | 2005-12-12 |
| NO20051833L (no) | 2005-06-14 |
| MXPA05002963A (es) | 2005-05-27 |
| CA2496315A1 (en) | 2004-03-25 |
| DE60311284D1 (de) | 2007-03-08 |
| IS7705A (is) | 2005-02-21 |
| EA200500287A1 (ru) | 2005-10-27 |
| KR20050043962A (ko) | 2005-05-11 |
| AU2003263422A1 (en) | 2004-04-30 |
| GB0223354D0 (en) | 2002-11-13 |
| HRP20050222A2 (en) | 2005-10-31 |
| ECSP055673A (es) | 2005-07-06 |
| EP1542679A1 (en) | 2005-06-22 |
| OA12920A (en) | 2006-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2004021968A3 (en) | Solution for ungual application | |
| EG25011A (en) | Amino-piperidin-1-yl-xanthines, the production thereof and the use of the same as medicaments. | |
| PL375551A1 (pl) | Pochodne pirazolowe, kompozycja lecznicza zawierająca te pochodne, ich lecznicze zastosowanie oraz produkty pośrednie do ich wytwarzania | |
| IL191790A0 (en) | Xanthine derivatives, production and use thereof as a medicament | |
| AU2003262262A1 (en) | Pyrazole derivatives, medicinal composition containing the same, and medicinal use thereof | |
| HRP20020968A2 (en) | Acylphenyl urea derivatives, methods for the production therof and use thereof as a medicament | |
| AU2003212282A1 (en) | Cdk inhibiting 2-heteroaryl pyrimidine, the production thereof, and use thereof as a medicament | |
| AU2001262318A1 (en) | Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament | |
| WO2003037864A1 (en) | Indole compound and medicinal use thereof | |
| WO2004072031A3 (en) | Phenylacetamides and their use as glucokinase modulators | |
| SI2308855T1 (sl) | 2,4-diaminopirimidinski derivati | |
| IL160707A0 (en) | 1, 8-naphthyridine derivatives as antidiabetics | |
| AU2002234640A1 (en) | Xanthine derivative, production and use thereof as a medicament | |
| AP2006003517A0 (en) | Hiv replication purine derivatives. | |
| ZA200104196B (en) | Azepinoindole derivatives, the production and use thereof. | |
| AP2006003514A0 (en) | Piperazine derivatives for the treatment of HIV infections. | |
| EP1577317A4 (en) | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, MEDICINAL COMPOSITIONS COMPRISING SAID DERIVATIVES AND MEDICAL USE OF SAID DERIVATIVES | |
| IL162669A0 (en) | Antichlinergic agents, method for producing the same and use thereof as medicaments | |
| DK1377556T3 (da) | Pyrazolderivater til behandling af HIV | |
| AU2003219100A1 (en) | Pyrazolopyridazine derivatives, process for preparation and use for the inhibition of gsk-3 | |
| AU2003243765A1 (en) | 2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors | |
| AU2003258145A1 (en) | Substituted phenylindoles for the treatment of hiv | |
| AP2006003688A0 (en) | 1,3-dioxane derivatives and analogues thereof useful in the treatment of I.A obesity and diabetes | |
| PL375976A1 (pl) | Pochodne 4-(3,5-dicyjanofenoksy)pirazolu do stosowania jako modulatory transkryptazy do leczenia m.in. HIV | |
| DK1532141T3 (da) | 2-pyrrolidin-2-yl-[1,3,4]-oxadiazol-derivater og anvendelse deraf som antidepressiv |