AP2006003552A0 - N3 - substituted imidazopyridine C-kit inhibitors. - Google Patents

N3 - substituted imidazopyridine C-kit inhibitors.

Info

Publication number: AP2006003552A0
Authority: AP; ARIPO
Prior art keywords: kit inhibitors; substituted imidazopyridine; imidazopyridine; substituted; inhibitors
Prior art date: 2003-08-21

Application number

AP2006003552A

Other languages

English (en)

Inventor

Han-Qing Dong

An-Hu Li

Smith Colin Peter Sambrrok

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-21

Filing date

2004-08-16

Publication date

2006-04-30

2004-08-16 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2006-04-30 Publication of AP2006003552A0 publication Critical patent/AP2006003552A0/xx

Links

102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 title 1
-1 N3 - substituted imidazopyridine Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Hematology (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2006003552A 2003-08-21 2004-08-16 N3 - substituted imidazopyridine C-kit inhibitors. AP2006003552A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49677603P	2003-08-21	2003-08-21
PCT/US2004/026483 WO2005021544A2 (en)	2003-08-21	2004-08-16	N3-substituted imidazopyridine-derivatives as c-kit inhibitors

Publications (1)

Publication Number	Publication Date
AP2006003552A0 true AP2006003552A0 (en)	2006-04-30

Family

ID=34272515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003552A AP2006003552A0 (en)	2003-08-21	2004-08-16	N3 - substituted imidazopyridine C-kit inhibitors.

Country Status (20)

Country	Link
EP (1)	EP1658289B1 (is)
JP (1)	JP2007502822A (is)
KR (1)	KR20060119871A (is)
CN (1)	CN1839132A (is)
AP (1)	AP2006003552A0 (is)
AR (1)	AR045388A1 (is)
AT (1)	ATE425977T1 (is)
AU (1)	AU2004268950A1 (is)
BR (1)	BRPI0413740A (is)
CA (1)	CA2536174A1 (is)
DE (1)	DE602004020073D1 (is)
IL (1)	IL173615A0 (is)
IS (1)	IS8318A (is)
MX (1)	MXPA06002019A (is)
MY (1)	MY138737A (is)
NO (1)	NO20060670L (is)
RU (1)	RU2006108799A (is)
SG (1)	SG131944A1 (is)
TW (1)	TW200519111A (is)
WO (1)	WO2005021544A2 (is)

Families Citing this family (30)

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HRP20150642T1 (hr)	2006-12-22	2015-08-14	Astex Therapeutics Limited	BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a
GB0625827D0 (en) *	2006-12-22	2007-02-07	Astex Therapeutics Ltd	New compounds
US8513276B2 (en)	2006-12-22	2013-08-20	Astex Therapeutics Limited	Imidazo[1,2-a]pyridine compounds for use in treating cancer
GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0720041D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New Compounds
PT2303270T (pt)	2008-05-05	2017-08-25	Sanofi Sa	Derivados fundidos do ácido ciclopentanocarboxílico substituídos por acilamino e sua utilização como produtos farmacêuticos
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
BRPI0917540A2 (pt) *	2008-08-05	2015-11-17	Daiichi Sankyo Co Ltd	composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável
US20110190336A1 (en) *	2008-10-16	2011-08-04	Cara Therapeutics, Inc.	Azabenzimidazolones
WO2010099139A2 (en)	2009-02-25	2010-09-02	Osi Pharmaceuticals, Inc.	Combination anti-cancer therapy
WO2010099138A2 (en)	2009-02-27	2010-09-02	Osi Pharmaceuticals, Inc.	Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099364A2 (en)	2009-02-27	2010-09-02	Osi Pharmaceuticals, Inc.	Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099363A1 (en)	2009-02-27	2010-09-02	Osi Pharmaceuticals, Inc.	Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
AR079022A1 (es)	2009-11-02	2011-12-21	Sanofi Aventis	Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
CA2785536C (en) *	2009-12-30	2018-02-27	Arqule, Inc.	Substituted imidazopyridinyl-aminopyridine compounds
WO2012149014A1 (en)	2011-04-25	2012-11-01	OSI Pharmaceuticals, LLC	Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
US8609688B2 (en) *	2011-06-24	2013-12-17	Arqule, Inc.	Substituted imidazopyridinyl-aminopyridine compounds
WO2013152252A1 (en)	2012-04-06	2013-10-10	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
MX365640B (es)	2012-12-21	2019-06-10	Plexxikon Inc	Compuestos y metodos para la modulacion de quinasas y sus indicaciones.
WO2015148464A1 (en) *	2014-03-24	2015-10-01	Arqule Inc.	Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine
EP3594205A1 (en)	2018-07-09	2020-01-15	Abivax	Phenyl-n-aryl derivatives for treating a rna virus infection
EP3594206A1 (en)	2018-07-09	2020-01-15	Abivax	Phenyl-n-quinoline derivatives for treating a rna virus infection
EA202192575A1 (ru)	2019-03-21	2022-01-14	Онксео	Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh)	2019-11-08	2022-07-15	Inserm(法国国家健康医学研究院)	对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
WO2021222442A1 (en)	2020-04-29	2021-11-04	Plexxikon Inc.	Synthesis of heterocyclic compounds
TW202428265A (zh) *	2022-11-30	2024-07-16	日商亞力維克希斯股份有限公司	Kit抑制劑、化合物、醫藥組合物、及其使用方法
CN121550254A (zh) *	2026-01-26	2026-02-24	浙江省肿瘤医院	一种提升胰腺癌治疗效果的药物组合物

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DE4129603A1 (de) *	1991-09-06	1993-03-11	Thomae Gmbh Dr K	Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW251284B (is) *	1992-11-02	1995-07-11	Pfizer
AU6966696A (en)	1995-10-05	1997-04-28	Warner-Lambert Company	Method for treating and preventing inflammation and atherosclerosis
US5990146A (en)	1997-08-20	1999-11-23	Warner-Lambert Company	Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation
US6326379B1 (en)	1998-09-16	2001-12-04	Bristol-Myers Squibb Co.	Fused pyridine inhibitors of cGMP phosphodiesterase
US6348032B1 (en)	1998-11-23	2002-02-19	Cell Pathways, Inc.	Method of inhibiting neoplastic cells with benzimidazole derivatives
US6534535B1 (en)	1999-08-12	2003-03-18	Millennium Pharmaceuticals, Inc.	Inhibitors of factor Xa
EP1214330A1 (en)	1999-09-21	2002-06-19	LION Bioscience AG	Benzimidazole derivatives and combinatorial libraries thereof
EP1255750A1 (en)	2000-02-01	2002-11-13	Millenium Pharmaceuticals, Inc.	INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa
WO2003020698A2 (en) *	2001-09-06	2003-03-13	Prochon Biotech Ltd.	Protein tyrosine kinase inhibitors

2004
- 2004-08-16 MX MXPA06002019A patent/MXPA06002019A/es unknown
- 2004-08-16 JP JP2006523956A patent/JP2007502822A/ja active Pending
- 2004-08-16 AU AU2004268950A patent/AU2004268950A1/en not_active Abandoned
- 2004-08-16 BR BRPI0413740-0A patent/BRPI0413740A/pt not_active IP Right Cessation
- 2004-08-16 AP AP2006003552A patent/AP2006003552A0/xx unknown
- 2004-08-16 KR KR1020067003586A patent/KR20060119871A/ko not_active Withdrawn
- 2004-08-16 SG SG200702982-0A patent/SG131944A1/en unknown
- 2004-08-16 RU RU2006108799/04A patent/RU2006108799A/ru not_active Application Discontinuation
- 2004-08-16 WO PCT/US2004/026483 patent/WO2005021544A2/en not_active Ceased
- 2004-08-16 AT AT04781205T patent/ATE425977T1/de not_active IP Right Cessation
- 2004-08-16 CN CNA2004800240419A patent/CN1839132A/zh active Pending
- 2004-08-16 EP EP04781205A patent/EP1658289B1/en not_active Expired - Lifetime
- 2004-08-16 CA CA002536174A patent/CA2536174A1/en not_active Abandoned
- 2004-08-16 DE DE602004020073T patent/DE602004020073D1/de not_active Expired - Lifetime
- 2004-08-20 TW TW093125235A patent/TW200519111A/zh unknown
- 2004-08-20 AR ARP040103009A patent/AR045388A1/es not_active Application Discontinuation
- 2004-08-20 MY MYPI20043423A patent/MY138737A/en unknown
2006
- 2006-02-08 IL IL173615A patent/IL173615A0/en unknown
- 2006-02-10 NO NO20060670A patent/NO20060670L/no not_active Application Discontinuation
- 2006-02-21 IS IS8318A patent/IS8318A/is unknown

Also Published As

Publication number	Publication date
AU2004268950A1 (en)	2005-03-10
BRPI0413740A (pt)	2006-10-24
ATE425977T1 (de)	2009-04-15
TW200519111A (en)	2005-06-16
MY138737A (en)	2009-07-31
NO20060670L (no)	2006-05-12
WO2005021544A2 (en)	2005-03-10
DE602004020073D1 (de)	2009-04-30
MXPA06002019A (es)	2006-05-31
CA2536174A1 (en)	2005-03-10
EP1658289B1 (en)	2009-03-18
AR045388A1 (es)	2005-10-26
IS8318A (is)	2006-02-21
KR20060119871A (ko)	2006-11-24
IL173615A0 (en)	2006-07-05
JP2007502822A (ja)	2007-02-15
CN1839132A (zh)	2006-09-27
WO2005021544A3 (en)	2005-06-16
EP1658289A2 (en)	2006-05-24
RU2006108799A (ru)	2006-07-27
SG131944A1 (en)	2007-05-28

Publication	Publication Date	Title
AP2006003552A0 (en)	2006-04-30	N3 - substituted imidazopyridine C-kit inhibitors.
AP2006003553A0 (en)	2006-04-30	N-substituted pyrazolyl-amidyl-benzimidazolyl C- kit inhibitors.
AP2006003549A0 (en)	2006-04-30	N-substituted benzimidazolyl C-kit inhibitors.
EG24774A (en)	2010-08-19	Quinoline derivatives as phosphodiesterase inhibitors.
IL196021A0 (en)	2009-02-11	Pyrazolopyridine derivatives uses
EP1539763A4 (en)	2007-08-01	Azaindole KINASE INHIBITORS
SI1697356T1 (sl)	2008-06-30	Pirido(2,3-d)pirimidin-2,4-diamini kot zaviralci PDE 2
IL164958A0 (en)	2005-12-18	Carbamate-substituted pyrazolopyridines
AP2005003353A0 (en)	2005-09-30	Diazepinoindole derivatives as kinase inhibitors.
IL173381A0 (en)	2006-06-11	2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
AP2321A (en)	2011-11-16	Quinoline derivatives for use as mycobactrial inhibitor.
AP2006003483A0 (en)	2006-02-28	Nicotinamide derivatives useful as PDE4 inhibitors.
EP1622615A4 (en)	2009-02-18	INHIBITORS OF THE INTEGRASE OF NAPHTHYRIDINE
IL164898A0 (en)	2005-12-18	Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
GB0311195D0 (en)	2003-06-18	Glyoxalase inhibitors
IL178774A0 (en)	2007-02-11	Imidazopyridine compound
GB0318913D0 (en)	2003-09-17	Apoptosis inhibitors
ZA200507861B (en)	2008-08-27	Imidazopyridine intermediates
GB0312619D0 (en)	2003-07-09	Complement inhibitors
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
HK1091741A (en)	2007-01-26	3-substituted imidazopyridine-derivatives as c-kit inhibitors
ZA200500496B (en)	2006-08-30	Azaindole kinase inhibitors
GB0329869D0 (en)	2004-01-28	Inhibitors
GB0300607D0 (en)	2003-02-12	Inhibitors
HK1091765A (en)	2007-01-26	N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors